Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease

ACS Applied Materials and Interfaces

Volumn 8, Issue 28, 2016, Pages 17955-17963

  Im, Hyung Jun ^a,b   England, Christopher G ^c   Feng, Liangzhu ^d   Graves, Stephen A ^c   Hernandez, Reinier ^c   Nickles, Robert J ^c   Liu, Zhuang ^d   Lee, Dong Soo ^b   Cho, Steve Y ^a   Cai, Weibo ^a,c,e  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Seoul National University   (South Korea)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d SOOCHOW UNIVERSITY   (China)

^e UNIVERSITY OF WISCONSIN   (United States)

Author keywords

accelerated blood clearance (ABC); anti PEG antibody; hindlimb ischemia; iron oxide nanoparticle (IONP); peripheral arterial disease; photoacoustic imaging; positron emission tomography (PET); reduced graphene oxide (RGO)

Indexed keywords

BLOOD; GRAPHENE; IRON OXIDES; MAMMALS; METAL NANOPARTICLES; POSITRON EMISSION TOMOGRAPHY; POSITRONS;

ACCELERATED BLOOD CLEARANCES; HIND LIMBS; IRON OXIDE NANOPARTICLE; PERIPHERAL ARTERIAL DISEASE; PHOTO-ACOUSTIC IMAGING; POSITRON EMISSION TOMOGRAPHY (PET); REDUCED GRAPHENE OXIDES (RGO);

NANOPARTICLES;

COPPER; FERRIC ION; FERRIC OXIDE; GRAPHITE; MACROGOL; NANOPARTICLE; OXIDE;

ANIMAL; BAGG ALBINO MOUSE; BLOOD; CHEMISTRY; DIAGNOSTIC IMAGING; FEMALE; HINDLIMB; METABOLISM; MOUSE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; POSITRON EMISSION TOMOGRAPHY; VASCULARIZATION;

ANIMALS; COPPER RADIOISOTOPES; FEMALE; FERRIC COMPOUNDS; GRAPHITE; HINDLIMB; MICE; MICE, INBRED BALB C; NANOPARTICLES; OXIDES; PERIPHERAL ARTERIAL DISEASE; POLYETHYLENE GLYCOLS; POSITRON-EMISSION TOMOGRAPHY;

EID: 84979300085     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.6b05840     Document Type: Article

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