Structure and mechanism of isopropylmalate dehydrogenase from Arabidopsis thaliana: Insights on leucine and aliphatic glucosinolate biosynthesis

Journal of Biological Chemistry

Volumn 291, Issue 26, 2016, Pages 13421-13430

  Lee, Soon Goo ^a   Nwumeh, Ronald ^a   Jez, Joseph M ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLATION; CHEMICAL ANALYSIS; ENZYMES; MOLECULES;

AMINO ACID SUBSTITUTION; BIOSYNTHESIS PATHWAYS; CONFORMATIONAL CHANGE; ISOPROPYLMALATE DEHYDROGENASE; ISOTHERMAL TITRATION CALORIMETRY; OXIDATIVE DECARBOXYLATION; SUBSTRATE SPECIFICITY; X RAY CRYSTAL STRUCTURES;

PLANTS (BOTANY);

3 ISOPROPYLMALATE DEHYDROGENASE; GLUCOSINOLATE; ISOPROPYLMALATE; LEUCINE; LYASE; MAGNESIUM ION; METHIONINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; ARABIDOPSIS PROTEIN;

ARABIDOPSIS THALIANA; ARTICLE; BIOSYNTHESIS; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME KINETIC ASSAY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; ARABIDOPSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

3-ISOPROPYLMALATE DEHYDROGENASE; ARABIDOPSIS; ARABIDOPSIS PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GLUCOSINOLATES; LEUCINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84976430995     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.730358     Document Type: Article

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