A randomized trial comparing the safety and efficacy of intravenous ibuprofen versus ibuprofen and acetaminophen in knee or hip arthroplasty

Pain Physician

Volumn 19, Issue 6, 2016, Pages 349-356

  Gupta, Anita ^a   Abubaker, Hawa ^a   Demas, Eleni ^a   Ahrendtsen, Leigh ^a  

^a HAHNEMANN UNIVERSITY HOSPITAL   (United States)

Author keywords

Acetaminophen; Acute pain; Analgesia; NSAID; Post operative pain; Randomized controlled trial; Surgery

Indexed keywords

IBUPROFEN; PARACETAMOL; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT;

ABDOMINAL HYSTERECTOMY; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HIP ARTHROPLASTY; HUMAN; KNEE ARTHROPLASTY; LENGTH OF STAY; MALE; MIDDLE AGED; PAIN SEVERITY; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; RECOVERY ROOM; DOUBLE BLIND PROCEDURE; HIP REPLACEMENT; KNEE REPLACEMENT; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; REPRODUCIBILITY;

ACETAMINOPHEN; ADULT; AGED; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IBUPROFEN; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; REPRODUCIBILITY OF RESULTS;

EID: 84979025816     PISSN: 15333159     EISSN: 21501149     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Gan TJ, Lubarsky DA, Flood EM, Thanh T, Mauskopf J, Mayne T, Chen C. Patient preferences for acute pain treatment. British Journal of Anaesthesia 2004; 92:681-688.
2. Maltoni, M. Opioids, pain, and fear. Annals of Oncology 2008; 19:5-7.
3. Cancer Research UK: www.cancerre-searchuk.org/about-cancer/coping-with-cancer/coping-physically/pain/ treatment/barriers-to-treating-pain
4. Koshy RC, Kuriakose R. Acute postoperative pain management: Patterns, preferences and problems. J Anaesth Clin Pharmacol 2004; 20:263-266.
5. Bookstaver PB, Miller AD, Rudisill CN, Norris LB. Intravenous ibuprofen: The first injectable product for the treatment of pain and fever. Journal of Pain Research 2010; 3:67-79.
6. Kroll PB. Intravenous ibuprofen for postoperative pain. Pain Management 2012; 2:47-54.
7. Kroll PB, Meadows L, Rock A, Pavliv L. A multicenter, randomized, double-blind, placebo-controlled trial of intravenous ibuprofen (iv-ibuprofen) in the manage- ment of postoperative pain following abdominal hysterectomy. Pain Practice 2011; 11:23-32.
8. Pavliv L, Voss B, Rock A. Pharmacokinet-ics, safety, and tolerability of a rapid infusion of iv ibuprofen in healthy adults. American Journal of Health-System Pharmacy 2011; 68:47-51.
9. Singla N, Rock A, Pavliv L. A multi-center, randomized, double-blind placebo-controlled trial of intravenous-ibuprofen (iv-ibuprofen) for treatment of pain in postoperative orthopedic adult patients. Pain Medicine 2010; 11:1284-1293.
10. Southworth S, Peters J, Rock A, Pavliv L. A multicenter, randomized, double-blind, placebo-controlled trial of intravenous ibuprofen 400 and 800 mg every 6 hours in the management of postoperative pain. Clinical Therapeutics 2009; 31:1922-1935.
11. Jahr JS, Lee VK. Intravenous acetaminophen. Anesthesiology Clinics 2010; 28:619-645.
12. Wininger SJ, Miller H, Minkowitz HS, Royal MA, Ang RY, Breitmeyer JB, Singla NK. A randomized, double-blind, placebo-controlled, multicenter, re-peat-dose study of two intravenous acetaminophen dosing regimens for the treatment of pain after abdominal laparoscopic surgery. Clinical Therapeutics 2010; 32:2348-2369.
13. Macario A, Royal MA. A literature review of randomized clinical trials of intravenous acetaminophen (paracetamol) for acute postoperative pain. Pain Practice 2011; 11:290-296.
14. Sinatra RS, Jahr JS, Reynolds LW, Viscusi ER, Groudine SB, Payen-Champenois C. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Anesthesiology-Hager-stown 2005; 102:822-831.
15. Duggan ST, Scott LJ. Intravenous paracetamol (acetaminophen). Drugs 2009; 69:101-113.
16. Moon Y-E, Lee Y-K, Lee J, Moon D-E. The effects of preoperative intravenous acetaminophen in patients undergoing abdominal hysterectomy. Archives of Gynecology and Obstetrics 2011; 284:1455-1460.
17. McNicol ED, Tzortzopoulou A, Cepeda MS, Francia MBD, Farhat T, Schumann R. Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: A systematic review and meta-analysis. British Journal of Anaesthesia 2011; 106:764-775.
18. Sinatra RS, Jahr JS, Reynolds L, Groudine SB, Royal MA, Breitmeyer JB, Viscusi ER. Intravenous acetaminophen for pain after major orthopedic surgery: An expanded analysis. Pain Practice 2012; 12:357-365.
19. Groudine S, Fossum S. Use of intravenous acetaminophen in the treatment of postoperative pain. Journal of Peri-Anesthesia Nursing 2011; 26:74-80.
20. Van Aken H, Thys L, Veekman L, Buerkle H. Assessing analgesia in single and repeated administrations of propacetamol for postoperative pain: Comparison with morphine after dental surgery. Anesthesia & Analgesia 2004; 98:159-165.
21. Dupont WD, Plummer WD. Power and sample size calculations: A review and computer program. Controlled Clinical Trials 1990; 11:116-128.
22. Smith HS. Perioperative intravenous acetaminophen and NSAIDs. Pain Medicine 2011; 12:961-981.
23. Ollendorf DA, Vera-Llonch M, Oster G. Cost of venous thromboembolism following major orthopedic surgery in hospitalized patients. American Journal of Health-System Pharmacy 2002; 59:1750-1754.
24. Karanicolas PJ, Farrokhyar F, Bhandari M. Blinding: Who, what, when, why, how?. Canadian Journal of Surgery 2010; 53:345.