Evaluation of physiological risk factors, oxidant-antioxidant imbalance, proteolytic and genetic variations of matrix metalloproteinase-9 in patients with pressure ulcer

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Latifa, Khlifi ^a   Sondess, Sahli ^a   Hajer, Graiet ^a   Manel, Ben Hadj Mohamed ^a   Souhir, Khelil ^a   Nadia, Bouzidi ^a   Abir, Jaballah ^a   Salima, Ferchichi ^a   Abdelhedi, Miled ^a  

^a FARHAT HACHED HOSPITAL   (Tunisia)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; MMP9 PROTEIN, HUMAN;

ADULT; AGED; CASE CONTROL STUDY; DECUBITUS; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; NUTRITIONAL STATUS; OXIDATIVE STRESS; PROTEIN DEGRADATION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TUNISIA;

ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; NUTRITIONAL STATUS; OXIDATIVE STRESS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRESSURE ULCER; PROTEOLYSIS; RISK FACTORS; TUNISIA;

EID: 84978376875     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep29371     Document Type: Article

References (60)

1. Black, J. M. et al. Medical device related pressure ulcers in hospitalized patients. Int Wound J. 7, 358-365 (2010).
2. Frankel, H., Sperry, J., Kaplan, L. Risk factors for pressure ulcer development in a best practice surgical intensive care unit. Am Surg. 73, 1215-1217 (2007).
3. Campbell, K. E. A new model to identify shared risk factors for pressure ulcers and frailty in older adults. Rehabil Nurs. 34, 242-247 (2009).
4. Reddy, M., Gill, S. S., Rochon, P. A. Preventing pressure ulcers: a systematic review. JAMA. 296, 974-984 (2006).
5. Vuagnat, H., Donnat, N., Trombert, V. Elderly and bedsores: prevention and treatment. Rev Med Suisse. 8, 2295-2302 (2012).
6. Shahin, E. S., Dassen, T., Halfens, R. J. Pressure ulcer prevalence and incidence in intensive care patients: a literature review. Nurs Crit Care. 13, 71-79 (2008).
7. Whitfield, M. D., Kaltenthaler, E. C., Akehurst, R. L., Walters, S. J., Paisley, S. How effective are prevention strategies in reducing the prevalence of pressure ulcers J. Wound Care. 9, 261-266 (2000).
8. Devillers, C., Piard-Franchimont, C., Giet-Lesuisse, M., Piard, G. E. How I explore . . a pressure ulcer. Rev Med Liege. 64, 535-537 (2009).
9. Lahmann, N. A., Kottner, J., Dassen, T., Tannen, A. Higher pressure ulcer risk on intensive care Comparison between general wards and intensive care units. J. Clin Nurs. 21, 354-361 (2012).
10. Lyder, C. H. Pressure ulcer prevention and management. JAMA. 289, 223-226 (2003).
11. Nijs, N. et al. Incidence and risk factors for pressure ulcers in the intensive care unit. J. Clin Nurs. 18, 1258-1266 (2009).
12. Allman, R. M. Pressure ulcer prevalence, incidence, risk factors, and impact. Clin Geriatr Med. 13, 421-437 (1997).
13. Lahmann, N. A., Dassen, T., Poehler, A., Kottner, J. Pressure ulcer prevalence rates from 2002 to 2008 in German long-term care facilities. Aging Clin Exp Res. 22, 152-156 (2010).
14. Sprigle, S., Sonenblum, S. Assessing evidence supporting redistribution of pressure for pressure ulcer prevention: a review. J. Rehabil Res Dev. 48, 203-213 (2011).
15. Mast, B. A., Schultz, G. S. Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Repair and Regeneration. 4, 411-420 (1996).
16. Velnar, T., Bailey, T., Smrkolj, V. The wound healing process: an overview of the cellular and molecular mechanisms. J. Int Med Res. 37, 1528-1542 (2009).
17. Cox, J. Predictors of pressure ulcers in adult critical care patients. Am J Crit Care. 20, 364-375 (2011).
18. Stamenkovic, I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J. Pathol. 200, 448-464 (2003).
19. Ladwig, G. P. et al. Ratios of activated matrix metalloproteinase-9 to tissue inhibitor of matrix metalloproteinase-1 in wound fluids are inversely correlated with healing of pressure ulcers. Wound Repair Regen. 10, 26-37 (2002).
20. Yager, D. R., Zhang, L. Y., Liang, H. X., Diegelmann, R. F., Cohen, I. K. Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids. J. Invest Dermatol. 107, 743-748 (1996).
21. Rayment, E. A., Upton, Z., Shooter, G. K. Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer. Br J Dermatol. 158, 951-961 (2008).
22. Vandooren, J., Van den Steen, P. E., Opdenakker, G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade. Crit Rev Biochem Mol Biol. 48, 222-272 (2013).
23. Ye, S. Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases. Matrix Biol. 19, 623-629 (2000).
24. Skarmoutsou, E. et al. Analysis of matrix metalloproteinase-9 gene polymorphism-1562C/T in patients suffering from systemic sclerosis with and without ulcers. Int J Mol Med. 27, 873-877 (2011).
25. Oliveira Costa, A. C., Sabino Pinho, C. P., Almeida Dos Santos, A. D., Santos do Nascimento, A. C. Pressure ulcer: incidence and demographic, clinical and nutrition factors associated in intensive care unit patients. Nutr Hosp. 32, 2242-2252 (2015).
26. Eckman, K. L. The prevalence of dermal ulcers among persons in the U.S. who have died. Decubitus. 2, 36-40 (1989).
27. Santos, C. T., Almeida Mde, A., Oliveira, M. C., Victor, M. A., Lucena Ade, F. Development of the nursing diagnosis risk for pressure ulcer. Rev Gaucha Enferm. 36, 113-121 (2015).
28. Coleman, S. et al. Patient risk factors for pressure ulcer development: systematic review. Int J Nurs Stud. 50, 974-1003 (2013).
29. Ek, A. C., Boman, G. A descriptive study of pressure sores: the prevalence of pressure sores and the characteristics of patients. J. Adv Nurs. 7, 51-57 (1982).
30. Brandeis, G. H., Ooi, W. L., Hossain, M., Morris, J. N., Lipsitz, L. A. A longitudinal study of risk factors associated with the formation of pressure ulcers in nursing homes. J. Am Geriatr Soc. 42, 388-392 (1994).
31. Blanes, L., Duarte, I. S., Calil, J. A., Ferreira, L. M. Clinical and epidemiological evaluation of pressure ulcers in hospitalized patients in the S Paulo hospital. Rev Assoc Med Bras. 50, 182-187 (2004).
32. O'Brien, S. P., Gahtan, V., Wind, S., Kerstein, M. D. What is the paradigm: hospital or home health care for pressure ulcers Am Surg. 65, 303-306 (1999).
33. Kemp, M. G., Keithley, J. K., Smith, D. W., Morreale, B. Factors that contribute to pressure sores in surgical patients. Res Nurs Health. 13, 293-301 (1990).
34. Nonnemacher, M. et al. Predicting pressure ulcer risk: a multifactorial approach to assess risk factors in a large university hospital population. J. Clin Nurs. 18, 99-107 (2009).
35. Mathus-Vliegen, E. M. Old Age, malnutrition, and pressure sores: an Ill-Fated Alliance. J. Gerontol A Biol Sci Med Sci. 59, 355-360 (2004).
36. Finucane, T. E. Malnutrition, tube feeding and pressure sores: data are incomplete. J. Am Geriatr Soc. 43, 447-451 (1995).
37. Roberts, S., Chaboyer, W., Desbrow, B. Nutrition care-related practices and factors affecting nutritional intakes in hospital patients at risk of pressure ulcers. J. Hum Nutr Diet. 28, 357-365 (2015).
38. Ebright, J. R. Microbiology of chronic leg and pressure ulcers: clinical significance and implications for treatment. Nurs Clin North Am. 40, 207-216 (2005).
39. Daltrey, D. C., Rhodes, B., Chattwood, J. G. Investigation into the microbial flora of healing and non-healing decubitus ulcers. J. Clin Pathol. 34, 701-705 (1981).
40. Percival, S. L., Hill, K. E., Williams, D. W., Hooper, S. J., Thomas, D. W., Costerton, J. W. A review of the scientific evidence for biofilms in wounds. Wound Repair Regen. 20, 647-657 (2012).
41. Martin, J. M., Zenilman, J. M., Lazarus, G. S. Molecular microbiology: new dimensions for cutaneous biology and wound healing. J. Invest Dermatol. 130, 38-48 (2010).
42. Gruys, E., Toussaint, M. J., Niewold, T. A., Koopmans, S. J. Acute phase reaction and acute phase proteins. J. Zhejiang Univ Sci B. 6, 1045-1056 (2005).
43. Betteridge, D. J. What is oxidative stress Metabolism. 49, 3-8 (2000).
44. Gutteridge, J. M. C. Free radicals in disease process a compilation of cause and consequence. Free Rad Res Comms. 19, 141-158 (1993).
45. Cordeiro, M. B. et al. Oxidative stress and acute-phase response in patients with pressure sores. Nutrition. 21, 901-907 (2005).
46. Taylor, R., James, T. The role of oxidative stress in the development and persistence of pressure ulcers (eds Bader, D., Bouten, C., Colin, D., Oomens, C.) 205-232 (Springer Berlin Heidelberg, 2005).
47. Hogg, N. The effect of cyst(e)ine on the auto-oxidation of homocysteine. Free Radic Biol Med. 27, 28-33 (1999).
48. Sekhon, B. S. Matrix metalloproteinases-an overview. Res Rep Biol. 1, 11-20 (2010).
49. Gumieiro, D. N. et al. Serum metalloproteinases 2 and 9 as predictors of gait status, pressure ulcer and mortality after hip fracture. PLoS One. 8, e57424 (2013).
50. Mast, B. A., Schultz, G. S. Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Rep Reg. 4, 411-420 (1996).
51. Yabluchanskiy, A., Ma, Y., Iyer, R. P., Hall, M. E., Lindsey, M. L. Matrix metalloproteinase-9: many shades of function in cardiovascular disease. Physiology. 28, 391-403 (2013).
52. Zhang, X., Cao, X., Xu, X., Li, A., Xu, Y. Correlation between the-1562C/T polymorphism in the matrix metalloproteinase-9 gene and hemorrhagic transformation of ischemic stroke. Exp Ther Med. 9, 1043-1047 (2015).
53. Singh, K., Agrawal, N. K., Gupta, S. K., Singh, K. A functional single nucleotide polymorphism-1562C> T in the Matrix Metalloproteinase-9 promoter is associated with type 2 diabetes and diabetic foot ulcers. Int J Low Extrem Wound 12, 199-204 (2013).
54. Blankenberg, S. et al. Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation. 107, 1579-1585 (2003).
55. Khlifi, L. et al. Analysis of tumor necrosis factor G238A and G308A gene polymorphisms in Tunisian patients with pressure ulcers. IJPSR. 7, 976-983 (2016).
56. Yagi, K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med. 15, 212-216 (1976).
57. Miller, N. J., Rice-Evans, C., Davies, M. J., Gopinathan, V., Milner, A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci. 84, 407-412 (1993).
58. Prendergast, J. M. et al. Clinical validation of a nutritional risk index. J. Community Health. 14, 125-135 (1989).
59. Ingenbleek, Y., Carpentier, Y. A. A prognostic inflammatory and nutritional index scoring critically ill patients. Int J Vitam Nutr Res. 55, 91-101 (1985).
60. Wang, L. et al. Association of MMP-9 gene polymorphisms with acute coronary syndrome in the Uygur population of China. World J Emerg Med. 2, 104-110 (2011).