Antimicrobial Stewardship with Pharmacist Intervention Improves Timeliness of Antimicrobials Across Thirty-three Hospitals in South Africa

Infectious Diseases and Therapy

Volumn 4, Issue , 2015, Pages 5-14

  Messina, Angeliki P ^a   van den Bergh, Dena ^a   Goff, Debra A ^b  

^a Netcare   (South Africa)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Antimicrobial stewardship; Antimicrobials; Pharmacist; South Africa

Indexed keywords

ANTIINFECTIVE AGENT;

ANTIMICROBIAL STEWARDSHIP; ARTICLE; HOSPITAL; HUMAN; MAJOR CLINICAL STUDY; MEDICAL ETHICS; MORTALITY; PATIENT COMPLIANCE; PHARMACIST; PRIORITY JOURNAL; PROSPECTIVE STUDY; SOUTH AFRICA;

EID: 84977074164     PISSN: 21938229     EISSN: 21936382     Source Type: Journal    
DOI: 10.1007/s40121-015-0082-x     Document Type: Article

References (13)

1. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34:1589–96.
2. Ferrer R, Martin-Loeches I, Phillips G, et al. Empiric Antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med. 2014;42(8):1749–55.
3. Cohen J, Vincent JL, Adhikari NKJ, et al. Sepsis: a roadmap for future research. Lancet Infect Dis. 2015;15:581–614.
4. Dellit TH, Owens RC, McGowan JE Jr, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44:159–77.
5. Varkey P, Reller K, Resar RK. Basics of quality improvement in healthcare. Mayo Clinic Proc. 2007;82(6):735–9.
6. The South African Pharmacy Council. 2015. Available at http://www.pharmcouncil.co.za/B_StatsPerByGender.asp. Accessed Mar 27, 2015.
7. Trivedi KK, Dumartin C, Gilcrest M, Wade P, Howard P. Identifying best practices across three countries: hospital antimicrobial stewardship in the United Kingdom, France, and the United States. Clin Infect Dis. 2014;59(S3):S170–8.
8. Bardon J, Aliberti S, Duvvuri P, et al. Early administration of the first antimicrobials should be considered a marker of optimal care of patients with community-acquired pneumonia rather than a predictor of outcomes. Int J Infect Dis. 2013;17:293–8.
9. Lack WD, Karunakar MA, Angerame MR, et al. Type III open Tibia fractures: immediate antibiotic prophylaxis minimizes infection. J Orthop Trauma. 2015;29(1):1–6.
10. Van Zanten ARH. The golden hour of antibiotic administration in severe sepsis: avoid a false start striving for gold. Crit Care Med. 2014;42(8):1931–2.
11. Gaieski DF, Pines JM, Band RA, et al. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med. 2010;38(3):1–9.
12. Chung AC, Buising KL. Delayed administration of antibiotics and mortality in patients with community-acquired pneumonia. Ann Emerg Med. 2009;53(5):6128–624.
13. Paruk F, Richards G, Scribante J, Bhagwanjee S, Mer M, Perrie H. Antibiotic prescription practices and their relationship to outcome in South African intensive care units: findings of the prevalence of infection in South African intensive care units (PISA) study. S Afr Med J. 2012;102(7):613–6.