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Volumn 5, Issue 7, 2016, Pages

PD-L1 expression as a predictive biomarker for cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma

Author keywords

Adjuvant CIK immunotherapy; hepatocellular carcinoma; immunohistochemistry; PD L1; survival benefit

Indexed keywords

CELL THERAPY AGENT; CYTOKINE; PD L1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84976402721     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2016.1176653     Document Type: Article
Times cited : (60)

References (48)
  • 1
    • 84937160953 scopus 로고    scopus 로고
    • Localized and Systemic Approaches to Treating Hepatocellular Carcinoma
    • 25918289
    • J.J.Knox, S.P.Cleary, L.A.Dawson. Localized and Systemic Approaches to Treating Hepatocellular Carcinoma. J Clin Oncol 2015; 33:1835-44; PMID:25918289; http://dx.doi.org/10.1200/JCO.2014.60.1153
    • (2015) J Clin Oncol , vol.33 , pp. 1835-1844
    • Knox, J.J.1    Cleary, S.P.2    Dawson, L.A.3
  • 2
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular Carcinoma
    • 22353262
    • F.Alejandro, M.L.Josep, B.Jordi. Hepatocellular Carcinoma. Lancet 2012; 379:1245-55; PMID:22353262; http://dx.doi.org/10.1016/S0140-6736(11)61347-0
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Alejandro, F.1    Josep, M.L.2    Jordi, B.3
  • 3
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • 21351269
    • F.Jacques, S.Hai-Rim, B.Freddie, F.David, M.Colin, M.P.Donald. Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008. Int J Cancer 2010; 127:2893-917; PMID:21351269; http://dx.doi.org/10.1002/ijc.25516
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Jacques, F.1    Hai-Rim, S.2    Freddie, B.3    David, F.4    Colin, M.5    Donald, M.P.6
  • 6
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • 21992124
    • B.Hashem, S.El-Serag. Hepatocellular carcinoma. N Engl J Med 2011; 365:1118-27; PMID:21992124; http://dx.doi.org/10.1056/NEJMra1001683
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • Hashem, B.1    El, S.2
  • 7
    • 0023126984 scopus 로고
    • Long-term growth of lymphokine-activated killer (LAK) cells: role of anti-CD3, β-IL 1, interferon-gamma and -β
    • 2435804
    • A.C.Ochoa, G.Gromo, B.J.Alter, P.M.Sondel, F.H.Bach Long-term growth of lymphokine-activated killer (LAK) cells:role of anti-CD3, β-IL 1, interferon-gamma and -β. J Immunol 1987; 138:2728-273; PMID:2435804
    • (1987) J Immunol , vol.138 , pp. 2273-2728
    • Ochoa, A.C.1    Gromo, G.2    Alter, B.J.3    Sondel, P.M.4    Bach, F.H.5
  • 8
    • 0035204217 scopus 로고    scopus 로고
    • Engineering hematopoietic grafts: purified allogeneic hematopoietic stem cells plus expanded CD8+ NK-T cells in the treatment of lymphoma
    • 11760085
    • M.R.Verneris, M.Ito., J.Baker, A.Arshi, R.S.Negrin, J.A.Shizuru. Engineering hematopoietic grafts:purified allogeneic hematopoietic stem cells plus expanded CD8+ NK-T cells in the treatment of lymphoma. Biol Blood Marrow Transplant 2001; 7:532-42; PMID:11760085; http://dx.doi.org/10.1016/S1083-8791(01)70014-6
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 532-542
    • Verneris, M.R.1    Ito, M.2    Baker, J.3    Arshi, A.4    Negrin, R.S.5    Shizuru, J.A.6
  • 9
    • 85014373324 scopus 로고    scopus 로고
    • Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells
    • 25922594
    • J.S.Kim, Y.G.Kim, M.Pyo, H.K.Lee, J.T.Hong, Y.Kim, S.B.Han. Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells. Immune Netw 2015; 15:58-65; PMID:25922594; http://dx.doi.org/10.4110/in.2015.15.2.58
    • (2015) Immune Netw , vol.15 , pp. 58-65
    • Kim, J.S.1    Kim, Y.G.2    Pyo, M.3    Lee, H.K.4    Hong, J.T.5    Kim, Y.6    Han, S.B.7
  • 10
    • 0034596475 scopus 로고    scopus 로고
    • Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial
    • 11022927
    • T.Takayama, T.Sekine, M.Makuuchi, S.Yamasaki, T.Kosuge, J.Yamamoto, K.Shimada, M.Sakamoto, S.Hirohashi, Y.Ohashi et al. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma:a randomised trial. Lancet 2000; 356:802-807; PMID:11022927; http://dx.doi.org/10.1016/S0140-6736(00)02654-4
    • (2000) Lancet , vol.356 , pp. 802-807
    • Takayama, T.1    Sekine, T.2    Makuuchi, M.3    Yamasaki, S.4    Kosuge, T.5    Yamamoto, J.6    Shimada, K.7    Sakamoto, M.8    Hirohashi, S.9    Ohashi, Y.10
  • 11
    • 57449105089 scopus 로고    scopus 로고
    • A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma
    • 18818130
    • D.Hui, L.Qiang, W.Jian, Z.Ti, K.Da-Lu. A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma. Dig Liver Dis 2009; 41:36-41; PMID:18818130; http://dx.doi.org/10.1016/j.dld.2008.04.007
    • (2009) Dig Liver Dis , vol.41 , pp. 36-41
    • Hui, D.1    Qiang, L.2    Jian, W.3    Ti, Z.4    Da-Lu, K.5
  • 12
    • 84892367840 scopus 로고    scopus 로고
    • The efficacy of cytokine-induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients
    • 23892527
    • K.Pan, Y.Q.Li, W.Wang, L.Xu, Y.J.Zhang, H.X.Zheng, J.J.Zhao, H.J.Qiu, D.S.Weng, J.J.Li et al. The efficacy of cytokine-induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients. Ann Surg Oncol 2013; 20:4305-11; PMID:23892527; http://dx.doi.org/10.1245/s10434-013-3144-x
    • (2013) Ann Surg Oncol , vol.20 , pp. 4305-4311
    • Pan, K.1    Li, Y.Q.2    Wang, W.3    Xu, L.4    Zhang, Y.J.5    Zheng, H.X.6    Zhao, J.J.7    Qiu, H.J.8    Weng, D.S.9    Li, J.J.10
  • 13
    • 84930018607 scopus 로고    scopus 로고
    • Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma
    • 25747273
    • J.H.Lee, Y.S.Lim, J.E.Yeon, T.J.Song, S.J.Yu, G.Y.Gwak, K.M.Kim, Y.J.Kim, J.W.Lee, J.H.Yoon. Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma. Gastroenterology 2015; 148:1383-1391; PMID:25747273; http://dx.doi.org/10.1053/j.gastro.2015.02.055
    • (2015) Gastroenterology , vol.148 , pp. 1383-1391
    • Lee, J.H.1    Lim, Y.S.2    Yeon, J.E.3    Song, T.J.4    Yu, S.J.5    Gwak, G.Y.6    Kim, K.M.7    Kim, Y.J.8    Lee, J.W.9    Yoon, J.H.10
  • 14
    • 84924942315 scopus 로고    scopus 로고
    • A nomogram for predicting the benefit of adjuvant cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma
    • 25776856
    • Q.Z.Pan, Q.J.Wang, J.Q.Dan, K.Pan, Y.Q.Li, Y.J.Zhang, J.J.Zhao, D.S.Weng, Y.Tang, L.X.Huang et al. A nomogram for predicting the benefit of adjuvant cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma. Sci Rep 2015; 5:9202; PMID:25776856; http://dx.doi.org/10.1038/srep09202
    • (2015) Sci Rep , vol.5 , pp. 9202
    • Pan, Q.Z.1    Wang, Q.J.2    Dan, J.Q.3    Pan, K.4    Li, Y.Q.5    Zhang, Y.J.6    Zhao, J.J.7    Weng, D.S.8    Tang, Y.9    Huang, L.X.10
  • 15
    • 84887876497 scopus 로고    scopus 로고
    • Bevacizumab improves the antitumor efficacy of adoptive cytokine-induced killer cells therapy in non-small cell lung cancer models
    • ; PMID:24271420
    • L.Tao, G.Huang, S.Shi, L.Chen. Bevacizumab improves the antitumor efficacy of adoptive cytokine-induced killer cells therapy in non-small cell lung cancer models. Med Oncol 2014; 31:777; PMID:24271420; http://dx.doi.org/10.1007/s12032-013-0777-3
    • (2014) Med Oncol , vol.31 , pp. 777
    • Tao, L.1    Huang, G.2    Shi, S.3    Chen, L.4
  • 16
    • 84940181428 scopus 로고    scopus 로고
    • The status, limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies
    • 25937774
    • H.Shi, X.Qi, B.Ma, Y.Cao, L.Wang, L.Sun, H.Niu. The status, limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies. Chin J Cancer Res 2015; 27:128-37; PMID:25937774; http://dx.doi.org/10.3978/j.issn.1000-9604.2014.12.15
    • (2015) Chin J Cancer Res , vol.27 , pp. 128-137
    • Shi, H.1    Qi, X.2    Ma, B.3    Cao, Y.4    Wang, L.5    Sun, L.6    Niu, H.7
  • 17
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • 12218188
    • Y.Iwai, M.Ishida, Y.Tanaka, T.Okazaki, T.Honjo, N.Minato. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A 2002; 99:12293-7; PMID:12218188; http://dx.doi.org/10.1073/pnas.192461099
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 19
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • 22437870
    • D.M.Pardoll, The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-64; PMID:22437870; http://dx.doi.org/10.1038/nrc3239
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 22
    • 84928342005 scopus 로고    scopus 로고
    • Peripheral and tumor immune correlates in patients with advanced melanoma treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) monotherapy or in combination with ipilimumab
    • M.Postow, J.Taube, R.Anders, C.Taylor, J.Wolchok. Peripheral and tumor immune correlates in patients with advanced melanoma treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) monotherapy or in combination with ipilimumab. J Transl Med 2014; 12:O8; http://dx.doi.org/10.1186/1479-5876-12-S1-O8
    • (2014) J Transl Med , vol.12 , pp. O8
    • Postow, M.1    Taube, J.2    Anders, R.3    Taylor, C.4    Wolchok, J.5
  • 24
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • ; PMID:22461641
    • J.M.Taube, R.A.Anders, G.D.Young, H.Xu, R.Sharma, T.L.McMiller, S.Chen, A.P.Klein, D.M.Pardoll, S.L.Topalian et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012; 4:127-37; PMID:22461641; http://dx.doi.org/10.1126/scitranslmed.3003689
    • (2012) Sci Transl Med , vol.4 , pp. 127-137
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6    Chen, S.7    Klein, A.P.8    Pardoll, D.M.9    Topalian, S.L.10
  • 26
    • 0034596475 scopus 로고    scopus 로고
    • Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial
    • 11022927
    • T.Takayama, T.Sekine, M.Makuuchi, S.Yamasaki, T.Kosuge, J.Yamamoto, K.Shimada, M.Sakamoto, S.Hirohashi, Y.Ohashi et al. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma:a randomised trial. Lancet 2000; 356:802-807; PMID:11022927; http://dx.doi.org/10.1016/S0140-6736(00)02654-4
    • (2000) Lancet , vol.356 , pp. 802-807
    • Takayama, T.1    Sekine, T.2    Makuuchi, M.3    Yamasaki, S.4    Kosuge, T.5    Yamamoto, J.6    Shimada, K.7    Sakamoto, M.8    Hirohashi, S.9    Ohashi, Y.10
  • 27
    • 84887427672 scopus 로고    scopus 로고
    • Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma
    • 23825037
    • J.Cui, N.Wang, H.Zhao, H.Jin, G.Wang, C.Niu, H.Terunuma, H.He, W.Li. Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma.Int J Cancer 2014; 134:342-51; PMID:23825037; http://dx.doi.org/10.1002/ijc.28372
    • (2014) Int J Cancer , vol.134 , pp. 342-351
    • Cui, J.1    Wang, N.2    Zhao, H.3    Jin, H.4    Wang, G.5    Niu, C.6    Terunuma, H.7    He, H.8    Li, W.9
  • 28
    • 4243096258 scopus 로고    scopus 로고
    • Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H, Nishimura M. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res 2004; 10:5094-5100; PMID:15297412;
    • Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H, Nishimura M. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res 2004; 10:5094-5100; PMID:15297412; http://dx.doi.org/10.1158/1078-0432.CCR-04-0428
  • 29
    • 70350247885 scopus 로고    scopus 로고
    • Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma
    • 19825956
    • R.Karim, E.S.Jordanova, S.J.Piersma, G.G.Kenter, L.Chen, J.M.Boer, C.J.Melief, S.H.van der Burg Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma. Clin Cancer Res 2009; 15:6341-7; PMID:19825956; http://dx.doi.org/10.1158/1078-0432.CCR-09-1652
    • (2009) Clin Cancer Res , vol.15 , pp. 6341-6347
    • Karim, R.1    Jordanova, E.S.2    Piersma, S.J.3    Kenter, G.G.4    Chen, L.5    Boer, J.M.6    Melief, C.J.7    van der Burg, S.H.8
  • 30
    • 77950283280 scopus 로고    scopus 로고
    • Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
    • 20143437
    • R.Hino, K.Kabashima, Y.Kato, H.Yagi, M.Nakamura, T.Honjo, T.Okazaki, Y.Tokura Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer 2010; 116:1757-66; PMID:20143437; http://dx.doi.org/10.1002/cncr.24899
    • (2010) Cancer , vol.116 , pp. 1757-1766
    • Hino, R.1    Kabashima, K.2    Kato, Y.3    Yagi, H.4    Nakamura, M.5    Honjo, T.6    Okazaki, T.7    Tokura, Y.8
  • 31
    • 20244384862 scopus 로고    scopus 로고
    • Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
    • 15837746
    • Y.Ohigashi, M.Sho, Y.Yamada, Y.Tsurui, K.Hamada, N.Ikeda, T.Mizuno, R.Yoriki, H.Kashizuka, K.Yane et al. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res 2005; 11:2947-53; PMID:15837746; http://dx.doi.org/10.1158/1078-0432.CCR-04-1469
    • (2005) Clin Cancer Res , vol.11 , pp. 2947-2953
    • Ohigashi, Y.1    Sho, M.2    Yamada, Y.3    Tsurui, Y.4    Hamada, K.5    Ikeda, N.6    Mizuno, T.7    Yoriki, R.8    Kashizuka, H.9    Yane, K.10
  • 32
    • 33646367200 scopus 로고    scopus 로고
    • The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors
    • 16611412
    • H.Ghebeh, S.Mohammed, A.Al-Omair, A.Qattan, C.Lehe, G.Al-Qudaihi, N.Elkum, M.Alshabanah, S.Bin Amer, A.Tulbah et al.The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma:correlation with important high-risk prognostic factors. Neoplasia 2006; 8:190-8; PMID:16611412; http://dx.doi.org/10.1593/neo.05733
    • (2006) Neoplasia , vol.8 , pp. 190-198
    • Ghebeh, H.1    Mohammed, S.2    Al-Omair, A.3    Qattan, A.4    Lehe, C.5    Al-Qudaihi, G.6    Elkum, N.7    Alshabanah, M.8    Amer, S.9    Tulbah, A.10
  • 33
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • 19188168
    • Q.Gao, X.Y.Wang, S.J.Qiu, I.Yamato, M.Sho, Y.Nakajima, J.Zhou, B.Z.Li, Y.H.Shi, Y.S.Xiao et al. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res 2009; 15:971-9; PMID:19188168; http://dx.doi.org/10.1158/1078-0432.CCR-08-1608
    • (2009) Clin Cancer Res , vol.15 , pp. 971-979
    • Gao, Q.1    Wang, X.Y.2    Qiu, S.J.3    Yamato, I.4    Sho, M.5    Nakajima, Y.6    Zhou, J.7    Li, B.Z.8    Shi, Y.H.9    Xiao, Y.S.10
  • 34
    • 84893157087 scopus 로고    scopus 로고
    • Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy
    • 24509608
    • Y.Umemoto, S.Okano, Y.Matsumoto, H.Nakagawara, R.Matono, S.Yoshiya, Y.Yamashita, T.Yoshizumi, T.Ikegami, Y.Soejima et al. Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy. J Gastroenterol 2015; 50:65-75; PMID:24509608; http://dx.doi.org/10.1007/s00535-014-0933-3
    • (2015) J Gastroenterol , vol.50 , pp. 65-75
    • Umemoto, Y.1    Okano, S.2    Matsumoto, Y.3    Nakagawara, H.4    Matono, R.5    Yoshiya, S.6    Yamashita, Y.7    Yoshizumi, T.8    Ikegami, T.9    Soejima, Y.10
  • 35
    • 84874084734 scopus 로고    scopus 로고
    • Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma
    • 23313965
    • V.Hernandez-Gea, S.Toffanin, S.L.Friedman, J.M.Llovet. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology 2013; 144:512-27; PMID:23313965; http://dx.doi.org/10.1053/j.gastro.2013.01.002
    • (2013) Gastroenterology , vol.144 , pp. 512-527
    • Hernandez-Gea, V.1    Toffanin, S.2    Friedman, S.L.3    Llovet, J.M.4
  • 36
    • 80052668582 scopus 로고    scopus 로고
    • Interaction of tumor cells with the microenvironment
    • 21914164
    • H.Ungefroren, S.Sebens, D.Seidl, H.Lehnert, R.Hass. Interaction of tumor cells with the microenvironment. Cell Commun Signal 2011; 9:18; PMID:21914164; http://dx.doi.org/10.1186/1478-811X-9-18
    • (2011) Cell Commun Signal , vol.9 , pp. 18
    • Ungefroren, H.1    Sebens, S.2    Seidl, D.3    Lehnert, H.4    Hass, R.5
  • 37
    • 84929606478 scopus 로고    scopus 로고
    • The yin and yang of evasion and immune activation in HCC
    • 25733155
    • O.V.Makarova-Rusher, J.Medina-Echeverz, A.G.Duffy, T.F.Greten. The yin and yang of evasion and immune activation in HCC. J Hepatol 2015; 62:1420-1429; PMID:25733155; http://dx.doi.org/10.1016/j.jhep.2015.02.038
    • (2015) J Hepatol , vol.62 , pp. 1420-1429
    • Makarova-Rusher, O.V.1    Medina-Echeverz, J.2    Duffy, A.G.3    Greten, T.F.4
  • 38
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • 19451266
    • D.M.Kuang, Q.Zhao, C.Peng, J.Xu, J.P.Zhang, C.Wu, L.Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 2009; 206:1327-37; PMID:19451266; http://dx.doi.org/10.1084/jem.20082173
    • (2009) J Exp Med , vol.206 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3    Xu, J.4    Zhang, J.P.5    Wu, C.6    Zheng, L.7
  • 39
    • 84855523406 scopus 로고    scopus 로고
    • Hepatocellular carcinoma–from immunobiology to immunotherapy
    • 22222798
    • T.Flecken, N.Schmidt, H.C.Spangenberg, R.Thimme. Hepatocellular carcinoma–from immunobiology to immunotherapy. Z Gastroenterol 2012; 50:47-56; PMID:22222798; http://dx.doi.org/10.1055/s-0031-1282002
    • (2012) Z Gastroenterol , vol.50 , pp. 47-56
    • Flecken, T.1    Schmidt, N.2    Spangenberg, H.C.3    Thimme, R.4
  • 40
    • 80053192743 scopus 로고    scopus 로고
    • Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity
    • 21821703
    • A.Pievani, G.Borleri, D.Pende, L.Moretta, A.Rambaldi, J.Golay, M.Introna. Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity. Blood 2011; 118:3301-10; PMID:21821703; http://dx.doi.org/10.1182/blood-2011-02-336321
    • (2011) Blood , vol.118 , pp. 3301-3310
    • Pievani, A.1    Borleri, G.2    Pende, D.3    Moretta, L.4    Rambaldi, A.5    Golay, J.6    Introna, M.7
  • 42
    • 77958012775 scopus 로고    scopus 로고
    • Gene signature in melanoma associated with clinical activity:a potential clue to unlock cancer immunotherapy
    • 20693853
    • T.F.Gajewski, J.Louahed, V.G.Brichard. Gene signature in melanoma associated with clinical activity:a potential clue to unlock cancer immunotherapy. Cancer J 2010; 16:399-403; PMID:20693853; http://dx.doi.org/10.1097/PPO.0b013e3181eacbd8
    • (2010) Cancer J , vol.16 , pp. 399-403
    • Gajewski, T.F.1    Louahed, J.2    Brichard, V.G.3
  • 43
    • 33745685010 scopus 로고    scopus 로고
    • Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans
    • 16516331
    • D.Sprengers, R.G.van der Molen, J.G.Kusters, R.A.De Man, H.G.Niesters, S.W.Schalm, H.L.Janssen. Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans. J Hepatol 2006; 45:182-9; PMID:16516331; http://dx.doi.org/10.1016/j.jhep.2005.12.022
    • (2006) J Hepatol , vol.45 , pp. 182-189
    • Sprengers, D.1    van der Molen, R.G.2    Kusters, J.G.3    De Man, R.A.4    Niesters, H.G.5    Schalm, S.W.6    Janssen, H.L.7
  • 44
    • 33645907546 scopus 로고    scopus 로고
    • Different composition of intrahepatic lymphocytes in the immune-tolerance and immune-clearance phase of chronic hepatitis B
    • 16555293
    • D.Sprengers, R.G.van der Molen, J.G.Kusters, B.Hansen, H.G.Niesters, S.W.Schalm, H.L.Janssen. Different composition of intrahepatic lymphocytes in the immune-tolerance and immune-clearance phase of chronic hepatitis B. J Med Virol 2006; 78:561-8; PMID:16555293; http://dx.doi.org/10.1002/jmv.20576
    • (2006) J Med Virol , vol.78 , pp. 561-568
    • Sprengers, D.1    van der Molen, R.G.2    Kusters, J.G.3    Hansen, B.4    Niesters, H.G.5    Schalm, S.W.6    Janssen, H.L.7
  • 45
    • 84924611985 scopus 로고    scopus 로고
    • Cytokine-induced killer (CIK) cells: from basic research to clinical translation
    • 25962508
    • Y.Guo, W.Han. Cytokine-induced killer (CIK) cells:from basic research to clinical translation. Chin J Cancer 2015; 34:99-107; PMID:25962508; http://dx.doi.org/10.1186/s40880-015-0002-1
    • (2015) Chin J Cancer , vol.34 , pp. 99-107
    • Guo, Y.1    Han, W.2
  • 48
    • 84901764003 scopus 로고    scopus 로고
    • Clinical activity of adjuvant cytokine-induced killer cell immunotherapy in patients with post-mastectomy triple-negative breast cancer
    • 24668644
    • K.Pan, X.X.Guan, Y.Q.Li, J.J.Zhao, J.J.Li, H.J.Qiu, D.S.Weng, Q.J.Wang, Q.Liu, L.X.Huang et al. Clinical activity of adjuvant cytokine-induced killer cell immunotherapy in patients with post-mastectomy triple-negative breast cancer. Clin Cancer Res 2014; 20:3003-11; PMID:24668644; http://dx.doi.org/10.1158/1078-0432.CCR-14-0082
    • (2014) Clin Cancer Res , vol.20 , pp. 3003-3011
    • Pan, K.1    Guan, X.X.2    Li, Y.Q.3    Zhao, J.J.4    Li, J.J.5    Qiu, H.J.6    Weng, D.S.7    Wang, Q.J.8    Liu, Q.9    Huang, L.X.10


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