메뉴 건너뛰기




Volumn 4, Issue 4, 2016, Pages 366-374

Prospective evaluation of cetuximab-mediated antibody-dependent cell cytotoxicity in metastatic colorectal cancer patients predicts treatment efficacy

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CETUXIMAB; FC RECEPTOR IIA; K RAS PROTEIN; PANITUMUMAB; ANTINEOPLASTIC AGENT; FC RECEPTOR; KRAS PROTEIN, HUMAN; PROTEIN P21;

EID: 84978255425     PISSN: 23266066     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-15-0184     Document Type: Article
Times cited : (66)

References (50)
  • 2
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan- refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan- refractory metastatic colorectal cancer. N Engl J Med 2004; 351:337-45.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 3
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment ofmetastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment ofmetastatic colorectal cancer. J Clin Oncol 2009;27:663-71.
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3    Hartmann, J.T.4    Aparicio, J.5    De Braud, F.6
  • 6
    • 77953276067 scopus 로고    scopus 로고
    • Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-typemetastatic colorectal cancer
    • Pander J, Gelderblom H, Antonini NF, Tol J, van Krieken JH, van der Straaten T, et al. Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-typemetastatic colorectal cancer. Eur J Cancer 2010;46:1829-34.
    • (2010) Eur J Cancer , vol.46 , pp. 1829-1834
    • Pander, J.1    Gelderblom, H.2    Antonini, N.F.3    Tol, J.4    Van Krieken, J.H.5    Van Der Straaten, T.6
  • 7
    • 79957790057 scopus 로고    scopus 로고
    • Development of a quantitative, cell-line based assay to measure ADCC activity mediated by therapeutic antibodies
    • Schnueriger A, Grau R, Sondermann P, Schreitmueller T, Marti S, Zocher M. Development of a quantitative, cell-line based assay to measure ADCC activity mediated by therapeutic antibodies. Mol Immunol 2011;48:1512-7.
    • (2011) Mol Immunol , vol.48 , pp. 1512-1517
    • Schnueriger, A.1    Grau, R.2    Sondermann, P.3    Schreitmueller, T.4    Marti, S.5    Zocher, M.6
  • 8
    • 65549139376 scopus 로고    scopus 로고
    • Fcg;RIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck
    • Taylor RJ, Chan SL, Wood A, Voskens CJ, Wolf JS, Lin W, et al. Fcg;RIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 2009; 58:997-1006.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 997-1006
    • Taylor, R.J.1    Chan, S.L.2    Wood, A.3    Voskens, C.J.4    Wolf, J.S.5    Lin, W.6
  • 9
    • 67849092283 scopus 로고    scopus 로고
    • Fcg receptors: Structure, function and role as genetic risk factors in SLE
    • Li X, Ptacek TS, Brown EE, Edberg JC. Fcg receptors: structure, function and role as genetic risk factors in SLE. Genes Immun 2009;10:380-9.
    • (2009) Genes Immun , vol.10 , pp. 380-389
    • Li, X.1    Ptacek, T.S.2    Brown, E.E.3    Edberg, J.C.4
  • 10
    • 37549036732 scopus 로고    scopus 로고
    • Fcgamma receptors as regulators of immune responses
    • Nimmerjahn F, Ravetch JV. Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 2008;8:34-47.
    • (2008) Nat Rev Immunol , vol.8 , pp. 34-47
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 11
    • 35348827319 scopus 로고    scopus 로고
    • Monoclonal antibody mechanisms of action in cancer
    • Weiner GJ. Monoclonal antibody mechanisms of action in cancer. Immunol Res 2007;39:271-8.
    • (2007) Immunol Res , vol.39 , pp. 271-278
    • Weiner, G.J.1
  • 12
    • 30744432128 scopus 로고    scopus 로고
    • Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies
    • Iannello A, Ahmad A. Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies. Cancer Metastatis Rev 2005;2:487-99.
    • (2005) Cancer Metastatis Rev , vol.2 , pp. 487-499
    • Iannello, A.1    Ahmad, A.2
  • 13
    • 37549011436 scopus 로고    scopus 로고
    • Elements related to heterogeneity of antibody-dependent cell cytotoxicity in patients under trastuzumab therapy for primary operable breast cancer overexpressing Her2
    • Varchetta S, Gibelli N, Oliviero B, Nardini E, Gennari R, Gatti G, et al. Elements related to heterogeneity of antibody-dependent cell cytotoxicity in patients under trastuzumab therapy for primary operable breast cancer overexpressing Her2. Cancer Res 2007;67: 11991-9.
    • (2007) Cancer Res , vol.67 , pp. 11991-11999
    • Varchetta, S.1    Gibelli, N.2    Oliviero, B.3    Nardini, E.4    Gennari, R.5    Gatti, G.6
  • 14
    • 69049115069 scopus 로고    scopus 로고
    • Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells
    • López-Albaitero A, Lee SC, Morgan S, Grandis JR, Gooding WE, Ferrone S, et al. Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells. Cancer Immunol Immunother 2009;58:1853-62.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1853-1862
    • López-Albaitero, A.1    Lee, S.C.2    Morgan, S.3    Grandis, J.R.4    Gooding, W.E.5    Ferrone, S.6
  • 15
    • 65549139376 scopus 로고    scopus 로고
    • FcgammaRIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck
    • Taylor RJ, Chan SL, Wood A, Voskens CJ, Wolf JS, Lin W, et al. FcgammaRIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 2009; 58:997-1006.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 997-1006
    • Taylor, R.J.1    Chan, S.L.2    Wood, A.3    Voskens, C.J.4    Wolf, J.S.5    Lin, W.6
  • 16
    • 34548509226 scopus 로고    scopus 로고
    • FcgR2A and FcgR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab
    • Zhang W, Gordon M, Schultheis AM, Yang DY, Nagashima F, Azuma M, et al. FcgR2A and FcgR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol 2007;25:3712-8.
    • (2007) J Clin Oncol , vol.25 , pp. 3712-3718
    • Zhang, W.1    Gordon, M.2    Schultheis, A.M.3    Yang, D.Y.4    Nagashima, F.5    Azuma, M.6
  • 17
    • 61449239114 scopus 로고    scopus 로고
    • Impact of FcRIIa-FcRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • Bibeau F, Lopez-Crapez E, Di Fiore F, Thezenas S, Ychou M, Blanchard F, et al. Impact of FcRIIa-FcRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J Clin Oncol 2009; 27:1122-9.
    • (2009) J Clin Oncol , vol.27 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di Fiore, F.3    Thezenas, S.4    Ychou, M.5    Blanchard, F.6
  • 18
    • 84864131126 scopus 로고    scopus 로고
    • Fc gamma receptor polymorphisms as predictive markers of Cetuximab efficacy in epidermal growth factor receptor downstream-mutated metastatic colorectal cancer
    • Rodŕguez J, Zarate R, Bandres E, Boni V, Hernandez A, Sola JJ, et al. Fc gamma receptor polymorphisms as predictive markers of Cetuximab efficacy in epidermal growth factor receptor downstream-mutated metastatic colorectal cancer. Eur J Cancer 2012;48:1774-80.
    • (2012) Eur J Cancer , vol.48 , pp. 1774-1780
    • Rodŕguez, J.1    Zarate, R.2    Bandres, E.3    Boni, V.4    Hernandez, A.5    Sola, J.J.6
  • 19
    • 77953276067 scopus 로고    scopus 로고
    • Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-typemetastatic colorectal cancer
    • Pander J, Gelderblom H, Antonini NF, Tol J, van Krieken JH, van der Straaten T, et al. Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-typemetastatic colorectal cancer. Eur J Cancer 2010;46:1829-34.
    • (2010) Eur J Cancer , vol.46 , pp. 1829-1834
    • Pander, J.1    Gelderblom, H.2    Antonini, N.F.3    Tol, J.4    Van Krieken, J.H.5    Van Der Straaten, T.6
  • 20
    • 84871922121 scopus 로고    scopus 로고
    • Cetuximab-mediated tumor regression depends on innate and adaptive immune responses
    • Yang X, Zhang X, Mortenson ED, Radkevich-Brown O, Wang Y, Fu YX. Cetuximab-mediated tumor regression depends on innate and adaptive immune responses. Mol Ther 2013;21:91-100.
    • (2013) Mol Ther , vol.21 , pp. 91-100
    • Yang, X.1    Zhang, X.2    Mortenson, E.D.3    Radkevich-Brown, O.4    Wang, Y.5    Fu, Y.X.6
  • 21
    • 84862822870 scopus 로고    scopus 로고
    • Genetic polymorphisms of FcgRIIa and FcgRIIIa are not predictive of clinical outcomes after cetuximab plus irinotecan chemotherapy in patients with metastatic colorectal cancer
    • Park SJ, Hong YS, Lee JL, Ryu MH, Chang HM, Kim KP, et al. Genetic polymorphisms of FcgRIIa and FcgRIIIa are not predictive of clinical outcomes after cetuximab plus irinotecan chemotherapy in patients with metastatic colorectal cancer. Oncology 2012;82:83-9.
    • (2012) Oncology , vol.82 , pp. 83-89
    • Park, S.J.1    Hong, Y.S.2    Lee, J.L.3    Ryu, M.H.4    Chang, H.M.5    Kim, K.P.6
  • 22
    • 77955950937 scopus 로고    scopus 로고
    • Immunoglobulin G fragment C receptor polymorphisms and KRAS mutations: Are they useful biomarkers of clinical outcome in advanced colorectal cancer treated with anti-EGFR-based therapy?
    • Paez D, Paré L, Espinosa I, Salazar J, del Rio E, Barnadas A, et al. Immunoglobulin G fragment C receptor polymorphisms and KRAS mutations: are they useful biomarkers of clinical outcome in advanced colorectal cancer treated with anti-EGFR-based therapy? Cancer Sci 2010;101:2048-53.
    • (2010) Cancer Sci , vol.101 , pp. 2048-2053
    • Paez, D.1    Paré, L.2    Espinosa, I.3    Salazar, J.4    Del Rio, E.5    Barnadas, A.6
  • 23
    • 84893651406 scopus 로고    scopus 로고
    • Role of immunoglobulin G fragment C receptor polymorphism-mediated antibody-dependant cellular cytotoxicity in colorectal cancer treated with cetuximab therapy
    • Negri FV, Musolino A, Naldi N, Bortesi B, Missale G, Laccabue D, et al. Role of immunoglobulin G fragment C receptor polymorphism-mediated antibody-dependant cellular cytotoxicity in colorectal cancer treated with cetuximab therapy. Pharmacogenomics J 2014;14:14-9.
    • (2014) Pharmacogenomics J , vol.14 , pp. 14-19
    • Negri, F.V.1    Musolino, A.2    Naldi, N.3    Bortesi, B.4    Missale, G.5    Laccabue, D.6
  • 24
    • 84869221346 scopus 로고    scopus 로고
    • Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti-EGFR antibodies and clinical outcome
    • Calemma R, Ottaiano A, Trotta AM, Nasti G, Romano C, Napolitano M, et al. Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti-EGFR antibodies and clinical outcome. J Transl Med 2012;10:232-40.
    • (2012) J Transl Med , vol.10 , pp. 232-240
    • Calemma, R.1    Ottaiano, A.2    Trotta, A.M.3    Nasti, G.4    Romano, C.5    Napolitano, M.6
  • 26
    • 84873709648 scopus 로고    scopus 로고
    • NK cells from pleural effusions are potent antitumor effector cells
    • Terme M, Fridman WH, Tartour E. NK cells from pleural effusions are potent antitumor effector cells. Eur J Immunol 2013;43:331-4.
    • (2013) Eur J Immunol , vol.43 , pp. 331-334
    • Terme, M.1    Fridman, W.H.2    Tartour, E.3
  • 27
    • 0032127376 scopus 로고    scopus 로고
    • Natural killer cell activity in patients with hepatocellular-carcinoma: A new prognostic indicator after hepatectomy
    • Taketomi A, Shimada M, Shirabe K, Kajiyama K, Gian T, Sugimachi K. Natural killer cell activity in patients with hepatocellular-carcinoma: a new prognostic indicator after hepatectomy. Cancer 1998;83:58-63.
    • (1998) Cancer , vol.83 , pp. 58-63
    • Taketomi, A.1    Shimada, M.2    Shirabe, K.3    Kajiyama, K.4    Gian, T.5    Sugimachi, K.6
  • 28
    • 0038513480 scopus 로고    scopus 로고
    • Natural killer (NK) cell function is a strong prognostic factor in colorectal carcinoma patients treated with the monoclonal antibody 17-1A
    • Liljefors M, Nilsson B, Hjelm Skog AL, Ragnhammar P, Mellstedt H, Frödin JE. Natural killer (NK) cell function is a strong prognostic factor in colorectal carcinoma patients treated with the monoclonal antibody 17-1A. Int J Cancer 2003;105:717-23.
    • (2003) Int J Cancer , vol.105 , pp. 717-723
    • Liljefors, M.1    Nilsson, B.2    Hjelm Skog, A.L.3    Ragnhammar, P.4    Mellstedt, H.5    Frödin, J.E.6
  • 29
    • 0030902366 scopus 로고    scopus 로고
    • The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma
    • Coca S, Perez-Piqueras J, Martinez D, Colmenarejo A, Saez MA, Vallejo C, et al. The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma. Cancer 1997;79:2320-8.
    • (1997) Cancer , vol.79 , pp. 2320-2328
    • Coca, S.1    Perez-Piqueras, J.2    Martinez, D.3    Colmenarejo, A.4    Saez, M.A.5    Vallejo, C.6
  • 30
    • 0031983254 scopus 로고    scopus 로고
    • Naturally occurring mutation in FcgRIIA: A Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor
    • Norris CF, Pricop L, Millard SS, Taylor SM, Surrey S, Schwartz E, et al. Naturally occurring mutation in FcgRIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor. Blood 1998;91:656-62.
    • (1998) Blood , vol.91 , pp. 656-662
    • Norris, C.F.1    Pricop, L.2    Millard, S.S.3    Taylor, S.M.4    Surrey, S.5    Schwartz, E.6
  • 31
    • 35748951343 scopus 로고    scopus 로고
    • FcgammaRIIIA and FcgammaRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab
    • Carlotti E, Palumbo GA, Oldani E, Tibullo D, Salmoiraghi S, Rossi A, et al. FcgammaRIIIA and FcgammaRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab. Haematologica 2007;92: 1127-30.
    • (2007) Haematologica , vol.92 , pp. 1127-1130
    • Carlotti, E.1    Palumbo, G.A.2    Oldani, E.3    Tibullo, D.4    Salmoiraghi, S.5    Rossi, A.6
  • 33
    • 0030611089 scopus 로고    scopus 로고
    • A novel polymorphism of FcgRIIIa (CD16) alters receptor function and predisposes to autoimmune disease
    • WuJ, Edberg JC, Redecha PB, Bansal V, Guyre PM, Coleman K, et al. A novel polymorphism of FcgRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J Clin Invest 1997;100:1059-70.
    • (1997) J Clin Invest , vol.100 , pp. 1059-1070
    • Wu, J.1    Edberg, J.C.2    Redecha, P.B.3    Bansal, V.4    Guyre, P.M.5    Coleman, K.6
  • 34
    • 34948881806 scopus 로고    scopus 로고
    • Increased natural killer cell expression of CD16, augmented binding andADCC activity to rituximab among individuals expressing the FcgRIIIa-158 V/V and V/F polymorphism
    • Hatjiharissi E, Xu L, Santos DD, Hunter ZR, Ciccarelli BT, Verselis S, et al. Increased natural killer cell expression of CD16, augmented binding andADCC activity to rituximab among individuals expressing the FcgRIIIa-158 V/V and V/F polymorphism. Blood 2007;110: 2561-4.
    • (2007) Blood , vol.110 , pp. 2561-2564
    • Hatjiharissi, E.1    Xu, L.2    Santos, D.D.3    Hunter, Z.R.4    Ciccarelli, B.T.5    Verselis, S.6
  • 37
    • 0002570409 scopus 로고
    • Assays of cell growth and cytotoxicity
    • Studzinski GP, editor. New York: Oxford University Press
    • Skehan P. Assays of cell growth and cytotoxicity. In: Studzinski GP, editor. Cell growth and apoptosis: a practical approach. New York: Oxford University Press; 1995. p. 169.
    • (1995) Cell Growth and Apoptosis: A Practical Approach , pp. 169
    • Skehan, P.1
  • 38
    • 84895835829 scopus 로고    scopus 로고
    • Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy
    • Oppenheim DE, Spreafico R, Etuk A, Malone D, Amofah E, Peña-Murillo C, et al. Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy. Br J Cancer 2014;110:1221-7
    • (2014) Br J Cancer , vol.110 , pp. 1221-1227
    • Oppenheim, D.E.1    Spreafico, R.2    Etuk, A.3    Malone, D.4    Amofah, E.5    Peña-Murillo, C.6
  • 39
    • 84908219488 scopus 로고
    • Statistical-methods for assessing agreement between 2 methods of clinical measurement
    • Bland JM, Altman DG: Statistical-methods for assessing agreement between 2 methods of clinical measurement. Lancet 1986;1:307-10.
    • (1986) Lancet , vol.1 , pp. 307-310
    • Bland, J.M.1    Altman, D.G.2
  • 40
    • 84962277989 scopus 로고    scopus 로고
    • Ex vivo antibody-dependent cellular cytotoxicity inducibility predicts efficacy of cetuximab
    • Taylor RJ, Saloura V, Jain A, Goloubeva O, Wong S, Kronsberg S, et al. Ex vivo antibody-dependent cellular cytotoxicity inducibility predicts efficacy of cetuximab. Cancer Immunol Res 2015;3:567-74.
    • (2015) Cancer Immunol Res , vol.3 , pp. 567-574
    • Taylor, R.J.1    Saloura, V.2    Jain, A.3    Goloubeva, O.4    Wong, S.5    Kronsberg, S.6
  • 41
    • 84875742535 scopus 로고    scopus 로고
    • Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: Assessment as prognostic and predictive biomarkers of response to panitumumab
    • Peeters M, Douillard JY, Van CutsemE, Siena S, Zhang K, Williams R, et al. Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab. J Clin Oncol 2013;31:759-65.
    • (2013) J Clin Oncol , vol.31 , pp. 759-765
    • Peeters, M.1    Douillard, J.Y.2    Van Cutseme Siena, S.3    Zhang, K.4    Williams, R.5
  • 42
    • 84908573757 scopus 로고    scopus 로고
    • FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): A randomised, open-label, phase 3 trial
    • Heinemann V, von Weikersthal LF, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol 2014;15:1065-75.
    • (2014) Lancet Oncol , vol.15 , pp. 1065-1075
    • Heinemann, V.1    Von Weikersthal, L.F.2    Decker, T.3    Kiani, A.4    Vehling-Kaiser, U.5    Al-Batran, S.E.6
  • 43
    • 79957576342 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of KRAS status as the determinant of response to anti-EGFR antibodies and the impact of partner chemotherapy in metastatic colorectal cancer
    • Adelstein BA, Dobbins TA, Harris CA, Marschner IC, Ward RL. A systematic review and meta-analysis of KRAS status as the determinant of response to anti-EGFR antibodies and the impact of partner chemotherapy in metastatic colorectal cancer. Eur J Cancer 2011;47: 1343-54.
    • (2011) Eur J Cancer , vol.47 , pp. 1343-1354
    • Adelstein, B.A.1    Dobbins, T.A.2    Harris, C.A.3    Marschner, I.C.4    Ward, R.L.5
  • 44
    • 78049341541 scopus 로고    scopus 로고
    • Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
    • De Roock W, Jonker DJ, Di Nicolantonio F, Sartore-Bianchi A, Tu D, Siena S, et al. Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA 2010;304:1812-20.
    • (2010) JAMA , vol.304 , pp. 1812-1820
    • De Roock, W.1    Jonker, D.J.2    Di Nicolantonio, F.3    Sartore-Bianchi, A.4    Tu, D.5    Siena, S.6
  • 45
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractorymetastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractorymetastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010;11:753-62
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5    Fountzilas, G.6
  • 46
    • 84898604815 scopus 로고    scopus 로고
    • Cetuximab-mediated ADCC activity is correlated with the cell surface expression level of EGFR but not with the KRAS/BRAF mutational status in colorectal cancer
    • Seo Y, Ishii Y, Ochiai H, Fukuda K, Akimoto S, Hayashida T, et al. Cetuximab-mediated ADCC activity is correlated with the cell surface expression level of EGFR but not with the KRAS/BRAF mutational status in colorectal cancer. Oncol Rep 2014;31:2115-22.
    • (2014) Oncol Rep , vol.31 , pp. 2115-2122
    • Seo, Y.1    Ishii, Y.2    Ochiai, H.3    Fukuda, K.4    Akimoto, S.5    Hayashida, T.6
  • 47
    • 84903694472 scopus 로고    scopus 로고
    • Final results from PRIME: Randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer
    • Douillard JY, Siena S,Cassidy J, Tabernero J, Burkes R, BarugelM, et al. Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer. Ann Oncol 2014;25:1346-55.
    • (2014) Ann Oncol , vol.25 , pp. 1346-1355
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3    Tabernero, J.4    Burkes, R.5    Barugel, M.6
  • 48
    • 84919339616 scopus 로고    scopus 로고
    • Predictive and prognostic markers in the treatment of metastatic colorectal cancer (mCRC): Personalized medicine at work
    • Stintzing S, Stremitzer S, Sebio A, Lenz HJ. Predictive and prognostic markers in the treatment of metastatic colorectal cancer (mCRC): personalized medicine at work. Hematol Oncol Clin North Am 2015; 29:43-60.
    • (2015) Hematol Oncol Clin North Am , vol.29 , pp. 43-60
    • Stintzing, S.1    Stremitzer, S.2    Sebio, A.3    Lenz, H.J.4
  • 49
    • 84856332921 scopus 로고    scopus 로고
    • Cetuximab +/- chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro
    • Correale P, Botta C, Cusi M, Del Vecchio MT, De Santi MM, Gori Savellini G, et al. Cetuximab +/- chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro. Int J Cancer 2012; 130:1577-89.
    • (2012) Int J Cancer , vol.130 , pp. 1577-1589
    • Correale, P.1    Botta, C.2    Cusi, M.3    Del Vecchio, M.T.4    De Santi, M.M.5    Gori Savellini, G.6
  • 50
    • 84897932227 scopus 로고    scopus 로고
    • Efficacy and immune mechanisms of cetuximab for the treatment of metastatic colorectal cancer
    • Zhuang H, Xue ZY, Wang L, Li XY, Zhang N, Zhang RX. Efficacy and immune mechanisms of cetuximab for the treatment of metastatic colorectal cancer. Clin Oncol Cancer Res 2011;8:207-14.
    • (2011) Clin Oncol Cancer Res , vol.8 , pp. 207-214
    • Zhuang, H.1    Xue, Z.Y.2    Wang, L.3    Li, X.Y.4    Zhang, N.5    Zhang, R.X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.