Inhibiting GPIbα shedding preserves post-Transfusion recovery and hemostatic function of platelets after prolonged storage

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 9, 2016, Pages 1821-1828

  Chen, Wenchun ^a   Liang, Xin ^a   Syed, Anum K ^a   Jessup, Paula ^a   Church, William R ^b   Ware, Jerry ^c   Josephson, Cassandra D ^a   Li, Renhao ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Green Mountain Antibodies   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Blood bank; Glycoprotein; Platelet transfusion; Proteolysis

Indexed keywords

COLLAGEN; GLYCOPROTEIN IB ALPHA; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5G6; UNCLASSIFIED DRUG; ADHESION RECEPTOR; THROMBIN RECEPTOR;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CLEARANCE; CONTROLLED STUDY; DEGRANULATION; EX VIVO STUDY; HEMOSTASIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PLATELET CLEARANCE; PLATELET DEGRANULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR FLOW; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE MEMBRANE; THROMBOCYTE PRESERVATION; THROMBOCYTE TRANSFUSION; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; APHERESIS; C57BL MOUSE; DRUG EFFECTS; GENETICS; GENOTYPE; METABOLISM; PHENOTYPE; SCID MOUSE; THROMBOCYTE; TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD COMPONENT REMOVAL; BLOOD PLATELETS; CELL DEGRANULATION; GENOTYPE; HEMOSTASIS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE, INBRED C57BL; MICE, SCID; MICE, TRANSGENIC; PHENOTYPE; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PLATELET TRANSFUSION; TIME FACTORS;

EID: 84978665398     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.307639     Document Type: Article

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