Health care segregation, physician recommendation, and racial disparities in BRCA1/2 testing among women with breast cancer

Journal of Clinical Oncology

Volumn 34, Issue 22, 2016, Pages 2610-2618

  McCarthy, Anne Marie ^a,b   Bristol, Mirar ^a   Domchek, Susan M ^c   Groeneveld, Peter W ^c   Kim, Younji ^a   Motanya, U Nkiru ^c   Shea, Judy A ^c   Armstrong, Katrina ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AFRICAN AMERICAN; ARTICLE; ATTITUDE; BREAST CANCER; CANCER CENTER; CANCER REGISTRY; ETHNIC OR RACIAL ASPECTS; EUROPEAN AMERICAN; FEMALE; FLORIDA; GENE MUTATION; HEALTH CARE DISPARITY; HUMAN; MAJOR CLINICAL STUDY; MEDICAL ONCOLOGIST; MEDICAL SOCIETY; MIDDLE AGED; ONCOLOGIST; PENNSYLVANIA; PRIORITY JOURNAL; RISK FACTOR; SURGEON; TUMOR SUPPRESSOR GENE; YOUNG ADULT; ADOLESCENT; BLACK PERSON; BREAST NEOPLASMS; CAUCASIAN; GENETICS; PERCEPTIVE DISCRIMINATION; PHYSICIAN; PSYCHOLOGY; QUESTIONNAIRE; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

BRAP PROTEIN, HUMAN; BRCA1 PROTEIN; BRCA2 PROTEIN; BRCA2 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; DISCRIMINATION (PSYCHOLOGY); EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FLORIDA; HEALTHCARE DISPARITIES; HUMANS; LOGISTIC MODELS; MIDDLE AGED; PENNSYLVANIA; PHYSICIANS; SURVEYS AND QUESTIONNAIRES; UBIQUITIN-PROTEIN LIGASES; YOUNG ADULT;

EID: 84979500451     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2015.66.0019     Document Type: Article

References (66)

1. Nelson HD, Pappas M, Zakher B, et al: Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: A systematic review to update the U.S. Preventive Services Task Force recommendation. Ann Intern Med 160: 255-266, 2014
2. Robson ME, Bradbury AR, Arun B, et al: American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility. J Clin Oncol 33:3660-3667, 2015
3. Moyer VA, U.S. Preventive Services Task Force: Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 160:271-281, 2014
4. Haffty BG, Choi DH, Goyal S, et al: Breast cancer in young women (YBC): Prevalence of BRCA1/2mutations and risk of secondary malignancies across diverse racial groups. Ann Oncol 20:1653-1659, 2009
5. Hall MJ, Reid JE, Burbidge LA, et al: BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breastovarian cancer. Cancer 115:2222-2233, 2009
6. Jagsi R, Griffith KA, Kurian AW, et al: Concerns about cancer risk and experiences with genetic testing in a diverse population of patients with breast cancer. J Clin Oncol 33:1584-1591, 2015
7. Frank TS, Deffenbaugh AM, Reid JE, et al: Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: Analysis of 10,000 individuals. J Clin Oncol 20:1480-1490, 2002
8. Newman B, Mu H, Butler LM, et al: Frequency of breast cancer attributable to BRCA1 in a populationbased series of American women. JAMA 279:915-921, 1998
9. John EM, Miron A, Gong G, et al: Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups. JAMA 298:2869-2876, 2007
10. Malone KE, Daling JR, Doody DR, et al: Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. Cancer Res 66:8297-8308, 2006
11. Pal T, Bonner D, Cragun D, et al: A high frequency of BRCA mutations in young black women with breast cancer residing in Florida. Cancer 121: 4173-4180, 2015
12. Lynce F, Smith KL, Stein J, et al: Deleterious BRCA1/2 mutations in an urban population of Black women. Breast Cancer Res Treat 153:201-209, 2015
13. Armstrong K, Micco E, Carney A, et al: Racial differences in the use of BRCA1/2 testing among women with a family history of breast or ovarian cancer. JAMA 293:1729-1736, 2005
14. Susswein LR, Skrzynia C, Lange LA, et al: Increased uptake of BRCA1/2 genetic testing among African American women with a recent diagnosis of breast cancer. J Clin Oncol 26:32-36, 2008
15. Levy DE, Byfield SD, Comstock CB, et al: Underutilization of BRCA1/2 testing to guide breast cancer treatment: Black and Hispanic women particularly at risk. Genet Med 13:349-355, 2011
16. Olaya W, Esquivel P, Wong JH, et al: Disparities in BRCA testing: When insurance coverage is not a barrier. Am J Surg 198:562-565, 2009
17. Gaskin DJ, Dinwiddie GY, Chan KS, et al: Residential segregation and disparities in health care services utilization. Med Care Res Rev 69:158-175, 2012
18. White K, Haas JS, Williams DR: Elucidating the role of place in health care disparities: The example of racial/ethnic residential segregation. Health Serv Res 47:1278-1299, 2012
19. Sarrazin MV, Campbell M, Rosenthal GE: Racial differences in hospital use after acute myocardial infarction: Does residential segregation play a role? Health Aff (Millwood) 28:w368-w378, 2009
20. Smith DB, Feng Z, Fennell ML, et al: Separate and unequal: Racial segregation and disparities in quality across U.S. nursing homes. Health Aff (Millwood) 26:1448-1458, 2007
21. Huang LC, Tran TB, Ma Y, et al: Factors that influence minority use of high-volume hospitals for colorectal cancer care. Dis Colon Rectum 58: 526-532, 2015
22. López L, Jha AK: Outcomes for whites and blacks at hospitals that disproportionately care for black Medicare beneficiaries. Health Serv Res 48: 114-128, 2013
23. Merchant RM, Becker LB, Yang F, et al: Hospital racial composition: A neglected factor in cardiac arrest survival disparities. Am Heart J 161: 705-711, 2011
24. Skinner J, Chandra A, Staiger D, et al: Mortality after acute myocardial infarction in hospitals that disproportionately treat black patients. Circulation 112:2634-2641, 2005
25. Barnato AE, Lucas FL, Staiger D, et al: Hospital-level racial disparities in acute myocardial infarction treatment and outcomes. Med Care 43: 308-319, 2005
26. Bach PB, Pham HH, Schrag D, et al: Primary care physicians who treat blacks and whites. N Engl J Med 351:575-584, 2004
27. Pollack CE, Bekelman JE, Liao KJ, et al: Hospital racial composition and the treatment of localized prostate cancer. Cancer 117:5569-5578, 2011
28. Pollack CE, Bekelman JE, Epstein AJ, et al: Racial disparities in changing to a high-volume urologist among men with localized prostate cancer. Med Care 49:999-1006, 2011
29. Shields AE, Burke W, Levy DE: Differential use of available genetic tests among primary care physicians in the United States: Results of a national survey. Genet Med 10:404-414, 2008
30. Smith TW (ed): Standard Definitions: Final Dispositions of Case Codes and Outcome Rates for Surveys (ed 4). Oakbrook Terrace, IL, American Association for Public Opinion Research (AAPOR), 2008
31. Bevers TB, Anderson BO, Bonaccio E, et al: NCCN clinical practice guidelines in oncology: Breast cancer screening and diagnosis. J Natl Compr Canc Netw 7:1060-1096, 2009
32. Escarce JJ, Bloom BS, Hillman AL, et al: Diffusion of laparoscopic cholecystectomy among general surgeons in the United States. Med Care 33: 256-271, 1995
33. Ferrence R: Diffusion theory and drug use. Addiction 96:165-173, 2001
34. Rogers EM: A prospective and retrospective look at the diffusion model. J Health Commun 9 (Suppl 1):13-19, 2004
35. Greenberg MR: The diffusion of public health innovations. Am J Public Health 96:209-210, 2006
36. Armstrong K, Weiner J, Weber B, et al: Early adoption of BRCA1/2 testing: Who and why. Genet Med 5:92-98, 2003
37. Hurt HT, Joseph K, Cook CD: Scales for the measurement of innovativeness. Hum Commun Res 4:58-65, 1977
38. Goldsmith RE: The validity of a scale to measure global innovativeness. J Appl Bus Res 7: 89-97, 1991
39. Goldsmith RE, Hofacker CF: Measuring consumer innovativeness. J Acad Mark Sci 19:209-221, 1991
40. Flynn LR, Goldsmith RE: A validation of the Goldsmith and Hofacker innovativeness scale. Educ Psychol Meas 53:1105-1116, 1993
41. Goldsmith RE, Freiden JB: The generality specificity issue in consumer innovativeness research. Technovation 15:601-612, 1995
42. Massey D, Denton N: The dimensions of residential segregation. Soc Forces 67:281-315, 1988
43. Massey D, Denton N: American Apartheid. Segregation and the Making of the Underclass. Cambridge, MA, Harvard University Press, 1993
44. Singletary SE, Allred C, Ashley P, et al: Staging system for breast cancer: Revisions for the 6th edition of the AJCC Cancer Staging Manual. Surg Clin North Am 83:803-819, 2003
45. Jameson JL, Longo DL: Precision medicine: Personalized, problematic, and promising. N Engl J Med 372:2229-2234, 2015
46. Collins FS, Varmus H: A new initiative on precision medicine. N Engl J Med 372:793-795, 2015
47. Tuckson RV, Newcomer L, De Sa JM: Accessing genomic medicine: Affordability, diffusion, and disparities. JAMA 309:1469-1470, 2013
48. Murff HJ, Byrne D, Haas JS, et al: Race and family history assessment for breast cancer. J Gen Intern Med 20:75-80, 2005
49. Wideroff L, Garceau AO, Greene MH, et al: Coherence and completeness of population-based family cancer reports. Cancer Epidemiol Biomarkers Prev 19:799-810, 2010
50. Graves KD, Christopher J, Harrison TM, et al: Providers' perceptions and practices regarding BRCA1/2 genetic counseling and testing in African American women. J Genet Couns 20:674-689, 2011
51. Eggington JM, Bowles KR, Moyes K, et al: A comprehensive laboratory-based program for classification of variants of uncertain significance in hereditary cancer genes. Clin Genet 86:229-237, 2014
52. Daly MB, Pilarski R, Axilbund JE, et al: Genetic/familial high-risk assessment: Breast and ovarian, version 1.2014. J Natl Compr Canc Netw 12: 1326-1338, 2014
53. Churpek JE, Walsh T, Zheng Y, et al: Inherited predisposition to breast cancer among African American women. Breast Cancer Res Treat 149:31-39, 2015
54. McCarthy AM, Yamartino P, Yang J, et al: Racial differences in false-positive mammogram rates: Results from the ACRIN Digital Mammographic Imaging Screening Trial (DMIST). Med Care 53: 673-678, 2015
55. Singal AK, Lin YL, Kuo YF, et al: Primary care physicians and disparities in colorectal cancer screening in the elderly. Health Serv Res 48:95-113, 2013
56. Spertus JA, Jones PG, Masoudi FA, et al: Factors associated with racial differences in myocardial infarction outcomes. Ann Intern Med 150: 314-324, 2009
57. Breslin TM, Morris AM, Gu N, et al: Hospital factors and racial disparities in mortality after surgery for breast and colon cancer. J Clin Oncol 27: 3945-3950, 2009
58. Rahman M, Foster AD: Racial segregation and quality of care disparity in US nursing homes. J Health Econ 39:1-16, 2015
59. White A, Vernon SW, Franzini L, et al: Racial disparities in colorectal cancer survival: To what extent are racial disparities explained by differences in treatment, tumor characteristics, or hospital characteristics? Cancer 116:4622-4631, 2010
60. Gooden KM, Howard DL, Carpenter WR, et al: The effect of hospital and surgeon volume on racial differences in recurrence-free survival after radical prostatectomy. Med Care 46:1170-1176, 2008
61. Armstrong K, Randall TC, Polsky D, et al: Racial differences in surgeons and hospitals for endometrial cancer treatment. Med Care 49:207-214, 2011
62. Hall MA, McEwen JE, Barton JC, et al: Concerns in a primary care population about genetic discrimination by insurers. Genet Med 7:311-316, 2005
63. Sheppard VB, Mays D, LaVeist T, et al: Medical mistrust influences black women's level of engagement in BRCA 1/2 genetic counseling and testing. J Natl Med Assoc 105:17-22, 2013
64. Sheppard VB, Graves KD, Christopher J, et al: African American women's limited knowledge and experiences with genetic counseling for hereditary breast cancer. J Genet Couns 23: 311-322, 2014
65. Glenn BA, Chawla N, Bastani R: Barriers to genetic testing for breast cancer risk among ethnic minority women: An exploratory study. Ethn Dis 22: 267-273, 2012
66. Peters N, Rose A, Armstrong K: The association between race and attitudes about predictive genetic testing. Cancer Epidemiol Biomarkers Prev 13:361-365, 2004