IgE-mediated allergy to chlorhexidine

Journal of Allergy and Clinical Immunology

Volumn 120, Issue 2, 2007, Pages 409-415

  Garvey, Lene Heise ^a   Krøigaard, Mogens ^a   Poulsen, Lars K ^b   Skov, Per Stahl ^c   Mosbech, Holger ^a,b   Venemalm, Lennart ^d   Degerbeck, Fredrik ^e   Husum, Bent ^a  

^a Danish Anaesthesia Allergy Centre   (Denmark)

^b Rigshospitalet   (Denmark)

^c Reference Laboratory   (Denmark)

^d Thermo Fisher Scientific   (United States)

^e Mälarinvest AB   (Sweden)

Author keywords

allergy; anaphylaxis; anesthesia; Chlorhexidine; drug allergy; histamine release; intradermal testing; skin prick testing; specific IgE

Indexed keywords

CHLORHEXIDINE GLUCONATE; HISTAMINE; IMMUNOGLOBULIN E; LATEX; MIVACURIUM; MORPHINE; PANCURONIUM; PENICILLIN G; TRYPTASE;

ADULT; AGED; ANAPHYLAXIS; ARTICLE; BLOOD ANALYSIS; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; FEMALE; HISTAMINE RELEASE; HUMAN; HYPOTENSION; IMMUNOGLOBULIN BLOOD LEVEL; MALE; PRIORITY JOURNAL; SENSITIZATION; SKIN TEST; UROLOGIC SURGERY;

ADULT; AGED; AGED, 80 AND OVER; CHLORHEXIDINE; DISINFECTANTS; DRUG HYPERSENSITIVITY; FEMALE; HISTAMINE RELEASE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; HYPOTENSION; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SKIN TESTS; TRYPTASES; UROLOGIC SURGICAL PROCEDURES;

EID: 34250374995     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.04.029     Document Type: Article

References (27)

1. Garvey L.H., Roed-Petersen J., Menne T., and Husum B. Danish Anaesthesia Allergy Centre: preliminary results. Acta Anaesthesiol Scand 45 (2001) 1204-1209
2. Calnan C.D. Contact dermatitis from drugs. Proc R Soc Med 55 (1962) 39-42
3. Krautheim A.B., Jermann T.H., and Bircher A.J. Chlorhexidine anaphylaxis: case report and review of the literature. Contact Dermatitis 50 (2004) 113-116
4. Garvey L.H., Roed-Petersen J., and Husum B. Anaphylactic reactions in anaesthetised patients: four cases of chlorhexidine allergy. Acta Anaesthesiol Scand 45 (2001) 1290-1294
5. Heinemann C., Sinaiko R., and Maibach H. Immunological contact urticaria and anaphylaxis to chlorhexidine: overview. Exogenous Dermatol 1 (2002) 186-194
6. Pham N.H., Weiner J.M., Reisner G.S., and Baldo B.A. Anaphylaxis to chlorhexidine: case report: implication of immunoglobulin E antibodies and identification of an allergenic determinant. Clin Exp Allergy 30 (2000) 1001-1007
7. Layton G.T., Stanworth D.R., and Amos H.E. The incidence of IgE and IgG antibodies to chlorhexidine. Clin Exp Allergy 19 (1989) 307-314
8. Ohtoshi T., Yamauchi N., Tadokoro K., Miyachi S., Suzuki S., Miyamoto T., et al. IgE antibody-mediated shock reaction caused by topical application of chlorhexidine. Clin Allergy 16 (1986) 155-161
9. Ebo D.G., Bridts C.H., and Stevens W.J. IgE-mediated anaphylaxis from chlorhexidine: diagnostic possibilities. Contact Dermatitis 55 (2006) 301-302
10. Revelle L.K., Rutter A.M., and Wilson J.A. Synthesis of chlorhexidine digluconate impurities. J Agric Food Chem 43 (1995) 1299-1301
11. Dirks C.G., Pedersen M.H., Platzer M.H., Bindslev-Jensen C., Skov P.S., and Poulsen L.K. Does absorption across the buccal mucosa explain early onset of food-induced allergic systemic reactions?. J Allergy Clin Immunol 115 (2005) 1321-1323
12. Untersmayr E., Poulsen L.K., Platzer M.H., Pedersen M.H., Boltz-Nitulescu G., Skov P.S., et al. The effects of astric digestion on codfish allergenicity. J Allergy Clin Immunol 115 (2005) 377-382
13. Sfar Working Group. Clinical practice guidelines: reducing the risk of anaphylaxis during anaesthesia. Ann Fr Reanim 21 suppl 1 (2002) 7-23
14. Aalto-Korte K., and Mäkinen-Kiljunen S. Symptoms of immediate chlorhexidine hypersensitivity in patients with a positive prick test. Contact Dermatitis 55 (2006) 173-177
15. Blanca M., Garcia J., Vega J.M., Miranda A., Carmona M.J., Mayorga C., et al. Anaphylaxis to penicillins after non-therapeutic exposure: an immunological investigation. Clin Exp Allergy 26 (1996) 335-340
16. Mosbech H., Christensen J., Dirksen A., and Søborg M. Insect allergy: predictive value of diagnostic tests: a three-year follow-up study. Clin Allergy 16 (1986) 433-440
17. Layton G.T., Stanworth D.R., and Amos H.E. The specificity of murine polyclonal and monoclonal antibodies to the haptenic drug chlorhexidine induced by chlorine-generated chlorhexidine-protein conjugates. Clin Exp Immunol 69 (1987) 157-165
18. Baldo B.A., Pham N.H., and Zhao Z. Chemistry of drug allergenicity. Curr Opin Allergy Clin Immunol 1 (2001) 327-335
19. Layton G.T., Stanworth D.R., and Amos H.E. Factors influencing the immunogenicity of the haptenic drug chlorhexidine in mice, part I: molecular requirements for the induction of IgE and IgG anti-hapten antibodies. Mol Immunol 24 (1987) 133-141
20. Garvey L.H., Roed-Petersen J., and Husum B. [Allergy to chlorhexidine: an important differential diagnosis]. Ugeskr Laeger 166 (2004) 382-383
21. Ebo D.G., Stevens W.J., Bridts C.H., and Matthieu L. Contact allergic dermatitis and life-threatening anaphylaxis to chlorhexidine. J Allergy Clin Immunol 101 (1998) 128-129
22. Cheung J., and O'Leary J.J. Allergic reaction to chlorhexidine in an anaesthetised patient. Anaesth Intensive Care 13 (1985) 429-430
23. Thune P. [Two patients with chlorhexidine allergy: anaphylactic reactions and eczema]. Tidsskr Nor Laegeforen 118 (1998) 3295-3296
24. Lauerma A.I. Simultaneous immediate and delayed hypersensitivity to chlorhexidine digluconate. Contact Dermatitis 44 (2001) 59
25. Bergqvist-Karlsson A. Delayed and immediate-type hypersensitivity to chlorhexidine. Contact Dermatitis 18 (1988) 84-88
26. Schwartz L.B., Bradford T.R., Rouse C., Irani A.M., Rasp G., Van der Zwan J.K., et al. Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis. J Clin Immunol 14 (1994) 190-204
27. Deliargyris E.N., Upadhya B., Sane D.C., Dehmer G.J., Pye J., Smith Jr. S.C., et al. Mast cell tryptase: a new biomarker in patients with stable coronary artery disease. Atherosclerosis 178 (2005) 381-386