Beating the odds: Successful establishment of a Phase II/III clinical research trial in resource-poor Liberia during the largest-ever Ebola outbreak

Contemporary Clinical Trials Communications

Volumn 4, Issue , 2016, Pages 68-73

  Doe Anderson, J ^a   Baseler, B ^a   Driscoll, P ^b   Johnson, M ^c   Lysander, J ^c   McNay, L ^b   Njoh, W S ^a   Smolskis, M ^b   Wehrlen, L ^d   Zuckerman, J ^b  

^a FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c The Mitchell Group   (Liberia)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Building capacity; Ebola; Ebola virus disease; Global clinical research partnerships; International clinical research; International partnerships; Vaccine clinical trials

Indexed keywords

EBOLA VACCINE;

ARTICLE; CAPACITY BUILDING; CLINICAL RESEARCH; EBOLA HEMORRHAGIC FEVER; EPIDEMIC; GOVERNMENT; HUMAN; INTERPERSONAL COMMUNICATION; KNOWLEDGE; LIBERIA; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); VACCINATION;

EID: 84979263701     PISSN: 24518654     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conctc.2016.06.008     Document Type: Article

References (22)

1. [1] World Health Organization. Emergencies Preparedness, Response. 5/11/2016]; Available from: http://who.int/csr/disease/ebola/health-systems-recovery/early-recovery/en/.
2. [2] Republic of Liberia, Ministry of Health. reportInvestment Plan for Building a Resilient Health System in Liberia: 2015 to 2021. [Report] 2015 5/11/2016 [cited 15 April 2015; 15 April 2015: [1–71]. Available from: http://pages.au.int/sites/default/files/LIBERIA%20Investment%20Plan%20for%20Building%20a%20Resilient%20Health%20System.pdf.
3. [3] Republic of Liberia, Executive Mansion, President Sirleaf Declares 90-Day State of Emergency, As Governments Steps up the Fight against the Spread of the Ebola Virus Disease – See more at: http://www.emansion.gov.lr/2press.php?news_id=3053&related=7&pg=sp#sthash.sqOz7Knj.pt5WUaOf.dpuf. 2014.
4. [4] Briand, S., et al. The international Ebola emergency. N. Engl. J. Med. 371:13 (2014), 1180–1183.
5. [5] Thompson, D., As Ebola crisis spreads in West Africa, Liberia's deterioration stands out. National Geographic, 2014.
6. [6] Liljas, P., Liberia's west point slum reels from the nightmare of Ebola. Time, 2014.
7. [7] Personal Communication: Letter from Walter Gwenigale to Sylvia Burwell.
8. [8] Pillai, S.K., et al. Morbidity and Mortality Weekly Report October 17, 2014 Developing an Incident Management System to Support Ebola Response — Liberia, July–August 2014, 63(41), 2014, 930–933 Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6341a4.htm.
9. [9] UNICEF. Communication for Development (C4D): Social mobilization. 24 June 2015; Available from: http://www.unicef.org/cbsc/index_42347.html.
10. [10] Republic of Liberia, National Ebola Response Strategy – Scaling up to the Challenge, 2014, 1–33.
11. [11] Abramowitz, S.A., et al. Community-centered responses to Ebola in urban Liberia: the view from below. PLoS Negl. Trop. Dis., 9(4), 2015, e0003706.
12. [12] Fast, S.M., Mekaru, S., Brownstein, J.S., Postlethwaite, T.A., Markuzon, N., The Role of Social Mobilization in Controlling Ebola Virus in Lofa County, Liberia, PLOS Currents Outbreaks, 2015 May 15 first ed., http://dx.doi.org/10.1371/currents.outbreaks.c3576278c66b22ab54a25e122fcdbec1.
13. [13] Nyenswah, T.G., et al. Ebola and its control in Liberia, 2014-2015. Emerg. Infect. Dis. 22:2 (2016), 169–177.
14. [14] PREVAIL Unpublished Trackers’ Weekly Reports and Notes Taken at Community Engagements, 2015.
15. [15] Onishi, N., Fink, S., Vaccines face same mistrust that fed Ebola. The New York Times, 2015.
16. [16] World Health Organization, Statement on the WHO Consultation on potential Ebola therapies and vaccines.
17. [17] Wise, J., Pfizer accused of testing new drug without ethical approval. BMJ, 22(7280), 2001, 194.
18. [18] Rusert, B., “A study in nature”: the Tuskegee experiments and the New South plantation. J. Med. Humanit 30:3 (2009), 155–171.
19. [19] Kretzschmar, M., et al. Ring vaccination and smallpox control. Emerg. Infect. Dis. 10:5 (2004), 832–841.
20. [20] Kucharski, A.J., et al. Effectiveness of ring vaccination as control strategy for Ebola virus disease. Emerg. Infect. Dis. 22:1 (2016), 105–108.
21. [21] Lane, H.C., Marston, H.D., Fauci, A.S., Conducting clinical trials in outbreak settings: points to consider. Clin. Trials 13:1 (2016), 92–95.
22. [22] National Bioethics Advisory Commission, Ethical and Policy Issues in International Research: Clinical Trials in Developing Countries, Executive Summary, 2001, 1–15.