How to interpret mast cell tests

Archives of Disease in Childhood: Education and Practice Edition

Volumn 101, Issue 5, 2016, Pages 246-251

  Waterfield, Thomas ^a   Dyer, Emma ^b   Wilson, Kathryn ^a   Boyle, Robert J ^c  

^a ROYAL BELFAST HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Allergy; anaphylaxis; General Paediatrics; mastocytosis; tryptase

Indexed keywords

IMMUNOGLOBULIN E; TRYPTASE;

ANAPHYLAXIS; ARTICLE; CAUSE OF DEATH; CELL FUNCTION; CHILD; ENZYME BLOOD LEVEL; FUTUROLOGY; HUMAN; MAST CELL; MASTOCYTOSIS; PRIORITY JOURNAL; METABOLISM; PHYSIOLOGY;

ANAPHYLAXIS; HUMANS; MAST CELLS; MASTOCYTOSIS; TRYPTASES;

EID: 84979082723     PISSN: 17430585     EISSN: 17430593     Source Type: Journal    
DOI: 10.1136/archdischild-2015-309887     Document Type: Article

References (20)

1. NICE Guideline CG134. Anaphylaxis: assessment and referral after emergency treatment. Published December 2011. https:// www.nice.org.uk/guidance/cg134/chapter/1-Recommendations (accessed Apr 2016)
2. Diseases National Institute of Allergy and Immunology. Guidelines for the diagnosis and management of food allergy in the United States; summary for patients, families, and caregivers. Doha: National Institutes of Health, 2011:25-8
3. Michalska-Krzanowska G. Tryptase in diagnosing adverse suspected anaphylactic reaction. Adv Clin Exp Med 2012;21:403-8
4. Schwartz LB, Yunginger JW, Miller J, et al. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. J Clin Invest 1989;83:1551-5
5. Sala-Cunill A, Cardona V, Labrador-Horrillo M, et al. Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis in 102 patients. Int Arch Allergy Immunol 2013;160:192-9
6. Schwartz LB, Bradford TR, Rouse C, et al. Development of a new, more sensitive immunoassay for human tryptase: use in systemic-anaphylaxis. J Clin Immunol 1994;14:190-204
7. Komarow HD, Hu Z, Brittain E, et al. Serum tryptase levels in atopic and nonatopic children. J Allergy Clin Immunol 2009;124:845-8
8. Belhocine W, Ibrahim Z, Grandn V, et al. Total serum tryptase levels are higher in young infants. Pediatr Allergy Immunol 2011;22:600-7
9. Ibrahim Z, Bongrand P, Carayon P, et al. Determination of the baseline tryptase level in a pediatric population. Rev Fr D Allergol 2009;49:524-7
10. Phadia Product Information. http://www.phadia.com/en/ Products/Allergy-testing-products/ImmunoCAP-Lab-Tests/ ImmunoCAP-Tryptase/ (accessed Apr 2016)
11. De Schryver S, Halbrich M, Clarke A, et al. Tryptase levels in children presenting with anaphylaxis: temporal trends and associated factors. J Allergy Clin Immunol 2016;137:1138-42
12. Brown SG, Stone SF, Fatovich DM, et al. Anaphylaxis: clinical patterns, mediator release, and severity. J Allergy Clin Immunol 2013;132:1141-49.e5
13. Yunginger JW, Nelson DR, Squillace DL, et al. Laboratory investigation of deaths due to anaphylaxis. J Forensic Sci 1991;36:857-65
14. Mayer DE, Krauskopf A, Hemmer W, et al. Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis. Forensic Sci Int 2011;212:96-101
15. Edston E, Eriksson O, van Hage M. Mast cell tryptase in postmortem serum-reference values and confounders. Int J Legal Med 2007;121:275-80
16. McLean-Tooke A, Goulding M, Bundell C, et al. Postmortem serum tryptase levels in anaphylactic and non-anaphylactic deaths. J Clin Pathol 2014;67:134-8
17. Yavuz ST, Sackesen C, Sahiner UM, et al. Importance of serum basal tryptase levels in children with insect venom allergy. Allergy 2013;68:386-91
18. Sahiner UM, Yavuz ST, Buyuktiryaki B, et al. Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy. Allergy 2014;69:265-8
19. Johnson MR, Verstovsek S, Jorgensen JL, et al. Utility of the World Health Organization classification criteria for the diagnosis of systemic mastocytosis in bone marrow. Mod Pathol 2009;22:50-7
20. Sperr WR, El-Samahi A, Kundi M, et al. Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology. Eur J Clin Invest 2009;39:914-23