Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Korai, Masaaki ^a,b   Kitazato, Keiko T ^a   Tada, Yoshiteru ^a   Miyamoto, Takeshi ^a   Shimada, Kenji ^a   Matsushita, Nobuhisa ^a   Kanematsu, Yasuhisa ^a   Satomi, Junichiro ^a   Hashimoto, Tomoki ^b   Nagahiro, Shinji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anterior communicating artery; Cerebral aneurysm rupture; Folic acid; Hyperhomocysteinemia; Macrophage; Matrix metalloproteinase 9; Methionine; Tissue inhibitor of metalloproteinase 2

Indexed keywords

FOLIC ACID; GELATINASE A; GELATINASE B; INTERLEUKIN 6; MESSENGER RNA; METHIONINE; CYSTEINE; CYTOKINE; NOX4 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TIMP1 PROTEIN, MOUSE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; VITAMIN B COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR COMMUNICATING ARTERY; ARTICLE; BRAIN ARTERY ANEURYSM RUPTURE; BRAIN CIRCULUS ARTERIOSUS; CAROTID ARTERY LIGATION; CELL INFILTRATION; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; FEMALE; HIGH SALT DIET; HYPERHOMOCYSTEINEMIA; MACROPHAGE; NONHUMAN; OVARIECTOMY; PATHOGENESIS; PROPENSITY SCORE; RAT; SUBARACHNOID HEMORRHAGE; ANEURYSM, RUPTURED; ANIMAL; ARTERY; BLOOD; BLOOD PRESSURE; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANEURYSM, RUPTURED; ANIMALS; ARTERIES; BLOOD PRESSURE; CYSTEINE; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FOLIC ACID; HYPERHOMOCYSTEINEMIA; MATRIX METALLOPROTEINASE 9; METHIONINE; NADPH OXIDASE; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; SUBARACHNOID HEMORRHAGE; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; VITAMIN B COMPLEX;

EID: 84976477057     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0634-3     Document Type: Article

References (36)

1. Wiebers DO, Whisnant JP, Huston 3rd J, Meissner I, Brown Jr RD, Piepgras DG, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003;362(9378):103-10.
2. Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem. 2004;50(1):3-32.
3. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274(13):1049-57.
4. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337(4):230-6.
5. Brunelli T, Prisco D, Fedi S, Rogolino A, Farsi A, Marcucci R, et al. High prevalence of mild hyperhomocysteinemia in patients with abdominal aortic aneurysm. J Vasc Surg. 2000;32(3):531-6.
6. Halazun KJ, Bofkin KA, Asthana S, Evans C, Henderson M, Spark JI. Hyperhomocysteinaemia is associated with the rate of abdominal aortic aneurysm expansion. Eur J Vasc Endovasc Surg. 2007;33(4):391-4. discussion 5-6.
7. Xu Y, Tian Y, Wei HJ, Dong JF, Zhang JN. Methionine diet-induced hyperhomocysteinemia accelerates cerebral aneurysm formation in rats. Neurosci Lett. 2011;494(2):139-44.
8. Semmler A, Linnebank M, Krex D, Gotz A, Moskau S, Ziegler A, et al. Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms. Cerebrovasc Dis. 2008;26(4):425-9.
9. Jamous MA, Nagahiro S, Kitazato KT, Satomi J, Satoh K. Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part I: experimental study of the effect of oophorectomy in rats. J Neurosurg. 2005;103(6):1046-51.
10. Jamous MA, Nagahiro S, Kitazato KT, Tamura T, Kuwayama K, Satoh K. Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part II: experimental study of the effects of hormone replacement therapy in rats. J Neurosurg. 2005;103(6):1052-7.
11. Tamura T, Jamous MA, Kitazato KT, Yagi K, Tada Y, Uno M, et al. Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats. J Hypertens. 2009;27(6):1284-92.
12. Tada Y, Kitazato KT, Tamura T, Yagi K, Shimada K, Kinouchi T, et al. Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats. Hypertension. 2009;54(3):552-7.
13. Yagi K, Tada Y, Kitazato KT, Tamura T, Satomi J, Nagahiro S. Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats. Neurosurgery. 2010;66(3):551-9. discussion 9.
14. +/water ratio is associated with cerebral aneurysm formation in oophorectomized rats. Hypertension. 2012;60(5):1309-15.
15. Tada Y, Kitazato KT, Yagi K, Shimada K, Matsushita N, Kinouchi T, et al. Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats. Stroke. 2011;42(8):2286-93.
16. Morita A, Kirino T, Hashi K, Aoki N, Fukuhara S, et al. The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med. 2012;366(26):2474-82.
17. Dai J, Li W, Chang L, Zhang Z, Tang C, Wang N, et al. Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis. Free Radic Biol Med. 2006;41(10):1566-77.
18. Lee H, Kim JM, Kim HJ, Lee I, Chang N. Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia. J Nutr. 2005;135(3):544-8.
19. Austin RC, Lentz SR, Werstuck GH. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ. 2004;11 Suppl 1:S56-64.
20. Jamous MA, Nagahiro S, Kitazato KT, Satoh K, Satomi J. Vascular corrosion casts mirroring early morphological changes that lead to the formation of saccular cerebral aneurysm: an experimental study in rats. J Neurosurg. 2005;102(3):532-5.
21. den Heijer M, Koster T, Blom HJ, Bos GM, Briet E, Reitsma PH, et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med. 1996;334(12):759-62.
22. Krishna SM, Dear A, Craig JM, Norman PE, Golledge J. The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation. Atherosclerosis. 2013;228(2):295-305.
23. Hofmann MA, Lalla E, Lu Y, Gleason MR, Wolf BM, Tanji N, et al. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest. 2001;107(6):675-83.
24. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354(15):1567-77.
25. Saposnik G, Ray JG, Sheridan P, McQueen M, Lonn E. Heart outcomes prevention evaluation I. Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke. 2009;40(4):1365-72.
26. Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF, et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA. 2015;313(13):1325-35.
27. Nakajima N, Nagahiro S, Sano T, Satomi J, Tada Y, Yagi K, et al. Kruppel-like zinc-finger transcription factor 5 (KLF5) is highly expressed in large and giant unruptured cerebral aneurysms. World Neurosurg. 2012;78(1-2):114-21.
28. Chalouhi N, Hoh BL, Hasan D. Review of cerebral aneurysm formation, growth, and rupture. Stroke. 2013;44(12):3613-22.
29. Tada Y, Yagi K, Kitazato KT, Tamura T, Kinouchi T, Shimada K, et al. Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats. J Hypertens. 2010;28(9):1883-91.
30. Hasan D, Chalouhi N, Jabbour P, Hashimoto T. Macrophage imbalance (M1 vs. M2) and upregulation of mast cells in wall of ruptured human cerebral aneurysms: preliminary results. J Neuroinflamm. 2012;9:222.
31. Yao JS, Zhai W, Fan Y, Lawton MT, Barbaro NM, Young WL, et al. Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells. J Cereb Blood Flow Metab. 2007;27(3):510-20.
32. Alfano JM, Kolega J, Natarajan SK, Xiang J, Paluch RA, Levy EI, et al. Intracranial aneurysms occur more frequently at bifurcation sites that typically experience higher hemodynamic stresses. Neurosurgery. 2013;73(3):497-505.
33. Nam SW, Choi S, Cheong Y, Kim YH, Park HK. Evaluation of aneurysm-associated wall shear stress related to morphological variations of circle of Willis using a microfluidic device. J Biomech. 2015;48(2):348-53.
34. Magid R, Murphy TJ, Galis ZS. Expression of matrix metalloproteinase-9 in endothelial cells is differentially regulated by shear stress. Role of c-Myc. J Biol Chem. 2003;278(35):32994-9.
35. Sho E, Sho M, Singh TM, Nanjo H, Komatsu M, Xu C, et al. Arterial enlargement in response to high flow requires early expression of matrix metalloproteinases to degrade extracellular matrix. Exp Mol Pathol. 2002;73(2):142-53.
36. Aoki T, Kataoka H, Morimoto M, Nozaki K, Hashimoto N. Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Stroke. 2007;38(1):162-9.