Racial differences in the use of BRCA1/2 testing among women with a family history of breast or ovarian cancer

JAMA

Volumn 293, Issue 14, 2005, Pages 1729-1736

  Armstrong, Katrina ^a,b,c,d,e   Micco, Ellyn ^a   Carney, Amy ^a   Stopfer, Jill ^a   Putt, Mary ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e 1204 Blockley Hall   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; BREAST CARCINOMA; CANCER RISK; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DOCTOR PATIENT RELATION; FAMILIAL CANCER; FAMILY HISTORY; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC COUNSELING; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; OVARY CARCINOMA; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RACE DIFFERENCE; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; SOCIOECONOMICS; ATTITUDE TO HEALTH; BREAST TUMOR; CASE CONTROL STUDY; CAUCASIAN; ETHNOLOGY; GENETICS; MIDDLE AGED; MUTATION; NEGRO; OVARY TUMOR; PSYCHOLOGICAL ASPECT; RISK FACTOR; STATISTICAL MODEL; STATISTICS; TUMOR SUPPRESSOR GENE; UNITED STATES; UTILIZATION REVIEW;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; ATTITUDE TO HEALTH; BREAST NEOPLASMS; CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC COUNSELING; GENETIC SCREENING; HUMANS; LOGISTIC MODELS; MIDDLE AGED; MUTATION; OVARIAN NEOPLASMS; PHILADELPHIA; RISK FACTORS; SOCIOECONOMIC FACTORS;

EID: 16444381731     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.293.14.1729     Document Type: Article

References (41)

1. Thompson D, Easton DF. Breast Cancer Linkage Consortium: cancer incidence in BRCA1 mutation carriers. J Natl Cancer Inst. 2002;94:1358-1365.
2. Grann VR, Jacobson JS, Thomason D, Hershman D, Heitjan DF, Neugut AI. Effect of prevention strategies on survival and quality-adjusted survival of women with BRCA1/2 mutations: an updated decision analysis. J Clin Oncol. 2002;20:2520-2529.
3. Domchek SM, Eisen A, Calzone K, Stopfer J, Blackwood A, Weber BL. Application of breast cancer risk prediction models in clinical practice. J Clin Oncol. 2003;21:593-601.
4. Andrykowski M, Lightmer R, Studts J, Munn R. Hereditary cancer risk notification and testing: how interested is the general population? J Clin Oncol. 1997;15:2139-2148.
5. Struewing J, Lerman C, Kase R, Giambarresi T, Tucker M. Anticipated uptake and impact of genetic testing in hereditary breast and ovarian cancer families. Cancer Epidemiol Biomarkers Prev. 1995;4:169-173.
6. Armstrong K, Ubel P, Weber B, Guerra C, Schwartz JS. Interest in BRCA1/2 testing in a primary care population. Prev Med. 2002;34.590-595.
7. Bosompra K, Flynn B, Ashikaga T, Rairikar C, Worden J, Solomon L. Likelihood of undergoing genetic testing for cancer risk: a population-based study. Prev Med. 2000;30:155-166.
8. Tambor E, Rimer B, Strigo T. Genetic testing for breast cancer susceptibility: awareness and interest among women in the general population. Am J Med Genet 1997;68:43-49.
9. Armstrong K, Calzone K, Stopfer J, Fitzgerald G, Coyne J, Weber B. Factors associated with decisions about clinical BRCA1/2 testing. Cancer Epidemiol Biomarkers Prev. 2000;9:1251-1254.
10. Lerman C, Narod S, Schulman K, Hughes C, Gomez-Caminero A. BRCA1 testing in families with hereditary breast-ovarian cancer: a prospective study of patient decision making and outcomes. JAMA. 1996;275:1885-1929.
11. Chen WY, Garber JE, Higham S, et al. BRCA1/2 genetic testing in the community setting. J Clin Oncol. 2002;20:4485-4492.
12. Thompson HS, Valdimarsdottir HB, Duteau-Buck C, et al. Psychosocial predictors of BRCA counseling and testing decisions among urban African-American women. Cancer Epidemiol Biomarkers Prev. 2002;11:1579-1585.
13. Lee S, Bernhardt B, Helzlsouer K. Utilization of BRCA1/2 genetic testing in the clinical setting: report from a single institution. Cancer. 2002;94:1876-1885.
14. Bluman L, Rimer B, Berry D, et al. Attitudes, knowledge, and risk perceptions of women with breast and/or ovarian cancer considering testing for BRCA1 and BRCA2. J Clin Oncol. 1999;17:1040-1046.
15. Institute of Medicine. Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care. Washington, DC: The National Academies Press; 2002.
16. Holtzman NA, Rothstein MA. Eugenics and genetic discrimination. Am J Hum Genet. 1992;50:457-459.
17. Ashton CM, Haidet P, Paterniti DA, et al. Racial and ethnic disparities in the use of health services: bias, preferences, or poor communication? J Gen Intern Med. 2003;18:146-152.
18. Centers for Disease Control and Prevention. Behavioral Risk Factor Surveillance System. Available at: http://www.cdc.gov/brfss/. Accessed March 1, 2005.
19. Grieco E, Cassidy R. Overview of Race and Hispanic Origin: Census 2000 Brief. Washington, DC: US Bureau of the Census; 2001.
20. Frank TS, Deffenbaugh AM, Reid JE, et al. Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol. 2002;20:1480-1490.
21. Mutation prevalence tables for BRCA1/2 genes: update 2004. Myriad Genetic Laboratories Web site. Available at: http://www.myriadtests.com/provider/ mutprev.htm. Accessed November 1, 2004.
22. Armstrong K, Popik S, Guerra C, Ubel PA. Beliefs about breast cancer risk and use of postmenopausal hormone replacement therapy. Med Decis Making. 2000;20:308-313.
23. Lerman C, Trock B, Rimer BK, Boyce A, Jepson C, Engstrom PF. Psychological and behavioral implications of abnormal mammograms. Ann Intern Med. 1991;114:657-661.
24. Peters N, Rose A, Armstrong K. The association between race and attitudes about predictive genetic testing. Cancer Epidemiol Biomarkers Prev. 2004;13:361-365.
25. Hughes C, Gomex-Caminero A, Benkendorf J, Kerner J. Ethnic differences in knowledge and attitudes about BRCA1 testing in women at increased risk. Patient Educ Couns. 1997;32:51-62.
26. Hughes C, Lerman C, Lustbader E. Ethnic differences in risk perception among women at increased risk for breast cancer. Breast Cancer Res Treat. 1996;40:25-30.
27. Lerman C, Hughes C, Benkendorf JL, Biesecker B. Racial differences in testing motivation and psychological distress following pretest education for BRCA1 gene testing. Cancer Epidemiol Biomarkers Prev. 1999;8:361-367.
28. Armstrong K, Weber B, Stopfer J, et al. Early use of clinical BRCA1/2 testing: associations with race and breast cancer risk. Am J Med Genet A. 2003;117:154-160.
29. Meijers-Heijboer H, Brekelmans CT, Menke-Pluymers M, et al. Use of genetic testing and prophylactic mastectomy and oophorectomy in women with breast or ovarian cancer from families with a BRCA1 or BRCA2 mutation. J Clin Oncol. 2003;21:1675-1681.
30. Lerman C, Hughes C, Croyle RT, et al. Prophylactic surgery decisions and surveillance practices one year following BRCA1/2 testing. Prev Med. 2000;31:75-80.
31. American Cancer Society. Cancer Facts and Figures 2002. Atlanta, Ga: American Cancer Society: 2002.
32. Panguluri RC, Brody LC, Modali R, et al. BRCA1 mutations in African Americans. Hum Genet. 1999;105:28-31.
33. Gao Q, Neuhausen S, Cummings S, Luce M, Olopade OI. Recurrent germ-line BRCA1 mutations in extended African American families with early-onset breast cancer. Am J Hum Cenet. 1997;60:1233-1236.
34. Olopade OI, Fackenthal JD, Dunston G, Tainsky MA, Collins F, Whitfield-Broome C. Breast cancer genetics in African Americans. Cancer. 2003;97:236-245.
35. Gao Q, Tomlinson G, Das S, et al. Prevalence of BRCA1 and BRCA2 mutations among clinic-based African American families with breast cancer. [erratum appears in Hum Genet 2001 Aug;109(2):239-40]. Hum Cenet. 2000;107:186-191.
36. Mefford HC, Baumbach L, Panguluri RC, et al. Evidence for a BRCA1 founder mutation in families of West African ancestry. Am J Hum Cenet. 1999;65:575-578.
37. Corbie-Smith G, Thomas S, Geroge D. Distrust, race and research. Arch Intern Med. 2002;162:2458-2463.
38. Rose A, Shea JA, Armstrong K. Development of the health care system distrust scale. J Gen Intern Med. 2004;19:57-63.
39. Berwick DM. Disseminating innovations in health care. JAMA. 2003;15:1969-1975.
40. Bach PB, Pham HH, Schrag D, Tate RC, Hargraves JL. Primary care physicians who treat blacks and whites. N Engl J Med. 2004;351:575-584.
41. Berry D, Iversen EJ, Gudbjartsson D, et al. BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes. J Clin Oncol. 2002;20:2701-2712.