Laboratory evaluation of the Alere q point-of-care system for early infant HIV diagnosis

PLoS ONE

Volumn 11, Issue 3, 2016, Pages

  Hsiao, Nei Yuan ^a   Dunning, Lorna ^a   Kroon, Max ^a   Myer, Landon ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENTION; CHILD; CONTROLLED STUDY; DIAGNOSIS; DIAGNOSTIC TEST ACCURACY STUDY; FIELD STUDY; HEALTH CARE QUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; INFANT; LABORATORY TEST; MAJOR CLINICAL STUDY; POINT OF CARE SYSTEM; POINT OF CARE TESTING; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; SOUTH AFRICA; DIAGNOSTIC KIT; EARLY DIAGNOSIS; EVALUATION STUDY; FEMALE; GENETICS; HIV INFECTIONS; ISOLATION AND PURIFICATION; LABORATORY; MALE; METABOLISM; NEWBORN; STANDARDS; VIROLOGY;

DIAGNOSTIC KIT; VIRUS RNA;

EARLY DIAGNOSIS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFANT, NEWBORN; LABORATORIES; MALE; POINT-OF-CARE TESTING; POLYMERASE CHAIN REACTION; REAGENT KITS, DIAGNOSTIC; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; SOUTH AFRICA;

EID: 84977557832     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0152672     Document Type: Article

References (22)

1. Bourne DE, Thompson M, Brody LL, Cotton M, Draper B, Laubscher R, et al. Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa. AIDS. 2009Jan 2; 23(1):101-6. PMID: 19065753
2. Eley B, Davies MA, Apolles P, Cowburn C, Buys H, Zampoli M, et al. Antiretroviral treatment for children. S Afr Med J. 2006Sep; 96(9 Pt 2):988-93. PMID: 17077930
3. Violari A, Cotton MF, Gibb DM, Babiker AG, Steyn J, Madhi SA, et al; CHER Study Team. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med. 2008Nov 20; 359(21):2233-44.
4. Ciaranello AL, Park JE, Ramirez-Avila L, Freedberg KA, Walensky RP, Leroy V. Early infant HIV-1 diagnosis programs in resource-limited settings: opportunities for improved outcomes and more cost-effective interventions. BMC Med. 2011May 20; 9:59. doi: 10.1186/1741-7015-9-59 PMID: 21599888
5. Hsiao NY, Stinson K, Myer L. Linkage of HIV-infected infants from diagnosis to antiretroviral therapy services across the Western Cape, South Africa. PLoS One. 2013; 8(2):e55308. doi: 10.1371/journal.pone.0055308 PMID: 23405133
6. Chatterjee A, Tripathi S, Gass R, Hamunime N, Panha S, Kiyaga C, et al. Implementing services for Early Infant Diagnosis (EID) of HIV: a comparative descriptive analysis of national programs in four countries. BMC Public Health. 2011Jul 13; 11:553. doi: 10.1186/1471-2458-11-553 PMID: 21749730
7. Motswere-Chirwa C, Voetsch A, Lu L, Letsholathebe V, Lekone P, Machakaire E, et al; Centers for Disease Control and Prevention (CDC). Follow-up of infants diagnosed with HIV - Early Infant Diagnosis Program, Francistown, Botswana, 2005-2012. MMWR Morb Mortal Wkly Rep. 2014 Feb 21; 63(7):158-60. PMID: 24553200
8. 2014 Progress report on the global plan towards the elimination of new HIV infection among children by 2015 and keeping their mothers alive, UNAIDS, Geneva, 2014.
9. Stringer JS, Stinson K, Tih PM, Giganti MJ, Ekouevi DK, Creek TL, et al. Measuring coverage in MNCH: population HIV-free survival among children under two years of age in four African countries. PLoS Med. 2013; 10(5):e1001424. doi: 10.1371/journal.pmed.1001424 PMID: 23667341
10. Nielsen-Saines K, Watts DH, Veloso VG, Bryson YJ, Joao EC, Pilotto JH, et al; NICHD HPTN 040/PACTG 1043 Protocol Team. Three postpartum antiretroviral regimens to prevent intrapartum HIV infection. N Engl J Med. 2012 Jun 21; 366(25):2368-79. doi: 10.1056/NEJMoa1108275 PMID: 22716975
11. Lilian RR, Kalk E, Technau KG, Sherman GG. Birth diagnosis of HIV infection in infants to reduce infant mortality and monitor for elimination of mother-to-child transmission. Pediatr Infect Dis J. 2013Oct; 32 (10):1080-5. doi: 10.1097/INF.0b013e318290622e PMID: 23574775
12. Lilian RR, Kalk E, Bhowan K, Berrie L, Carmona S, Technau K, et al. Early diagnosis of in utero and intrapartum HIV infection in infants prior to 6 weeks of age. J Clin Microbiol. 2012Jul; 50(7):2373-7. doi: 10.1128/JCM.00431-12 PMID: 22518871
13. World Health Organization (2004) Rapid HIV Tests: Guidelines for use in HIV testing and counseling services in resource-constrained settings. Available: http://applications.emro.who.int/aiecf/web28.pdf. Accessed 2015 July 31.
14. Jani IV, Sitoe NE, Alfai ER, Chongo PL, Quevedo JI, Rocha BM, et al. Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort study. Lancet. 2011Oct 29; 378(9802):1572-9. doi: 10.1016/S0140-6736(11)61052-0 PMID: 21951656
15. UNITAID. HIV/AIDS Diagnostic technology landscape, 4th edition, UNITAID, Geneva, 2014.
16. World Health Organisation. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach June 2013. World Health Organisation, Geneva, 2013.
17. Feucht U, Forsyth B, Kruger M. False-positive HIV DNA PCR testing of infants: Implications in a changing epidemic. S Afr Med J 2012; 102:149-152. PMID: 22380909
18. Maritz J, van Zyl GU, Preiser W. Irreproducible positive results on the Cobas AmpliPrep/Cobas TaqMan HIV-1 Qual test are different qualitatively from confirmed positive results. J Med Virol. 2014Jan; 86 (1):82-7. doi: 10.1002/jmv.23811 PMID: 24136657
19. King CC, Kourtis AP, Persaud D, Nelson JA, Ziemniak C, Hudgens MG, et al. Delayed HIV detection among infants exposed to postnatal antiretroviral prophylaxis during breastfeeding. 2015Sep 24; 29 (15):1953-61.
20. Sutcliffe CG, Moss WJ, Thuma PE. False-positive HIV test results in infancy and management of uninfected children receiving antiretroviral therapy. Pediatr Infect Dis J. 2015Jun; 34(6):607-9. doi: 10.1097/INF.0000000000000684 PMID: 25973939
21. Oladokun R, Korsman S, Ndabambi N, Hsiao N, Hans L, Williamson C, et al. False negative HIV-1 PCR in a 15-months old boy with subtype C HIV infection. SAMJ. 2015Oct; 105(10):877.
22. March 2014 supplement of World Health Organisation. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. World Health Organisation, Geneva, 2014.