Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome

Fertility and Sterility

Volumn 106, Issue 3, 2016, Pages 757-765.e1

  Wu, Xiao Ke ^a,b   Wang, Yong Yan ^b,i   Liu, Jian Ping ^c   Liang, Rui Ning ^d   Xue, Hui Ying ^e   Ma, Hong Xia ^f   Shao, Xiao Guang ^g   Ng, Ernest H Y ^h   Hou, Li Hui ⁱ   Tian, Feng ⁱ   Xie, Yan Ming ⁱ   Zhang, Jin Feng ⁱ   Gao, Ya Qin ⁱ   Du, Shao Min ⁱ   Yan, Ying ⁱ   Li, Pei Lin ⁱ   Fu, Jin Ying ⁱ   Li, Wei Li ⁱ   Tan, Zhen Yu ⁱ   He, Feng Jie ⁱ   Ding, Cai Fei ⁱ   Li, Xiao Bin ⁱ   Shen, Xian Ji ⁱ   An, Mu Er ⁱ   Yu, Guang Zhu ⁱ   Silver, Robert M ⁱ   Stener Victorin, Elisabet ⁱ   more..

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d Jiangxi University of Chinese Medicine   (China)

^e Huai'an Maternal and Child Health Care Center   (China)

^f GUANGZHOU MEDICAL UNIVERSITY   (China)

^g Shahekou Maternal and Child Hospital   (China)

^h UNIVERSITY OF HONG KONG   (Hong Kong)

ⁱ NONE

Author keywords

berberine; infertility; letrozole; live birth; PCOS; RCT

Indexed keywords

BERBERINE; C PEPTIDE; FOLLITROPIN; GESTAGEN; INSULIN; LETROZOLE; LUTEINIZING HORMONE; MEDROXYPROGESTERONE ACETATE; PLACEBO; PROGESTERONE; PROLACTIN; THYROTROPIN; FERTILITY PROMOTING AGENT; NITRILE; TRIAZOLE DERIVATIVE;

ABORTION; ADULT; ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONCEPTION; CONSTIPATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG WITHDRAWAL; ECTOPIC PREGNANCY; FATIGUE; FEMALE; FEMALE INFERTILITY; FETUS DISEASE; HOT FLUSH; HUMAN; LIVE BIRTH; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NAUSEA; OUTCOME ASSESSMENT; OVARY POLYCYSTIC DISEASE; OVULATION; PREECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATION; PREGNANCY DIABETES MELLITUS; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPRODUCTION; TREATMENT DURATION; TWINS; CHINA; CLINICAL TRIAL; COMBINATION DRUG THERAPY; COMPLICATION; DRUG ADMINISTRATION; DRUG EFFECTS; FERTILITY; INFERTILITY, FEMALE; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; POLYCYSTIC OVARY SYNDROME; PREGNANCY RATE; TIME FACTOR; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; BERBERINE; CHINA; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FERTILITY; FERTILITY AGENTS, FEMALE; HUMANS; INFERTILITY, FEMALE; LIVE BIRTH; NITRILES; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PREGNANCY RATE; TIME FACTORS; TREATMENT OUTCOME; TRIAZOLES;

EID: 84978396733     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2016.05.022     Document Type: Article

References (21)

1. 1 Li, R., Zhang, Q., Yang, D., Li, S., Lu, S., Wu, X., et al. Prevalence of polycystic ovary syndrome in women in China: a large community-based study. Hum Reprod 28 (2013), 2562–2569.
2. 2 Li, R., Qiao, J., Yang, D., Li, S., Lu, S., Wu, X., et al. Epidemiology of hirsutism among women of reproductive age in the community: a simplified scoring system. Eur J Obstet Gynecol Reprod Biol 163 (2012), 165–169.
3. 3 Li, R., Yu, G., Yang, D., Li, S., Lu, S., Wu, X., et al. Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS: a cross-sectional study. BMC Endocr Disord, 14, 2014, 76.
4. 4 Wu, X.K., Polycystic ovary syndrome. Hou, L.H., Wang, Y.T., Wu, X.K., (eds.) Today gynecology in traditional Chinese medicine, 2010, People's Medical Publishing House, Beijing, 118–145.
5. 5 Legro, R.S., Barnhart, H.X., Schlaff, W.D., Carr, B.R., Diamond, M.P., Carson, S.A., et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med 356 (2007), 551–566.
6. 6 Legro, R.S., Brzyski, R.G., Diamond, M.P., Coutifaris, C., Schlaff, W.D., Casson, P., et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med 371 (2014), 119–129.
7. 7 Dong, H., Wang, N., Zhao, L., Lu, F., Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med, 2012, 2012, 591654.
8. 8 Dong, H., Zhao, Y., Zhao, L., Lu, F., The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med 79 (2013), 437–446.
9. 9 Xu H. Analysis of market outlook in 2014: Cortex Phellodendri high-quality stocks. Available at: http://www.kmzyw.com.cn/pages/channel_467/1140 320 467.1395293714000.2579.shtml. Accessed April 14, 2014.
10. 10 Zhao, L., Li, W., Han, F., Hou, L., Baillargeon, J.P., Kuang, H., et al. Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro. Fertil Steril 95 (2011), 461–463.
11. 11 Li, Y., Ma, H., Zhang, Y., Kuang, H., Ng, E.H., Hou, L., et al. Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial. Trials, 14, 2013, 226.
12. 12 Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., et al. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol 166 (2012), 99–105.
13. 13 Li, Y., Kuang, H., Shen, W., Ma, H., Zhang, Y., Stener-Victorin, E., et al. Letrozole, berberine, or their combination for anovulatory infertility in women with polycystic ovary syndrome: study design of a double-blind randomised controlled trial. BMJ Open, 3, 2013, e003934.
14. 14 Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81 (2004), 19–25.
15. 15 Tang, T., Lord, J.M., Norman, R.J., Yasmin, E., Balen, A.H., Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, d-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev, 2012, CD003053.
16. 16 Liu, Y., Zhang, L., Song, H., Ji, G., Update on berberine in nonalcoholic fatty liver disease. Evid Based Complement Alternat Med, 2013, 2013, 308134.
17. 17 Imani, B., Eijkemans, M.J., te Velde, E.R., Habbema, J.D., Fauser, B.C., A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. Fertil Steril 77 (2002), 91–97.
18. 18 Koivunen, R., Pouta, A., Franks, S., Martikainen, H., Sovio, U., Hartikainen, A.L., et al. Fecundability and spontaneous abortions in women with self-reported oligo-amenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. Hum Reprod 23 (2008), 2134–2139.
19. 19 Franik, S., Kremer, J.A., Nelen, W.L., Farquhar, C., Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev, 2014, CD010287.
20. 20 Davies, M.J., Moore, V.M., Willson, K.J., van Essen, P., Priest, K., Scott, H., et al. Reproductive technologies and the risk of birth defects. N Engl J Med 366 (2012), 1803–1813.
21. 21 Harbin Consensus Conference Workshop Group. Improving the Reporting of Clinical Trials of Infertility Treatments (IMPRINT): modifying the CONSORT statement. Hum Reprod 29 (2014), 2075–2082.