Platelet transfusion practices among very-low-birth-weight infants

JAMA Pediatrics

Volumn 170, Issue 7, 2016, Pages 687-694

  Sparger, Katherine A ^a,b   Assmann, Susan F ^c   Granger, Suzanne ^c   Winston, Abigail ^a   Christensen, Robert D ^d   Widness, John A ^e   Josephson, Cassandra ^f   Stowell, Sean R ^f   Saxonhouse, Matthew ^g   Sola Visner, Martha ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NEW ENGLAND RESEARCH INSTITUTES   (United States)

^d INTERMOUNTAIN HEALTHCARE   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BRAIN HEMORRHAGE; COHORT ANALYSIS; DISEASE SEVERITY; FEMALE; GESTATIONAL AGE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEWBORN; NEWBORN INTENSIVE CARE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; VERY LOW BIRTH WEIGHT; BRAIN VENTRICLE; CEREBRAL HEMORRHAGE; CLINICAL DECISION MAKING; CLINICAL PRACTICE; CLINICAL TRIAL; COMPLICATION; INCIDENCE; INFANT, PREMATURE, DISEASES; MULTICENTER STUDY; NEONATAL INTENSIVE CARE UNIT; PREMATURITY; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME; UNITED STATES; UTILIZATION;

CEREBRAL HEMORRHAGE; CEREBRAL VENTRICLES; CLINICAL DECISION-MAKING; FEMALE; HUMANS; INCIDENCE; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INFANT, VERY LOW BIRTH WEIGHT; INTENSIVE CARE UNITS, NEONATAL; LINEAR MODELS; MALE; PLATELET TRANSFUSION; PRACTICE PATTERNS, PHYSICIANS'; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; THROMBOCYTOPENIA; TREATMENT OUTCOME; UNITED STATES;

EID: 84978138977     PISSN: 21686203     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2016.0507     Document Type: Article

References (36)

1. Andrew M, Castle V, Saigal S, Carter C, Kelton JG. Clinical impact of neonatal thrombocytopenia. J Pediatr. 1987;110(3):457-464.
2. Castle V, Andrew M, Kelton J, Giron D, Johnston M, Carter C. Frequency and mechanism of neonatal thrombocytopenia. J Pediatr. 1986;108(5, pt 1): 749-755.
3. Mehta P, Vasa R, Neumann L, Karpatkin M. Thrombocytopenia in the high-risk infant. J Pediatr. 1980;97(5):791-794.
4. Christensen RD, Henry E, Wiedmeier SE, et al. Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system. J Perinatol. 2006;26(6):348-353.
5. Del Vecchio A, Sola MC, Theriaque DW, et al. Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. Transfusion. 2001;41(6):803-808.
6. Andrew M, Vegh P, Caco C, et al. A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants. J Pediatr. 1993;123(2):285-291.
7. Josephson CD, Su LL, Christensen RD, et al. Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. Pediatrics. 2009;123(1):278-285.
8. Cremer M, Sola-Visner M, Roll S, et al. Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland. Transfusion. 2011;51(12): 2634-2641.
9. Garcia MG, Duenas E, Sola MC, Hutson AD, Theriaque D, Christensen RD. Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit. J Perinatol. 2001;21(7):415-420.
10. Baer VL, Lambert DK, Henry E, Snow GL, Sola-Visner MC, Christensen RD. Do platelet transfusions in the NICU adversely affect survival? analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system. J Perinatol. 2007; 27(12):790-796.
11. Bonifacio L, Petrova A, Nanjundaswamy S, Mehta R. Thrombocytopenia related neonatal outcome in preterms. Indian J Pediatr. 2007;74(3): 269-274.
12. Nathan DG, Oski FA. Hematology of Infancy and Childhood. 4th ed. Philadelphia, PA: Saunders; 1992.
13. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978; 92(4):529-534.
14. Murray NA, Howarth LJ, McCloy MP, Letsky EA, Roberts IA. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med. 2002;12(1):35-41.
15. Stanworth SJ, Clarke P, Watts T, et al; Platelets and Neonatal Transfusion Study Group. Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics. 2009;124(5):e826-e834.
16. Israels SJ, Odaibo FS, Robertson C, McMillan EM, McNicol A. Deficient thromboxane synthesis and response in platelets from premature infants. Pediatr Res. 1997;41(2):218-223.
17. Setzer ES, Webb IB, Wassenaar JW, Reeder JD, Mehta PS, Eitzman DV. Platelet dysfunction and coagulopathy in intraventricular hemorrhage in the premature infant. J Pediatr. 1982;100(4):599-605.
18. Sitaru AG, Holzhauer S, Speer CP, et al. Neonatal platelets from cord blood and peripheral blood. Platelets. 2005;16(3-4):203-210.
19. Rajasekhar D, Kestin AS, Bednarek FJ, Ellis PA, Barnard MR, Michelson AD. Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood. Thromb Haemost. 1994;72 (6):957-963.
20. Bednarek FJ, Bean S, Barnard MR, Frelinger AL, Michelson AD. The platelet hyporeactivity of extremely low birth weight neonates is age-dependent. Thromb Res. 2009;124(1):42-45.
21. Andrew M, Paes B, Bowker J, Vegh P. Evaluation of an automated bleeding time device in the newborn. Am J Hematol. 1990;35(4):275-277.
22. Boudewijns M, Raes M, Peeters V, et al. Evaluation of platelet function on cord blood in 80 healthy term neonates using the Platelet Function Analyser (PFA-100): shorter in vitro bleeding times in neonates than adults. Eur J Pediatr. 2003;162(3): 212-213.
23. Israels SJ, Cheang T, McMillan-Ward EM, Cheang M. Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer. J Pediatr. 2001;138(1):116-119.
24. Del Vecchio A, Latini G, Henry E, Christensen RD. Template bleeding times of 240 neonates born at 24 to 41 weeks gestation. J Perinatol. 2008;28 (6):427-431.
25. Saxonhouse MA, Garner R, Mammel L, et al. Closure times measured by the platelet function analyzer PFA-100 are longer in neonatal blood compared to cord blood samples. Neonatology. 2010;97(3):242-249.
26. Uçar T, Gurman C, Arsan S, Kemahli S. Platelet aggregation in term and preterm newborns. Pediatr Hematol Oncol. 2005;22(2):139-145.
27. Horbar JD, Badger GJ, Carpenter JH, et al; Members of the Vermont Oxford Network. Trends in mortality and morbidity for very low birth weight infants, 1991-1999. Pediatrics. 2002;110(1, pt 1): 143-151.
28. von Lindern JS, van den Bruele T, Lopriore E, Walther FJ. Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study. BMC Pediatr. 2011;11(1):16.
29. Muthukumar P, Venkatesh V, Curley A, et al; Platelets Neonatal Transfusion Study Group. Severe thrombocytopenia and patterns of bleeding in neonates: results from a prospective observational study and implications for use of platelet transfusions. Transfus Med. 2012;22(5):338-343.
30. Baer VL, Lambert DK, Henry E, Christensen RD. Severe thrombocytopenia in the NICU. Pediatrics. 2009;124(6):e1095-e1100.
31. von Lindern JS, Hulzebos CV, Bos AF, Brand A, Walther FJ, Lopriore E. Thrombocytopaenia and intraventricular haemorrhage in very premature infants: a tale of two cities. Arch Dis Child Fetal Neonatal Ed. 2012;97(5):F348-F352.
32. Josephson CD, Granger S, Assmann SF, et al. Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia. Blood. 2012;120(4):748-760.
33. Christensen RD, ed. Blood Banking and Transfusion Issues in Perinatal Medicine. Philadelphia, PA:WB Saunders; 2000.
34. Kuehnert MJ, Roth VR, Haley NR, et al. Transfusion-transmitted bacterial infection in the United States, 1998 through 2000. Transfusion. 2001;41(12):1493-1499.
35. Benjamin RJ, Stramer SL, Leiby DA, Dodd RY, Fearon M, Castro E. Trypanosoma cruzi infection in North America and Spain: evidence in support of transfusion transmission. Transfusion. 2012;52(9): 1913-1921.
36. Agapova M, Busch MP, Custer B. Cost-effectiveness of screening the US blood supply for Trypanosoma cruzi. Transfusion. 2010;50 (10):2220-2232.