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Volumn 6, Issue , 2016, Pages

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CD147 ANTIGEN; IMMUNOGLOBULIN G; MALARIA VACCINE; MONOCLONAL ANTIBODY; RH5 PROTEIN, PLASMODIUM FALCIPARUM;

EID: 84979587974     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep30357     Document Type: Article
Times cited : (54)

References (60)
  • 1
    • 84937422078 scopus 로고    scopus 로고
    • Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: Final results of a phase 3, individually randomised, controlled trial
    • Rts, S. C. T. P. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet 386, 31-45 (2015).
    • (2015) Lancet , vol.386 , pp. 31-45
    • Rts, S.C.T.P.1
  • 2
    • 77952862926 scopus 로고    scopus 로고
    • Blood-stage malaria vaccines-recent progress and future challenges
    • Goodman, A. L. & Draper, S. J. Blood-stage malaria vaccines-recent progress and future challenges. Ann Trop Med Parasitol 104, 189-211 (2010).
    • (2010) Ann Trop Med Parasitol , vol.104 , pp. 189-211
    • Goodman, A.L.1    Draper, S.J.2
  • 3
    • 84927725516 scopus 로고    scopus 로고
    • Toward the development of effective transmission-blocking vaccines for malaria
    • Nikolaeva, D., Draper, S. J. & Biswas, S. Toward the development of effective transmission-blocking vaccines for malaria. Expert. Rev. Vaccines, 1-28 (2015).
    • (2015) Expert. Rev. Vaccines , pp. 1-28
    • Nikolaeva, D.1    Draper, S.J.2    Biswas, S.3
  • 4
    • 76749133362 scopus 로고    scopus 로고
    • Extreme polymorphism in a vaccine antigen and risk of clinical malaria: Implications for vaccine development
    • Takala, S. L. et al. Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine development. Sci. Transl. Med. 1, 2ra5 (2009).
    • (2009) Sci. Transl. Med. , vol.1 , pp. 2ra5
    • Takala, S.L.1
  • 5
    • 84897450410 scopus 로고    scopus 로고
    • Plasmodium falciparum erythrocyte invasion: Combining function with immune evasion
    • Wright, G. J. & Rayner, J. C. Plasmodium falciparum erythrocyte invasion: combining function with immune evasion. PLoS Pathog 10, e1003943 (2014).
    • (2014) PLoS Pathog , vol.10
    • Wright, G.J.1    Rayner, J.C.2
  • 6
    • 0023143240 scopus 로고
    • Kinetic constraints on the development of a malaria vaccine
    • Saul, A. Kinetic constraints on the development of a malaria vaccine. Parasite Immunol. 9, 1-9 (1987).
    • (1987) Parasite Immunol. , vol.9 , pp. 1-9
    • Saul, A.1
  • 7
    • 84455194899 scopus 로고    scopus 로고
    • The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
    • Douglas, A. D. et al. The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody. Nat. Commun. 2, 601 (2011).
    • (2011) Nat. Commun. , vol.2 , pp. 601
    • Douglas, A.D.1
  • 8
    • 80053440948 scopus 로고    scopus 로고
    • An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum
    • Chen, L. et al. An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum. PLoS Pathog 7, e1002199 (2011).
    • (2011) PLoS Pathog , vol.7
    • Chen, L.1
  • 9
    • 84921782696 scopus 로고    scopus 로고
    • Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion
    • Reddy, K. S. et al. Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion. Proc. Natl. Acad. Sci. USA 112, 1179-1184 (2015).
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 1179-1184
    • Reddy, K.S.1
  • 10
    • 84883799054 scopus 로고    scopus 로고
    • Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum
    • Healer, J. et al. Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum. PLoS One 8, e72504 (2013).
    • (2013) PLoS One , vol.8
    • Healer, J.1
  • 11
    • 84924664942 scopus 로고    scopus 로고
    • PfRH5 as a candidate vaccine for Plasmodium falciparum malaria
    • Drew, D. R. & Beeson, J. G. PfRH5 as a candidate vaccine for Plasmodium falciparum malaria. Trends Parasitol 31, 87-88 (2015).
    • (2015) Trends Parasitol , vol.31 , pp. 87-88
    • Drew, D.R.1    Beeson, J.G.2
  • 12
    • 21144469605 scopus 로고    scopus 로고
    • Phase 1 clinical trial of apical membrane antigen 1: An asexual blood-stage vaccine for Plasmodium falciparum malaria
    • Malkin, E. M. et al. Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria. Infect. Immun. 73, 3677-3685 (2005).
    • (2005) Infect. Immun. , vol.73 , pp. 3677-3685
    • Malkin, E.M.1
  • 13
    • 84920932154 scopus 로고    scopus 로고
    • A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys
    • Douglas, A. D. et al. A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys. Cell Host Microbe 17, 130-139 (2015).
    • (2015) Cell Host Microbe , vol.17 , pp. 130-139
    • Douglas, A.D.1
  • 14
    • 33746645179 scopus 로고    scopus 로고
    • Immunity to recombinant plasmodium falciparum merozoite surface protein 1 (MSP1): Protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity
    • Singh, S. et al. Immunity to recombinant plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity. Infect. Immun. 74, 4573-4580 (2006).
    • (2006) Infect. Immun. , vol.74 , pp. 4573-4580
    • Singh, S.1
  • 15
    • 79957837863 scopus 로고    scopus 로고
    • Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT protects against blood-stage challenge in rhesus macaques
    • Mahdi Abdel Hamid, M. et al. Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT protects against blood-stage challenge in rhesus macaques. PLoS One 6, e20547 (2011).
    • (2011) PLoS One , vol.6
    • Mahdi Abdel Hamid, M.1
  • 16
    • 84870778753 scopus 로고    scopus 로고
    • Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens
    • Williams, A. R. et al. Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens. PLoS Pathog 8, e1002991 (2012).
    • (2012) PLoS Pathog , vol.8
    • Williams, A.R.1
  • 17
    • 84871375692 scopus 로고    scopus 로고
    • A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
    • Bustamante, L. Y. et al. A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants. Vaccine 31, 373-379 (2013).
    • (2013) Vaccine , vol.31 , pp. 373-379
    • Bustamante, L.Y.1
  • 18
    • 84890825277 scopus 로고    scopus 로고
    • Bacterially Expressed Full-Length Recombinant Plasmodium falciparum RH5 Protein Binds Erythrocytes and Elicits Potent Strain-Transcending Parasite-Neutralizing Antibodies
    • Reddy, K. S. et al. Bacterially Expressed Full-Length Recombinant Plasmodium falciparum RH5 Protein Binds Erythrocytes and Elicits Potent Strain-Transcending Parasite-Neutralizing Antibodies. Infect. Immun. 82, 152-164 (2014).
    • (2014) Infect. Immun. , vol.82 , pp. 152-164
    • Reddy, K.S.1
  • 19
    • 58549099716 scopus 로고    scopus 로고
    • Reticulocyte-binding protein homologue 5-an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum
    • Baum, J. et al. Reticulocyte-binding protein homologue 5-an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum. Int. J. Parasitol. 39, 371-380 (2009).
    • (2009) Int. J. Parasitol. , vol.39 , pp. 371-380
    • Baum, J.1
  • 20
    • 53249098591 scopus 로고    scopus 로고
    • PfRH5: A novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor
    • Rodriguez, M., Lustigman, S., Montero, E., Oksov, Y. & Lobo, C. A. PfRH5: a novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor. PLoS One 3, e3300 (2008).
    • (2008) PLoS One , vol.3
    • Rodriguez, M.1    Lustigman, S.2    Montero, E.3    Oksov, Y.4    Lobo, C.A.5
  • 21
    • 84355161568 scopus 로고    scopus 로고
    • Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
    • Crosnier, C. et al. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature 480, 534-537 (2011).
    • (2011) Nature , vol.480 , pp. 534-537
    • Crosnier, C.1
  • 22
    • 46949089322 scopus 로고    scopus 로고
    • Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion
    • Hayton, K. et al. Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion. Cell Host Microbe 4, 40-51 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 40-51
    • Hayton, K.1
  • 23
    • 84891084707 scopus 로고    scopus 로고
    • Neutralization of Plasmodium falciparum Merozoites by Antibodies against PfRH5
    • Douglas, A. D. et al. Neutralization of Plasmodium falciparum Merozoites by Antibodies against PfRH5. J. Immunol. 192, 245-258 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 245-258
    • Douglas, A.D.1
  • 24
    • 84943387382 scopus 로고    scopus 로고
    • Analysis of Erythrocyte Invasion Mechanisms of Plasmodium falciparum Clinical Isolates Across 3 Malaria-Endemic Areas in Ghana
    • Mensah-Brown, H. E. et al. Analysis of Erythrocyte Invasion Mechanisms of Plasmodium falciparum Clinical Isolates Across 3 Malaria-Endemic Areas in Ghana. J. Infect. Dis. 212, 1288-1297 (2015).
    • (2015) J. Infect. Dis. , vol.212 , pp. 1288-1297
    • Mensah-Brown, H.E.1
  • 25
    • 84941113488 scopus 로고    scopus 로고
    • Basigin is a druggable target for host-oriented antimalarial interventions
    • Zenonos, Z. A. et al. Basigin is a druggable target for host-oriented antimalarial interventions. J. Exp. Med. 212, 1145-1151 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 1145-1151
    • Zenonos, Z.A.1
  • 26
    • 84894289219 scopus 로고    scopus 로고
    • Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection from Malaria
    • Tran, T. M. et al. Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From Malaria. J. Infect. Dis. 209, 789-798 (2014).
    • (2014) J. Infect. Dis. , vol.209 , pp. 789-798
    • Tran, T.M.1
  • 27
    • 84874724297 scopus 로고    scopus 로고
    • Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats
    • Hayton, K. et al. Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats. Mol. Biochem. Parasitol. 187, 103-110 (2013).
    • (2013) Mol. Biochem. Parasitol. , vol.187 , pp. 103-110
    • Hayton, K.1
  • 28
    • 84890810831 scopus 로고    scopus 로고
    • RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum
    • Wanaguru, M., Liu, W., Hahn, B. H., Rayner, J. C. & Wright, G. J. RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 110, 20735-20740 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 20735-20740
    • Wanaguru, M.1    Liu, W.2    Hahn, B.H.3    Rayner, J.C.4    Wright, G.J.5
  • 29
    • 49149104386 scopus 로고    scopus 로고
    • Effective induction of high-titer antibodies by viral vector vaccines
    • Draper, S. J. et al. Effective induction of high-titer antibodies by viral vector vaccines. Nat. Med. 14, 819-821 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 819-821
    • Draper, S.J.1
  • 30
    • 84890588493 scopus 로고    scopus 로고
    • A library of functional recombinant cell-surface and secreted P. Falciparum merozoite proteins
    • Crosnier, C. et al. A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteins. Molecular & cellular proteomics: MCP 12, 3976-3986 (2013).
    • (2013) Molecular & Cellular Proteomics: MCP , vol.12 , pp. 3976-3986
    • Crosnier, C.1
  • 31
    • 80052680892 scopus 로고    scopus 로고
    • The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus
    • de Cassan, S. C. et al. The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus. J. Immunol. 187, 2602-2616 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 2602-2616
    • De Cassan, S.C.1
  • 32
    • 84950997226 scopus 로고    scopus 로고
    • Recent advances in recombinant protein-based malaria vaccines
    • Draper, S. J. et al. Recent advances in recombinant protein-based malaria vaccines. Vaccine 33, 7433-7443 (2015).
    • (2015) Vaccine , vol.33 , pp. 7433-7443
    • Draper, S.J.1
  • 33
    • 84904914505 scopus 로고    scopus 로고
    • Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria
    • Chiu, C. Y. et al. Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria. Front Microbiol. 5, 314 (2014).
    • (2014) Front Microbiol. , vol.5 , pp. 314
    • Chiu, C.Y.1
  • 34
    • 84888604265 scopus 로고    scopus 로고
    • Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans
    • Patel, S. D. et al. Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. J. Infect. Dis. 208, 1679-1687 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 1679-1687
    • Patel, S.D.1
  • 35
    • 85017305881 scopus 로고    scopus 로고
    • Crystal structure of PfRh5, an essential P. Falciparum ligand for invasion of human erythrocytes
    • Chen, L. et al. Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes. eLife 3, (2014).
    • (2014) ELife , vol.3
    • Chen, L.1
  • 36
    • 84855794722 scopus 로고    scopus 로고
    • Targeting sialic acid dependent and independent pathways of invasion in Plasmodium falciparum
    • Ord, R. L. et al. Targeting sialic acid dependent and independent pathways of invasion in Plasmodium falciparum. PLoS One 7, e30251 (2012).
    • (2012) PLoS One , vol.7
    • Ord, R.L.1
  • 37
    • 84891775537 scopus 로고    scopus 로고
    • Optimising the drosophila s2 expression system for production of therapeutic vaccines
    • Dyring, C. Optimising the Drosophila S2 Expression System for Production of Therapeutic Vaccines. BioProcessing Journal 10, 28-35 (2011).
    • (2011) BioProcessing Journal , vol.10 , pp. 28-35
    • Dyring, C.1
  • 38
    • 70349230744 scopus 로고    scopus 로고
    • The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1
    • Lee, J. & Blaber, M. The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. J. Mol. Biol. 393, 113-127 (2009).
    • (2009) J. Mol. Biol. , vol.393 , pp. 113-127
    • Lee, J.1    Blaber, M.2
  • 39
    • 74049123779 scopus 로고    scopus 로고
    • Characterization of antibody aggregation: Role of buried, unpaired cysteines in particle formation
    • Brych, S. R. et al. Characterization of antibody aggregation: role of buried, unpaired cysteines in particle formation. Journal of pharmaceutical sciences 99, 764-781 (2010).
    • (2010) Journal of Pharmaceutical Sciences , vol.99 , pp. 764-781
    • Brych, S.R.1
  • 40
    • 84911497016 scopus 로고    scopus 로고
    • Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies
    • Wright, K. E. et al. Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies. Nature 515, 427-430 (2014).
    • (2014) Nature , vol.515 , pp. 427-430
    • Wright, K.E.1
  • 42
    • 0036173260 scopus 로고    scopus 로고
    • Drosophila windpipe codes for a leucine-rich repeat protein expressed in the developing trachea
    • Huff, J. L., Kingsley, K. L., Miller, J. M. & Hoshizaki, D. K. Drosophila windpipe codes for a leucine-rich repeat protein expressed in the developing trachea. Mechanisms of development 111, 173-176 (2002).
    • (2002) Mechanisms of Development , vol.111 , pp. 173-176
    • Huff, J.L.1    Kingsley, K.L.2    Miller, J.M.3    Hoshizaki, D.K.4
  • 43
    • 84978689385 scopus 로고    scopus 로고
    • Demonstration of the Blood-Stage Controlled Human Malaria Infection Model to Assess Efficacy of the Plasmodium falciparum AMA1 Vaccine FMP2.1/AS01
    • Payne, R. O. et al. Demonstration of the Blood-Stage Controlled Human Malaria Infection Model to Assess Efficacy of the Plasmodium falciparum AMA1 Vaccine FMP2.1/AS01. J. Infect. Dis. 213, 1743-1751 (2016).
    • (2016) J. Infect. Dis. , vol.213 , pp. 1743-1751
    • Payne, R.O.1
  • 44
    • 67650370079 scopus 로고    scopus 로고
    • Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting plasmodium falciparum growth, as determined by the in vitro growth inhibition assay
    • Miura, K. et al. Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting plasmodium falciparum growth, as determined by the in vitro growth inhibition assay. Clin. Vaccine Immunol. 16, 963-968 (2009).
    • (2009) Clin. Vaccine Immunol. , vol.16 , pp. 963-968
    • Miura, K.1
  • 45
    • 84927173990 scopus 로고    scopus 로고
    • Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial
    • Hodgson, S. H. et al. Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial. Mol. Ther. 22, 2142-2154 (2014).
    • (2014) Mol. Ther. , vol.22 , pp. 2142-2154
    • Hodgson, S.H.1
  • 46
    • 0033118395 scopus 로고    scopus 로고
    • Protein glycosylation in the malaria parasite
    • Gowda, D. C. & Davidson, E. A. Protein glycosylation in the malaria parasite. Parasitol Today 15, 147-152 (1999).
    • (1999) Parasitol Today , vol.15 , pp. 147-152
    • Gowda, D.C.1    Davidson, E.A.2
  • 47
    • 84879543616 scopus 로고    scopus 로고
    • Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development
    • Sampath, S. et al. Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development. PLoS Pathog 9, e1003420 (2013).
    • (2013) PLoS Pathog , vol.9
    • Sampath, S.1
  • 48
    • 84931292044 scopus 로고    scopus 로고
    • Comparative Assessment of Transmission-Blocking Vaccine Candidates against Plasmodium falciparum
    • Kapulu, M. C. et al. Comparative Assessment of Transmission-Blocking Vaccine Candidates against Plasmodium falciparum. Sci. Rep. 5, 11193 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 11193
    • Kapulu, M.C.1
  • 49
    • 77949872891 scopus 로고    scopus 로고
    • Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth
    • Bruder, J. T. et al. Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth. Vaccine 28, 3201-3210 (2010).
    • (2010) Vaccine , vol.28 , pp. 3201-3210
    • Bruder, J.T.1
  • 50
    • 0032532278 scopus 로고    scopus 로고
    • Comparison of humoral immune responses elicited by DNA and protein vaccines based on merozoite surface protein-1 from Plasmodium yoelii, a rodent malaria parasite
    • Kang, Y., Calvo, P. A., Daly, T. M. & Long, C. A. Comparison of humoral immune responses elicited by DNA and protein vaccines based on merozoite surface protein-1 from Plasmodium yoelii, a rodent malaria parasite. J. Immunol. 161, 4211-4219 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 4211-4219
    • Kang, Y.1    Calvo, P.A.2    Daly, T.M.3    Long, C.A.4
  • 51
    • 0037039356 scopus 로고    scopus 로고
    • A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum
    • Stowers, A. W. et al. A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 99, 339-344 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 339-344
    • Stowers, A.W.1
  • 52
    • 84922756512 scopus 로고    scopus 로고
    • Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits
    • Boes, A. et al. Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits. Plant biotechnology journal 13, 222-234 (2015).
    • (2015) Plant Biotechnology Journal , vol.13 , pp. 222-234
    • Boes, A.1
  • 53
    • 21544455223 scopus 로고    scopus 로고
    • Posttranslational modification of recombinant Plasmodium falciparum apical membrane antigen 1: Impact on functional immune responses to a malaria vaccine candidate
    • Giersing, B. et al. Posttranslational modification of recombinant Plasmodium falciparum apical membrane antigen 1: impact on functional immune responses to a malaria vaccine candidate. Infect. Immun. 73, 3963-3970 (2005).
    • (2005) Infect. Immun. , vol.73 , pp. 3963-3970
    • Giersing, B.1
  • 54
    • 84950988936 scopus 로고    scopus 로고
    • Development of pregnancy-associated malaria vaccines using the expres2 insect cell expression system
    • Dyring, C. Development of Pregnancy-Associated Malaria Vaccines Using the ExpreS2 Insect Cell Expression System. Bio. Processing Journal 11, 14-19 (2012).
    • (2012) Bio. Processing Journal , vol.11 , pp. 14-19
    • Dyring, C.1
  • 55
    • 77649270249 scopus 로고    scopus 로고
    • Development of a recombinant tetravalent dengue virus vaccine: Immunogenicity and efficacy studies in mice and monkeys
    • Clements, D. E. et al. Development of a recombinant tetravalent dengue virus vaccine: immunogenicity and efficacy studies in mice and monkeys. Vaccine 28, 2705-2715 (2010).
    • (2010) Vaccine , vol.28 , pp. 2705-2715
    • Clements, D.E.1
  • 56
    • 79954594132 scopus 로고    scopus 로고
    • Proteomic-based identification of CD4-interacting proteins in human primary macrophages
    • Raposo, R. A., Thomas, B., Ridlova, G. & James, W. Proteomic-based identification of CD4-interacting proteins in human primary macrophages. PLoS One 6, e18690 (2011).
    • (2011) PLoS One , vol.6
    • Raposo, R.A.1    Thomas, B.2    Ridlova, G.3    James, W.4
  • 57
    • 3042934967 scopus 로고
    • Tissue sulfhydryl groups
    • Ellman, G. L. Tissue sulfhydryl groups. Arch Biochem Biophys 82, 70-77 (1959).
    • (1959) Arch Biochem Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 58
    • 84860390192 scopus 로고    scopus 로고
    • Phase Ia Clinical Evaluation of the Plasmodium falciparum Blood-stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors
    • Sheehy, S. H. et al. Phase Ia Clinical Evaluation of the Plasmodium falciparum Blood-stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors. Mol. Ther. 19, 2269-2276 (2011).
    • (2011) Mol. Ther. , vol.19 , pp. 2269-2276
    • Sheehy, S.H.1
  • 59
    • 37249043123 scopus 로고    scopus 로고
    • Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines
    • Miura, K. et al. Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines. Vaccine 26, 193-200 (2008).
    • (2008) Vaccine , vol.26 , pp. 193-200
    • Miura, K.1
  • 60
    • 34247849493 scopus 로고    scopus 로고
    • Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo
    • Aoki, K. et al. Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. J. Biol. Chem. 282, 9127-9142 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 9127-9142
    • Aoki, K.1


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