In vitro uptake of recombinant factor VIIa by megakaryocytes with subsequent production of platelets containing functionally active drug

British Journal of Haematology

Volumn 178, Issue 3, 2017, Pages 482-486

  Schut, Anne Marieke ^a   Kirschbaum, Marc ^a   Adelmeijer, Jelle ^a   de Groot, Philip G ^b   Lisman, Ton ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

blood platelets; haemophilia; megakaryocytes; prophylaxis; recombinant FVIIa

Indexed keywords

ENDOTHELIAL PROTEIN C RECEPTOR; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RECOMBINANT THROMBOPOIETIN; BLOOD CLOTTING FACTOR 7A; PROCR PROTEIN, HUMAN; RECOMBINANT PROTEIN;

CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG UPTAKE; HEMOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LETTER; MEGAKARYOCYTE; PRIORITY JOURNAL; THROMBOCYTOPOIESIS; CELL LINE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

CELL LINE; ENDOTHELIAL PROTEIN C RECEPTOR; FACTOR VIIA; HUMANS; MEGAKARYOCYTES; RECOMBINANT PROTEINS; THROMBOPOIESIS;

EID: 84977473017     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.14149     Document Type: Letter

References (10)

1. Cecchetti, L., Tolley, N.D., Michetti, N., Bury, L., Weyrich, A.S. & Gresele, P. (2011) Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood, 118, 1903–1911.
2. Clark, C.A., Vatsyayan, R., Hedner, U., Esmon, C.T., Pendurthi, U.R. & Rao, L.V. (2012) Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa. Journal of Thrombosis and Haemostasis, 10, 2383–2391.
3. Gopalakrishnan, R., Hedner, U., Ghosh, S., Nayak, R.C., Allen, T.C., Pendurthi, U.R. & Rao, L.V. (2010) Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa). Journal of Thrombosis and Haemostasis, 8, 301–310.
4. Kirschbaum, M., Karimian, G., Adelmeijer, J., Giepmans, B.N., Porte, R.J. & Lisman, T. (2015) Horizontal RNA transfer mediates platelet-induced hepatocyte proliferation. Blood, 126, 798–806.
5. Konkle, B.A., Ebbesen, L.S., Erhardtsen, E., Bianco, R.P., Lissitchkov, T., Rusen, L. & Serban, M.A. (2007) Randomized, prospective clinical trial of recombinant factor VIIa for secondary prophylaxis in hemophilia patients with inhibitors. Journal of Thrombosis and Haemostasis, 5, 1904–1913.
6. Lisman, T. & de Groot, P.G. (2015) The role of cell surfaces and cellular receptors in the mode of action of recombinant factor VIIa. Blood Reviews, 29, 223–229.
7. Pavani, G., Ivanciu, L., Faella, A., Marcos-Contreras, O.A. & Margaritis, P. (2014) The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo. Blood, 124, 1157–1165.
8. Schut, A.M., Hyseni, A., Adelmeijer, J., Meijers, J.C., De Groot, P.G. & Lisman, T. (2014) Sustained pro-haemostatic activity of rFVIIa in plasma and platelets in non-bleeding pigs may explain the efficacy of a once-daily prophylaxis in humans. Thrombosis and Haemostasis, 112, 304–310.
9. Sundaram, J., Keshava, S., Gopalakrishnan, R., Esmon, C.T., Pendurthi, U.R. & Rao, L.V. (2014) Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo. Journal of Thrombosis and Haemostasis, 12, 690–700.
10. Young, G., Auerswald, G., Jimenez-Yuste, V., Lambert, T., Morfini, M., Santagostino, E. & Blanchette, V. (2012) PRO-PACT: retrospective observational study on the prophylactic use of recombinant factor VIIa in hemophilia patients with inhibitors. Thrombosis Research, 130, 864–870.