Efficacy of topical mosquito repellent (picaridin) plus long-lasting insecticidal nets versus long-lasting insecticidal nets alone for control of malaria: a cluster randomised controlled trial

The Lancet Infectious Diseases

Volumn 16, Issue 10, 2016, Pages 1169-1177

  Sluydts, Vincent ^a,b   Durnez, Lies ^a   Heng, Somony ^b,c   Gryseels, Charlotte ^a,d   Canier, Lydie ^e   Kim, Saorin ^e   Van Roey, Karel ^a   Kerkhof, Karen ^a   Khim, Nimol ^e   Mao, Sokny ^c   Uk, Sambunny ^c   Sovannaroth, Siv ^c   Grietens, Koen Peeters ^a,f,g   Sochantha, Tho ^c   Menard, Didier ^e   Coosemans, Marc ^a,b  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c National Center for Parasitology Entomology and Malaria Control   (Cambodia)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e INSTITUT PASTEUR DU CAMBODGE   (Cambodia)

^f NAGASAKI UNIVERSITY   (Japan)

^g Partners for Applied Social Sciences   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ICARIDIN; INSECT REPELLENT; PIPERIDINE DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; CAMBODIA; CHILD; CONTROLLED STUDY; DISEASE TRANSMISSION; FEMALE; HUMAN; INSECTICIDE TREATED NET; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALARIA; MALARIA CONTROL; MALE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; CLUSTER ANALYSIS; CROSS-SECTIONAL STUDY; DRUG EFFECTS; INSECT VECTOR; MALARIA, FALCIPARUM; MALARIA, VIVAX; MOSQUITO CONTROL; PREVALENCE; PROCEDURES; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; ANIMALS; CAMBODIA; CHILD; CLUSTER ANALYSIS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INSECT REPELLENTS; INSECT VECTORS; INSECTICIDE-TREATED BEDNETS; MALARIA, FALCIPARUM; MALARIA, VIVAX; MALE; MOSQUITO CONTROL; PIPERIDINES; PREVALENCE;

EID: 84978532233     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(16)30148-7     Document Type: Article

References (30)

1. 1 Bhatt, S, Weiss, DJ, Cameron, E, et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature 526 (2015), 207–211.
2. 2 Curtis, CF, Jana-Kara, B, Maxwell, CA, Insecticide treated nets: Impact on vector populations and relevance of initial intensity of transmission and pyrethroid resistance. J Vector Borne Dis 40 (2003), 1–8.
3. 3 Durnez, L, Coosemans, M, Residual transmission of malaria: an old issue for new approaches. Manguin, S, (eds.) Anopheles mosquitoes. New insights into malaria vectors, 2013, InTech, Croatia, 671–704.
4. 4 WHO. Control of residual malaria parasite transmission. http://www.who.int/malaria/publications/atoz/technical-note-control-of-residual-malaria-parasite-transmission-sep14.pdf, 2014 (accessed June 18, 2015).
5. 5 Rowland, M, Downey, G, Rab, A, et al. DEET mosquito repellent provides personal protection against malaria: a household randomized trial in an Afghan refugee camp in Pakistan. Trop Med Int Health 9 (2004), 335–342.
6. 6 Hill, N, Lenglet, A, Arnéz, AM, Carneiro, I, Plant based insect repellent and insecticide treated bed nets to protect against malaria in areas of early evening biting vectors: double blind randomised placebo controlled clinical trial in the Bolivian Amazon. BMJ, 335, 2007, 1023.
7. 7 McGready, R, Simpson, JA, Htway, M, White, NL, Nosten, F, Lindsay, SW, A double-blind randomized therapeutic trial of insect repellents for the prevention of malaria in pregnancy. Trans R Soc Trop Med Hyg 95 (2001), 137–138.
8. 8 Chen-Hussey, V, Carneiro, I, Keomanila, H, et al. Can topical insect repellents reduce malaria? A cluster-randomised controlled trial of the insect repellent N,N-diethyl-m-toluamide (DEET) in Lao PDR. PLoS One, 8, 2013, e70664.
9. 9 Sangoro, O, Turner, E, Simfukwe, E, Miller, JE, Moore, SJ, A cluster-randomized controlled trial to assess the effectiveness of using 15% DEET topical repellent with long-lasting insecticidal nets (LLINs) compared to a placebo lotion on malaria transmission. Malar J, 13, 2014, 324.
10. 10 Deressa, W, Yihdego, YY, Kebede, Z, Batisso, E, Tekalegne, A, Dagne, GA, Effect of combining mosquito repellent and insecticide treated net on malaria prevalence in southern Ethiopia: a cluster-randomised trial. Parasit Vectors, 7, 2014, 132.
11. 11 Dadzie, S, Boakye, D, Asoala, V, Koram, K, Kisweski, A, Appawu, M, A community-wide study of malaria reduction: Evaluating efficacy and user-acceptance of a low-cost repellent in Northern Ghana. Am J Trop Med Hyg 88 (2013), 309–314.
12. 12 Dutta, P, Khan, AM, Khan, SA, Borah, J, Sharma, CK, Mahanta, J, Malaria control in a forest fringe area of Assam, India: a pilot study. Trans R Soc Trop Med Hyg 105 (2011), 327–332.
13. 13 Wilson, AL, Chen-Hussey, V, Logan, JG, Lindsay, SW, Are topical insect repellents effective against malaria in endemic populations? A systematic review and meta-analysis. Malar J, 13, 2014, 446.
14. 14 Wilson, AL, Boelaert, M, Kleinschmidt, I, et al. Evidence-based vector control? Improving the quality of vector control trials. Trends Parasitol 31 (2015), 1–11.
15. 15 Maia, MF, Onyango, SP, Thele, M, Simfukwe, ET, Turner, EL, Moore, SJ, Do topical repellents divert mosquitoes within a community? Health equity implications of topical repellents as a mosquito bite prevention tool. PLoS One, 8, 2013, e84875.
16. 16 Clarke, SE, Bøgh, C, Brown, RC, Pinder, M, Walraven, GE, Lindsay, SW, Do untreated bednets protect against malaria?. Trans R Soc Trop Med Hyg 95 (2001), 457–462.
17. 17 Trung, HD, Bortel, WV, Sochantha, T, Keokenchanh, K, Briët, OJ, Coosemans, M, Behavioural heterogeneity of anopheles species in ecologically different localities in southeast Asia: a challenge for vector control. Trop Med Int Health 10 (2005), 251–262.
18. 18 Durnez, L, Mao, S, Denis, L, Roelants, P, Sochantha, T, Coosemans, M, Outdoor malaria transmission in forested villages of Cambodia. Malar J, 12, 2013, 329.
19. 19 Sluydts, V, Heng, S, Coosemans, M, et al. Spatial clustering and risk factors of malaria infections in Ratanakiri Province, Cambodia. Malar J, 13, 2014, 387.
20. 20 Gryseels, C, Uk, S, Sluydts, V, et al. Factors influencing the use of topical repellents: implications for the effectiveness of malaria elimination strategies. Sci Rep, 5, 2015, 16847.
21. 21 Heng, S, Durnez, L, Gryseels, C, et al. Assuring access to topical mosquito repellents within an intensive distribution scheme: a case study in a remote province of Cambodia. Malar J, 14, 2015, 468.
22. 22 Van Roey, K, Sokny, M, Denis, L, et al. Field evaluation of picaridin repellents reveals differences in repellent sensitivity between southeast Asian vectors of malaria and arboviruses. PLoS Negl Trop Dis, 8, 2014, e3326.
23. 23 Hayes, RJ, Moulton, LH, Cluster randomised trials, 2009, CRC Press, Taylor & Francis Group, Boca Raton, FL.
24. 24 Canier, L, Khim, N, Kim, S, et al. An innovative tool for moving malaria PCR detection of parasite reservoir into the field. Malar J, 12, 2013, 405.
25. 25 Maude, RJ, Nguon, C, Ly, P, et al. Spatial and temporal epidemiology of clinical malaria in Cambodia 2004–2013. Malar J, 13, 2014, 385.
26. 26 Kerkhof, K, Sluydts, V, Canier, L, et al. Implementation and application of a multiplex assay to detect malaria-specific antibodies: a promising tool for assessing malaria transmission in southeast Asian pre-elimination areas. Malar J, 14, 2015, 338.
27. 27 Corran, P, Coleman, P, Riley, E, Drakeley, C, Serology: a robust indicator of malaria transmission intensity?. Trends Parasitol 23 (2007), 575–582.
28. 28 Yman, V, White, MT, Rono, J, et al. Antibody acquisition models: A new tool for serological surveillance of malaria transmission intensity. Sci Rep, 6, 2016, 19472.
29. 29 Eo, S-H, Pak, D, Choi, J, Cho, H, Outlier detection using projection quantile regression for mass spectrometry data with low replication. BMC Res Notes, 5, 2012, 236.
30. 30 Peng, RD, Dominici, F, Zeger, SL, Reproducible epidemiologic research. Am J Epidemiol 163 (2006), 783–789.