Membrane-anchored human Rab GTPases directly mediate membrane tethering in vitro

Biology Open

Volumn 3, Issue 11, 2014, Pages 1108-1115

  Tamura, Naoki ^a   Mima, Joji ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Liposome; Membrane tethering; Membrane traffic; Rab gtpase; Reconstitution

Indexed keywords

EID: 84979896386     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20149340     Document Type: Article

References (22)

1. Blümer, J., Rey, J., Dehmelt, L., Mazel, T., Wu, Y. W., Bastiaens, P., Goody, R. S. and Itzen, A. (2013). RabGEFs are a major determinant for specific Rab membrane targeting. J. Cell Biol. 200, 287-300.
2. Bonifacino, J. S. and Glick, B. S. (2004). The mechanisms of vesicle budding and fusion. Cell 116, 153-166.
3. Cai, H., Reinisch, K. and Ferro-Novick, S. (2007). Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev. Cell 12, 671-682.
4. Drin, G., Casella, J. F., Gautier, R., Boehmer, T., Schwartz, T. U. and Antonny, B. (2007). A general amphipathic a-helical motif for sensing membrane curvature. Nat. Struct. Mol. Biol. 14, 138-146.
5. Drin, G., Morello, V., Casella, J. F., Gounon, P. and Antonny, B. (2008). Asymmetric tethering of flat and curved lipid membranes by a golgin. Science 320, 670-673.
6. Gerondopoulos, A., Langemeyer, L., Liang, J. R., Linford, A. and Barr, F. A. (2012). BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor. Curr. Biol. 22, 2135-2139.
7. Grosshans, B. L., Ortiz, D. and Novick, P. (2006). Rabs and their effectors: achieving specificity in membrane traffic. Proc. Natl. Acad. Sci. USA 103, 11821-11827.
8. Hickey, C. M. and Wickner, W. (2010). HOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assembly. Mol. Biol. Cell 21,2297-2305.
9. Hutagalung, A. H. and Novick, P. J. (2011). Role of Rab GTPases in membrane traffic and cell physiology. Physiol. Rev. 91, 119-149.
10. Jahn, R. and Scheller, R. H. (2006). SNAREs - engines for membrane fusion. Nat. Rev. Mol. Cell Biol. 7, 631-643.
11. Lo, S. Y., Brett, C. L., Plemel, R. L., Vignali, M., Fields, S., Gonen, T. and Merz, A. J. (2012). Intrinsic tethering activity of endosomal Rab proteins. Nat. Struct. Mol. Biol. 19, 40-47.
12. Louis-Jeune, C., Andrade-Navarro, M. A. and Perez-Iratxeta, C. (2012).Prediction of protein secondary structure from circular dichroism using theoretically derived spectra. Proteins 80, 374-381.
13. Ohki, S., Düzgüne?, N. and Leonards, K. (1982). Phospholipid vesicle aggregation: effect of monovalent and divalent ions. Biochemistry 21, 2127-2133.
14. Pfeffer, S. R. (1999). Transport-vesicle targeting: tethers before SNAREs. Nat. Cell Biol. 1, E17-E22.
15. Rizo, J. and Südhof, T. C. (2012). The membrane fusion enigma: SNAREs, Sec1/ Munc18 proteins, and their accomplices - guilty as charged? Annu. Rev. Cell Dev. Biol. 28, 279-308.
16. Soldati, T., Shapiro, A. D., Svejstrup, A. B. and Pfeffer, S. R. (1994). Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange. Nature 369, 76-78.
17. Stenmark, H. (2009). Rab GTPases as coordinators of vesicle traffic. Nat. Rev. Mol. Cell Biol. 10, 513-525.
18. Stroupe, C., Hickey, C. M., Mima, J., Burfeind, A. S. and Wickner, W. (2009). Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components. Proc. Natl. Acad. Sci. USA 106, 17626-17633.
19. Ullrich, O., Horiuchi, H., Bucci, C. and Zerial, M. (1994). Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange. Nature 368, 157-160.
20. Ungermann, C., Sato, K. and Wickner, W. (1998). Defining the functions of trans-SNARE pairs. Nature 396, 543-548.
21. Wickner, W. (2010). Membrane fusion: five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuoles. Annu. Rev. Cell Dev. Biol. 26, 115-136.
22. Yu, I. M. and Hughson, F. M. (2010). Tethering factors as organizers of intracellular vesicular traffic. Annu. Rev. Cell Dev. Biol. 26, 137-156.