MALAT1 induces tongue cancer cells' EMT and inhibits apoptosis through Wnt/β-catenin signaling pathway

Journal of Oral Pathology and Medicine

Volumn 46, Issue 2, 2017, Pages 98-105

  Liang, Jun ^a   Liang, Lizhong ^a   Ouyang, Kexiong ^b   Li, Zhiqiang ^c   Yi, Xianping ^a  

^a THE FIFTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

epithelial to mesenchymal transition; invasion; MALAT1; migration; tongue squamous cell carcinoma

Indexed keywords

BETA CATENIN; LONG UNTRANSLATED RNA; PROTEIN BAX; UVOMORULIN; VIMENTIN; WNT PROTEIN; MALAT1 LONG NON-CODING RNA, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER TISSUE; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CERVICAL LYMPH NODE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MALAT1 GENE; MALE; MTT ASSAY; ONCOGENE; PLASMID; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TONGUE CARCINOMA; UPREGULATION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TONGUE TUMOR;

BETA CATENIN; CARCINOMA, SQUAMOUS CELL; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; HUMANS; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; TONGUE NEOPLASMS; UP-REGULATION; WNT PROTEINS;

EID: 84977539877     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/jop.12466     Document Type: Article

References (25)

1. Leemans CR, Tiwari R, Nauta JJ, et al. Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma. Cancer 1993; 71: 452.
2. Chua HL, Bhat-Nakshatri P, Clare SE, et al. NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 2007; 26: 711–24.
3. Eger A, Stockinger A, Schaffhauser B, et al. Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity. J Cell Biol 2000; 148: 173–88.
4. Gutschner T, Hämmerle M, Diederichs S. MALAT1 - a paradigm for long noncoding RNA function in cancer. J Mol Med 2013; 91: 791–801.
5. Ji P, Diederichs S, Wang W, et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 2003; 22: 8031–41.
6. Guffanti A, Iacono M, Pelucchi P, et al. A transcriptional sketch of a primary human breast cancer by 454 deep sequencing. BMC Genom 2009; 10: 163.
7. Yamada K, Kano J, Tsunoda H, et al. Phenotypic characterization of endometrial stromal sarcoma of the uterus. Cancer Sci 2006; 97: 106–12.
8. Lin R, Maeda S, Liu C, et al. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene 2007; 26: 851–8.
9. Luo JH, Ren B, Keryanov S, et al. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology 2006; 44: 1012–24.
10. Tano K, Mizuno R, Okada T, et al. MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression ofmotility-related genes. FEBS Lett 2010; 584: 4575–80.
11. Lin Z, Sun L, Chen W, et al. miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1. Cancer Sci 2014; 105: 1288–98.
12. Liang YJ, Liu HC, Su YX, et al. Foxp3 expressed by tongue squamous cell carninoma cells correlates with clinicopathologic features and overall survival in tongue squamous cell carcinoma patients. Oral Oncol 2011; 47: 566–70.
13. Hauptman N, Glavač D. Long non-coding RNA in cancer. Int J Mol Sci 2013; 14: 4655–69.
14. Fellenberg J, Bernd L, Delling G, et al. Prognostic significance of drug-regulated genes in high-grade osteosarcoma. Mod Pathol 2007; 20: 1085–94.
15. Tang H, Wu Z, Zhang J, et al. Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Mol Med Rep 2013; 7: 761–6.
16. Zhou X, Liu S, Cai G, et al. Long non coding RNA MALAT1 promotes tumor growth and metastasis by inducing epithelial-mesenchymal transition in oral squamous cell carcinoma. Sci Rep 2015; 5: 15972.
17. Liang Y, Chen Q, Wang Y, et al. Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol Biosyst 2012; 8: 2289–94.
18. Shiah SG, Shieh YS, Chang JY. The Role of Wnt signaling in squamous cell carcinoma. J Dent Res 2016; 95: 129–34.
19. Iwai S, Yonekawa A, Harada C, et al. Involvement of the Wnt-β-catenin pathway in invasion and migration of oral squamous carcinoma cells. Int J Oncol 2010; 37: 1095–103.
20. Fan Y, Shen B, Tan M, et al. TGF-β-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12. Clin Cancer Res 2014; 20: 1531–41.
21. Sun R, Qin C, Jiang B, et al. Down-regulation of MALAT1 inhibits cervical cancer cell invasion and metastasis by inhibition of epithelial-mesenchymal transition. Mol Biosyst 2016; 12: 952–62.
22. Hirata H, Hinoda Y, Shahryari V, et al. Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205. Cancer Res 2015; 75: 1322–31.
23. Jung HY, Jun S, Lee M, et al. PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation. Mol Cell 2013; 52: 193–205.
24. Guo F, Li Y, Liu Y, et al. Inhibition of metastasis associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. Acta Biochim Biophys Sin (Shanghai) 2010; 42: 224–9.
25. Han Y, Liu Y, Nie L, et al. Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. Urology 2013; 81: 209.e1–7.