Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 10, 2016, Pages 2526-2530

  Zhong, Yan ^a   Xu, Yi ^b   Zhang, Ai Xia ^b   Li, Xiao Feng ^b   Xu, Zhao Ying ^b   Li, Ping ^b   Wu, Bin ^b  

^a SOUTHEAST UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Aryloxyacetamide; Caspase 3; Cerebral ischemic stroke; Neuroprotective activity

Indexed keywords

ACETAMIDE DERIVATIVE; CASPASE 3; GLUTAMIC ACID; NEUROPROTECTIVE AGENT; NORPHENAZONE; PROCASPASE 3; ACETAMIDE;

ALKYLATION; AMINOLYSIS; ANIMAL CELL; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; BROMINATION; CELL DEATH; CELL VIABILITY; CELLS; CHLORINATION; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; IN VITRO STUDY; MTT ASSAY; NEUROPROTECTION; NONHUMAN; PC12 CELL LINE; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; ANIMAL; CELL DIFFERENTIATION; CHEMISTRY; DRUG EFFECTS; HIGH THROUGHPUT SCREENING; PRECLINICAL STUDY; PROCEDURES; SYNTHESIS;

ACETAMIDES; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG EVALUATION, PRECLINICAL; GLUTAMIC ACID; HIGH-THROUGHPUT SCREENING ASSAYS; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84978328071     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.03.094     Document Type: Article

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