Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice

Cancer Immunology, Immunotherapy

Volumn 65, Issue 9, 2016, Pages 1075-1083

  Selmi, Abderraouf ^a   Vascotto, Fulvia ^a   Kautz Neu, Kordula ^a   Türeci, Özlem ^b   Sahin, Ugur ^a,c   von Stebut, Esther ^a   Diken, Mustafa ^a,c   Kreiter, Sebastian ^a,c  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b Cluster for Individualized Immune Intervention   (Germany)

^c BIONTECH AG   (Germany)

Author keywords

Cancer immunotherapy; Dermal dendritic cell; Intradermal vaccination; Macropinocytosis; Naked RNA; RNA vaccine

Indexed keywords

CD8 ANTIGEN; NAKED RNA; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; DERMIS; FEMALE; KINETICS; MOUSE; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL; RNA IMMUNIZATION; RNA TRANSLATION; SKIN CELL; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; HUMAN; IMMUNOLOGY; INTRADERMAL DRUG ADMINISTRATION; METABOLISM;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; HUMANS; INJECTIONS, INTRADERMAL; MICE; MICE, INBRED C57BL; PINOCYTOSIS; RNA;

EID: 84978909884     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-016-1869-7     Document Type: Article

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