Polypharmacy in a Belgian cohort of community-dwelling oldest old (80+)

Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine

Volumn 71, Issue 3, 2016, Pages 158-166

  Wauters, Maarten ^a   Elseviers, Monique ^a   Vaes, Bert ^b,c   Degryse, Jan ^b,c   Dalleur, Olivia ^b   Vander Stichele, Robert ^a   Van Bortel, Luc ^a   Azermai, Majda ^a  

^a GHENT UNIVERSITY   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

aged, 80 and over; comorbidity; Drug utilisation; polypharmacy; primary health care

Indexed keywords

ANTICOAGULANT AGENT; ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE;

AGED; ALCOHOL CONSUMPTION; ARTICLE; ASSESSMENT OF HUMANS; CARE AND CARING; COGNITIVE DEFECT; COMORBIDITY; CUMULATIVE ILLNESS RATING SCALE; DAILY LIFE ACTIVITY; DEMOGRAPHY; DEPRESSION; DRUG USE; EDUCATIONAL STATUS; FEMALE; GENDER; GERIATRIC DEPRESSION SCALE; HUMAN; LASA PHYSICAL ACTIVITY QUESTIONNAIRE; MALE; MINI MENTAL STATE EXAMINATION; PHYSICAL ACTIVITY; POLYPHARMACY; PROSPECTIVE STUDY; STRUCTURED QUESTIONNAIRE; VERY ELDERLY; BELGIUM; CROSS-SECTIONAL STUDY; DRUG THERAPY; EPIDEMIOLOGY; HOME FOR THE AGED; STATISTICS AND NUMERICAL DATA;

AGED, 80 AND OVER; BELGIUM; COMORBIDITY; CROSS-SECTIONAL STUDIES; DRUG THERAPY; FEMALE; HOMES FOR THE AGED; HUMANS; MALE; POLYPHARMACY; PROSPECTIVE STUDIES;

EID: 84976412075     PISSN: 17843286     EISSN: 22953337     Source Type: Journal    
DOI: 10.1080/17843286.2016.1148298     Document Type: Article

References (41)

1. S.Gerkens, S.Merkur Belgium: health system review. Health Syst Transit [Internet]. 2010 Jan [cited 2014 Aug 11]; 12(5):1–266, xxv. Available from http://www.ncbi.nlm.nih.gov/pubmed/21224177.
2. Bureau F planning. Demographic prospects 2013–2060 [Internet]. Brussels; 2013 [cited 2014 Oct 31]. Available from http://www.plan.be/admin/uploaded/201403180825130.PC_demo_vooruitzichten_20140318.pdf.
3. P.Willemé, Peter, The Long-Term Care System for the Elderly in Belgium (May 28, 2010). ENEPRI Research Report No. 70. Available at http://dx.doi.org/10.2139/ssrn.2033672
4. W.Sermeus, M.Pirson, L.Paquay, J.Pacolet, F.Falez, S.Stordeur, Financing of home nursing in Belgium. Health Services Research (HSR) [Internet]. Brussels: Belgian Health Care Knowledge Centre (KCE); 2010 [cited 2014 Aug 11]. Available from http://kce.fgov.be/sites/default/files/page_documents/d20101027307.pdf
5. E.M.Crimmins. Trends in the health of the elderly. Annu Rev Public Health [Internet]. Annual Reviews. 2004 Jan 11 [cited 2014 May 19]; 25:79–98. Available from http://www.annualreviews.org/doi/abs/10.1146/annurev.publhealth.25.102802.124401.10.1146/annurev.publhealth.25.102802.124401
6. M.M.Fulton, E.R.Allen. Polypharmacy in the elderly: a literature review. J Am Acad Nurse Pract. 2002;17:132–132.
7. J.L.Wolff, B.Starfield, G.Anderson. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med [Internet]. 2002 [cited Nov 11]; 162(20):2269–2276. Available from http://www.ncbi.nlm.nih.gov/pubmed/12418941.10.1001/archinte.162.20.2269
8. S.Shi, K.Mörike, U.Klotz. The clinical implications of ageing for rational drug therapy. Eur J Clin Pharmacol [Internet]. 2008 Feb [cited 2014 Apr 25]; 64(2):183–199. Available from http://www.ncbi.nlm.nih.gov/pubmed/18180915.10.1007/s00228-007-0422-1
9. J.H.Gurwitz, T.S.Field, J.Avorn, D.McCormick, S.Jain, M.Eckler,. Incidence and preventability of adverse drug events in nursing homes. Am J Med [Internet]. 2000 [cited Aug 1]; 109(2):87–94. Available from http://www.ncbi.nlm.nih.gov/pubmed/10967148.10.1016/S0002-9343(00)00451-4
10. K.Wester, A.K.Jönsson, O.Spigset, H.Druid, S.Hägg. Incidence of fatal adverse drug reactions: a population based study. Br J Clin Pharmacol [Internet]. 2008 Apr [cited 2014 Mar 7]; 65(4):573–579. Available from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2291376&tool=pmcentrez&rendertype=abstract.10.1111/j.1365-2125.2007.03064.x
11. T.Linjakumpu, S.Hartikainen, T.Klaukka, J.Veijola, S.-L.Kivelä, R.Isoaho. Use of medications and polypharmacy are increasing among the elderly. J Clin Epidemiol [Internet]. 2002 Aug; 55(8):809–817. Available from http://www.ncbi.nlm.nih.gov/pubmed/12384196.10.1016/S0895-4356(02)00411-0
12. G.Bahat, F.Tufan, Z.Bahat, Y.Aydin, A.Tufan, T.S.Akpinar,. Assessments of functional status, comorbidities, polypharmacy, nutritional status and sarcopenia in Turkish community-dwelling male elderly. Aging Male [Internet]. 2013 Jun [cited 2014 Aug 8]; 16(2):67–72. Available from http://www.ncbi.nlm.nih.gov/pubmed/23461711.10.3109/13685538.2013.771329
13. A.Morandi, G.Bellelli, E.E.Vasilevskis, R.Turco, F.Guerini, T.Torpilliesi,. Predictors of rehospitalization among elderly patients admitted to a rehabilitation hospital: the role of polypharmacy, functional status, and length of stay. J Am Med Dir Assoc [Internet]. 2013 Oct [cited 2014 Aug 8]; 14(10):761–767. Available from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4100936&tool=pmcentrez&rendertype=abstract.10.1016/j.jamda.2013.03.013
14. H.Enlund, P.Lavikainen, R.Sulkava, S.Hartikainen, J.Jyrkka Association of polypharmacy with nutritional status, functional ability and cognitive capacity over a three-year period in an elderly population. 2011:514–522.
15. P.Mand, K.Roth, F.Biertz, M.Kersting, C.Kruschinski, G.Schmiemann,. Drug-disease interaction in elderly patients in family practice. Int J Clin Pharmacol Ther [Internet]. 2014 May [cited 2014 Aug 7]; 52(5):337–345. Available from http://www.ncbi.nlm.nih.gov/pubmed/24691059.10.5414/CP202003
16. N.Husson, G.Watfa, M.-C.Laurain, C.Perret-Guillaume, J.-Y.Niemier, P.Miget,. Characteristics of polymedicated (≥ 4) elderly: a survey in a community-dwelling population aged 60 years and over. J Nutr Health Aging [Internet]. 2014 Jan [cited 2014 Aug 7]; 18(1):87–91. Available from http://www.ncbi.nlm.nih.gov/pubmed/24402395.10.1007/s12603-013-0337-8
17. J.Jyrkkä, H.Enlund, P.Lavikainen, R.Sulkava, S.Hartikainen. Association of polypharmacy with nutritional status, functional ability and cognitive capacity over a three-year period in an elderly population. Pharmacoepidemiol Drug Saf. 2011 May;20(5):514–22.
18. I.Barat, F.Andreasen, E.M.Damsgaard. The consumption of drugs by 75-year-old individuals living in their own homes. Eur J Clin Pharmacol [Internet]. 2000 Sep; 56(6–7):501–509. Available from http://www.ncbi.nlm.nih.gov/pubmed/11049014.10.1007/s002280000157
19. B.Vaes, A.Pasquet, P.Wallemacq, N.Rezzoug, H.Mekouar, P.A.Olivier,. The BELFRAIL (BFC80+) study: a population-based prospective cohort study of the very elderly in Belgium. BMC Geriatr [Internet]. 2010 Jan; 10:39. Available from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2906485&tool=pmcentrez&rendertype=abstract.10.1186/1471-2318-10-39
20. P.Boeckxstaens, B.Vaes, D.Legrand, O.Dalleur, A.De Sutter, J.M.Degryse. The relationship of multimorbidity with disability and frailty in the oldest patients: a cross-sectional analysis of three measures of multimorbidity in the BELFRAIL cohort. Eur J Gen Pract [Internet]. 2014 Jul 1 [cited 2014 Oct 23]; (April 2013):1–6. Available from http://www.ncbi.nlm.nih.gov/pubmed/24980394.
21. M.D.Miller, C.F.Paradis, P.R.Houck, S.Mazumdar, J.A.Stack, A.H.Rifai,. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res. 1992 Mar;41(3):237–48.
22. C.Hudon, M.Fortin, H.Soubhi. Abbreviated guidelines for scoring the cumulative illness rating scale (CIRS) in family practice. J Clin Epidemiol [Internet]. 2007 Feb [cited 2014 Apr 16]; 60(2):212. Available from http://www.ncbi.nlm.nih.gov/pubmed/17208130.
23. S.Katz, T.D.Downs, H.R.Cash, R.C.Grotz. Progress in development of the index of ADL. Gerontologist [Internet]. 1970 Jan [cited 2014 Jul 16]; 10(1):20–30. Available from http://www.ncbi.nlm.nih.gov/pubmed/5420677.10.1093/geront/10.1_Part_1.20
24. L.E.Voorrips, A.C.Ravelli, P.C.Dongelmans, P.Deurenberg, W.A.Van Staveren. A physical activity questionnaire for the elderly. Med Sci Sports Exerc [Internet]. 1991 Aug [cited 2014 Jul 16]; 23(8):974–979. Available from http://www.ncbi.nlm.nih.gov/pubmed/1956274.
25. V.S.Stel, J.H.Smit, S.M.F.Pluijm, M.Visser, D.J.H.Deeg, P.Lips. Comparison of the LASA physical activity questionnaire with a 7-day diary and pedometer. J Clin Epidemiol [Internet]. 2004 Mar [cited 2014 Nov 13]; 57(3):252–258. Available from http://www.ncbi.nlm.nih.gov/pubmed/15066685.10.1016/j.jclinepi.2003.07.008
26. M.F.Folstein, S.E.Folstein, P.R.McHugh. Mini-mental state A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res [Internet]. 1975 Nov [cited 2014 Jul 9]; 12(3):189–198. Available from http://www.ncbi.nlm.nih.gov/pubmed/120220410.1016/0022-3956(75)90026-6.
27. R.M.Crum. Population-based norms for the mini-mental state examination by age and educational level. JAMA J Am Med Assoc [Internet]. American Medical Association; 1993 May 12 [cited 2014 Jun 18]; 269(18):2386. Available from http://jama.jamanetwork.com/article.aspx?articleid=40597310.1001/jama.1993.03500180078038.
28. J.I.Sheikh, J.A.Yesavage. Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clin Gerontol A Guid to Assess Interv [Internet]. Routledge; 1986 Nov 18 [cited 2014 Jul 16]; 5(1–2):165–173. Available from http://dx.doi.org/10.1300/J018v05n01_09.
29. A.J.Mitchell, V.Bird, M.Rizzo, N.Meader. Diagnostic validity and added value of the geriatric depression scale for depression in primary care: a meta-analysis of GDS30 and GDS15. J Affect Disord [Internet]. Elsevier B.V. 2010 Sep [cited 2014 Jan 21]; 125(1–3):10–17. Available from http://www.ncbi.nlm.nih.gov/pubmed/1980013210.1016/j.jad.2009.08.019.
30. J.Jyrkkä, H.Enlund, M.J.Korhonen, R.Sulkava, S.Hartikainen. Patterns of drug use and factors associated with polypharmacy and excessive polypharmacy in elderly persons: results of the Kuopio 75+ study: a cross-sectional analysis. Drugs Aging [Internet]. 2009 Jan [cited 2014 Dec 8]; 26(6):493–503. Available from http://www.ncbi.nlm.nih.gov/pubmed/1959152410.2165/00002512-200926060-00006.
31. M.Azermai, M.M.Elseviers, M.Petrovic, L.Van Bortel, R.R.Vander Stichele. Geriatric drug utilisation of psychotropics in Belgian nursing homes. Hum Psychopharmacol Clin Exp. 2011;26(1):12–20.10.1002/hup.v26.1
32. M.M.Elseviers, R.Vander Stichele, L.Van Bortel. Drug utilization in Belgian nursing homes: impact of residents’ and institutional characteristics. Pharmacoepidemiol Drug Saf. 2010;19(10):1041–1048.10.1002/pds.v19:10
33. S.Hoeck, J.Van der Heyden, J.Geerts, G.Van Hal. Equity in GP and specialist contacts by older persons in Belgium. Int J Public Health [Internet]. 2013 Aug [cited 2014 Aug 4]; 58(4):593–602. Available from http://www.ncbi.nlm.nih.gov/pubmed/2320347910.1007/s00038-012-0431-4.
34. J.Van Der Heyden. Contacts with general practitioners. Belgium: Brussels; 2008.
35. J.De Wolf. Evolution of drug utilization in nursing homes in Belgium. Clin Pharmacol Biopharm [Internet]. 2014;3(2):2–4. Available from http://omicsgroup.org/journals/evolution-of-drug-utilization-in-nursing-homes-in-belgium-2167-065X.1000124.php?aid=31483
36. D.W.Kaufman, J.P.Kelly, L.Rosenberg, T.E.Anderson, A.A.Mitchell. Recent patterns of medication use in the ambulatory adult population of the United States. 2014;287(3):337–344.
37. R.A.Payne, G.A.Abel, A.J.Avery, S.W.Mercer, M.O.Roland. Is polypharmacy always hazardous? A retrospective cohort analysis using linked electronic health records from primary and secondary care. Br J Clin Pharmacol [Internet]. 2014 Jun [cited 2014 Jun 1]; 77(6):1073–1082. Available from http://www.ncbi.nlm.nih.gov/pubmed/2442859110.1111/bcp.2014.77.issue-6.
38. P.M.Mannucci, A.Nobili. Multimorbidity and polypharmacy in the elderly: lessons from REPOSI. Intern Emerg Med [Internet]. 2014 Oct [cited 2014 Dec 8]; 9(7):723–734. Available from http://www.ncbi.nlm.nih.gov/pubmed/2516441310.1007/s11739-014-1124-1.
39. K.Kimura, A.Yasunaga, L.-Q.Wang. Correlation between moderate daily physical activity and neurocognitive variability in healthy elderly people. Arch Gerontol Geriatr [Internet]. cited 2014 Dec 3; 56(1):109–117. Available from http://www.ncbi.nlm.nih.gov/pubmed/23137935.
40. D.-C.D.Chan, Y.-T.Hao, S.-C.Wu. Polypharmacy among disabled Taiwanese elderly: a longitudinal observational study. Drugs Aging [Internet]. 2009 Jan [cited 2014 Dec 12]; 26(4):345–354. Available from http://www.ncbi.nlm.nih.gov/pubmed/1947640110.2165/00002512-200926040-00005
41. S.Hoeck, G.Van Hal. Unhealthy drinking in the Belgian elderly population: prevalence and associated characteristics. Eur J Public Health [Internet]. 2013 Dec 1 [cited 2014 Dec 8]; 23(6):1069–1075. Available from http://eurpub.oxfordjournals.org/content/23/6/1069.long10.1093/eurpub/cks152.