Vitamin D deficiency in adults: Searching for the proper loading dose

Journal of Biological Regulators and Homeostatic Agents

Volumn 29, Issue 4, 2015, Pages 87-94

  Vicenti, G ^a   Pesce, V ^a   Abate, A ^b   Carrozzo, M ^a   Cagnetta, V ^c   Rifino, F ^a   Solarino, G ^a   Moretti, B ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Monsignor Raffaele Dimiccoli Hospital   (Italy)

^c IRCCS   (Italy)

Author keywords

25 hydroxycholecalciferol; Bone health; Cholecalciferol; Musculoskeletal health; Osteoporosis; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; COLECALCIFEROL; PARATHYROID HORMONE;

ADULT; AGE; AGED; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MENOPAUSE; PAIN INTENSITY; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID HORMONE RELEASE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SPINE FRACTURE; VISUAL ANALOG SCALE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; WRIST FRACTURE;

EID: 84979151575     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Marx SJ, Liberman UA, Eil C. Calciferols: actions and deficiencies in action. Vitamins & Hormones 1983; 40:235-308.
2. Costa EM, Blau HM, Feldman D. Dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells. Endocrinology 1986; 119(5):2214-20.
3. Valtueña J, Gracia-Marco L, Huybrechts I, et al. Cardiorespiratory fitness in males, and upper limbs muscular strength in females, are positively related with 25-hydroxyvitamin D plasma concentrations in European adolescents: the HELENA Study. QJM 2013; 106(9):809-21.
4. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80(6):1678S-88S.
5. Annweiler C, Allali G, Allain P, Bridenbaugh S, Schott AM, Kressig RW, Beauchet O. Vitamin D and cognitive performance in adults: a systematic review. Europ J Neurol 2009; 16(10)1083-9.
6. Yoshikawa S, Nakamura T, Tanabe H, Imamura T. Osteomalacic myopathy. Endocrin Jap 1979; 26:65-72
7. Adami S, Giannini S, Bianchi G, Sinigaglia L, Di Munno O, Fiore CE, Minisola S, Rossini M. Vitamin D status and response to treatment in postmenopausal osteoporosis. Osteoporosis Int 2009; 20:239-44.
8. Chel V, Wijnhoven HA, Smit JH, Ooms M, Lips P. Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents. Osteoporos Int 2008; 19(5):663-71.
9. Ish-Shalom S, Segal E, Salganik T, Raz B, Bromberg IL, Vieth R. Comparison of daily, weekly and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients. J Clin Endocrinol Metab 2008; 93(9):3430-5.
10. Bacon CJ, Gamble GD, Horne AM, Scott MA, Reid IR. High dose oral vitamin D3 supplementation in the elderly. Osteoporos Int 2009; 20(8):1407-15.
11. Von Restorff C, Bischoff-Ferrari HA, Theiler R. High dose oral vitamin D3 supplementation in rheumatology patients with severe vitamin D3 deficiency. Bone 2009; 45(4):747-9.
12. Hoeck HC, Li B, Qvist P. Changes in 25-hydroxyvitamin D3 to oral treatment with vitamin D3 in postmenopausal females with osteoporosis. Osteoporos Int 2009; 20:1329-35.
13. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999; 69(5):842-56.
14. Aloia JF, Patel M, DiMaano R, Li M, Talwar SA, Mikhail M, Pollack S, Yeh JK. Vitamin D intake to attain desired serum 25-hydroxyvitamin D concentration. Am J Clin Nutr 2008; 87(6):1952-8.
15. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation. JAMA 2005; 293:2257-64.
16. Heikinheimo RJ, Inkovaara JA, Harju EJ, et al. Annual injection of vitamin D and fractures of aged bones. Calcif Tissue Int 1992; 51(2):105-10.
17. Bischoff-Ferrari HA. How to select the doses of vitamin D in the management of osteoporosis. Osteoporos Int 2007; 18(4):401-7.
18. Prince RL, Devine A, Dhaliwal SS, Dick IM. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 2006; 166:869-75.
19. Shea B, Wells G, Cranney A, et al. Meta-analysis of calcium supplementation for the prevention of postmenopausal osteoporosis. Endocr Rev 2002; 23:552-9.
20. Boonen S1, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 2007; 92:1415-23.
21. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005; 16:713-6.
22. Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 2007; 92:1415-23.
23. Chapuy MC, Pamphile R, Paris E, Kempf C, Schlichting M, Arnaud S, Garnero P, Meunier PJ. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int 2002; 13:257-64.
24. Sahota O, Mundey MK, San P, Godber IM, Lawson N, Hosking DJ. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone 2004; 35:312-9.