Protein Complexation and pH Dependent Release Using Boronic Acid Containing PEG-Polypeptide Copolymers

Macromolecular Bioscience

Volumn 17, Issue 1, 2017, Pages

  Negri, Graciela E ^a   Deming, Timothy J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Engineering IV   (United States)

Author keywords

block copolymer; boronic acid; polypeptide; protein delivery

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BLOCK COPOLYMERS; ORGANIC ACIDS; PH; POLYETHYLENE OXIDES; POLYPEPTIDES; PROTEINS;

ACIDIC CONDITIONS; BORONIC ACID; CARBOHYDRATE BINDING; INTRACELLULAR PROTEIN DELIVERY; NANOSCALE COMPLEXES; PH-DEPENDENT RELEASE; PHENYLBORONIC ACIDS; PROTEIN DELIVERY;

POLYETHYLENE GLYCOLS;

BENZENEBORONIC ACID; BORONIC ACID DERIVATIVE; CARBOHYDRATE; COPOLYMER; GLYCOSYLATED PROTEIN; LYSINE; MACROGOL; POLYPEPTIDE; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; DRUG COMBINATION; KI 67 ANTIGEN; MACROCYCLIC LACTAM; MACROGOL DERIVATIVE; MICELLE; PACLITAXEL; PEPTIDE; POLYESTER; POLYLACTIDE; POLYMER; PROTEIN; PROTEIN KINASE B; RAPAMYCIN; TRIOLIMUS;

ARTICLE; COMPLEX FORMATION; MOLECULAR STABILITY; PH; A-549 CELL LINE; ANIMAL; CELL CLONE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG COMBINATION; DRUG EFFECTS; FEMALE; IMMUNOHISTOCHEMISTRY; METABOLISM; MICELLE; NECROSIS; NEOPLASMS; NUDE MOUSE; PATHOLOGY;

A549 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOQUINONES; BORONIC ACIDS; CELL PROLIFERATION; CELL SURVIVAL; CLONE CELLS; DRUG COMBINATIONS; FEMALE; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LACTAMS, MACROCYCLIC; MICE, NUDE; MICELLES; NECROSIS; NEOPLASMS; PACLITAXEL; PEPTIDES; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIROLIMUS;

EID: 84976887084     PISSN: 16165187     EISSN: 16165195     Source Type: Journal    
DOI: 10.1002/mabi.201600136     Document Type: Article

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