Relationship between white matter lesions and regional cerebral blood flow changes during longitudinal follow up in Alzheimer's disease

Geriatrics and Gerontology International

Volumn 16, Issue 7, 2016, Pages 836-842

  Hanaoka, Takuya ^a   Kimura, Noriyuki ^a   Aso, Yasuhiro ^a   Takemaru, Makoto ^a   Kimura, Yuki ^a   Ishibashi, Masato ^a   Matsubara, Etsuro ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; brain perfusion single photon emission computed tomography; regional cerebral blood flow; white matter lesions

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD FLOW; BRAIN DYSFUNCTION; BRAIN PERFUSION; CLINICAL ARTICLE; COGNITIVE DEFECT; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; FOLLOW UP; HUMAN; IMAGE ANALYSIS; LONGITUDINAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; WHITE MATTER LESION;

EID: 84978689308     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/ggi.12563     Document Type: Article

References (23)

1. Brun A, Englund E. A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann Neurol 1986; 19: 253–262.
2. Fazekas F, Chawluk JB, Alavi A et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. Am J Roentgenol 1987; 149: 351–356.
3. Mineura K, Sasajima H, Kikuchi K et al. White matter hyperintensity in neurologically asymptomatic subjects. Acta Neurol Scand 1995; 92: 151–156.
4. Amar K, Bucks RS, Lewis T et al. The effect of white matter low attenuation on cognitive performance in dementia of the Alzheimer type. Age Ageing 1996; 25: 443–448.
5. Blennow K, Wallin A, Uhlemann C et al. White-matter lesions on CT in Alzheimer patients: relation to clinical symptomatology and vascular factors. Acta Neurol Scand 1991; 83: 187–193.
6. Marder K, Richards M, Bello J et al. Clinical correlates of Alzheimer's disease with and without silent radiographic abnormalities. Arch Neurol 1995; 52: 146–151.
7. Heo JH, Lee ST, Kon Chu et al. White matter hyperintensities and cognitive dysfunction in Alzheimer disease. J Geriatr Psychiatry Neurol 2009; 22: 207–212.
8. Stenset V, Hofoss D, Berstad AE et al. White matter lesion subtypes and cognitive deficits in patients with memory impairment. Dement Geriatr Cogn Disord 2008; 26: 424–431.
9. Kimura N, Nakama H, Nakamura N et al. Effect of white matter lesions on brain perfusion in Alzheimer's disease. Dement Geriatr Cogn Disord 2012; 34: 256–261.
10. Kimura N, Nakama H, Nakamura K et al. Relationship between white matter lesions and progression of cognitive decline in Alzheimer's disease. Dement Geriatr Cogn Dis Extra 2013; 29: 96–101.
11. Hanyu H, Sato T, Hirao K et al. The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study. J Neurol Sci 2010; 15: 96–101.
12. McKhann G, Drachman D, Folstein M et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939–944.
13. Molgaard CA. Multivariate analysis of Hachinski's Scale for discriminating senile dementia of the Alzheimer's Type from multiinfarct dementia. Neuroepidemiology 1987; 6: 153–160.
14. Takeuchi R, Sengoku T, Matsumura K. Usefulness of fully automated constant ROI analysis software for the brain: 3DSRT and FineSRT. Radiat Med 2006; 24: 538–544.
15. Harrell LE, Duvall E, Folks DG et al. The relationship of high-intensity signals on magnetic resonance images to cognitive and psychiatric state in Alzheimer's disease. Arch Neurol 1991; 48: 1136–1140.
16. Waldemar G, Christiansen P, Larsson HB et al. White matter magnetic resonance hyperintensities in dementia of the Alzheimer type: morphological and regional cerebral blood flow correlates. J Neurol Neurosurg Psychiatry 1994; 57: 1458–1465.
17. DeCarli C, Grady CL, Clark CM et al. Comparison of positron emission tomography, cognition, and brain volume in Alzheimer's disease with and without severe abnormalities of white matter. J Neurol Neurosurg Psychiatry 1996; 60: 158–167.
18. Almkvist O, Wahlund LO, Andersson-Lundman G et al. White-matter hyperintensity and neuropsychological functions in dementia and healthy aging. Arch Neurol 1992; 49: 626–632.
19. Zekry D, Duyckaerts C, Moulias R et al. Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. Acta Neuropathol 2002; 103: 481–487.
20. Iadecola C, Gorelick PB. Converging pathogenic mechanisms in vascular and neurodegenerative dementia. Stroke 2003; 34: 335–337.
21. Sadowski M, Pankiewicz J, Scholtzova H et al. Links between the pathology of Alzheimer's disease and vascular dementia. Neurochem Res 2004; 29: 1257–1266.
22. Kleiman T, Zdanys K, Black B et al. Apolipoprotein E epsilon 4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis. Dement Geriatr Cogn Disord 2006; 22: 73–82.
23. Murphy GM, Taylor J, Kraemer HC et al. No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease. Am J Psychiatry 1997; 154: 603–608.