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Volumn 34, Issue 3, 2015, Pages 1-9

Cytokine-induced killer (CIK) cells: From basic research to clinical translation

Author keywords

Antitumor effect; Cancer therapy; Clinical trials; Cytokine induced killer cells; Immunotherapy

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD56 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 4; INTERLEUKIN 7; TUMOR NECROSIS FACTOR ALPHA;

EID: 84924611985     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.1186/s40880-015-0002-1     Document Type: Review
Times cited : (57)

References (65)
  • 1
    • 0025856106 scopus 로고
    • Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent anti-tumor cell activity
    • Schmidt-Wolf IG, Negrin RS, Kiem HP, Blume KG, Weissman IL. Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent anti-tumor cell activity. J Exp Med. 1991;174:139–49.
    • (1991) J Exp Med , vol.174 , pp. 139-149
    • Schmidt-Wolf, I.G.1    Negrin, R.S.2    Kiem, H.P.3    Blume, K.G.4    Weissman, I.L.5
  • 2
    • 0024407251 scopus 로고
    • In vivo antitumor activity of anti-CD3- induced activated killer cells
    • Yun YS, Hargrove ME, Ting CC. In vivo antitumor activity of anti-CD3- induced activated killer cells. Cancer Res. 1989;49:4770–4.
    • (1989) Cancer Res , vol.49 , pp. 4770-4774
    • Yun, Y.S.1    Hargrove, M.E.2    Ting, C.C.3
  • 3
    • 0027860412 scopus 로고
    • Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine induced killer cells
    • Schmidt-Wolf IG, Lefterova P, Mehta BA, Fernandez LP, Huhn D, Blume KG, et al. Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine induced killer cells. Exp Hematol. 1993;21:1673.
    • (1993) Exp Hematol , vol.21 , pp. 1673
    • Schmidt-Wolf, I.G.1    Lefterova, P.2    Mehta, B.A.3    Fernandez, L.P.4    Huhn, D.5    Blume, K.G.6
  • 4
    • 1842526956 scopus 로고    scopus 로고
    • Role of NKG2D signalling in the cytotoxicity of activated and expanded CD8+ T cells
    • Verneris MR, Karami M, Baker J, Jayaswal A, Negrin RS. Role of NKG2D signalling in the cytotoxicity of activated and expanded CD8+ T cells. Blood. 2004;103:3065–72.
    • (2004) Blood , vol.103 , pp. 3065-3072
    • Verneris, M.R.1    Karami, M.2    Baker, J.3    Jayaswal, A.4    Negrin, R.S.5
  • 5
    • 0028874988 scopus 로고
    • Two pathways of exocytosis of cytoplasmatic granule contents and target cell killing by cytokine-induced CD3+CD56+ killer cells
    • Metha BA, Schmidt-Wolf IG, Weissmann IL, Negrin RS. Two pathways of exocytosis of cytoplasmatic granule contents and target cell killing by cytokine-induced CD3+CD56+ killer cells. Blood. 1995;86:3493–9.
    • (1995) Blood , vol.86 , pp. 3493-3499
    • Metha, B.A.1    Schmidt-Wolf, I.G.2    Weissmann, I.L.3    Negrin, R.S.4
  • 6
    • 58149165343 scopus 로고    scopus 로고
    • Prospective study of chemotherapy in combination with CIK cells in patients suffering from advanced non-small cell lung cancer
    • Wu C, Jiang J, Shi L, Xu N. Prospective study of chemotherapy in combination with CIK cells in patients suffering from advanced non-small cell lung cancer. Anticancer Res. 2008;28:3997–4002.
    • (2008) Anticancer Res , vol.28 , pp. 3997-4002
    • Wu, C.1    Jiang, J.2    Shi, L.3    Xu, N.4
  • 7
    • 78650799848 scopus 로고    scopus 로고
    • Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients
    • Jiang JT, Shen YP, Wu CP, Zhu YB, Wei WX, Chen LJ, et al. Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients. World J Gastroenterol. 2010;16:6155–62.
    • (2010) World J Gastroenterol , vol.16 , pp. 6155-6162
    • Jiang, J.T.1    Shen, Y.P.2    Wu, C.P.3    Zhu, Y.B.4    Wei, W.X.5    Chen, L.J.6
  • 8
    • 0032698796 scopus 로고    scopus 로고
    • Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma
    • Schmidt-Wolf IG, Finke S, Trojaneck B, Denkena A, Lefterova P, Schwella N, et al. Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma. Br J Cancer. 1999;81:1009–16.
    • (1999) Br J Cancer , vol.81 , pp. 1009-1016
    • Schmidt-Wolf, I.G.1    Finke, S.2    Trojaneck, B.3    Denkena, A.4    Lefterova, P.5    Schwella, N.6
  • 9
    • 80053210017 scopus 로고    scopus 로고
    • Adoptive immunotherapy with cytokine-induced killer cells for patients with relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation
    • Laport GG, Sheehan K, Baker J, Armstrong R, Wong RM, Lowsky R, et al. Adoptive immunotherapy with cytokine-induced killer cells for patients with relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2007;17:1679–87.
    • (2007) Biol Blood Marrow Transplant , vol.17 , pp. 1679-1687
    • Laport, G.G.1    Sheehan, K.2    Baker, J.3    Armstrong, R.4    Wong, R.M.5    Lowsky, R.6
  • 10
    • 2342437804 scopus 로고    scopus 로고
    • Autologous cytokineinduced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma
    • Shi M, Zhang B, Tang ZR, Lei ZY, Wang HF, Feng YY, et al. Autologous cytokineinduced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma. World J Gastroenterol. 2004;10:1146–51.
    • (2004) World J Gastroenterol , vol.10 , pp. 1146-1151
    • Shi, M.1    Zhang, B.2    Tang, Z.R.3    Lei, Z.Y.4    Wang, H.F.5    Feng, Y.Y.6
  • 11
    • 79952734945 scopus 로고    scopus 로고
    • Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies
    • Niu Q, Wang W, Li Y, Qin S, Wang Y, Wan G, et al. Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies. Int Immunopharmacol. 2011;11:449–56.
    • (2011) Int Immunopharmacol , vol.11 , pp. 449-456
    • Niu, Q.1    Wang, W.2    Li, Y.3    Qin, S.4    Wang, Y.5    Wan, G.6
  • 12
    • 84859597239 scopus 로고    scopus 로고
    • Preconditioning chemotherapy with cisplatin enhances the antitumor activity of cytokineinduced killer cells in a murine melanoma model
    • Chen J, Huang X, Huang G, Chen Y, Chen L, Song H. Preconditioning chemotherapy with cisplatin enhances the antitumor activity of cytokineinduced killer cells in a murine melanoma model. Cancer Biother Radiopharm. 2012;27:210–20.
    • (2012) Cancer Biother Radiopharm , vol.27 , pp. 210-220
    • Chen, J.1    Huang, X.2    Huang, G.3    Chen, Y.4    Chen, L.5    Song, H.6
  • 13
    • 84887123089 scopus 로고    scopus 로고
    • IL-15 improves the cytotoxicity of cytokine-induced killer cells against leukemia cells by upregulating CD3+CD56+ cells and downregulating regulatory T cells as well as IL-35
    • Tao Q, Chen T, Tao L, Wang H, Pan Y, Xiong S, et al. IL-15 improves the cytotoxicity of cytokine-induced killer cells against leukemia cells by upregulating CD3+CD56+ cells and downregulating regulatory T cells as well as IL-35. J Immunother. 2013;36:462–7.
    • (2013) J Immunother , vol.36 , pp. 462-467
    • Tao, Q.1    Chen, T.2    Tao, L.3    Wang, H.4    Pan, Y.5    Xiong, S.6
  • 14
    • 6844240228 scopus 로고    scopus 로고
    • Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptormediated transfection with the interleukin-7 gene
    • Finke S, Trojaneck B, Lefterova P, Csipai M, Wagner E, Kircheis R, et al. Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptormediated transfection with the interleukin-7 gene. Gene Ther. 1998;5:31–9.
    • (1998) Gene Ther , vol.5 , pp. 31-39
    • Finke, S.1    Trojaneck, B.2    Lefterova, P.3    Csipai, M.4    Wagner, E.5    Kircheis, R.6
  • 15
    • 84883244302 scopus 로고    scopus 로고
    • Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133high cancer stem cells in vitro and in vivo
    • Huang J, Li C, Wang Y, Lv H, Guo Y, Dai H, et al. Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133high cancer stem cells in vitro and in vivo. Clin Immunol. 2013;149:156–68.
    • (2013) Clin Immunol , vol.149 , pp. 156-168
    • Huang, J.1    Li, C.2    Wang, Y.3    Lv, H.4    Guo, Y.5    Dai, H.6
  • 16
    • 84874997536 scopus 로고    scopus 로고
    • CIK cells from recurrent or refractory AML patients can be efficiently expanded in vitro and used for reduction of leukemic blasts in vivo
    • Wang Y, Bo J, Dai HR, Lu XC, Lv HY, Yang B, et al. CIK cells from recurrent or refractory AML patients can be efficiently expanded in vitro and used for reduction of leukemic blasts in vivo. Exp Hematol. 2013;41:241–52.
    • (2013) Exp Hematol , vol.41 , pp. 241-252
    • Wang, Y.1    Bo, J.2    Dai, H.R.3    Lu, X.C.4    Lv, H.Y.5    Yang, B.6
  • 17
    • 84855606037 scopus 로고    scopus 로고
    • Clinical study of autologous cytokine-induced killer cells for the treatment of elderly patients with diffuse large B-cell lymphoma
    • Lu XC, Yang B, Yu RL, Chi XH, Tuo S, Tuo CW, et al. Clinical study of autologous cytokine-induced killer cells for the treatment of elderly patients with diffuse large B-cell lymphoma. Cell Biochem Biophys. 2012;62:257–65.
    • (2012) Cell Biochem Biophys , vol.62 , pp. 257-265
    • Lu, X.C.1    Yang, B.2    Yu, R.L.3    Chi, X.H.4    Tuo, S.5    Tuo, C.W.6
  • 18
    • 0036162007 scopus 로고    scopus 로고
    • Generation of cytokine-induced killer cells from leukaemic samples with in vitro cytotoxicity against autologous and allogeneic leukaemic blasts
    • Linn YC, Lau LC, Hui KM. Generation of cytokine-induced killer cells from leukaemic samples with in vitro cytotoxicity against autologous and allogeneic leukaemic blasts. Br J Haematol. 2002;116:78–86.
    • (2002) Br J Haematol , vol.116 , pp. 78-86
    • Linn, Y.C.1    Lau, L.C.2    Hui, K.M.3
  • 19
    • 0028103808 scopus 로고
    • A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency
    • Lu PH, Negrin RS. A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J Immunol. 1994;153:1687–96.
    • (1994) J Immunol , vol.153 , pp. 1687-1696
    • Lu, P.H.1    Negrin, R.S.2
  • 20
    • 45749097431 scopus 로고    scopus 로고
    • Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: Implications for their infusion across major HLA barriers
    • Sangiolo D, Martinuzzi E, Todorovic M, Vitaggio K, Vallario A, Jordaney N, et al. Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers. Int Immunol. 2008;20:841–8.
    • (2008) Int Immunol , vol.20 , pp. 841-848
    • Sangiolo, D.1    Martinuzzi, E.2    Todorovic, M.3    Vitaggio, K.4    Vallario, A.5    Jordaney, N.6
  • 21
    • 14244263846 scopus 로고    scopus 로고
    • A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma
    • Leemhuis T, Wells S, Scheffold C, Edinger M, Negrin RS. A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2005;11:181–7.
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 181-187
    • Leemhuis, T.1    Wells, S.2    Scheffold, C.3    Edinger, M.4    Negrin, R.S.5
  • 22
    • 77951691641 scopus 로고    scopus 로고
    • Cytokine-induced NK-like T cells: From bench to bedside
    • Linn YC, Hui KM. Cytokine-induced NK-like T cells: from bench to bedside. J Biomed Biotechnol. 2010;2010:435745.
    • (2010) J Biomed Biotechnol , vol.2010
    • Linn, Y.C.1    Hui, K.M.2
  • 23
    • 59449109417 scopus 로고    scopus 로고
    • Characterization of the recognition and functional heterogeneity exhibited by cytokine-induced killer cell subsets against acute myeloid leukaemia target cell
    • Linn YC, Lau SK, Liu BH, Ng LH, Yong HX, Hui KM. Characterization of the recognition and functional heterogeneity exhibited by cytokine-induced killer cell subsets against acute myeloid leukaemia target cell. Immunology. 2009;126:423–35.
    • (2009) Immunology , vol.126 , pp. 423-435
    • Linn, Y.C.1    Lau, S.K.2    Liu, B.H.3    Ng, L.H.4    Yong, H.X.5    Hui, K.M.6
  • 24
    • 19444383219 scopus 로고    scopus 로고
    • Comparative gene expression profiling of cytokine-induced killer cells in response to acute myloid leukemic and acute lymphoblastic leukemic stimulators using oligonucleotide arrays
    • Linn YC, Wang SM, Hui KM. Comparative gene expression profiling of cytokine-induced killer cells in response to acute myloid leukemic and acute lymphoblastic leukemic stimulators using oligonucleotide arrays. Exp Hematol. 2005;33:671–81.
    • (2005) Exp Hematol , vol.33 , pp. 671-681
    • Linn, Y.C.1    Wang, S.M.2    Hui, K.M.3
  • 25
    • 55249095629 scopus 로고    scopus 로고
    • In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity
    • Nishimura R, Baker J, Beilhack A, Zeiser R, Olson JA, Sega EI, et al. In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity. Blood. 2008;112:2563–74.
    • (2008) Blood , vol.112 , pp. 2563-2574
    • Nishimura, R.1    Baker, J.2    Beilhack, A.3    Zeiser, R.4    Olson, J.A.5    Sega, E.I.6
  • 26
    • 84875282081 scopus 로고    scopus 로고
    • Cytokine-induced killer cells promote antitumor Immunity
    • Jiang J, Wu C, Lu B. Cytokine-induced killer cells promote antitumor Immunity. J Transl Med. 2013;11:83.
    • (2013) J Transl Med , vol.11
    • Jiang, J.1    Wu, C.2    Lu, B.3
  • 27
    • 0037438371 scopus 로고    scopus 로고
    • Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging
    • Edinger M, Cao YA, Verneris MR, Bachmann MH, Contag CH, Negrin RS. Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging. Blood. 2003;101:640–8.
    • (2003) Blood , vol.101 , pp. 640-648
    • Edinger, M.1    Cao, Y.A.2    Verneris, M.R.3    Bachmann, M.H.4    Contag, C.H.5    Negrin, R.S.6
  • 28
    • 0035874525 scopus 로고    scopus 로고
    • Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production
    • Baker J, Verneris MR, Ito M, Shizuru JA, Negrin RS. Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production. Blood. 2001;97:2923–31.
    • (2001) Blood , vol.97 , pp. 2923-2931
    • Baker, J.1    Verneris, M.R.2    Ito, M.3    Shizuru, J.A.4    Negrin, R.S.5
  • 29
    • 80053192743 scopus 로고    scopus 로고
    • Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity
    • Pievani A, Borleri G, Pende D, Moretta L, Rambaldi A, Golay J, et al. Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity. Blood. 2011;118:3301–10.
    • (2011) Blood , vol.118 , pp. 3301-3310
    • Pievani, A.1    Borleri, G.2    Pende, D.3    Moretta, L.4    Rambaldi, A.5    Golay, J.6
  • 32
    • 79251579272 scopus 로고    scopus 로고
    • Growth of human colorectal cancer SW1116 cells is inhibited by cytokine-induced killer cells
    • Wang Y, Dai H, Li H, Lv H, Wang T, Fu X, et al. Growth of human colorectal cancer SW1116 cells is inhibited by cytokine-induced killer cells. Clin Dev Immunol. 2011;2011:621414.
    • (2011) Clin Dev Immunol , vol.2011
    • Wang, Y.1    Dai, H.2    Li, H.3    Lv, H.4    Wang, T.5    Fu, X.6
  • 33
    • 0035204217 scopus 로고    scopus 로고
    • Engineering hematopoietic grafts: Purified allogeneic hematopoietic stem cells plus expanded CD8+ NK-T cells in the treatment of lymphoma
    • Verneris MR, Ito M, Baker J, Arshi A, Negrin RS, Shizuru JA. Engineering hematopoietic grafts: purified allogeneic hematopoietic stem cells plus expanded CD8+ NK-T cells in the treatment of lymphoma. Biol Blood Marrow Transplant. 2001;7:532–42.
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 532-542
    • Verneris, M.R.1    Ito, M.2    Baker, J.3    Arshi, A.4    Negrin, R.S.5    Shizuru, J.A.6
  • 34
    • 84924572977 scopus 로고    scopus 로고
    • Adoptive immunotherapy strategies with cytokine-induced killer (CIK) cells in the treatment of hematological malignancies
    • Schmeel FC, Schmeel LC, Gast SM, Schmidt-Wolf IG. Adoptive immunotherapy strategies with cytokine-induced killer (CIK) cells in the treatment of hematological malignancies. Int J Mol Sci. 2014;15:14632–48.
    • (2014) Int J Mol Sci , vol.15 , pp. 14632-14648
    • Schmeel, F.C.1    Schmeel, L.C.2    Gast, S.M.3    Schmidt-Wolf, I.G.4
  • 35
    • 84906938534 scopus 로고    scopus 로고
    • Clinical trial of ex vivo-expanded cytokine-induced killer cells therapy in advanced pancreatic cancer
    • Chung MJ, Park JY, Bang S, Park SW, Song SY. Phase II clinical trial of ex vivo-expanded cytokine-induced killer cells therapy in advanced pancreatic cancer. Cancer Immunol Immunother. 2014;63:939–46.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 939-946
    • Chung, M.J.1    Park, J.Y.2    Bang, S.3    Park, S.W.4    Song, S.Y.5    Phase, I.I.6
  • 36
    • 84893207600 scopus 로고    scopus 로고
    • Autologous CIK cell immunotherapy in patients with renal cell carcinoma after radical nephrectomy
    • Epub 2013 Dec 9
    • Zhang Y, Wang J, Wang Y, Lu XC, Fan H, Liu Y, et al. Autologous CIK cell immunotherapy in patients with renal cell carcinoma after radical nephrectomy. Clin Dev Immunol. 2013;2013:195691. doi:10.1155/2013/195691. Epub 2013 Dec 9.
    • (2013) Clin Dev Immunol , vol.2013
    • Zhang, Y.1    Wang, J.2    Wang, Y.3    Lu, X.C.4    Fan, H.5    Liu, Y.6
  • 37
    • 84896829817 scopus 로고    scopus 로고
    • Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients
    • Zhao M, Li H, Li L, Zhang Y. Effects of a gemcitabine plus platinum regimen combined with a dendritic cell-cytokine induced killer immunotherapy on recurrence and survival rate of non-small cell lung cancer patients. Exp Ther Med. 2014;7:1403–7.
    • (2014) Exp Ther Med , vol.7 , pp. 1403-1407
    • Zhao, M.1    Li, H.2    Li, L.3    Zhang, Y.4
  • 38
    • 59849117144 scopus 로고    scopus 로고
    • Viral suppression correlates with dendritic cell restoration in chronic hepatitis B patients with autologous cytokine-induced killer cell transfusion
    • Shi M, Fu J, Shi F, Zhang B, Tang Z, Zhang Z, et al. Viral suppression correlates with dendritic cell restoration in chronic hepatitis B patients with autologous cytokine-induced killer cell transfusion. Liver Int. 2009;29:466–74.
    • (2009) Liver Int , vol.29 , pp. 466-474
    • Shi, M.1    Fu, J.2    Shi, F.3    Zhang, B.4    Tang, Z.5    Zhang, Z.6
  • 40
    • 29144497339 scopus 로고    scopus 로고
    • Functionally distinct NKT cell subsets and subtypes
    • Seino K, Taniguchi M. Functionally distinct NKT cell subsets and subtypes. J Exp Med. 2005;202:1623.
    • (2005) J Exp Med , vol.202 , pp. 1623
    • Seino, K.1    Taniguchi, M.2
  • 41
    • 84883898505 scopus 로고    scopus 로고
    • Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: Experiments and practice
    • Kim N, Im KI, Lim JY, Jeon EJ, Nam YS, Kim EJ, et al. Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: experiments and practice. Ann Hematol. 2013;92:1295–308.
    • (2013) Ann Hematol , vol.92 , pp. 1295-1308
    • Kim, N.1    Im, K.I.2    Lim, J.Y.3    Jeon, E.J.4    Nam, Y.S.5    Kim, E.J.6
  • 45
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 2011;17:4550–7.
    • (2011) Clin Cancer Res , vol.17 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3    Kammula, U.S.4    Hughes, M.S.5    Phan, G.Q.6
  • 46
    • 0022473607 scopus 로고
    • A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes
    • Rosenberg SA, Spiess P, Lafreniere R. A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science. 1986;233:1318–21.
    • (1986) Science , vol.233 , pp. 1318-1321
    • Rosenberg, S.A.1    Spiess, P.2    Lafreniere, R.3
  • 47
    • 0021170244 scopus 로고
    • Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin-2
    • Mule JJ, Shu S, Schwarz SL, Rosenberg SA. Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin-2. Science. 1984;225:1487–9.
    • (1984) Science , vol.225 , pp. 1487-1489
    • Mule, J.J.1    Shu, S.2    Schwarz, S.L.3    Rosenberg, S.A.4
  • 48
    • 80053465574 scopus 로고    scopus 로고
    • Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression
    • Parkhurst MR, Riley JP, Dudley ME, Rosenberg SA. Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression. Clin Cancer Res. 2011;17:6287–97.
    • (2011) Clin Cancer Res , vol.17 , pp. 6287-6297
    • Parkhurst, M.R.1    Riley, J.P.2    Dudley, M.E.3    Rosenberg, S.A.4
  • 49
    • 0019835981 scopus 로고
    • Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor
    • Lotze MT, Grimm EA, Mazumder A, Strausser JL, Rosenberg SA. Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor. Cancer Res. 1981;41:4420–5.
    • (1981) Cancer Res , vol.41 , pp. 4420-4425
    • Lotze, M.T.1    Grimm, E.A.2    Mazumder, A.3    Strausser, J.L.4    Rosenberg, S.A.5
  • 50
    • 84859701718 scopus 로고    scopus 로고
    • Improved activation toward primary colorectal cancer cells by antigen-specific targeting autologous cytokine-induced killer cells
    • Schlimper C, Hombach AA, Abken H, Schmidt-Wolf IG. Improved activation toward primary colorectal cancer cells by antigen-specific targeting autologous cytokine-induced killer cells. Clin Dev Immunol. 2012;2012:238924.
    • (2012) Clin Dev Immunol , vol.2012
    • Schlimper, C.1    Hombach, A.A.2    Abken, H.3    Schmidt-Wolf, I.G.4
  • 51
    • 0023864495 scopus 로고
    • Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins
    • Uckun FM, Jaszcz W, Ambrus JL, Fauci AS, Gajl-Peczalska K, Song CW, et al. Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins. Blood. 1988;71:13–29.
    • (1988) Blood , vol.71 , pp. 13-29
    • Uckun, F.M.1    Jaszcz, W.2    Ambrus, J.L.3    Fauci, A.S.4    Gajl-Peczalska, K.5    Song, C.W.6
  • 52
    • 84896539102 scopus 로고    scopus 로고
    • Genetically modified T cells for the treatment of malignant disease
    • Wieczorek A, Uharek L. Genetically modified T cells for the treatment of malignant disease. Transfus Med Hemother. 2013;40:388–402.
    • (2013) Transfus Med Hemother , vol.40 , pp. 388-402
    • Wieczorek, A.1    Uharek, L.2
  • 53
    • 64249142143 scopus 로고    scopus 로고
    • Cytokine-induced killer cells are terminally differentiated activated CD8 cytotoxic T-EMRA lymphocytes
    • Franceschetti M, Pievani A, Borleri G, Vago L, Fleischhauer K, Golay J, et al. Cytokine-induced killer cells are terminally differentiated activated CD8 cytotoxic T-EMRA lymphocytes. Exp Hematol. 2009;37:616–28.
    • (2009) Exp Hematol , vol.37 , pp. 616-628
    • Franceschetti, M.1    Pievani, A.2    Borleri, G.3    Vago, L.4    Fleischhauer, K.5    Golay, J.6
  • 54
    • 84905714921 scopus 로고    scopus 로고
    • Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo
    • Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Spinelli O, et al. Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo. Leukemia. 2014;28:1596–605.
    • (2014) Leukemia , vol.28 , pp. 1596-1605
    • Pizzitola, I.1    Anjos-Afonso, F.2    Rouault-Pierre, K.3    Lassailly, F.4    Tettamanti, S.5    Spinelli, O.6
  • 55
    • 84864347928 scopus 로고    scopus 로고
    • The effects of cytokineinduced killer cells for the treatment of patients with solid tumors: A clinical retrospective study
    • Zhang J, Zhu L, Wei J, Liu L, Yin Y, Gu Y, et al. The effects of cytokineinduced killer cells for the treatment of patients with solid tumors: a clinical retrospective study. J Cancer Res Clin Oncol. 2012;138:1057–62.
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 1057-1062
    • Zhang, J.1    Zhu, L.2    Wei, J.3    Liu, L.4    Yin, Y.5    Gu, Y.6
  • 56
    • 67650360317 scopus 로고    scopus 로고
    • Immunotherapy with cytokine induced killer cells in solid and hematopoietic tumours: A pilot clinical trial
    • Olioso P, Giancola R, DiRiti M, Contento A, Accorsi P, Iacone A. Immunotherapy with cytokine induced killer cells in solid and hematopoietic tumours: a pilot clinical trial. Hematol Oncol. 2009;27:130–9.
    • (2009) Hematol Oncol , vol.27 , pp. 130-139
    • Olioso, P.1    Giancola, R.2    Diriti, M.3    Contento, A.4    Accorsi, P.5    Iacone, A.6
  • 57
    • 33750151607 scopus 로고    scopus 로고
    • Rapid and massive expansion of cord blood-derived cytokine-induced killer cells: An innovative proposal for the treatment of leukemia relapse after cord blood transplantation
    • Introna M, Franceschetti M, Ciocca A, Borleri G, Conti E, Golay J, et al. Rapid and massive expansion of cord blood-derived cytokine-induced killer cells: an innovative proposal for the treatment of leukemia relapse after cord blood transplantation. Bone Marrow Transplant. 2006;38:621–7.
    • (2006) Bone Marrow Transplant , vol.38 , pp. 621-627
    • Introna, M.1    Franceschetti, M.2    Ciocca, A.3    Borleri, G.4    Conti, E.5    Golay, J.6
  • 58
    • 79952737224 scopus 로고    scopus 로고
    • Clinical studies on combined CIK and DCs from different tissues to treat patients of moderate and advanced stage lung cancer
    • Deng XW. Clinical studies on combined CIK and DCs from different tissues to treat patients of moderate and advanced stage lung cancer. Sci Technol Rev. 2008;11:35–8.
    • (2008) Sci Technol Rev , vol.11 , pp. 35-38
    • Deng, X.W.1
  • 59
    • 84862496486 scopus 로고    scopus 로고
    • A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR
    • Torikai H, Reik A, Liu PQ, Zhou Y, Zhang L, Maiti S, et al. A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR. Blood. 2012;119:5697–705.
    • (2012) Blood , vol.119 , pp. 5697-5705
    • Torikai, H.1    Reik, A.2    Liu, P.Q.3    Zhou, Y.4    Zhang, L.5    Maiti, S.6
  • 60
    • 84886849781 scopus 로고    scopus 로고
    • Toward eliminating HLA class I expression to generate universal cells from allogeneic donors
    • Torikai H, Reik A, Soldner F, Warren EH, Yuen C, Zhou Y, et al. Toward eliminating HLA class I expression to generate universal cells from allogeneic donors. Blood. 2013;122:1341–9.
    • (2013) Blood , vol.122 , pp. 1341-1349
    • Torikai, H.1    Reik, A.2    Soldner, F.3    Warren, E.H.4    Yuen, C.5    Zhou, Y.6
  • 61
    • 84885397947 scopus 로고    scopus 로고
    • Modification of hematopoietic stem/progenitor cells with CD19- specific chimeric antigen receptors as a novel approach for cancer immunotherapy
    • De Oliveira SN, Ryan C, Giannoni F, Hardee CL, Tremcinska I, Katebian B, et al. Modification of hematopoietic stem/progenitor cells with CD19- specific chimeric antigen receptors as a novel approach for cancer immunotherapy. Hum Gene Ther. 2013;24:824–39.
    • (2013) Hum Gene Ther , vol.24 , pp. 824-839
    • De Oliveira, S.N.1    Ryan, C.2    Giannoni, F.3    Hardee, C.L.4    Tremcinska, I.5    Katebian, B.6
  • 63
    • 84885612102 scopus 로고    scopus 로고
    • Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
    • Themeli M, Kloss CC, Ciriello G, Fedorov VD, Perna F, Gonen M, et al. Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy. Nat Biotechnol. 2013;31:928–33.
    • (2013) Nat Biotechnol , vol.31 , pp. 928-933
    • Themeli, M.1    Kloss, C.C.2    Ciriello, G.3    Fedorov, V.D.4    Perna, F.5    Gonen, M.6
  • 65
    • 60849131758 scopus 로고    scopus 로고
    • The antitumor effects of CIK cells combined with docetaxel against drug-resistant lung adenocarcinoma cell line SPC-A1/DTX in vitro and in vivo
    • Liu PY, Chen LB, Huang X. The antitumor effects of CIK cells combined with docetaxel against drug-resistant lung adenocarcinoma cell line SPC-A1/DTX in vitro and in vivo. Cancer Biother Radiopharm. 2009;24:91–8.
    • (2009) Cancer Biother Radiopharm , vol.24 , pp. 91-98
    • Liu, P.Y.1    Chen, L.B.2    Huang, X.3


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