Efficacy of Schwann cell transplantation for spinal cord repair is improved with combinatorial strategies

Journal of Physiology

Volumn 594, Issue 13, 2016, Pages 3533-3538

  Bunge, Mary Bartlett ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; MYELIN; N ACETYLGALACTOSAMINE 4 SULFATASE; NEUROTROPHIN; STEROID;

ASTROCYTE; AUTOTRANSPLANTATION; AXON; BRAIN STEM; CELL INTERACTION; CELL TRANSPLANTATION; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL (TOPIC); DISEASE MODEL; FIBROBLAST; FOOD AND DRUG ADMINISTRATION; HINDLIMB; HUMAN; MYELINATED NERVE; MYELINATION; NERVE REGENERATION; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NONHUMAN; OLFACTORY ENSHEATHING CELL; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REVIEW; SCHWANN CELL; SENSORY NERVE CELL; SPINAL CORD INJURY; SPINAL CORD REGENERATION;

EID: 84977505204     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP271531     Document Type: Review

References (35)

1. Blight AR & Young W (1989). Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells. J Neurol Sci 91, 15–34.
2. Blits B, Oudega M, Boer GJ, Bunge MB & Verhaagen J (2003). Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hindlimb function. Neuroscience 118, 271–281.
3. Bunge MB & Wood PM (2012). Realizing the maximum potential of Schwann cells to promote recovery from spinal cord injury. In Handbook of Clinical Neurology, Spinal Cord Injury, 3rd Series, ed. Verhaagan J & McDonald JW, vol. 109, Ch. 34, pp. 523–540. Elsevier, New York.
4. Bunge MB, Bunge RP, Carey DJ, Cornbrooks CJ, Eldridge CF, Williams AK & Wood PM (1983). Axonal and nonaxonal influences on Schwann cell development. In: Developing and Regenerating Vertebrate Nervous Systems, eds Coates PW, Markwald RR & Kenny AD, pp. 71–105. Alan R. Liss, New York.
5. Bunge MB, Clark MB, Dean AC, Eldridge CF & Bunge RP (1990). Schwann cell function depends upon axonal signals and basal lamina components. Ann NY Acad Sci 580, 281–287.
6. Bunge MB, Williams AK, Wood PM, Uitto J & Jeffrey JJ (1980). Comparison of nerve cell and nerve cell plus Schwann cell cultures, with particular emphasis on basal lamina and collagen formation. J Cell Biol 84, 184–202.
7. Bunge MB, Wood PM, Tynan LB, Bates ML & Sanes JR (1989). Perineurium originates from fibroblasts: demonstration in vitro with a retroviral marker. Science 243, 229–231.
8. Bunge, RP (1975). The changing uses of nerve tissue culture 1950–1975. In: The Nervous System, ed. Tower DB, vol 1, The Basic Neurosciences, pp. 31–42. Raven Press, New York.
9. Bunge RP (1994). The role of the Schwann cell in trophic support and regeneration. J Neurol 242(Suppl 1), S19–S21.
10. Bunge RP & Bunge MB (1983). Interrelationship between Schwann cell function and extracellular matrix production. Trends Neurosci 6, 499–505.
11. Chen A, Xu XM, Kleitman N & Bunge MB (1996). Methylprednisolone administration improves axonal regeneration into Schwann cell grafts in transected adult rat thoracic spinal cord. Exp Neurol 138, 261–276.
12. Clark MB & Bunge MB (1989). Cultured Schwann cells assemble normal-appearing basal lamina only when they ensheathe axons. Dev Biol 133, 393–404.
13. Eldridge CF, Bunge MB & Bunge RP (1989). Differentiation of axon-related Schwann cells in vitro: II. Control of myelin formation by basal lamina. J Neurosci 9, 625–638.
14. Eldridge CF, Bunge MB, Bunge RP & Wood PM (1987). Differentiation of axon-related Schwann cells in vitro. I. Ascorbic acid regulates basal lamina assembly and myelin formation. J Cell Biol 105, 1023–1034.
15. Enomoto M, Bunge MB & Tsoulfas P (2013). A multifunctional neurotrophin with reduced affinity to p75NTR enhances transplanted Schwann cell survival and axon growth after spinal cord injury. Exp Neurol 248, 170–182.
16. Flora G, Joseph G, Patel S, Singh A, Bleicher D, Barakat DJ, Louro J, Fenton S, Garg M, Bunge MB & Pearse DD (2013). Combining neurotrophin transduced Schwann cells and rolipram to promote functional recovery from spinal cord injury. Cell Transplant 22, 2203–2217.
17. Fouad K, Schnell L, Bunge MB, Schwab ME, Liebscher T & Pearse DD (2005). Combining Schwann cell bridges and olfactory ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J Neurosci 25, 1169–1178.
18. Fortun J, Hill CE & Bunge MB (2009). Combinatorial strategies with Schwann cell transplantation to improve repair of the injured spinal cord. Neurosci Letters 456, 124–132.
19. Gilmore SA & Sims TJ (1993). Patterns of Schwann cell myelination of axons within the spinal cord. J Chem Neuroanat 6, 191–199.
20. Golden KL, Pearse DD, Blits B, Garg M, Oudega M, Wood PM & Bunge MB (2007). Transduced Schwann cells promote axon growth and myelination after spinal cord injury. Exp Neurol 207, 203–217.
21. Guest J, Santamaria AJ & Benavides FD (2013). Clinical translation of autologous Schwann cell transplantation for the treatment of spinal cord injury. Curr Opin Organ Transplant 18, 682–689.
22. Guest JD, Rao A, Bunge MB & Bunge RP (1997). The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord. Exp Neurol 48, 502–522.
23. Kanno H, Pressman Y, Moody A, Berg R, Muir EM, Rogers JH, Ozawa H, Itoi E, Pearse DD & Bunge MB (2014). Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury. J Neurosci 34, 1838–1855.
24. Menei P, Montero-Menei C, Whittemore SR, Bunge RP & Bunge MB (1998). Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord. Eur J Neurosci 10, 607–621.
25. Pearse DD, Marcillo AE, Oudega M, Lynch MP, Wood PM & Bunge MB (2004a). Transplantation of Schwann cells and olfactory ensheathing glia after spinal cord injury: Does pretreatment with methylprednisolone and interleukin-10 enhance recovery? J Neurotrauma 21, 1223–1239.
26. Pearse DD, Pereira FC, Marcillo AE, Bates ML, Berrocal YA, Filbin MT & Bunge MB (2004b). cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med 10, 610–616.
27. Pearse DD, Sanchez AR, Pereira FC, Andrade CM, Puzis R, Pressman Y, Golden KL, Kitay BM, Blits B, Wood PM & Bunge MB (2007). Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: survival, migration, axon association and functional recovery. Glia 55, 976–1000.
28. Plant GW, Christensen CL, Oudega M & Bunge MB (2003). Delayed transplantation of olfactory ensheathing glia promotes sparing/regeneration of supraspinal axons in the moderately contused adult rat spinal cord. J Neurotrauma 20, 1–16.
29. Richardson PM, McGuinness UM & Aguayo AJ (1980). Axons from CNS neurons regenerate into PNS grafts. Nature 284, 264–5.
30. Takami T, Oudega M, Bates ML, Wood PM, Kleitman N & Bunge MB (2002). Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord. J Neurosci 22, 6670–6681.
31. Tetzlaff W, Okon EB, Karimi-Abdolrezaee S, Hill CE, Sparling JS, Plemel JR, Plunet WT, Tsai EC, Baptiste D, Smithson LJ, Kawaja MD, Fehlings MG & Kwon BK (2011). A systematic review of cellular transplantation therapies for spinal cord injury. J Neurotrauma 28, 1611–1682.
32. Williams RR, Henao M, Pearse DD & Bunge MB (2015). Permissive Schwann cell graft/spinal cord interfaces for axon regeneration. Cell Transplant 24, 115–131.
33. Wood PM & Bunge RP (1975). Evidence that sensory axons are mitogenic for Schwann cells. Nature 256, 662–664.
34. Xu XM, Chen A, Guénard V, Kleitman N & Bunge MB (1997). Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord. J Neurocytol 26, 1–16.
35. Xu XM, Guénard V, Kleitman N, Aebischer P & Bunge MB (1995). A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Exp Neurol 134, 261–272.