Hypermucoviscous Klebsiella syndrome without liver abscess in a patient with immunoglobulin G2 immune deficiency

Open Forum Infectious Diseases

Volumn 1, Issue 2, 2014, Pages

  Alsaedi, Asim ^a   Janower, Amber ^a   Wang, Jin Town ^c   Nichol, Kim ^d   Karlowsky, James ^d   Orr, Pamela ^a   Keynan, Yoav ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c National Taiwan Hospital   (Taiwan)

^d Diagnostic Services of Manitoba Inc   (Canada)

Author keywords

Hypermucoviscous; IgG2 deficiency; Klebsiella pneumonia

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BICARBONATE; BILIRUBIN; BRONCHODILATING AGENT; CALCIUM; CEFALEXIN; CEFAZOLIN; CEFTRIAXONE; COTRIMOXAZOLE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; ITRACONAZOLE; POTASSIUM; SODIUM; THIAZIDE DIURETIC AGENT; UREA;

ADULT; ARTICLE; BACTERIUM ISOLATION; BLOOD CELL COUNT; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; ECHOGRAPHY; ERYTHROCYTE SEDIMENTATION RATE; FOLLOW UP; HUMAN; HYPERGAMMAGLOBULINEMIA; HYPERMUCOVISCOUS KLEBSIELLA PNEUMONIAE INFECTION; IMMUNOGLOBULIN G DEFICIENCY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LEUKOCYTE COUNT; LIVER ABSCESS; LIVER BIOPSY; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STENOTROPHOMONAS MALTOPHILIA; TRANSTHORACIC ECHOCARDIOGRAPHY;

EID: 84978328247     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofu080     Document Type: Article

References (28)

1. Fang CT, Chuang YP, Shun CT, et al. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med 2004; 199:697-705.
2. Fang CT, Lai SY, Yi WC, et al. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis 2007; 45:284-93.
3. Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 1998; 11:589-603.
4. Kang CI, Kim SH, Park WB, et al. Bloodstream infections caused by antibiotic- resistant Gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother 2005; 49:760-6.
5. Al-Hasan MN, Eckel-Passow JE, Baddour LM. Recurrent Gram-negative bloodstream infection: a 10-year population-based cohort study. J Infect 2010; 61:28-33.
6. Ko WC, Paterson DL, Sagnimeni AJ, et al. Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg Infect Dis 2002; 8:160-6.
7. Yeh KM, Kurup A, Siu LK, et al. Capsular serotype K1 or K2, rather than magA and rmpA, is a major virulence determinant for Klebsiella pneumoniae liver abscess in Singapore and Taiwan. J Clin Microbiol 2007; 45:466-71.
8. Lee KH, Hui KP, Tan WC, et al. Klebsiella bacteraemia: a report of 101 cases from National University Hospital, Singapore. J Hosp Infect 1994; 27:299-305.
9. Chung DR, Lee SS, Lee HR, et al. Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea. J Infect 2007; 54: 578-83.
10. Okano H, Shiraki K, Inoue H, et al. Clinicopathological analysis of liver abscess in Japan. Int J Mol Med 2002; 10:627-30.
11. Nadasy KA, Domiati-Saad R, Tribble MA. Invasive Klebsiella pneumoniae syndrome in North America. Clin Infect Dis 2007; 45:e25-8.
12. Rahimian J, Wilson T, Oram V, et al. Pyogenic liver abscess: recent trends in etiology and mortality. Clin Infect Dis 2004; 39:1654-9.
13. Wang JH, Liu YC, Lee SS, et al. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis 1998; 26:1434-8.
14. Russo TA, Olson R, Macdonald U, et al. Infect Immun 2014; 82: 2356-67.
15. Cryz SJ Jr, Mortimer PM, Mansfield V, et al. Seroepidemiology of Klebsiella bacteremic isolates and implications for vaccine development. J Clin Microbiol 1986; 23:687-90.
16. Pan Q, Hammarstrom L. Molecular basis of IgG subclass deficiency. Immunol Rev 2000; 178:99-110.
17. Siber GR, Schur PH, Aisenberg AC, et al. Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens. N Engl J Med 1980; 303:178-82.
18. Morgan G, Levinsky RJ. Clinical significance of IgG subclass deficiency. Arch Dis Child 1988; 63:771-3.
19. Shackelford PG, Granoff DM, Madassery JV, et al. Clinical and immunologic characteristics of healthy children with subnormal serum concentrations of IgG2. Pediatr Res 1990; 27:16-21.
20. Kim JH, Park HJ, Choi GS, et al. Immunoglobulin G subclass deficiency is the major phenotype of primary immunodeficiency in a Korean adult cohort. J Korean Med Sci 2010; 25:824-8.
21. Visitsunthorn N, Hengcrawit W, Jirapongsananuruk O, et al. Immunoglobulin G (IgG) subclass deficiency in Thai children. Asian Pac J Allergy Immunol 2011; 29:332-7.
22. Bass JL, Nuss R, Mehta KA, et al. Recurrent meningococcemia associated with IgG2-subclass deficiency. N Engl J Med 1983; 309:430.
23. Ohga S, Okada K, Asahi T, et al. Recurrent pneumococcal meningitis in a patient with transient IgG subclass deficiency. Acta Paediatr Jpn 1995; 37:196-200.
24. Escobar-Perez X, Dorta-Contreras AJ, Interian-Morales MT, et al. IgG2 immunodeficiency: association to pediatric patients with bacterial meningoencephalitis. Arq Neuropsiquiatr 2000; 58:141-5.
25. Berger M. Principles of and advances in immunoglobulin replacement therapy for primary immunodeficiency. Immunol Allergy Clin North Am 2008; 28:413-37 x.
26. Orange JS, Grossman WJ, Navickis RJ, et al. Impact of trough IgG on pneumonia incidence in primary immunodeficiency: a meta-analysis of clinical studies. Clin Immunol 2010; 137:21-30.
27. Abdou NI, Greenwell CA, Mehta R, et al. Efficacy of intravenous gammaglobulin for immunoglobulin G subclass and/or antibody deficiency in adults. Int Arch Allergy Immunol 2009; 149:267-74.
28. Nolte MT, Pirofsky B, Gerritz GA, et al. Intravenous immunoglobulin therapy for antibody deficiency. Clin Exp Immunol 1979; 36:237-43.