Endothelial Dysfunction in Obesity: Role of Inflammation

High Blood Pressure and Cardiovascular Prevention

Volumn 23, Issue 2, 2016, Pages 83-85

  Virdis, Agostino ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Cytokines; Endothelium; Microcirculation; Obesity; Oxidative stress

Indexed keywords

CYTOKINE; AUTACOID; NITRIC OXIDE;

ADIPOSE TISSUE; ARTICLE; BLOOD VESSEL WALL; ENDOTHELIAL DYSFUNCTION; HUMAN; OBESITY; OXIDATIVE STRESS; PERIVASCULAR ADIPOSE TISSUE; PRIORITY JOURNAL; VASCULARIZATION; ABDOMINAL OBESITY; ANIMAL; CARDIOVASCULAR DISEASE; IMMUNOLOGY; INFLAMMATION; METABOLISM; PATHOPHYSIOLOGY; PROGNOSIS; RISK FACTOR; VASCULAR ENDOTHELIUM;

ADIPOSE TISSUE; ANIMALS; CARDIOVASCULAR DISEASES; CYTOKINES; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; NITRIC OXIDE; OBESITY, ABDOMINAL; OXIDATIVE STRESS; PROGNOSIS; RISK FACTORS;

EID: 84977079193     PISSN: 11209879     EISSN: 11791985     Source Type: Journal    
DOI: 10.1007/s40292-016-0133-8     Document Type: Article

References (16)

1. Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340(2):115–26.
2. Virdis A, Ghiadoni L, Versari D, Giannarelli C, Salvetti A, Taddei S. Endothelial function assessment in complicated hypertension. Curr Pharm Des. 2008;14(18):1761–70.
3. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation. 2005;111(3):363–8.
4. Virdis A, Neves MF, Duranti E, Bernini G, Taddei S. Microvascular endothelial dysfunction in obesity and hypertension. Curr Pharm Des. 2013;19(13):2382–9.
5. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89(6):2548–56.
6. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24(1):29–33.
7. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension. 2003;42(3):231–4.
8. Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab. 2004;89(6):2563–8.
9. Yudkin JS. Adipose tissue, insulin action and vascular disease: inflammatory signals. Int J Obes Relat Metab Disord. 2003;27(Suppl 3):S25–8.
10. Dodd-o JM, Welsh LE, Salazar JD, Walinsky PL, Peck EA, Shake JG, et al. Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury. Am J Physiol Heart Circ Physiol. 2004;287(2):H927–36.
11. Mercurio F, Manning AM. Multiple signals converging on NF-kappaB. Curr Opin Cell Biol. 1999;11(2):226–32.
12. Virdis A, Schiffrin EL. Vascular inflammation: a role in vascular disease in hypertension? Curr Opin Nephrol Hypertens. 2003;12(2):181–7.
13. Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation. 2009;119(12):1661–70.
14. Tesauro M, Schinzari F, Rovella V, Di Daniele N, Lauro D, Mores N, et al. Ghrelin restores the endothelin 1/nitric oxide balance in patients with obesity-related metabolic syndrome. Hypertension. 2009;54(5):995–1000.
15. Virdis A, Duranti E, Rossi C, Dell’Agnello U, Santini E, Anselmino M, et al. Tumour necrosis factor-alpha participates on the endothelin-1/nitric oxide imbalance in small arteries from obese patients: role of perivascular adipose tissue. Eur Heart J. 2015;36(13):784–94.
16. Virdis A, Santini F, Colucci R, Duranti E, Salvetti G, Rugani I, et al. Vascular generation of tumor necrosis factor-alpha reduces nitric oxide availability in small arteries from visceral fat of obese patients. J Am Coll Cardiol. 2011;58(3):238–47.