Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review

World Journal of Gastroenterology

Volumn 22, Issue 27, 2016, Pages 6318-6327

  Golabi, Pegah ^a   Locklear, Cameron T ^b   Austin, Patrick ^a   Afdhal, Sophie ^a   Byrns, Melinda ^b   Gerber, Lynn ^a,b   Younossi, Zobair M ^a,b  

^a BETTY AND GUY BEATTY CENTER FOR INTEGRATED RESEARCH   (United States)

^b INOVA FAIRFAX HOSPITAL   (United States)

Author keywords

Diet; Exercise; Fat mobilization; Lifestyle modification; Non alcoholic fatty liver disease

Indexed keywords

TRIACYLGLYCEROL;

AEROBIC EXERCISE; DIET; EXERCISE; EXERCISE INTENSITY; GLYCEMIC CONTROL; HEPATIC FAT MOBILIZATION; HUMAN; INSULIN SENSITIVITY; LIPID TRANSPORT; LIVER BIOPSY; NONALCOHOLIC FATTY LIVER; PROTON NUCLEAR MAGNETIC RESONANCE; RESISTANCE TRAINING; REVIEW; SYSTEMATIC REVIEW; WEIGHT REDUCTION; BIOPSY; DIAGNOSTIC IMAGING; DIET THERAPY; INSULIN RESISTANCE; KINESIOTHERAPY; LIPID METABOLISM; LIVER; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY;

BIOPSY; DIET THERAPY; EXERCISE THERAPY; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; NON-ALCOHOLIC FATTY LIVER DISEASE; TRIGLYCERIDES;

EID: 84978474492     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v22.i27.6318     Document Type: Review

References (42)

1. Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. The diagnosis and management of nonalcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012; 142: 1592-1609 [PMID: 22656328 DOI: 10.1053/j.gastro.2012.04.001]
2. Montecucco F, Mach F. Does non-alcoholic fatty liver disease (NAFLD) increase cardiovascular risk? Endocr Metab Immune Disord Drug Targets 2008; 8: 301-307 [PMID: 19075784 DOI: 10.2174/187153008786848268]
3. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Metaanalytic assessment of prevalence, incidence, and outcomes. Hepatology 2016; 64: 73-84 [PMID: 26707365 DOI: 10.1002/hep.28431]
4. Masarone M, Federico A, Abenavoli L, Loguercio C, Persico M. Non alcoholic fatty liver: epidemiology and natural history. Rev Recent Clin Trials 2014; 9: 126-133 [PMID: 25514916 DOI: 10.217 4/1574887109666141216111143]
5. Mishra A, Younossi ZM. Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease. J Clin Exp Hepatol 2012; 2: 135-144 [PMID: 25755422 DOI: 10.1016/S0973-6883(12)60102-9]
6. Golabi P, Sayiner M, Fazel Y, Koenig A, Henry L, Younossi ZM. Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis. Expert Rev Gastroenterol Hepatol 2016; 10: 63-71 [PMID: 26469309 DOI: 10.1586/174741 24.2016.1099433]
7. Stepanova M, Rafiq N, Makhlouf H, Agrawal R, Kaur I, Younoszai Z, McCullough A, Goodman Z, Younossi ZM. Predictors of all-cause mortality and liver-related mortality in patients with non-alcoholic fatty liver disease (NAFLD). Dig Dis Sci 2013; 58: 3017-3023 [PMID: 23775317 DOI: 10.1007/s10620-013-2743-5]
8. Attar BM, Van Thiel DH. Current concepts and management approaches in nonalcoholic fatty liver disease. ScientificWorldJournal 2013; 2013: 481893 [PMID: 23576902 DOI: 10.1155/2013/481893]
9. Musso G, Cassader M, Rosina F, Gambino R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia 2012; 55: 885-904 [PMID: 22278337 DOI: 10.1007/s00125-011-2446-4]
10. Sdiri W, Romdhane H, Mbarek D, Ben Abdallah H, Longo S, Abdelli MN, Boujnah MR. Non alcoholic fatty liver disease: a new risk factor for cardiovascular disease?. Tunis Med 2013; 91: 171-174 [PMID: 23588628]
11. Baran B, Akyüz F. Non-alcoholic fatty liver disease: what has changed in the treatment since the beginning? World J Gastroenterol 2014; 20: 14219-14229 [PMID: 25339808 DOI: 10.3748/wjg.v20. i39.14219]
12. Wong VW, Chan RS, Wong GL, Cheung BH, Chu WC, Yeung DK, Chim AM, Lai JW, Li LS, Sea MM, Chan FK, Sung JJ, Woo J, Chan HL. Community-based lifestyle modification programme for non-alcoholic fatty liver disease: a randomized controlled trial. J Hepatol 2013; 59: 536-542 [PMID: 23623998 DOI: 10.1016/j.jhep.2013.04.013]
13. Abenavoli L, Milic N, Peta V, Alfieri F, De Lorenzo A, Bellentani S. Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean diet. World J Gastroenterol 2014; 20: 16831-16840 [PMID: 25492997 DOI: 10.3748/wjg.v20.i45.16831]
14. Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for healthrelated research. Public Health Rep 1985; 100: 126-131 [PMID: 3920711]
15. Johnson NA, Keating SE, George J. Exercise and the liver: implications for therapy in fatty liver disorders. Semin Liver Dis 2012; 32: 65-79 [PMID: 22418889 DOI: 10.1055/s-0032-1306427]
16. American College of Sports Medicine. US Department of Health and Human Services, 2008 Physical Activity Guidelines for Americans. 2008. Available from: URL: http://www.health.gov/paguidelines/pdf/paguide.pdf
17. Guo R, Liong EC, So KF, Fung ML, Tipoe GL. Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease. Hepatobiliary Pancreat Dis Int 2015; 14: 139-144 [PMID: 25865685 DOI: 10.1016/S1499-3872(15)60355-1]
18. Miyakoshi N. Therapeutic exercise. Clin Calcium 2008; 18: 1611-1615 [PMID: 18974450]
19. American Gastroenterological Association. American Gastroenterological Association medical position statement: nonalcoholic fatty liver disease. Gastroenterology 2002; 123: 1702-1704 [PMID: 12404244 DOI: 10.1053/gast.2002.36569]
20. McPherson S, Jonsson JR, Cowin GJ, O'Rourke P, Clouston AD, Volp A, Horsfall L, Jothimani D, Fawcett J, Galloway GJ, Benson M, Powell EE. Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered. J Hepatol 2009; 51: 389-397 [PMID: 19505740 DOI: 10.1016/j.jhep.2009.04.012]
21. Fabbrini E, Conte C, Magkos F. Methods for assessing intrahepatic fat content and steatosis. Curr Opin Clin Nutr Metab Care 2009; 12: 474-481 [PMID: 19550313 DOI: 10.1097/MCO.0b013e32832eb587]
22. Banerjee R, Pavlides M, Tunnicliffe EM, Piechnik SK, Sarania N, Philips R, Collier JD, Booth JC, Schneider JE, Wang LM, Delaney DW, Fleming KA, Robson MD, Barnes E, Neubauer S. Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease. J Hepatol 2014; 60: 69-77 [PMID: 24036007 DOI: 10.1016/j.jhep.2013.09.002]
23. Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, Hobbs HH, Dobbins RL. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005; 288: E462-E468 [PMID: 15339742 DOI: 10.1152/ajpendo.00064.2004]
24. Frimel TN, Deivanayagam S, Bashir A, O'Connor R, Klein S. Assessment of intrahepatic triglyceride content using magnetic resonance spectroscopy. J Cardiometab Syndr 2007; 2: 136-138 [PMID: 17684473 DOI: 10.1111/j.1559-4564.2007.07168.x]
25. Reeder SB, Cruite I, Hamilton G, Sirlin CB. Quantitative Assessment of Liver Fat with Magnetic Resonance Imaging and Spectroscopy. J Magn Reson Imaging 2011; 34: spcone [PMID: 22025886 DOI: 10.1002/jmri.22775]
26. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 2011; 43: 1334-1359 [PMID: 21694556 DOI: 10.1249/MSS.0b013e318213fefb]
27. Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, Day CP, Trenell MI. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut 2011; 60: 1278-1283 [PMID: 21708823 DOI: 10.1136/gut.2011.242073]
28. Sullivan S, Kirk EP, Mittendorfer B, Patterson BW, Klein S. Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology 2012; 55: 1738-1745 [PMID: 22213436 DOI: 10.1002/hep.25548]
29. Bacchi E, Negri C, Targher G, Faccioli N, Lanza M, Zoppini G, Zanolin E, Schena F, Bonora E, Moghetti P. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatology 2013; 58: 1287-1295 [PMID: 23504926 DOI: 10.1002/hep.26393]
30. Pugh CJ, Spring VS, Kemp GJ, Richardson P, Shojaee-Moradie F, Umpleby AM, Green DJ, Cable NT, Jones H, Cuthbertson DJ. Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease. Am J Physiol Heart Circ Physiol 2014; 307: H1298-H1306 [PMID: 25193471 DOI: 10.1152/ajpheart.00306.2014]
31. Cuthbertson DJ, Shojaee-Moradie F, Sprung VS, Jones H, Pugh CJ, Richardson P, Kemp GJ, Barrett M, Jackson NC, Thomas EL, Bell JD, Umpleby AM. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 2016; 130: 93-104 [PMID: 26424731 DOI: 10.1042/CS20150447]
32. Hallsworth K, Thoma C, Hollingsworth KG, Cassidy S, Anstee QM, Day CP, Trenell MI. Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial. Clin Sci (Lond) 2015; 129: 1097-1105 [PMID: 26265792 DOI: 10.1042/CS20150308]
33. Eckard C, Cole R, Lockwood J, Torres DM, Williams CD, Shaw JC, Harrison SA. Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial. Therap Adv Gastroenterol 2013; 6: 249-259 [PMID: 23814606 DOI: 10.1177/1756283X13484078]
34. European Association for the Study of the Liver, European Association for the Study of Diabetes, European Association for the Study of Obesity. EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease. Obes Facts 2016; 9: 65-90 [PMID: 27055256 DOI: 10.1159/000443344]
35. Federico A, Zulli C, de Sio I, Del Prete A, Dallio M, Masarone M, Loguercio C. Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease. World J Gastroenterol 2014; 20: 16841-16857 [PMID: 25492998 DOI: 10.3748/wjg.v20. i45.16841]
36. Ordonez R, Carbajo-Pescador S, Mauriz JL, Gonzalez-Gallego J. Understanding nutritional interventions and physical exercise in nonalcoholic fatty liver disease. Curr Mol Med 2015; 15: 3-26 [PMID: 25601465 DOI: 10.2174/1566524015666150114110551]
37. Kantartzis K, Thamer C, Peter A, Machann J, Schick F, Schraml C, Königsrainer A, Königsrainer I, Kröber S, Niess A, Fritsche A, Häring HU, Stefan N. High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease. Gut 2009; 58: 1281-1288 [PMID: 19074179 DOI: 10.1136/gut.2008.151977]
38. Johnson NA, Sachinwalla T, Walton DW, Smith K, Armstrong A, Thompson MW, George J. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 2009; 50: 1105-1112 [PMID: 19637289 DOI: 10.1002/hep.23129]
39. Keating SE, Hackett DA, George J, Johnson NA. Exercise and nonalcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol 2012; 57: 157-166 [PMID: 22414768 DOI: 10.1016/j.jhep.2012.02.023]
40. Thoma C, Day CP, Trenell MI. Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. J Hepatol 2012; 56: 255-266 [PMID: 21723839 DOI: 10.1016/j.jhep.2011.06.010]
41. Whitsett M, VanWagner LB. Physical activity as a treatment of non-alcoholic fatty liver disease: A systematic review. World J Hepatol 2015; 7: 2041-2052 [PMID: 26261693 DOI: 10.4254/wjh. v7.i16.2041]
42. Yoshimura E, Kumahara H, Tobina T, Matsuda T, Ayabe M, Kiyonaga A, Anzai K, Higaki Y, Tanaka H. Lifestyle intervention involving calorie restriction with or without aerobic exercise training improves liver fat in adults with visceral adiposity. J Obes 2014; 2014: 197216 [PMID: 24864199 DOI: 10.1155/2014/197216]