메뉴 건너뛰기




Volumn 50, Issue 13, 2016, Pages 6698-6707

Rapid Screening for Exposure to "non-Target" Pharmaceuticals from Wastewater Effluents by Combining HRMS-Based Suspect Screening and Exposure Modeling

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED SLUDGE PROCESS; BIOCHEMISTRY; ECOLOGY; ECOSYSTEMS; IONIZATION POTENTIAL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; WASTEWATER TREATMENT; WATER RESOURCES;

EID: 84979022042     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/acs.est.5b03332     Document Type: Article
Times cited : (133)

References (55)
  • 2
    • 84937793253 scopus 로고    scopus 로고
    • A review on emerging contaminants in wastewaters and the environment: Current knowledge, understudied areas and recommendations for future monitoring
    • Petrie, B.; Barden, R.; Kasprzyk-Hordern, B. A review on emerging contaminants in wastewaters and the environment: Current knowledge, understudied areas and recommendations for future monitoring Water Res. 2015, 72, 3-27 10.1016/j.watres.2014.08.053
    • (2015) Water Res. , vol.72 , pp. 3-27
    • Petrie, B.1    Barden, R.2    Kasprzyk-Hordern, B.3
  • 3
    • 84931082876 scopus 로고    scopus 로고
    • Pharmaceuticals and personal care products: A critical review of the impacts on fish reproduction
    • Overturf, M. D.; Anderson, J. C.; Pandelides, Z.; Beyger, L.; Holdway, D. A. Pharmaceuticals and personal care products: A critical review of the impacts on fish reproduction Crit. Rev. Toxicol. 2015, 45, 469-491 10.3109/10408444.2015.1038499
    • (2015) Crit. Rev. Toxicol. , vol.45 , pp. 469-491
    • Overturf, M.D.1    Anderson, J.C.2    Pandelides, Z.3    Beyger, L.4    Holdway, D.A.5
  • 4
    • 30644479441 scopus 로고    scopus 로고
    • Ecotoxicology of human pharmaceuticals
    • Fent, K.; Weston, A. A.; Caminada, D. Ecotoxicology of human pharmaceuticals Aquat. Toxicol. 2006, 76, 122-159 10.1016/j.aquatox.2005.09.009
    • (2006) Aquat. Toxicol. , vol.76 , pp. 122-159
    • Fent, K.1    Weston, A.A.2    Caminada, D.3
  • 6
    • 84865449733 scopus 로고    scopus 로고
    • Organic Micropollutants in Rivers Downstream of the Megacity Beijing: Sources and Mass Fluxes in a Large-Scale Wastewater Irrigation System
    • Heeb, F.; Singer, H.; Pernet-Coudrier, B.; Qi, W. X.; Liu, H. J.; Longree, P.; Muller, B.; Berg, M. Organic Micropollutants in Rivers Downstream of the Megacity Beijing: Sources and Mass Fluxes in a Large-Scale Wastewater Irrigation System Environ. Sci. Technol. 2012, 46, 8680-8688 10.1021/es301912q
    • (2012) Environ. Sci. Technol. , vol.46 , pp. 8680-8688
    • Heeb, F.1    Singer, H.2    Pernet-Coudrier, B.3    Qi, W.X.4    Liu, H.J.5    Longree, P.6    Muller, B.7    Berg, M.8
  • 8
    • 84856446159 scopus 로고    scopus 로고
    • Emerging organic contaminants in groundwater: A review of sources, fate and occurrence
    • Lapworth, D. J.; Baran, N.; Stuart, M. E.; Ward, R. S. Emerging organic contaminants in groundwater: A review of sources, fate and occurrence Environ. Pollut. 2012, 163, 287-303 10.1016/j.envpol.2011.12.034
    • (2012) Environ. Pollut. , vol.163 , pp. 287-303
    • Lapworth, D.J.1    Baran, N.2    Stuart, M.E.3    Ward, R.S.4
  • 9
    • 84924937135 scopus 로고    scopus 로고
    • Trends in liquid chromatography coupled to high-resolution mass spectrometry for multi-residue analysis of organic micropollutants in aquatic environments
    • Vergeynst, L.; Van Langenhove, H.; Demeestere, K. Trends in liquid chromatography coupled to high-resolution mass spectrometry for multi-residue analysis of organic micropollutants in aquatic environments TrAC, Trends Anal. Chem. 2015, 67, 192-208 10.1016/j.trac.2015.01.010
    • (2015) TrAC, Trends Anal. Chem. , vol.67 , pp. 192-208
    • Vergeynst, L.1    Van Langenhove, H.2    Demeestere, K.3
  • 10
    • 84911996851 scopus 로고    scopus 로고
    • Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry
    • Hernández, F.; Ibáñez, M.; Bade, R.; Bijlsma, L.; Sancho, J. V. Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry TrAC, Trends Anal. Chem. 2014, 63, 140-157 10.1016/j.trac.2014.08.003
    • (2014) TrAC, Trends Anal. Chem. , vol.63 , pp. 140-157
    • Hernández, F.1    Ibáñez, M.2    Bade, R.3    Bijlsma, L.4    Sancho, J.V.5
  • 11
    • 77953357464 scopus 로고    scopus 로고
    • Recent trends in the liquid chromatography-mass spectrometry analysis of organic contaminants in environmental samples
    • Petrovic, M.; Farré, M.; de Alda, M. L.; Perez, S.; Postigo, C.; Köck, M.; Radjenovic, J.; Gros, M.; Barcelo, D. Recent trends in the liquid chromatography-mass spectrometry analysis of organic contaminants in environmental samples J. Chromatogr. A 2010, 1217, 4004-4017 10.1016/j.chroma.2010.02.059
    • (2010) J. Chromatogr. A , vol.1217 , pp. 4004-4017
    • Petrovic, M.1    Farré, M.2    De Alda, M.L.3    Perez, S.4    Postigo, C.5    Köck, M.6    Radjenovic, J.7    Gros, M.8    Barcelo, D.9
  • 12
    • 84859697884 scopus 로고    scopus 로고
    • Coupled chromatographic and mass-spectrometric techniques for the analysis of emerging pollutants in the aquatic environment
    • Wille, K.; De Brabander, H. F.; Vanhaecke, L.; De Wulf, E.; Van Caeter, P.; Janssen, C. R. Coupled chromatographic and mass-spectrometric techniques for the analysis of emerging pollutants in the aquatic environment TrAC, Trends Anal. Chem. 2012, 35, 87-108 10.1016/j.trac.2011.12.003
    • (2012) TrAC, Trends Anal. Chem. , vol.35 , pp. 87-108
    • Wille, K.1    De Brabander, H.F.2    Vanhaecke, L.3    De Wulf, E.4    Van Caeter, P.5    Janssen, C.R.6
  • 13
    • 84879470022 scopus 로고    scopus 로고
    • Advances in the analysis of legal and illegal drugs in the aquatic environment
    • Vazquez-Roig, P.; Blasco, C.; Picó, Y. Advances in the analysis of legal and illegal drugs in the aquatic environment TrAC, Trends Anal. Chem. 2013, 50, 65-77 10.1016/j.trac.2013.04.008
    • (2013) TrAC, Trends Anal. Chem. , vol.50 , pp. 65-77
    • Vazquez-Roig, P.1    Blasco, C.2    Picó, Y.3
  • 14
    • 63649142301 scopus 로고    scopus 로고
    • Development of a common priority list of pharmaceuticals relevant for the water cycle
    • de Voogt, P.; Janex-Habibi, M. L.; Sacher, F.; Puijker, L.; Mons, M. Development of a common priority list of pharmaceuticals relevant for the water cycle Water Sci. Technol. 2009, 59, 39-46 10.2166/wst.2009.764
    • (2009) Water Sci. Technol. , vol.59 , pp. 39-46
    • De Voogt, P.1    Janex-Habibi, M.L.2    Sacher, F.3    Puijker, L.4    Mons, M.5
  • 15
    • 84921633473 scopus 로고    scopus 로고
    • An integrated approach for prioritizing pharmaceuticals found in the environment for risk assessmerit, monitoring and advanced research
    • Caldwell, D. J.; Mastrocco, F.; Margiotta-Casaluci, L.; Brooks, B. W. An integrated approach for prioritizing pharmaceuticals found in the environment for risk assessmerit, monitoring and advanced research Chemosphere 2014, 115, 4-12 10.1016/j.chemosphere.2014.01.021
    • (2014) Chemosphere , vol.115 , pp. 4-12
    • Caldwell, D.J.1    Mastrocco, F.2    Margiotta-Casaluci, L.3    Brooks, B.W.4
  • 16
    • 43849096292 scopus 로고    scopus 로고
    • Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment
    • Cooper, E. R.; Siewicki, T. C.; Phillips, K. Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment Sci. Total Environ. 2008, 398, 26-33 10.1016/j.scitotenv.2008.02.061
    • (2008) Sci. Total Environ. , vol.398 , pp. 26-33
    • Cooper, E.R.1    Siewicki, T.C.2    Phillips, K.3
  • 17
    • 37549008799 scopus 로고    scopus 로고
    • Human pharmaceuticals in surface waters implementation of a prioritization methodology and application to the French situation
    • Besse, J. P.; Garric, J. Human pharmaceuticals in surface waters implementation of a prioritization methodology and application to the French situation Toxicol. Lett. 2008, 176, 104-123 10.1016/j.toxlet.2007.10.012
    • (2008) Toxicol. Lett. , vol.176 , pp. 104-123
    • Besse, J.P.1    Garric, J.2
  • 18
    • 23844466898 scopus 로고    scopus 로고
    • Public health care management of water pollution with pharmaceuticals: Environmental classification and analysis of pharmaceutical residues in sewage water
    • Wennmalm, A.; Gunnarsson, B. Public health care management of water pollution with pharmaceuticals: Environmental classification and analysis of pharmaceutical residues in sewage water Drug Inf. J. 2005, 39, 291-297 10.1177/009286150503900307
    • (2005) Drug Inf. J. , vol.39 , pp. 291-297
    • Wennmalm, A.1    Gunnarsson, B.2
  • 20
    • 77958109721 scopus 로고    scopus 로고
    • Pharmaceuticals, personal care products and endocrine-disrupting chemicals in U.S surface and finished drinking waters: A proposed ranking system
    • Kumar, A.; Xagoraraki, I. Pharmaceuticals, personal care products and endocrine-disrupting chemicals in U.S. surface and finished drinking waters: A proposed ranking system Sci. Total Environ. 2010, 408, 5972-5989 10.1016/j.scitotenv.2010.08.048
    • (2010) Sci. Total Environ. , vol.408 , pp. 5972-5989
    • Kumar, A.1    Xagoraraki, I.2
  • 21
    • 55649113302 scopus 로고    scopus 로고
    • Ranking potential impacts of priority and emerging pollutants in urban wastewater through life cycle impact assessment
    • Munoz, I.; Gomez, M. J.; Molina-Diaz, A.; Huijbregts, M. A. J.; Fernandez-Alba, A. R.; Garcia-Calvo, E. Ranking potential impacts of priority and emerging pollutants in urban wastewater through life cycle impact assessment Chemosphere 2008, 74, 37-44 10.1016/j.chemosphere.2008.09.029
    • (2008) Chemosphere , vol.74 , pp. 37-44
    • Munoz, I.1    Gomez, M.J.2    Molina-Diaz, A.3    Huijbregts, M.A.J.4    Fernandez-Alba, A.R.5    Garcia-Calvo, E.6
  • 22
    • 2342652328 scopus 로고    scopus 로고
    • A theoretical model for utilizing mammalian pharmacology and safety data to prioritize potential impacts of human pharmaceuticals to fish
    • Huggett, D. B.; Cook, J. C.; Ericson, J. F.; Williams, R. T. A theoretical model for utilizing mammalian pharmacology and safety data to prioritize potential impacts of human pharmaceuticals to fish Hum. Ecol. Risk Assess. 2003, 9, 1789-1799 10.1080/714044797
    • (2003) Hum. Ecol. Risk Assess. , vol.9 , pp. 1789-1799
    • Huggett, D.B.1    Cook, J.C.2    Ericson, J.F.3    Williams, R.T.4
  • 23
    • 36049043771 scopus 로고    scopus 로고
    • Risks to aquatic organisms posed by human pharmaceutical use
    • Kostich, M. S.; Lazorchak, J. M. Risks to aquatic organisms posed by human pharmaceutical use Sci. Total Environ. 2008, 389, 329-339 10.1016/j.scitotenv.2007.09.008
    • (2008) Sci. Total Environ. , vol.389 , pp. 329-339
    • Kostich, M.S.1    Lazorchak, J.M.2
  • 24
    • 77955673275 scopus 로고    scopus 로고
    • Occurrence and fate of micropollutants in the Vidy Bay of Lake Geneva, Switzerland. Part I: Priority list for environmental risk assessment of pharmaceuticals
    • Perazzolo, C.; Morasch, B.; Kohn, T.; Magnet, A.; Thonney, D.; Chevre, N. Occurrence and fate of micropollutants in the Vidy Bay of Lake Geneva, Switzerland. Part I: Priority list for environmental risk assessment of pharmaceuticals Environ. Toxicol. Chem. 2010, 29, 1649-1657 10.1002/etc.221
    • (2010) Environ. Toxicol. Chem. , vol.29 , pp. 1649-1657
    • Perazzolo, C.1    Morasch, B.2    Kohn, T.3    Magnet, A.4    Thonney, D.5    Chevre, N.6
  • 26
    • 80051748642 scopus 로고    scopus 로고
    • Identifying New Persistent and Bioaccumulative Organics among Chemicals in Commerce II: Pharmaceuticals
    • Howard, P. H.; Muir, D. C. G. Identifying New Persistent and Bioaccumulative Organics Among Chemicals in Commerce II: Pharmaceuticals Environ. Sci. Technol. 2011, 45, 6938-6946 10.1021/es201196x
    • (2011) Environ. Sci. Technol. , vol.45 , pp. 6938-6946
    • Howard, P.H.1    Muir, D.C.G.2
  • 27
    • 75749144557 scopus 로고    scopus 로고
    • Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals
    • Berninger, J. P.; Brooks, B. W. Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals Toxicol. Lett. 2010, 193, 69-78 10.1016/j.toxlet.2009.12.006
    • (2010) Toxicol. Lett. , vol.193 , pp. 69-78
    • Berninger, J.P.1    Brooks, B.W.2
  • 28
    • 75449087350 scopus 로고    scopus 로고
    • Highly active human pharmaceuticals in aquatic systems: A concept for their identification based on their mode of action
    • Christen, V.; Hickmann, S.; Rechenberg, B.; Fent, K. Highly active human pharmaceuticals in aquatic systems: A concept for their identification based on their mode of action Aquat. Toxicol. 2010, 96, 167-181 10.1016/j.aquatox.2009.11.021
    • (2010) Aquat. Toxicol. , vol.96 , pp. 167-181
    • Christen, V.1    Hickmann, S.2    Rechenberg, B.3    Fent, K.4
  • 29
    • 80051984155 scopus 로고    scopus 로고
    • A Multivariate Chemical Similarity Approach to Search for Drugs of Potential Environmental Concern
    • Andersson, P. L.; Fick, J.; Rannar, S. A Multivariate Chemical Similarity Approach to Search for Drugs of Potential Environmental Concern J. Chem. Inf. Model. 2011, 51, 1788-1794 10.1021/ci200107b
    • (2011) J. Chem. Inf. Model. , vol.51 , pp. 1788-1794
    • Andersson, P.L.1    Fick, J.2    Rannar, S.3
  • 30
    • 84858298180 scopus 로고    scopus 로고
    • Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection
    • Roos, V.; Gunnarsson, L.; Fick, J.; Larsson, D. G. J.; Ruden, C. Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection Sci. Total Environ. 2012, 421, 102-110 10.1016/j.scitotenv.2012.01.039
    • (2012) Sci. Total Environ. , vol.421 , pp. 102-110
    • Roos, V.1    Gunnarsson, L.2    Fick, J.3    Larsson, D.G.J.4    Ruden, C.5
  • 32
    • 84894259913 scopus 로고    scopus 로고
    • Identifying small molecules via high resolution mass spectrometry: Communicating confidence
    • Schymanski, E.; Jeon, J.; Gulde, R.; Fenner, K.; Ruff, M.; Singer, H.; Hollender, J. Identifying small molecules via high resolution mass spectrometry: Communicating confidence Environ. Sci. Technol. 2014, 48, 2097-2098 10.1021/es5002105
    • (2014) Environ. Sci. Technol. , vol.48 , pp. 2097-2098
    • Schymanski, E.1    Jeon, J.2    Gulde, R.3    Fenner, K.4    Ruff, M.5    Singer, H.6    Hollender, J.7
  • 33
    • 70349118535 scopus 로고    scopus 로고
    • Identification of Transformation Products of Organic Contaminants in Natural Waters by Computer-Aided Prediction and High-Resolution Mass Spectrometry
    • Kern, S.; Fenner, K.; Singer, H. P.; Schwarzenbach, R. P.; Hollender, J. Identification of Transformation Products of Organic Contaminants in Natural Waters by Computer-Aided Prediction and High-Resolution Mass Spectrometry Environ. Sci. Technol. 2009, 43, 7039-7046 10.1021/es901979h
    • (2009) Environ. Sci. Technol. , vol.43 , pp. 7039-7046
    • Kern, S.1    Fenner, K.2    Singer, H.P.3    Schwarzenbach, R.P.4    Hollender, J.5
  • 34
    • 84887707082 scopus 로고    scopus 로고
    • Alleviating the Reference Standard Dilemma Using a Systematic Exact Mass Suspect Screening Approach with Liquid Chromatography-High Resolution Mass Spectrometry
    • Moschet, C.; Piazzoli, A.; Singer, H.; Hollender, J. Alleviating the Reference Standard Dilemma Using a Systematic Exact Mass Suspect Screening Approach with Liquid Chromatography-High Resolution Mass Spectrometry Anal. Chem. 2013, 85, 10312-10320 10.1021/ac4021598
    • (2013) Anal. Chem. , vol.85 , pp. 10312-10320
    • Moschet, C.1    Piazzoli, A.2    Singer, H.3    Hollender, J.4
  • 35
    • 84923205185 scopus 로고    scopus 로고
    • Balancing the False Negative and Positive Rates in Suspect Screening with High-Resolution Orbitrap Mass Spectrometry Using Multivariate Statistics
    • Vergeynst, L.; Van Langenhove, H.; Demeestere, K. Balancing the False Negative and Positive Rates in Suspect Screening with High-Resolution Orbitrap Mass Spectrometry Using Multivariate Statistics Anal. Chem. 2015, 87, 2170-2177 10.1021/ac503426k
    • (2015) Anal. Chem. , vol.87 , pp. 2170-2177
    • Vergeynst, L.1    Van Langenhove, H.2    Demeestere, K.3
  • 36
    • 84979067651 scopus 로고    scopus 로고
    • IMS Health GmbH. Consumption of pharmaceuticals in Switzerland. Data purchased byEawag, (2009.
    • IMS Health GmbH. Consumption of pharmaceuticals in Switzerland. Data purchased byEawag, (2009.
  • 37
    • 84979067652 scopus 로고    scopus 로고
    • IMS Health GmbH. Consumption of pharmaceuticals in Germany (IMS MIDAS® 2009).Data purchased by Umweltbundesamt, (2009.
    • IMS Health GmbH. Consumption of pharmaceuticals in Germany (IMS MIDAS® 2009).Data purchased by Umweltbundesamt, (2009.
  • 39
    • 48349095400 scopus 로고    scopus 로고
    • Exposure assessment of pharmaceuticals and their metabolites in the aquatic environment: Application to the French situation and preliminary prioritization
    • Besse, J. P.; Kausch-Barreto, C.; Garric, J. Exposure assessment of pharmaceuticals and their metabolites in the aquatic environment: Application to the French situation and preliminary prioritization Hum. Ecol. Risk Assess. 2008) 14, 665-695 10.1080/10807030802235078
    • (2008) Hum. Ecol. Risk Assess. , vol.14 , pp. 665-695
    • Besse, J.P.1    Kausch-Barreto, C.2    Garric, J.3
  • 41
    • 77956157233 scopus 로고    scopus 로고
    • High-throughput identification of microbial transformation products of organic micropollutants
    • Helbling, D. E.; Hollender, J.; Kohler, H.-P. E.; Fenner, K. High-throughput identification of microbial transformation products of organic micropollutants Environ. Sci. Technol. 2010, 44, 6621-6627 10.1021/es100970m
    • (2010) Environ. Sci. Technol. , vol.44 , pp. 6621-6627
    • Helbling, D.E.1    Hollender, J.2    Kohler, H.-P.E.3    Fenner, K.4
  • 42
    • 84893524340 scopus 로고    scopus 로고
    • Strategies to Characterize Polar Organic Contamination in Wastewater: Exploring the Capability of High Resolution Mass Spectrometry
    • Schymanski, E. L.; Singer, H. P.; Longrée, P.; Loos, M.; Ruff, M.; Stravs, M. A.; Ripollés Vidal, C.; Hollender, J. Strategies to Characterize Polar Organic Contamination in Wastewater: Exploring the Capability of High Resolution Mass Spectrometry Environ. Sci. Technol. 2014, 48, 1811-1818 10.1021/es4044374
    • (2014) Environ. Sci. Technol. , vol.48 , pp. 1811-1818
    • Schymanski, E.L.1    Singer, H.P.2    Longrée, P.3    Loos, M.4    Ruff, M.5    Stravs, M.A.6    Ripollés Vidal, C.7    Hollender, J.8
  • 43
    • 84942100251 scopus 로고    scopus 로고
    • Quantitative target and systematic non-target analysis of polar organic micro-pollutants along the river Rhine using high-resolution mass-spectrometry - Identification of unknown sources and compounds
    • Ruff, M.; Mueller, M. S.; Loos, M.; Singer, H. P. Quantitative target and systematic non-target analysis of polar organic micro-pollutants along the river Rhine using high-resolution mass-spectrometry-Identification of unknown sources and compounds Water Res. 2015, 87, 145-154 10.1016/j.watres.2015.09.017
    • (2015) Water Res. , vol.87 , pp. 145-154
    • Ruff, M.1    Mueller, M.S.2    Loos, M.3    Singer, H.P.4
  • 45
    • 84979079694 scopus 로고    scopus 로고
    • enviMass version 1.2. (accessed July 2)
    • Singer, H.; Loos, M.; Schymanski, E. enviMass version 1.2. http://www.eawag.ch/en/department/uchem/software/envimass/ (accessed July 2, 2015).
    • (2015)
    • Singer, H.1    Loos, M.2    Schymanski, E.3
  • 46
    • 84930675191 scopus 로고    scopus 로고
    • Accelerated Isotope Fine Structure Calculation Using Pruned Transition Trees
    • Loos, M.; Gerber, C.; Corona, F.; Hollender, J.; Singer, H. Accelerated Isotope Fine Structure Calculation Using Pruned Transition Trees Anal. Chem. 2015, 87, 5738-5744 10.1021/acs.analchem.5b00941
    • (2015) Anal. Chem. , vol.87 , pp. 5738-5744
    • Loos, M.1    Gerber, C.2    Corona, F.3    Hollender, J.4    Singer, H.5
  • 47
    • 34248231583 scopus 로고    scopus 로고
    • EMEA. Committee for Medicinal Products for Human Use (CHMP); European Medicines Agency (EMEA): London, 01 June, p 12
    • EMEA. Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use; Committee for Medicinal Products for Human Use (CHMP); European Medicines Agency (EMEA): London, 01 June, 2006; p 12.
    • (2006) Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use
  • 48
    • 84978970117 scopus 로고    scopus 로고
    • Arzneimittelkompendium. (accessed: July 9)
    • Arzneimittelkompendium. http://www.compendium.ch (accessed: July 9, 2015).
    • (2015)
  • 49
    • 34250866191 scopus 로고    scopus 로고
    • Screening method for ecotoxicological hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes
    • Lienert, J.; Gudel, K.; Escher, B. I. Screening method for ecotoxicological hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes Environ. Sci. Technol. 2007, 41, 4471-4478 10.1021/es0627693
    • (2007) Environ. Sci. Technol. , vol.41 , pp. 4471-4478
    • Lienert, J.1    Gudel, K.2    Escher, B.I.3
  • 50
    • 84979088261 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency. Estimation ProgramsInterface Suite for Microsoft® Windows (EPI Suite), v 4.00. (accessed: July 4)
    • U.S. Environmental Protection Agency. Estimation ProgramsInterface Suite for Microsoft® Windows (EPI Suite), v 4.00. http://www.epa.gov/opptintr/exposure/pubs/episuitedl.htm (accessed: July 4, 2012).
    • (2012)
  • 51
    • 27744498927 scopus 로고    scopus 로고
    • Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants
    • Clara, M.; Strenn, B.; Gans, O.; Martinez, E.; Kreuzinger, N.; Kroiss, H. Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants Water Res. 2005, 39, 4797-4807 10.1016/j.watres.2005.09.015
    • (2005) Water Res. , vol.39 , pp. 4797-4807
    • Clara, M.1    Strenn, B.2    Gans, O.3    Martinez, E.4    Kreuzinger, N.5    Kroiss, H.6
  • 52
    • 84867085924 scopus 로고    scopus 로고
    • Micropollutant Biotransformation Kinetics Associate with WWTP Process Parameters and Microbial Community Characteristics
    • Helbling, D. E.; Johnson, D. R.; Honti, M.; Fenner, K. Micropollutant Biotransformation Kinetics Associate with WWTP Process Parameters and Microbial Community Characteristics Environ. Sci. Technol. 2012, 46, 10579-10588 10.1021/es3019012
    • (2012) Environ. Sci. Technol. , vol.46 , pp. 10579-10588
    • Helbling, D.E.1    Johnson, D.R.2    Honti, M.3    Fenner, K.4
  • 53
    • 80052233631 scopus 로고    scopus 로고
    • Phylogenetic Diversity and Metabolic Potential of Activated Sludge Microbial Communities in Full-Scale Wastewater Treatment Plants
    • Yang, C.; Zhang, W.; Liu, R.; Li, Q.; Li, B.; Wang, S.; Song, C.; Qiao, C.; Mulchandani, A. Phylogenetic Diversity and Metabolic Potential of Activated Sludge Microbial Communities in Full-Scale Wastewater Treatment Plants Environ. Sci. Technol. 2011, 45, 7408-7415 10.1021/es2010545
    • (2011) Environ. Sci. Technol. , vol.45 , pp. 7408-7415
    • Yang, C.1    Zhang, W.2    Liu, R.3    Li, Q.4    Li, B.5    Wang, S.6    Song, C.7    Qiao, C.8    Mulchandani, A.9
  • 54
    • 84907610844 scopus 로고    scopus 로고
    • Fluoroquinolone antibiotics: An emerging class of environmental micropollutants
    • Van Doorslaer, X.; Dewulf, J.; Van Langenhove, H.; Demeestere, K. Fluoroquinolone antibiotics: An emerging class of environmental micropollutants Sci. Total Environ. 2014, 500, 250-269 10.1016/j.scitotenv.2014.08.075
    • (2014) Sci. Total Environ. , vol.500 , pp. 250-269
    • Van Doorslaer, X.1    Dewulf, J.2    Van Langenhove, H.3    Demeestere, K.4
  • 55
    • 84872679392 scopus 로고    scopus 로고
    • Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: A review
    • Michael, I.; Rizzo, L.; McArdell, C. S.; Manaia, C. M.; Merlin, C.; Schwartz, T.; Dagot, C.; Fatta-Kassinos, D. Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: A review Water Res. 2013, 47, 957-995 10.1016/j.watres.2012.11.027
    • (2013) Water Res. , vol.47 , pp. 957-995
    • Michael, I.1    Rizzo, L.2    McArdell, C.S.3    Manaia, C.M.4    Merlin, C.5    Schwartz, T.6    Dagot, C.7    Fatta-Kassinos, D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.