Positive serum specific IgE has a short half-life in patients with penicillin allergy and reversal does not always indicate tolerance

Clinical and Translational Allergy

Volumn 4, Issue 1, 2014, Pages

  Hjortlund, Janni ^a   Mortz, Charlotte Gotthard ^a   Stage, Tore Bjerregaard ^b   Skov, Per Stahl ^a   Dahl, Ronald ^a   Bindslev Jensen, Carsten ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

7 day oral challenge; Half life; Penicillin allergy; Prolonged challenge; Specific IgE to penicillin

Indexed keywords

IMMUNOGLOBULIN E; PENICILLIN DERIVATIVE;

ADULT; AGED; ANGIONEUROTIC EDEMA; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; IMMUNE RESPONSE; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PENICILLIN ALLERGY; PLASMA HALF LIFE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROVOCATION TEST; URTICARIA; YOUNG ADULT;

EID: 84978023520     PISSN: None     EISSN: 20457022     Source Type: Journal    
DOI: 10.1186/2045-7022-4-34     Document Type: Article

References (25)

1. Hjortlund J, Mortz CG, Skov PS, Eller E, Poulsen JM, Borch JE, Bindslev Jensen C: One-week oral challenge with penicillin in diagnosis of penicillin allergy. Acta Derm Venereol 2012, 92:307-312.
2. Hjortlund J, Mortz CG, Skov PS, Bindslev-Jensen C: Diagnosis of penicillin allergy revisited: The value of case history, skin testing, specific IgE and prolonged challenge. Allergy 2013, 68:1057-1064.
3. Torres MJ, Blanca M, Fernandez J, Romano A, Weck A, Aberer W, Brockow K, Pichler WJ, Demoly P: Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy 2003, 58:961-972.
4. Romano A, Blanca M, Torres MJ, Bircher A, Aberer W, Brockow K, Pichler W, Demoly P: Diagnosis of nonimmediate reactions to beta-lactam antibiotics. Allergy 2004, 59:1153-1160.
5. Blanca M, Romano A, Torres MJ, Fernandez J, Mayorga C, Rodriguez J, Demoly P, Bousquet PJ, Merk HF, Sanz ML, Ott H, Atanaskovic-Markovic M: Update on the evaluation of hypersensitivity reactions to betalactams. Allergy 2009, 64:183-193.
6. Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, Khan DA, Lang DM, Park HS, Pichler W, Sanchez-Borges M, Shiohara T, Thong BY: International consensus on drug allergy. Allergy 2014, 69:420-437.
7. Silva R, Cruz L, Botelho C, Castro E, Cadinha S, Castel-Branco MG, Rodrigues J: Immediate hypersensitivity to penicillins with negative skin tests-the value of specific IgE. Eur Ann Allergy Clin Immunol 2009, 41:117-119.
8. Fontaine C, Mayorga C, Bousquet PJ, Arnoux B, Torres MJ, Blanca M, Demoly P: Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergy. Allergy 2007, 62:47-52.
9. Mayorga C, Sanz ML, Gamboa PM, Garcia BE, Caballero MT, Garcia JM, Labrador M, Lahoz C, Longo AN, Lopez HM, Martinez QJ, Monteseirin FJ: In vitro diagnosis of immediate allergic reactions to drugs: An update. J Investig Allergol Clin Immunol 2010, 20:103-109.
10. Fernandez T, Torres MJ, Pena R, Fuentes MS, Robles S, Mayorga C, Blanca M: Decrease of selective immunoglobulin E response to amoxicillin despite repeated administration of benzylpenicillin and penicillin V. Clin Exp Allergy 2005, 35:1645-1650.
11. Fernandez TD, Torres MJ, Blanca-Lopez N, Rodriguez-Bada JL, Gomez E, Canto G, Mayorga C, Blanca M: Negativization rates of IgE radioimmunoassay and basophil activation test in immediate reactions to penicillins. Allergy 2009, 64:242-248.
12. Kraft D, Roth A, Mischer P, Pichler H, Ebner H: Specific and total serum IgE measurements in the diagnosis of penicillin allergy. A long term follow-up study. Clin allergy 1977, 7:21-28.
13. Garvey LH, Kroigaard M, Poulsen LK, Skov PS, Mosbech H, Venemalm L, Degerbeck F, Husum B: IgE-mediated allergy to chlorhexidine. J Allergy Clin Immunol 2007, 120:409-415.
14. Mosbech H, Christensen J, Dirksen A, Soborg M: Insect allergy. Predictive value of diagnostic tests: A three-year follow-up study. Clin allergy 1986, 16:433-440.
15. Macy E, Goldberg B, Poon KY: Use of commercial anti-penicillin IgE fluorometric enzyme immunoassays to diagnose penicillin allergy. Ann Allergy Asthma Immunol 2010, 105:136-141.
16. Geyer E, Derhaschnig J, Aberer W: IgE response to penicillin. Allergy 1997, 52:671.
17. Aberer W, Zidarn M, Kranke B: IgE antibodies to penicillin are indicative for but not conclusive proof of penicillin allergy. Br J Dermatol 2006, 154:1209-1210.
18. Aberer W, Kranke B, Hager A, Wick G: In vitro allergy testing needs better standardization-test results from different laboratories lack comparability mostly due to missing effective standards. Int Arch Allergy Immunol 1995, 108:82-88.
19. Torres MJ, Mayorga C, Cornejo-Garcia JA, Romano A, Blanca M: IgE antibodies to penicillin in skin test negative patients. Allergy 2002, 57:965.
20. Blanca M, Mayorga C, Torres MJ, Reche M, Moya MC, Rodriguez JL, Romano A, Juarez C: Clinical evaluation of pharmacia CAP system RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy 2001, 56:862-870.
21. Demoly P, Bousquet J: Drug allergy diagnosis work up. Allergy 2002, 57:37-40.
22. Schnyder B, Pichler W: Nonimmediate drug allergy: diagnostic benefit of skin testing and practical approach. J Allergy Clin Immunol 2012, 129:1170-1171.
23. Johansson SG, Adedoyin J, Van HM, Gronneberg R, Nopp A: False-positive penicillin immunoassay: An unnoticed common problem. J Allergy Clin Immunol 2013, 132:235-237.
24. Kopac P, Zidarn M, Kosnik M: Epidemiology of hypersensitivity reactions to penicillin in Slovenia. Acta DermatovenerolAlp Panonica Adriat 2012, 21:65-67.
25. Zidarn M, Silar M, Vegnuti M, Korosec P, Kosnik M: The specificity of tests for anti-beta-lactam IgE antibodies declines progressively with increase of total serum IgE. Wien Klin Wochenschr 2009, 121:353-356.