Folic acid and autism: What do we know?

Nutritional Neuroscience

Volumn 19, Issue 7, 2016, Pages 310-317

  Castro, Kamila ^a,b,c   Klein, Luciana da Silveira ^a   Baronio, Diego ^a,b   Gottfried, Carmem ^b   Riesgo, Rudimar ^a,b   Perry, Ingrid Schweigert ^a,d  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b Translational Research Group in Autism Spectrum Disorder (GETTEA)   (Brazil)

^c Instituto de Pesquisas Biomédicas   (Brazil)

^d Universidade do Extremo Sul de Santa Catarina   (Brazil)

Author keywords

Autistic disorder; Folic acid; Vitamins

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHIONINE; PYRIDOXINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ARTICLE; AUTISM; FOOD INTAKE; HUMAN; NUTRITIONAL STATUS; PREGNANCY; PRESCRIPTION; PRIORITY JOURNAL; SYSTEMATIC REVIEW; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; ADOLESCENT; ADOLESCENT NUTRITION; ADVERSE EFFECTS; AUTISM SPECTRUM DISORDER; BLOOD; CHILD; CHILD NUTRITION; DIET; DIET THERAPY; DIETARY SUPPLEMENT; EVIDENCE BASED MEDICINE; FEMALE; FETUS DEVELOPMENT; FOLIC ACID DEFICIENCY; HYPERHOMOCYSTEINEMIA; INCIDENCE; MALE; MATERNAL NUTRITION; PATHOPHYSIOLOGY; REPRODUCIBILITY; RISK FACTOR;

ADOLESCENT; ADOLESCENT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; AUTISM SPECTRUM DISORDER; CHILD; CHILD NUTRITIONAL PHYSIOLOGICAL PHENOMENA; DIET; DIETARY SUPPLEMENTS; EVIDENCE-BASED MEDICINE; FEMALE; FETAL DEVELOPMENT; FOLIC ACID; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INCIDENCE; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PREGNANCY; REPRODUCIBILITY OF RESULTS; RISK FACTORS;

EID: 84978496057     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830514Y.0000000142     Document Type: Article

References (29)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington:American Psychiatric Association; 2013.
2. C.Gadia, R.Tuchman, N.T.Rotta. Autism and pervasive developmental disorders. J Pediatr 2004;80:S83–94.
3. I.Rapin, R.F.Tuchman. Autism:definition, neurobiology, screening, diagnosis. Pediatr Clin North Am 2008;55:1129–46. doi:10.1016/j.pcl.2008.07.005
4. I.Hertz-Picciotto, L.A.Croen, R.Hansen, C.R.Jones, J.van de Water, I.N.Pessah. The CHARGE study:an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect 2006;114:1119–25. doi:10.1289/ehp.8483
5. L.Klei, S.J.Sanders, M.T.Murtha, V.Hus, J.K.Lowe, A.J.Willsey, Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism 2012;3:9–22. doi:10.1186/2040-2392-3-9
6. A.L.Christianson, N.Chesler, J.G.Kromberg. Fetal valproate syndrome:clinical and neuro-developmental features in two sibling pairs. Dev Med Child Neurol 1994;36:361–9. doi:10.1111/j.1469-8749.1994.tb11858.x
7. S.A.Currenti. Understanding and determining the etiology of autism. Cell Mol Neurobiol 2010;30:161–71. doi:10.1007/s10571-009-9453-8
8. H.Atladóttir, T.B.Henriksen, D.E.Schendel, E.T.Parner. Autism after infection, febrile episodes, and antibiotic use during pregnancy:an exploratory study. Pediatrics 2012;130:1447–54. doi:10.1542/peds.2012-1107
9. Y.M.Al-Farsi, M.I.Waly, R.C.Deth, M.M.Al-Sharbati, M.Al-Shafaee, O.Al-Farsi, Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism. Nutrition 2013;29:537–41. doi:10.1016/j.nut.2012.09.014
10. A.Ali, M.I.Waly, Y.M.Al-Farsi, M.M.Essa, M.M.Al-Sharbati, R.C.Deth. Hyperhomocysteinemia among Omani autistic children:a case-control study. Acta Biochim Pol 2011;58:547–51.
11. B.J.Lee, P.T.Lin, Y.P.Liaw, S.J.Chang, C.H.Cheng, Y.C.Huang. Homocysteine and risk of coronary artery disease:folate is the important determinant of plasma homocysteine concentration. Nutrition 2003;19:577–83. doi:10.1016/S0899-9007(02)01098-5
12. S.J.James, S.Melnyk, G.Fuchs, T.Reid, S.Jernigan, O.Pavliv, Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr 2009;89:425–30. doi:10.3945/ajcn.2008.26615
13. V.T.Ramaekers, N.Blau, J.M.Sequeira, M.C.Nassogne, E.V.Quadros. Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits. Neuropediatrics 2007;38:276–81. doi:10.1055/s-2008-1065354
14. P.Surén, C.Roth, M.Bresnahan, M.Haugen, M.Hornig, D.Hirtz, Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA 2013;309:570–7. doi:10.1001/jama.2012.155925
15. M.Yeargin-Allsopp, C.Rice, T.Karapurkar, N.Doernberg, C.Boyle, C.Murphy. Prevalence of autism in a US metropolitan area. JAMA 2003;289:49–55. doi:10.1001/jama.289.1.49
16. C.M.Beard, L.A.Panser, S.K.Katusic. Is excess folic acid supplementation a risk factor for autism? Med Hypotheses 2011;77:15–7. doi:10.1016/j.mehy.2011.03.013
17. P.Moretti, S.U.Peters, D.Del Gaudio, T.Sahoo, K.Hyland, T.Bottiglieri, Brief report:autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency. J Autism Dev Disord 2008;38:1170–7. doi:10.1007/s10803-007-0492-z
18. S.L.Hyman, P.A.Stewart, B.Schmidt, U.Cain, N.Lemcke, J.T.Foley, Nutrient intake from food in children with autism. Pediatrics 2012;130:S145–53. doi:10.1542/peds.2012-0900L
19. J.Kałużna-Czaplińska, M.Michalska, J.Rynkowski. Vitamin supplementation reduces the level of homocysteine in the urine of autistic children. Nutr Res 2011;31:318–21. doi:10.1016/j.nutres.2011.03.009
20. P.Moretti, T.Sahoo, K.Hyland, T.Bottiglieri, S.Peters, D.del Gaudio, Cerebral folate deficiency with developmental delay, autism, and response to folinic acid. Neurology 2005;64:1088–90. doi:10.1212/01.WNL.0000154641.08211.B7
21. R.J.Schmidt, D.J.Tancredi, S.Ozonoff, R.L.Hansen, J.Hartiala, H.Allayee, Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr 2012;96:80–9. doi:10.3945/ajcn.110.004416
22. S.E.Soden, C.B.Garrison, A.M.Egan, A.M.Beckwith. Nutrition, physical activity, and bone mineral density in youth with autistic spectrum disorders. J Dev Behav Pediatr 2012;33:618–24. doi:10.1097/DBP.0b013e318260943c
23. W.Xia, Y.Zhou, C.Sun, J.Wang, L.Wu. A preliminary study on nutritional status and intake in Chinese children with autism. Eur J Pediatr 2010;169:1201–6. doi:10.1007/s00431-010-1203-x
24. A.Cosar, O.M.Ipcioglu. Re. Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism. Nutrition 2013;29:1170. doi:10.1016/j.nut.2013.01.007
25. J.B.Adams, C.Holloway. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. J Altern Complement Med 2004;10:1033–9. doi:10.1089/acm.2004.10.1033
26. P.M.Finglas, K.de Meer, A.Molloy, P.Verhoef, K.Pietrzik, H.J.Powers, Research goals for folate and related B vitamin in Europe. Eur J Clin Nutr 2006;60:287–94. doi:10.1038/sj.ejcn.1602315
27. L.G.Bandini, S.E.Anderson, C.Curtin, S.Cermak, E.W.Evans, R.Scampini, Food selectivity in children with autism spectrum disorders and typically developing children. J Pediatr 2010;157:259–64. doi:10.1016/j.jpeds.2010.02.013
28. J.S.Beighley, J.L.Matson, R.D.Rieske, H.L.Adams. Food selectivity in children with and without an autism spectrum disorder:investigation of diagnosis and age. Res Dev Disabil 2013;34:3497–503. doi:10.1016/j.ridd.2013.07.026
29. T.Anjos, S.Altmäe, P.Emmett, H.Tiemeier, R.Closa-Monasterolo, V.Luque, Nutrition and neurodevelopment in children:focus on NUTRIMENTHE project. Eur J Nutr 2013;52:1825–42. doi:10.1007/s00394-013-0560-4