Optogenetic stimulation of neural grafts enhances neurotransmission and downregulates the inflammatory response in experimental stroke model

Cell Transplantation

Volumn 25, Issue 7, 2016, Pages 1371-1380

  Daadi, Marcel M ^a   Klausner, Jill Q ^a   Bajar, Bryce ^a   Goshen, Inbal ^a   Lee Messer, Christopher ^a   Lee, Soo Yeun ^a   Winge, Mårten C G ^a   Ramakrishnan, Charu ^a   Lo, Maisie ^a   Sun, Guohua ^a   Deisseroth, Karl ^a   Steinberg, Gary K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Neural stem cells (NSCs); Neural transplantation; Optogenetic stimulation; Sensorimotor behavior; Stroke

Indexed keywords

CATION CHANNEL; CHANNELRHODOPSIN 2; CHLORDANE; CLADE A; COLONY STIMULATING FACTOR 2 RECEPTOR BETA; DECTIN 1; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON GAMMA INDUCIBLE PROTEIN 47; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBFAMILY J; MONOCYTE CHEMOTACTIC PROTEIN 1; NEPHROBLASTOMA OVEREXPRESSED GENE; NERVE CELL ADHESION MOLECULE; NEUROGENIC DIFFERENTIATION 6; NEUROGENIC DIFFERENTIATION FACTOR; NEURON SPECIFIC NUCLEAR PROTEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; POTASSIUM CHANNEL; PROTEIN; R SPONDIN 3; RING FINGER PROTEIN 39; RT1 CLASS II LOCUS DA; SERINE; SODIUM CHANNEL; SOLUTE CARRIER FAMILY 30 MEMEBER 3; SYNAPTOPHYSIN; TUJ1 PROTEIN; UNCLASSIFIED DRUG; RHODOPSIN;

ACTION POTENTIAL; ADULT; ANIMAL CELL; ANIMAL MODEL; ARTICLE; AXON; BRAIN ISCHEMIA; CONTROLLED STUDY; CORPUS STRIATUM; DEPOLARIZATION; DOWN REGULATION; GENE EXPRESSION; INFLAMMATION; MALE; MOTOR ACTIVITY; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVE GRAFT; NERVE REGENERATION; NEURAL STEM CELL TRANSPLANTATION; NEUROTRANSMISSION; NONHUMAN; OPEN FIELD TEST; OPTOGENETICS; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; STIMULATION; UPREGULATION; ANIMAL; CELL SEPARATION; COMPLICATION; CYTOLOGY; DISEASE MODEL; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETIC TRANSDUCTION; GENETICS; HUMAN; HUMAN EMBRYONIC STEM CELL; METABOLISM; NEOSTRIATUM; NEURAL STEM CELL; PROCEDURES; SPRAGUE DAWLEY RAT; STROKE; SYNAPTIC TRANSMISSION; TRANSGENE; TRANSPLANTATION;

ANIMALS; CELL SEPARATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION PROFILING; HUMAN EMBRYONIC STEM CELLS; HUMANS; INFLAMMATION; MALE; NEOSTRIATUM; NEURAL STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OPTOGENETICS; RATS, SPRAGUE-DAWLEY; RHODOPSIN; STROKE; SYNAPTIC TRANSMISSION; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 84978175087     PISSN: 09636897     EISSN: 15553892     Source Type: Journal    
DOI: 10.3727/096368915X688533     Document Type: Article

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