Functional connectivity density alterations in schizophrenia

Frontiers in Behavioral Neuroscience

Volumn 8, Issue NOV, 2014, Pages

  Zhuo, Chuanjun ^a,b,c   Zhu, Jiajia ^a   Qin, Wen ^a   Qu, Hongru ^c   Ma, Xiaolei ^c   Tian, Hongjun ^b   Xu, Qingying ^c   Yu, Chunshui ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b SHANDONG MENTAL HEALTH CENTER   (China)

^c PR China   (China)

Author keywords

Functional connectivity density; Functional connectivity strength; Functional magnetic resonance imaging; Resting state; Schizophrenia

Indexed keywords

CHLORPROMAZINE; NEUROLEPTIC AGENT;

ADULT; AGE DISTRIBUTION; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE DURATION; DISEASE SEVERITY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCIPITAL CORTEX; PARIETAL CORTEX; RESTING STATE FUNCTIONAL CONNECTIVITY DENSITY; RIGHT OCCIPITAL CORTEX; SCHIZOPHRENIA; SENSORIMOTOR CORTEX; SEX DIFFERENCE;

EID: 84979941526     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2014.00404     Document Type: Article

References (56)

1. Abi-Dargham, A., and Moore, H. (2003). Prefrontal DA transmission at D1 receptors and the pathology of schizophrenia. Neuroscientist 9, 404-416. doi: 10.1177/1073858403252674
2. Argyelan, M., Ikuta, T., DeRosse, P., Braga, R. J., Burdick, K. E., John, M., et al. (2014). Resting-state FMRI connectivity impairment in schizophrenia and bipolar disorder. Schizophr. Bull. 40, 100-110. doi: 10.1093/schbul/sbt092
3. Biswal, B., Yetkin, F. Z., Haughton, V. M., and Hyde, J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn. Reson. Med. 34, 537-541. doi: 10.1002/mrm.1910340409
4. Calderone, D. J., Hoptman, M. J., Martinez, A., Nair-Collins, S., Mauro, C. J., Bar, M., et al. (2013). Contributions of low and high spatial frequency processing to impaired object recognition circuitry in schizophrenia. Cereb. Cortex 23, 1849-1858. doi: 10.1093/cercor/bhs169
5. Chua, S. E., Deng, Y., Chen, E. Y., Law, C. W., Chiu, C. P., Cheung, C., et al. 2009. Early striatal hypertrophy in first-episode psychosis within 3 weeks of initiating antipsychotic drug treatment. Psychol. Med. 39, 793-800. doi: 10.1017/S0033291708004212
6. Collin, G., Hulshoff Pol, H. E., Haijma, S. V., Cahn, W., Kahn, R. S., and van den Heuvel, M. P. (2011). Impaired cerebellar functional connectivity in schizophrenia patients and their healthy siblings. Front. Psychiatry 2:73. doi: 10.3389/fpsyt.2011.00073
7. Damaraju, E., Allen, E. A., Belger, A., Ford, J. M., McEwen, S., Mathalon, D. H., et al. (2014). Dynamic functional connectivity analysis reveals transient states of dysconnectivity in schizophrenia. Neuroimage Clin. 5, 298-308. doi: 10.1016/j.nicl.2014.07.003
8. Davis, K. L., Kahn, R. S., Ko, G., and Davidson, M. (1991). Dopamine in schizophrenia: a review and reconceptualization. Am. J. Psychiatry 148, 1474-1486.
9. Epstein, J., Stern, E., and Silbersweig, D. (1999). Mesolimbic activity associated with psychosis in schizophrenia. Symptom-specific PET studies. Ann. N.Y. Acad. Sci. 877, 562-574. doi: 10.1111/j.1749-6632.1999.tb09289.x
10. Gardner, D. M., Murphy, A. L., O’Donnell, H., Centorrino, F., and Baldessarini, R. J. 2009. International consensus study of antipsychotic dosing. Am. J. Psychiatry 167, 686-693. doi: 10.1176/appi.ajp.2009.09060802
11. Goldman-Rakic, P. S., Castner, S. A., Svensson, T. H., Siever, L. J., and Williams, G. V. (2004). Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology (Berl.) 174, 3-16. doi: 10.1007/s00213-004-1793-y
12. Grace, A. A. (2012). Dopamine system dysregulation by the hippocampus: implications for the pathophysiology and treatment of schizophrenia. Neuropharmacology 62, 1342-1348. doi: 10.1016/j.neuropharm.2011.05.011
13. Gustavsson, A., Svensson, M., Jacobi, F., Allgulander, C., Alonso, J., Beghi, E., et al. (2011). Cost of disorders of the brain in Europe 2010. Eur. Neuropsychopharmacol. 21, 718-779. doi: 10.1016/j.euroneuro.2011.08.008
14. Hoffman, R. E., Fernandez, T., Pittman, B., and Hampson, M. (2011). Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia. Biol. Psychiatry 69, 407-414. doi: 10.1016/j.biopsych.2010.09.050
15. Hoptman, M. J., Zuo, X. N., Butler, P. D., Javitt, D. C., D’Angelo, D., Mauro, C. J., et al. (2010). Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study. Schizophr. Res. 117, 13-20. doi: 10.1016/j.schres.2009.09.030
16. Howes, O. D., and Kapur, S. (2009). The dopamine hypothesis of schizophrenia: version III-the final common pathway. Schizophr. Bull. 35, 549-562. doi: 10.1093/schbul/sbp006
17. Karbasforoushan, H., and Woodward, N. D. (2012). Resting-state networks in schizophrenia. Curr. Top. Med. Chem. 12, 2404-2414. doi: 10.2174/156802612805289863
18. Klingner, C. M., Langbein, K., Dietzek, M., Smesny, S., Witte, O. W., Sauer, H., et al. (2014). Thalamocortical connectivity during resting state in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 264, 111-119. doi: 10.1007/s00406-013-0417-0
19. Koch, K., Rus, O. G., Reess, T. J., Schachtzabel, C., Wagner, G., Schultz, C. C., et al. (2014). Functional connectivity and grey matter volume of the striatum in schizophrenia. Br. J. Psychiatry 205, 204-213. doi: 10.1192/bjp.bp.113.138099
20. Kraguljac, N. V., White, D. M., Hadley, J., Reid, M. A., and Lahti, A.C (2014). Hippocampal-parietal dysconnectivity and glutamate abnormalities in unmedicated patients with schizophrenia. Hippocampus. doi: 10.1002/hipo.22332.[Epub ahead of print]
21. Laruelle, M. (2014). Schizophrenia: from dopaminergic to glutamatergic interventions. Curr. Opin. Pharmacol. 14, 97-102. doi: 10.1016/j.coph.2014.01.001
22. Liang, M., Zhou, Y., Jiang, T., Liu, Z., Tian, L., Liu, H., et al. (2006). Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging. Neuroreport 17, 209-213. doi: 10.1097/01.wnr.0000198434.06518.b8
23. Liu, H., Liu, Z., Liang, M., Hao, Y., Tan, L., Kuang, F., et al. (2006). Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study. Neuroreport 17, 19-22. doi: 10.1097/01.wnr.0000195666.22714.35
24. Liu, H., Tang, Y., Womer, F., Fan, G., Lu, T., Driesen, N., et al. (2014). Differentiating patterns of amygdala-frontal functional connectivity in schizophrenia and bipolar disorder. Schizophr. Bull. 40, 469-477. doi: 10.1093/schbul/sbt044
25. Liu, J., Qiu, M., Constable, R. T., and Wexler, B. E. (2012). Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophr. Res. 140, 143-148. doi: 10.1016/j.schres.2012.06.028
26. Malaspina, D., Harkavy-Friedman, J., Corcoran, C., Mujica-Parodi, L., Printz, D., Gorman, J. M., et al. (2004). Resting neural activity distinguishes subgroups of schizophrenia patients. Biol. Psychiatry 56, 931-937. doi: 10.1016/j.biopsych.2004.09.013
27. Moran, L. V., Tagamets, M. A., Sampath, H., O’Donnell, A., Stein, E. A., Kochunov, P., et al. (2013). Disruption of anterior insula modulation of large-scale brain networks in schizophrenia. Biol. Psychiatry 74, 467-474. doi: 10.1016/j.biopsych.2013.02.029
28. Onitsuka, T., McCarley, R. W., Kuroki, N., Dickey, C. C., Kubicki, M., Demeo, S. S., et al. (2007). Occipital lobe gray matter volume in male patients with chronic schizophrenia: a quantitative MRI study. Schizophr. Res. 92, 197-206. doi: 10.1016/j.schres.2007.01.027
29. Orliac, F., Naveau, M., Joliot, M., Delcroix, N., Razafimandimby, A., Brazo, P., et al. (2013). Links among resting-state default-mode network, salience network, and symptomatology in schizophrenia. Schizophr. Res. 148, 74-80. doi: 10.1016/j.schres.2013.05.007
30. Perez-Costas, E., Melendez-Ferro, M., and Roberts, R. C. (2010). Basal ganglia pathology in schizophrenia: dopamine connections and anomalies. J. Neurochem. 113, 287-302. doi: 10.1111/j.1471-4159.2010.06604.x
31. Pinkham, A., Loughead, J., Ruparel, K., Wu, W. C., Overton, E., Gur, R., et al. 2009. Resting quantitative cerebral blood flow in schizophrenia measured by pulsed arterial spin labeling perfusion MRI. Psychiatry Res. 194, 64-72. doi: 10.1016/j.pscychresns.2011.06.013
32. Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., and Petersen, S.C (2012). Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59, 2142-2154. doi: 10.1016/j.neuroimage.2011.10.018
33. Ren, W., Lui, S., Deng, W., Li, F., Li, M., Huang, X., et al. (2013). Anatomical and functional brain abnormalities in drug-naive first-episode schizophrenia. Am. J. Psychiatry 170, 1308-1316. doi: 10.1176/appi.ajp.2013.12091148
34. Rubinov, M., and Bullmore, E. (2013). Schizophrenia and abnormal brain network hubs. Dialogues Clin. Neurosci. 15, 339-349.
35. Salvador, R., Sarro, S., Gomar, J. J., Ortiz-Gil, J., Vila, F., Capdevila, A., et al. (2010). Overall brain connectivity maps show cortico-subcortical abnormalities in schizophrenia. Hum. Brain Mapp. 31, 2003-2014. doi: 10.1002/hbm.20993
36. Scheef, L., Manka, C., Daamen, M., Kuhn, K. U., Maier, W., Schild, H. H., et al. (2010). Resting-state perfusion in nonmedicated schizophrenic patients: a continuous arterial spin-labeling 3.0-T MR study. Radiology 256, 253-260. doi: 10.1148/radiol.10091224
37. Schmauss, C., Haroutunian, V., Davis, K. L., and Davidson, M. (1993). Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 90, 8942-8946. doi: 10.1073/pnas.90.19.8942
38. Shinn, A. K., Baker, J. T., Cohen, B. M., and Ongur, D. (2013). Functional connectivity of left Heschl’s gyrus in vulnerability to auditory hallucinations in schizophrenia. Schizophr. Res. 143, 260-268. doi: 10.1016/j.schres.2012.11.037
39. Spencer, M. D., Moorhead, T. W., McIntosh, A. M., Stanfield, A. C., Muir, W. J., Hoare, P., et al. (2007). Grey matter correlates of early psychotic symptoms in adolescents at enhanced risk of psychosis: a voxel-based study. Neuroimage 35, 1181-1191. doi: 10.1016/j.neuroimage.2007.01.008
40. Tang, Y., Wang, L., Cao, F., and Tan, L. (2012). Identifyschizophreniausing resting- state functional connectivity: an exploratoryresearch and analysis. Biomed. Eng. Online 11, 50. doi: 10.1186/1475-925X-11-50
41. Tian, T., Qin, W., Liu, B., Jiang, T., and Yu, C. (2013). Functional connectivity in healthy subjects is nonlinearly modulated by the COMT and DRD2 polymorphisms in a functional system-dependent manner. J. Neurosci. 33, 17519-17526. doi: 10.1523/JNEUROSCI.2163-13.2013
42. Tomasi, D., and Volkow, N. D. (2010). Functional connectivity density mapping. Proc. Natl. Acad. Sci. U.S.A. 107, 9885-9890. doi: 10.1073/pnas.1001414107
43. Tomasi, D., and Volkow, N. D. (2011a). Association between functional connectivity hubs and brain networks. Cereb. Cortex 21, 2003-2013. doi: 10.1093/cer-cor/bhq268
44. Tomasi, D., andVolkow, N. D. (2011b). Functional connectivityhubs in the human brain. Neuroimage 57, 908-917. doi: 10.1016/j.neuroimage.2011.05.024
45. Tomasi, D., and Volkow, N. D. (2012a). Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder. Biol. Psychiatry 71, 443-450. doi: 10.1016/j.biopsych.2011.11.003
46. Tomasi, D., and Volkow, N. D. (2012b). Aging and functional brain networks. Mol. Psychiatry 17, 471, 549-458. doi: 10.1038/mp.2011.81
47. Tomasi, D., and Volkow, N. D. (2014). Mapping small-world properties through development in the human brain: disruption in schizophrenia. PLoS ONE 9:e96176. doi: 10.1371/journal.pone.0096176
48. Turner, J. A., Damaraju, E., van Erp, T. G., Mathalon, D. H., Ford, J. M., Voyvodic, J., et al. (2013). A multi-site resting state fMRI study on the amplitude oflowfrequency fluctuations in schizophrenia. Front. Neurosci. 7:137. doi: 10.3389/fnins.2013.00137
49. van den Heuvel, M. P., Mandl, R. C., Stam, C. J., Kahn, R. S., and Hulshoff Pol, H. E. (2010). Aberrant frontal and temporal complex network structure in schizophrenia: a graph theoretical analysis. J. Neurosci. 30, 15915-15926. doi: 10.1523/JNEUROSCI.2874-10.2010
50. van den Heuvel, M. P., Sporns, O., Collin, G., Scheewe, T., Mandl, R. C., Cahn, W., et al. (2013). Abnormal rich club organization and functional brain dynamics in schizophrenia. JAMA Psychiatry 70, 783-792. doi: 10.1001/jamapsychia-try.2013.1328
51. van Os, J., and Kapur, S. (2009). Schizophrenia. Lancet 374, 635-645. doi: 10.1016/S0140-6736(09)60995-8
52. Venkataraman, A., Whitford, T. J., Westin, C. F., Golland, P., and Kubicki, M. 2009 Whole brain resting state functional connectivity abnormalities in schizophrenia. Schizophr. Res. 139, 7-12. doi: 10.1016/j.schres.2012.04.021
53. Wang, Q., Su, T. P., Zhou, Y., Chou, K. H., Chen, I. Y., Jiang, T., et al. (2012). Anatomical insights into disrupted small-world networks in schizophrenia. Neuroimage 59, 1085-1093. doi: 10.1016/j.neuroimage.2011.09.035
54. Woodward, N. D., Karbasforoushan, H., and Heckers, S. (2012). Thalamocortical dysconnectivity in schizophrenia. Am. J. Psychiatry 169, 1092-1099. doi: 10.1176/appi.ajp.2012.12010056
55. Wynn, J. K., Green, M. F., Engel, S., Korb, A., Lee, J., Glahn, D., et al. (2008). Increased extent of object-selective cortexin schizophrenia. Psychiatry Res. 164, 97-105. doi: 10.1016/j.pscychresns.2008.01.005
56. Yu, R., Hsieh, M. H., Wang, H. L., Liu, C. M., Liu, C. C., Hwang, T. J., et al. Frequency dependent alterations in regional homogeneity of baseline brain activity in schizophrenia. PLoS ONE 8:e57516. doi: 10.1371/journal.pone.0057516