Functional coupling of chloride-proton exchanger ClC-5 to gastric H+,K+-ATPase

Biology Open

Volumn 3, Issue 1, 2014, Pages 12-21

  Takahashi, Yuji ^a   Fujii, Takuto ^a   Fujita, Kyosuke ^a   Shimizu, Takahiro ^a   Higuchi, Taiga ^a   Tabuchi, Yoshiaki ^a   Sakamoto, Hisato ^b   Naito, Ichiro ^c   Manabe, Koji ^d   Uchida, Shinichi ^e   Sasaki, Sei ^e   Ikari, Akira ^f   Tsukada, Kazuhiro ^a   Sakai, Hideki ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d Shigei Medical Research Institute   (Japan)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^f GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

ClC 5; Gastric acid; H+,K+ ATPase; Parietal cell; Tubulovesicle

Indexed keywords

EID: 84979555296     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20136205     Document Type: Article

References (40)

1. - channel in hog gastric vesicles is part of the function of H, K-ATPase. J. Biol. Chem. 262, 13263-13268.
2. +-ATPase. Biochem. J. 299, 59-64.
3. +-ATPase in rat oxyntic mucosa. Biochim. Biophys. Acta 1190, 355-359.
4. Calhoun, B. C. and Goldenring, J. R. (1997). Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles. Biochem. J. 325, 559-564.
5. Carmosino, M., Procino, G., Nicchia, G. P., Mannucci, R., Verbavatz, J.-M., Gobin, R., Svelto, M. and Valenti, G. (2001). Histamine treatment induces rearrangements of orthogonal arrays of particles (OAPs) in human AQP4-expressing gastric cells. J. Cell Biol. 154, 1235-1244.
6. Devuyst, O., Christie, P. T., Courtoy, P. J., Beauwens, R. and Thakker, R. V. (1999). Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease. Hum. Mol. Genet. 8, 247-257.
7. +-ATPase in the apical canalicular membrane of gastric parietal cells. J. Biol. Chem. 284, 619-629.
8. Günther, W., Lüchow, A., Cluzeaud, F., Vandewalle, A. and Jentsch, T. J. (1998). ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells. Proc. Natl. Acad. Sci. USA 95, 8075-8080.
9. Günther, W., Piwon, N. and Jentsch, T. J. (2003). The ClC-5 chloride channel knockout mouse - an animal model for Dent's disease. Pflügers Arch. 445, 456-462.
10. - secretory mechanism of gastric parietal cells? FEBS Lett. 575, 105-108.
11. Jentsch, T. J. (2008). CLC chloride channels and transporters: from genes to protein structure, pathology and physiology. Crit. Rev. Biochem. Mol. Biol. 43, 3-36.
12. - channels gleaned from human genetic disease and mouse models. Annu. Rev. Physiol. 67, 779-807.
13. Karam, S. M., Yao, X. and Forte, J. G. (1997). Functional heterogeneity of parietal cells along the pit-gland axis. Am. J. Physiol. 272, G161-G171.
14. +-ATPase. J. Biol. Chem. 277, 20671-20677.
15. - channel from the renal cell line A6. Am. J. Physiol. 273, C1176-C1185.
16. Lloyd, S. E., Pearce, S. H., Fisher, S. E., Steinmeyer, K., Schwappach, B., Scheinman, S. J., Harding, B., Bolino, A., Devoto, M., Goodyer, P. et al. (1996). A common molecular basis for three inherited kidney stone diseases. Nature 379, 445-449.
17. McDaniel, N., Pace, A. J., Spiegel, S., Engelhardt, R., Koller, B. H., Seidler, U. and Lytle, C. (2005). Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen. Am. J. Physiol. 289, G550-G560.
18. Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Van, B., Yamamoto, S., Kakizawa, S. et al. (2012). TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells. J. Biol. Chem. 287, 33523-33532.
19. Nishizawa, T., Nagao, T., Iwatsubo, T., Forte, J. G. and Urushidani, T. (2000). Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells. J. Biol. Chem. 275, 11164-11173.
20. Novarino, G., Weinert, S., Rickheit, G. and Jentsch, T. J. (2010). Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. Science 328, 1398-1401.
21. - exchanger PAT1 and gastric HK-ATPase in stomach parietal cells. Am. J. Physiol. 283, G1207-G1216.
22. Picollo, A. and Pusch, M. (2005). Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature 436, 420-423.
23. --channel disruption impairs endocytosis in a mouse model for Dent's disease. Nature 408, 369-373.
24. Rothberg, K. G., Heuser, J. E., Donzell, W. C., Ying, Y.-S., Glenney, J. R. and Anderson, R. G. W. (1992). Caveolin, a protein component of caveolae membrane coats. Cell 68, 673-682.
25. Sachs, G. (2001). Improving on PPI-based therapy of GORD. Eur. J. Gastroenterol. Hepatol. 13 Suppl 1, S35-S41.
26. Sachs, G., Shin, J. M., Vagin, O., Lambrecht, N., Yakubov, I. and Munson, K. (2007). The gastric H, K ATPase as a drug target: past, present, and future. J. Clin. Gastroenterol. 41 Suppl 2, S226-S242.
27. +-ATPase α3-isoform and down-regulation of the a1-isoform in human colorectal cancer. FEBS Lett. 563, 151-154.
28. - channels. J. Biol. Chem. 271, 10210-10216.
29. +- ATPase. Am. J. Physiol. 277, F957-F965.
30. Scheel, O., Zdebik, A. A., Lourdel, S. and Jentsch, T. J. (2005). Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature 436, 424-427.
31. Sidani, S. M., Kirchhoff, P., Socrates, T., Stelter, L., Ferreira, E., Caputo, C., Roberts, K. E., Bell, R. L., Egan, M. E. and Geibel, J. P. (2007). DeltaF508 mutation results in impaired gastric acid secretion. J. Biol. Chem. 282, 6068-6074.
32. + exchanger. J. Physiol. 588, 2033-2045.
33. Steinmeyer, K., Schwappach, B., Bens, M., Vandewalle, A. and Jentsch, T. J. (1995). Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease. J. Biol. Chem. 270, 31172-31177.
34. Vandewalle, A., Cluzeaud, F., Peng, K.-C., Bens, M., Lüchow, A., Günther, W. and Jentsch, T. J. (2001). Tissue distribution and subcellular localization of the ClC-5 chloride channel in rat intestinal cells. Am. J. Physiol. 280, C373-C381.
35. Wang, S. S., Devuyst, O., Courtoy, P. J., Wang, X.-T., Wang, H., Wang, Y., Thakker, R. V., Guggino, S. and Guggino, W. B. (2000). Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum. Mol. Genet. 9, 2937-2945.
36. Wang, Y., Cai, H., Cebotaru, L., Hryciw, D. H., Weinman, E. J., Donowitz, M., Guggino, S. E. and Guggino, W. B. (2005). ClC-5: role in endocytosis in the proximal tubule. Am. J. Physiol. 289, F850-F862.
37. Wrong, O. M., Norden, A. G. W. and Feest, T. G. (1994). Dent's disease; a familial proximal renal tubular syndrome with low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, metabolic bone disease, progressive renal failure and a marked male predominance. QJM 87, 473-493.
38. Xu, J., Song, P., Miller, M. L., Borgese, F., Barone, S., Riederer, B., Wang, Z., Alper, S. L., Forte, J. G., Shull, G. E. et al. (2008). Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc. Natl. Acad. Sci. USA 105, 17955-17960.
39. Yoda, A. and Hokin, L. E. (1970). On the reversibility of binding of cardiotonic steroids to a partially purified (Na+K)-activated adenosinetriphosphatase from beef brain. Biochem. Biophys. Res. Commun. 40, 880-886.
40. + antiporter by a single point mutation. EMBO J. 28, 175-182.