Field Evaluation of Picaridin Repellents Reveals Differences in Repellent Sensitivity between Southeast Asian Vectors of Malaria and Arboviruses

PLoS Neglected Tropical Diseases

Volumn 8, Issue 12, 2014, Pages

  Van Roey, Karel ^a   Sokny, Mao ^b   Denis, Leen ^a   Van den Broeck, Nick ^a   Heng, Somony ^b,c   Siv, Sovannaroth ^b   Sluydts, Vincent ^a   Sochantha, Tho ^b   Coosemans, Marc ^a   Durnez, Lies ^a  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b National Center for Parasitology Entomology and Malaria Control   (Cambodia)

^c INSTITUT PASTEUR DU CAMBODGE   (Cambodia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CIRCUMSPOROZOITE PROTEIN; DIETHYLTOLUAMIDE; ICARIDIN; INSECT REPELLENT; PIPERIDINE DERIVATIVE;

AEDES AEGYPTI; AEDES ALBOPICTUS; AEROSOL; ANOPHELES; ARBOVIRUS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CULEX; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG SENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIELD STUDY; INFECTION RATE; LOTION; MALARIA; MANSONIA; MOSQUITO; MOSQUITO BITE; NONHUMAN; NORMAL HUMAN; PARASITE INCIDENCE; POLYMERASE CHAIN REACTION; PROTECTION; VECTOR CONTROL; ANIMAL; CAMBODIA; INSECT VECTOR; INSECTICIDE RESISTANCE; PARASITOLOGY; TRANSMISSION; VIROLOGY; VIRUS INFECTION;

ANIMALS; ARBOVIRUS INFECTIONS; CAMBODIA; CULICIDAE; INSECT REPELLENTS; INSECT VECTORS; INSECTICIDE RESISTANCE; MALARIA; PIPERIDINES;

EID: 84928242297     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003326     Document Type: Article

References (62)

1. McGraw EA, O'Neill SL, (2013) Beyond insecticides: new thinking on an ancient problem. Nat Rev Microbiol 11: 181–193.
2. Tolle MA, (2009) Mosquito-borne diseases. Curr Probl Pediatr Adolesc Health Care 39: 97–140.
3. Gubler DJ, (2002) The global emergence/resurgence of arboviral diseases as public health problems. Arch Med Res 33: 330–342.
4. Durnez L, Coosemans M (2013) Residual Transmission of Malaria: An Old Issue for New Approaches. In: Manguin S, editor. Anopheles mosquitoes - New insights into malaria vectors.Intech.pp. 671–704. Available: http://www.intechopen.com/books/anopheles-mosquitoes-new-insights-into-malaria-vectors/residual-transmission-of-malaria-an-old-issue-for-new-approaches.
5. WHO (2013) World Malaria Report 2013. Geneva. Available: http://www.who.int/malaria/publications/world_malaria_report_2013/en/.
6. Russell TL, Govella NJ, Azizi S, Drakeley CJ, Kachur SP, et al. (2011) Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania. Malar J 10: 80.
7. Van Bortel W, Trung HD, Hoi LX, Van Ham N, Van Chut N, et al. (2010) Malaria transmission and vector behaviour in a forested malaria focus in central Vietnam and the implications for vector control. Malar J 9: 373.
8. Durnez L, Mao S, Denis L, Roelants P, Sochantha T, et al. (2013) Outdoor malaria transmission in forested villages of Cambodia. Malar J 12: 329.
9. Delacollette C, D'Souza C, Christophel E, Thimasarn K, Abdur R, et al. (2009) Malaria trends and challenges in the Greater Mekong Subregion. Southeast Asian J Trop Med Public Health 40: 674–691.
10. Thisyakorn U, Thisyakorn C, (2014) Latest developments and future directions in dengue vaccines. Ther Adv vaccines 2: 3–9.
11. Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, et al. (2013) Chikungunya virus infection: an overview. New Microbiol 36: 211–227.
12. Bettadapura J, Herrero LJ, Taylor A, Mahalingam S, (2013) Approaches to the treatment of disease induced by chikungunya virus. Indian J Med Res 138: 762–765.
13. Thavara U, Tawatsin A, Chansang C, Kong-ngamsuk W, Paosriwong S, et al. (2001) Larval occurrence, oviposition behavior and biting activity of potential mosquito vectors of dengue on Samui Island, Thailand. J Vector Ecol 26: 172–180.
14. Moore SJ, Debboun M (2007) History of Insect Repellents. In: Debboun M, Frances SP, Strickman D, editors. Insect Repellents.Principles, Methods, and Uses. New York: CRC Press. pp. 3–29.
15. Badolo A, Ilboudo-Sanogo E, Ouédraogo AP, Costantini C, (2004) Evaluation of the sensitivity of Aedes aegypti and Anopheles gambiae complex mosquitoes to two insect repellents: DEET and KBR 3023. Trop Med Int Health 9: 330–334.
16. Yap HH, Jahangir K, Chong AS, Adanan CR, Chong NL, et al. (1998) Field efficacy of a new repellent, KBR 3023, against Aedes albopictus (Skuse) and Culex quinquefasciatus (Say) in a tropical environment. J Vector Ecol 23: 62–68.
17. Yap HH, Jahangir K, Zairi J, (2000) Field efficacy of four insect repellent products against vector mosquitoes in a tropical environment. J Am Mosq Control Assoc 16: 241–244.
18. Uzzan B, Konate L, Diop A, Nicolas P, Dia I, et al. (2009) Efficacy of four insect repellents against mosquito bites: a double-blind randomized placebo-controlled field study in Senegal. Fundam Clin Pharmacol 23: 589–594.
19. Frances SP, Waterson DGE, Beebe NW, Cooper RD, (2004) Field evaluation of repellent formulations containing deet and picaridin against mosquitoes in Northern Territory, Australia. J Med Entomol 41: 414–417.
20. Barnard DR, Bernier UR, Posey KH, Xue R-D, (2002) Repellency of IR3535, KBR3023, para-menthane-3,8-diol, and deet to black salt marsh mosquitoes (Diptera: Culicidae) in the Everglades National Park. J Med Entomol 39: 895–899.
21. Costantini C, Badolo A, Ilboudo-Sanogo E, (2004) Field evaluation of the efficacy and persistence of insect repellents DEET, IR3535, and KBR 3023 against Anopheles gambiae complex and other Afrotropical vector mosquitoes. Trans R Soc Trop Med Hyg 98: 644–652.
22. Hill N, Lenglet A, Arnéz AM, Carneiro I, (2007) Plant based insect repellent and insecticide treated bed nets to protect against malaria in areas of early evening biting vectors: double blind randomised placebo controlled clinical trial in the Bolivian Amazon. BMJ 335: 1023.
23. Dutta P, Khan AM, Khan SA, Borah J, Sharma CK, et al. (2011) Malaria control in a forest fringe area of Assam, India: a pilot study. Trans R Soc Trop Med Hyg 105: 327–332.
24. Rowland M, Downey G, Rab A, Freeman T, Mohammad N, et al. (2004) DEET mosquito repellent provides personal protection against malaria: a household randomized trial in an Afghan refugee camp in Pakistan. Trop Med Int Health 9: 335–342.
25. Dadzie S, Boakye D, Asoala V, Koram K, Kiszewski A, et al. (2013) A community-wide study of malaria reduction: evaluating efficacy and user-acceptance of a low-cost repellent in northern Ghana. Am J Trop Med Hyg 88: 309–314.
26. Prakash A, Bhattacharyya DR, Mohapatra PK, Barua U, Phukan A, et al. (2003) Malaria control in a forest camp in an oil exploration area of Upper Assam. Natl Med J India 16: 135–138.
27. Chen-Hussey V, Carneiro I, Keomanila H, Gray R, Bannavong S, et al. (2013) Can topical insect repellents reduce malaria? A cluster-randomised controlled trial of the insect repellent N, N-diethyl-m-toluamide (DEET) in Lao PDR. PLoS One 8: e70664.
28. Kiszewski AE, Darling ST, (2010) Estimating a mosquito repellent ' s potential to reduce malaria in communities. J Vector Borne Dis 47: 217–221.
29. WHO (2009) Guidelines for efficacy testing of mosquito repellents for human skin. Geneva. Available: http://whqlibdoc.who.int/hq/2009/WHO_HTM_NTD_WHOPES_2009.4_eng.pdf.
30. Moore SJ, Davies CR, Hill N, Cameron MM, (2007) Are mosquitoes diverted from repellent-using individuals to non-users? Results of a field study in Bolivia. Trop Med Int Health 12: 532–539.
31. MR4 (2011) Methods in Anopheles Research. Malaria Research and Reference Reagent Resource Center. Available: http://www.mr4.org/Publications/MethodsinAnophelesResearch.aspx.
32. Durnez L, Van Bortel W, Denis L, Roelants P, Veracx A, et al. (2011) False positive circumsporozoite protein ELISA: a challenge for the estimation of the entomological inoculation rate of malaria and for vector incrimination. Malar J 10: 195.
33. Newcombe RG, (1998) Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med 17: 857–872.
34. O'Hara RB, Kotze DJ, (2010) Do not log-transform count data. Methods Ecol Evol 1: 118–122.
35. Maia MF, Onyango SP, Thele M, Simfukwe ET, Turner EL, et al. (2013) Do topical repellents divert mosquitoes within a community? Health equity implications of topical repellents as a mosquito bite prevention tool. PLoS One 8: e84875.
36. Frances SP, Debboun M (2007) User acceptability: public perceptions of insect repellents. In: Debboun M, Frances SP, Strickman D, editors. Insect Repellents.Principles, Methods, and Uses. Boca Raton: CRC Press. p. 495.
37. Boulanger N, de Gentile L (2012) Les répulsifs cutanés. In: Duvallet G, de Gentile L, editors. Protection personnelle antivectorielle. Marseille: IRD éditions. p. 352.
38. Xue R-D, Ali A, Day JF (2007) Commercially available insect repellents and criteria for their use. In: Debboun M, Frances SP, Strickman D, editors. Insect Repellents.Principles, Methods, and Uses.Boca Raton: CRC Press. p. 495.
39. Sinka ME, Bangs MJ, Manguin S, Coetzee M, Mbogo CM, et al. (2010) The dominant Anopheles vectors of human malaria in Africa, Europe and the Middle East: occurrence data, distribution maps and bionomic précis. Parasit Vectors 3: 117.
40. Sinka ME, Bangs MJ, Manguin S, Chareonviriyaphap T, Patil AP, et al. (2011) The dominant Anopheles vectors of human malaria in the Asia-Pacific region: occurrence data, distribution maps and bionomic précis. Parasit Vectors 4: 89.
41. Schofield S, Tepper M, Gadawski R, (2007) Laboratory and field evaluation of the impact of exercise on the performance of regular and polymer-based deet repellents. J Med Entomol 44: 1026–1031.
42. Lupi E, Hatz C, Schlagenhauf P, (2013) The efficacy of repellents against Aedes, Anopheles, Culex and Ixodes spp. - a literature review. Travel Med Infect Dis 11: 374–411.
43. Curtis CF, Lines JD, Ijumba J, Callaghan A, Hill N, et al. (1987) The relative efficacy of repellents against mosquito vectors of disease. Med Vet Entomol 1: 109–119.
44. Spitzen J, Takken W, (2005) Malaria mosquito rearing - maintaining quality and quantity of laboratory-reared insects. Proc Neth Entomol Soc Meet. p 16: 95–100.
45. Xue RD, Barnard DR, (1996) Human host avidity in Aedes albopictus: influence of mosquito body size, age, parity, and time of day. J Am Mosq Control Assoc 12: 58–63.
46. Trung HD, Bortel W Van, Sochantha T, Keokenchanh K, Briët OJT, et al. (2005) Behavioural heterogeneity of Anopheles species in ecologically different localities in Southeast Asia: a challenge for vector control. Trop Med Int Health 10: 251–262.
47. Stanczyk NM, Brookfield JFY, Ignell R, Logan JG, Field LM, (2010) Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function. Proc Natl Acad Sci USA 107: 8575–8580.
48. Frances SP, Eikarat N, Sripongsai B, Eamsila C, (1993) Response of Anopheles dirus and Aedes albopictus to repellents in the laboratory. J Am Mosq Control Assoc 9: 474–476.
49. Hallem EA, Dahanukar A, Carlson JR, (2006) Insect odor and taste receptors. Annu Rev Entomol 51: 113–135.
50. Pellegrino M, Steinbach N, Stensmyr MC, Hansson BS, Vosshall LB, (2011) A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor. Nature 478: 511–514.
51. Fradin MS, (1998) Mosquitoes and Mosquito Repellents: A Clinician's Guide. 128: 931–940.
52. Liu C, Pitts RJ, Bohbot JD, Jones PL, Wang G, et al. (2010) Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. PLoS Biol 8: 1–17.
53. Ditzen M, Pellegrino M, Vosshall LB, (2008) Insect odorant receptors are molecular targets of the insect repellent DEET. Science 319: 1838–1842.
54. DeGennaro M, McBride CS, Seeholzer L, Nakagawa T, Dennis EJ, et al. (2013) Orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET. Nature 498: 487–491.
55. Kain P, Boyle SM, Tharadra SK, Guda T, Pham C, et al. (2013) Odour receptors and neurons for DEET and new insect repellents. Nature 502: 507–514.
56. Jones WD, Nguyen T-AT, Kloss B, Lee KJ, Vosshall LB, (2005) Functional conservation of an insect odorant receptor gene across 250 million years of evolution. Curr Biol 15: R119–21.
57. Bohbot JD, Dickens JC, (2010) Insect repellents: modulators of mosquito odorant receptor activity. PLoS One 5: e12138.
58. Cornet S, Nicot A, Rivero A, Gandon S, (2013) Malaria infection increases bird attractiveness to uninfected mosquitoes. Ecol Lett 16: 323–329.
59. Qualls WA, Day JF, Xue R, Bowers DF, (2012) Altered behavioral responses of Sindbis virus-infected Aedes aegypti (Diptera: Culicidae) to DEET and non-DEET based insect repellents. Acta Trop 122: 284–290.
60. Copeland RS, Walker TW, Robert LL, Githure JI, Wirtz RA, et al. (1995) Response of wild Anopheles funestus to repellent-protected volunteers is unaffected by malaria infection of the vector. J Am Mosq Control Assoc 11: 438–440.
61. Frances SP, Sithiprasasna R, Linthicum KJ, (2011) Laboratory evaluation of the response of Aedes aegypti and Aedes albopictus uninfected and infected with dengue virus to deet. J Med Entomol 48: 334–336.
62. Mouchet J, Carnevale P, Manguin S (2008) Biodiversity of Malaria in the World. John Libbey Eurotext.