-
1
-
-
74449093973
-
A comprehensive catalogue of somatic mutations from a human cancer genome
-
Pleasance, E. D. et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463, 191-196 (2010).
-
(2010)
Nature
, vol.463
, pp. 191-196
-
-
Pleasance, E.D.1
-
2
-
-
55549101623
-
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
-
Ley, T. J. et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456, 66-72 (2008).
-
(2008)
Nature
, vol.456
, pp. 66-72
-
-
Ley, T.J.1
-
3
-
-
77951115122
-
International network of cancer genome projects
-
Hudson, T. J. et al. International network of cancer genome projects. Nature 464, 993-998 (2010).
-
(2010)
Nature
, vol.464
, pp. 993-998
-
-
Hudson, T.J.1
-
4
-
-
84864258996
-
A landscape of driver mutations in melanoma
-
Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012).
-
(2012)
Cell
, vol.150
, pp. 251-263
-
-
Hodis, E.1
-
6
-
-
84884994218
-
Cancer Genome Atlas Research Network. The Cancer Genome Atlas Pan-Cancer analysis project
-
Cancer Genome Atlas Research Network. The Cancer Genome Atlas Pan-Cancer analysis project. Nat. Genet. 45, 1113-1120 (2013).
-
(2013)
Nat. Genet
, vol.45
, pp. 1113-1120
-
-
-
7
-
-
84908335908
-
Cancer Genome Atlas Research Network. Integrated genomic characterization of papillary thyroid carcinoma
-
Cancer Genome Atlas Research Network. Integrated genomic characterization of papillary thyroid carcinoma. Cell 159, 676-690 (2014).
-
(2014)
Cell
, vol.159
, pp. 676-690
-
-
-
8
-
-
84978630374
-
The Cancer Genome Atlas Pan-Cancer analysis project
-
Wilks, C. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Database 2014, bau093 (2014).
-
(2014)
Database
, vol.2014
, pp. bau093
-
-
Wilks, C.1
-
9
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214-218 (2013).
-
(2013)
Nature
, vol.499
, pp. 214-218
-
-
Lawrence, M.S.1
-
10
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558 (2013).
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
-
11
-
-
84863541457
-
Recurrent hemizygous deletions in cancers may optimize proliferative potential
-
Solimini, N. L. et al. Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science 337, 104-109 (2012).
-
(2012)
Science
, vol.337
, pp. 104-109
-
-
Solimini, N.L.1
-
12
-
-
84875758730
-
Lessons from the cancer genome
-
Garraway, L. A. & Lander, E. S. Lessons from the cancer genome. Cell 153, 17-37 (2013).
-
(2013)
Cell
, vol.153
, pp. 17-37
-
-
Garraway, L.A.1
Lander, E.S.2
-
13
-
-
84864598664
-
MuSiC: Identifying mutational significance in cancer genomes
-
Dees, N. D. et al. MuSiC: identifying mutational significance in cancer genomes. Genome Res. 22, 1589-1598 (2012).
-
(2012)
Genome Res
, vol.22
, pp. 1589-1598
-
-
Dees, N.D.1
-
14
-
-
79955166265
-
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
-
Mermel, C. H. et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12, R41 (2011).
-
(2011)
Genome Biol
, vol.12
, pp. R41
-
-
Mermel, C.H.1
-
15
-
-
84885129618
-
Comprehensive identification of mutational cancer driver genes across 12 tumor types
-
Tamborero, D. et al. Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci. Rep. 3, 2650 (2013).
-
(2013)
Sci. Rep
, vol.3
, pp. 2650
-
-
Tamborero, D.1
-
16
-
-
84924279179
-
Silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities
-
Rubio-Perez, C. et al. In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities. Cancer Cell 27, 382-396 (2015).
-
(2015)
Cancer Cell
, vol.27
, pp. 382-396
-
-
Rubio-Perez, C.1
-
17
-
-
84873802661
-
Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers
-
Reimand, J. & Bader, G. D. Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers. Mol. Syst. Biol. 9, 637 (2013).
-
(2013)
Mol. Syst. Biol
, Issue.9
, pp. 637
-
-
Reimand, J.1
Bader, G.D.2
-
18
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence, M. S. et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495-501 (2014).
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
-
19
-
-
64749094310
-
The cancer genome
-
Stratton, M. R., Campbell, P. J. & Futreal, P. A. The cancer genome. Nature 458, 719-724 (2009).
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
Campbell, P.J.2
Futreal, P.A.3
-
20
-
-
84908894973
-
Genome-wide analysis of noncoding regulatory mutations in cancer
-
Weinhold, N., Jacobsen, A., Schultz, N., Sander, C. & Lee, W. Genome-wide analysis of noncoding regulatory mutations in cancer. Nat. Genet. 46, 1160-1165 (2014).
-
(2014)
Nat. Genet
, vol.46
, pp. 1160-1165
-
-
Weinhold, N.1
Jacobsen, A.2
Schultz, N.3
Sander, C.4
Lee, W.5
-
21
-
-
77951720395
-
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
-
Meindl, A. et al. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat. Genet. 42, 410-414 (2010).
-
(2010)
Nat. Genet
, vol.42
, pp. 410-414
-
-
Meindl, A.1
-
22
-
-
25844519550
-
HSP90 and the chaperoning of cancer
-
Whitesell, L. & Lindquist, S. L. HSP90 and the chaperoning of cancer. Nat. Rev. Cancer 5, 761-772 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
23
-
-
0020132123
-
Isolation of a transforming sequence from a human bladder carcinoma cell line
-
Shih, C. & Weinberg, R. A. Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell 29, 161-169 (1982).
-
(1982)
Cell
, vol.29
, pp. 161-169
-
-
Shih, C.1
Weinberg, R.A.2
-
24
-
-
33845989934
-
Retroviral insertion mutagenesis in mice as a comparative oncogenomics tool to identify disease genes in human leukemia
-
Touw, I. P. & Erkeland, S. J. Retroviral insertion mutagenesis in mice as a comparative oncogenomics tool to identify disease genes in human leukemia. Mol. Ther. 15, 13-19 (2007).
-
(2007)
Mol. Ther
, vol.15
, pp. 13-19
-
-
Touw, I.P.1
Erkeland, S.J.2
-
25
-
-
0034676455
-
Surfing the p53 network
-
Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307-310 (2000).
-
(2000)
Nature
, vol.408
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
26
-
-
0027433563
-
Genetic linkage analysis in familial breast and ovarian cancer: Results from 214 families. The Breast Cancer Linkage Consortium
-
Easton, D. F., Bishop, D. T., Ford, D. & Crockford, G. P. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. Am. J. Hum. Genet. 52, 678-701 (1993).
-
(1993)
Am. J. Hum. Genet
, vol.52
, pp. 678-701
-
-
Easton, D.F.1
Bishop, D.T.2
Ford, D.3
Crockford, G.P.4
-
27
-
-
0027210981
-
Gain of function mutations in p53
-
Dittmer, D. et al. Gain of function mutations in p53. Nat. Genet. 4, 42-46 (1993).
-
(1993)
Nat. Genet
, vol.4
, pp. 42-46
-
-
Dittmer, D.1
-
28
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth, C. et al. Mutational landscape and significance across 12 major cancer types. Nature 502, 333-339 (2013).
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
-
30
-
-
84883467378
-
OncodriveCLUST: Exploiting the positional clustering of somatic mutations to identify cancer genes
-
Tamborero, D., Gonzalez-Perez, A. & Lopez-Bigas, N. OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes. Bioinformatics 29, 2238-2244 (2013).
-
(2013)
Bioinformatics
, vol.29
, pp. 2238-2244
-
-
Tamborero, D.1
Gonzalez-Perez, A.2
Lopez-Bigas, N.3
-
31
-
-
84926157747
-
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
-
Leiserson, M. D. et al. Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat. Genet. 47, 106-114 (2015).
-
(2015)
Nat. Genet
, vol.47
, pp. 106-114
-
-
Leiserson, M.D.1
-
32
-
-
84856532705
-
De novo discovery of mutated driver pathways in cancer
-
Vandin, F., Upfal, E. & Raphael, B. J. De novo discovery of mutated driver pathways in cancer. Genome Res. 22, 375-385 (2012).
-
(2012)
Genome Res
, vol.22
, pp. 375-385
-
-
Vandin, F.1
Upfal, E.2
Raphael, B.J.3
-
33
-
-
84929852263
-
The landscape and therapeutic relevance of cancerassociated transcript fusions
-
Yoshihara, K. et al. The landscape and therapeutic relevance of cancerassociated transcript fusions. Oncogene 34, 4845-4854 (2014).
-
(2014)
Oncogene
, vol.34
, pp. 4845-4854
-
-
Yoshihara, K.1
-
34
-
-
75549087826
-
COSMIC (the Catalogue of Somatic Mutations in Cancer a resource to investigate acquired mutations in human cancer
-
Forbes, S. A. et al. COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer. Nucleic Acids Res. 38, D652-D657 (2010).
-
(2010)
Nucleic Acids Res
, vol.38
, pp. D652-D657
-
-
Forbes, S.A.1
-
35
-
-
84946069451
-
UniProt: A hub for protein information
-
UniProt, C. UniProt: a hub for protein information. Nucleic Acids Res. 43, D204-D212 (2015).
-
(2015)
Nucleic Acids Res
, vol.43
, pp. D204-D212
-
-
UniProt, C.1
-
36
-
-
84923884337
-
DISEASES: Text mining and data integration of disease-gene associations
-
Pletscher-Frankild, S., Palleja, A., Tsafou, K., Binder, J. X. & Jensen, L. J. DISEASES: text mining and data integration of disease-gene associations. Methods 74, 83-89 (2015).
-
(2015)
Methods
, vol.74
, pp. 83-89
-
-
Pletscher-Frankild, S.1
Palleja, A.2
Tsafou, K.3
Binder, J.X.4
Jensen, L.J.5
-
37
-
-
84876592729
-
Atlas of genetics and cytogenetics in oncology and haematology in 2013
-
Huret, J. L. et al. Atlas of genetics and cytogenetics in oncology and haematology in 2013. Nucleic Acids Res. 41, D920-D924 (2013).
-
(2013)
Nucleic Acids Res
, vol.41
, pp. D920-D924
-
-
Huret, J.L.1
-
38
-
-
79958135926
-
Molecular signatures database (MSigDB) 3.0
-
Liberzon, A. et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27, 1739-1740 (2011).
-
(2011)
Bioinformatics
, vol.27
, pp. 1739-1740
-
-
Liberzon, A.1
-
39
-
-
84941067326
-
The Candidate Cancer Gene Database: A database of cancer driver genes from forward genetic screens in mice
-
Abbott, K. L. et al. The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice. Nucleic Acids Res. 43, D844-D848 (2015).
-
(2015)
Nucleic Acids Res
, vol.43
, pp. D844-D848
-
-
Abbott, K.L.1
-
40
-
-
84925867952
-
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
-
Cowley, G. S. et al. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci. Data 1, 140035 (2014).
-
(2014)
Sci. Data
, vol.1
, pp. 140035
-
-
Cowley, G.S.1
-
41
-
-
84978761257
-
Incidence and mortality web-based report
-
Group, U. S. C. S. W. United States Cancer Statistics 1999-2010 (Atlanta U.S. Department of Health and Human Services Centers for Disease Control and Prevention and National Cancer Institute
-
Group, U. S. C. S. W. United States Cancer Statistics: 1999-2010 Incidence and Mortality Web-based Report. in cdc.gov (Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, 2014).
-
(2014)
In CDC.gov
-
-
-
42
-
-
84884524540
-
Frequency of TERT promoter mutations in human cancers
-
Vinagre, J. et al. Frequency of TERT promoter mutations in human cancers. Nat. Commun. 4, 2185 (2013).
-
(2013)
Nat. Commun
, vol.4
, pp. 2185
-
-
Vinagre, J.1
-
43
-
-
84874189784
-
Highly recurrent TERT promoter mutations in human melanoma
-
Huang, F. W. et al. Highly recurrent TERT promoter mutations in human melanoma. Science 339, 957-959 (2013).
-
(2013)
Science
, vol.339
, pp. 957-959
-
-
Huang, F.W.1
-
44
-
-
84930638395
-
Whole-genome characterization of chemoresistant ovarian cancer
-
Patch, A. M. et al. Whole-genome characterization of chemoresistant ovarian cancer. Nature 521, 489-494 (2015).
-
(2015)
Nature
, vol.521
, pp. 489-494
-
-
Patch, A.M.1
-
45
-
-
84877278637
-
Implementing personalized cancer genomics in clinical trials
-
Simon, R. & Roychowdhury, S. Implementing personalized cancer genomics in clinical trials. Nat. Rev. Drug Discov. 12, 358-369 (2013).
-
(2013)
Nat. Rev. Drug Discov
, vol.12
, pp. 358-369
-
-
Simon, R.1
Roychowdhury, S.2
-
46
-
-
84908117009
-
The clinical response to vemurafenib in a patient with a rare BRAFV600DK601del mutation-positive melanoma
-
Trudel, S. et al. The clinical response to vemurafenib in a patient with a rare BRAFV600DK601del mutation-positive melanoma. BMC Cancer 14, 727 (2014).
-
(2014)
BMC Cancer
, vol.14
, pp. 727
-
-
Trudel, S.1
-
47
-
-
84954318418
-
Extended survival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis
-
Johung, K. L. et al. Extended survival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis. J. Clin. Oncol. 34, 123-129 (2016).
-
(2016)
J. Clin. Oncol
, vol.34
, pp. 123-129
-
-
Johung, K.L.1
-
48
-
-
84861417677
-
BRAF inhibition in refractory hairy-cell leukemia
-
Dietrich, S. et al. BRAF inhibition in refractory hairy-cell leukemia. N. Engl. J. Med. 366, 2038-2040 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 2038-2040
-
-
Dietrich, S.1
-
49
-
-
84928254065
-
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
-
McGranahan, N. et al. Clonal status of actionable driver events and the timing of mutational processes in cancer evolution. Sci. Transl. Med. 7, 283ra54 (2015).
-
(2015)
Sci. Transl. Med
, vol.7
, pp. 283ra54
-
-
McGranahan, N.1
-
50
-
-
84978727822
-
A next generation sequencing-based approach to detect gene mutations, copy number changes and IGH translocations in multiple myeloma
-
Bolli, N. et al. A next generation sequencing-based approach to detect gene mutations, copy number changes and IGH translocations in multiple myeloma. Blood 124, 3364-3364 (2014).
-
(2014)
Blood
, vol.124
, pp. 3364
-
-
Bolli, N.1
-
51
-
-
84887491073
-
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
-
Frampton, G. M. et al. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat. Biotechnol. 31, 1023-1031 (2013).
-
(2013)
Nat. Biotechnol
, vol.31
, pp. 1023-1031
-
-
Frampton, G.M.1
-
52
-
-
84983535287
-
Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors
-
Hovelson, D. H. et al. Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors. Neoplasia 17, 385-399 (2015).
-
(2015)
Neoplasia
, vol.17
, pp. 385-399
-
-
Hovelson, D.H.1
-
53
-
-
84875978905
-
ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens
-
Shao, D. D. et al. ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens. Genome Res. 23, 665-678 (2013).
-
(2013)
Genome Res
, vol.23
, pp. 665-678
-
-
Shao, D.D.1
|