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Volumn 12, Issue 7, 2016, Pages

A putative urinary biosignature for diagnosis and follow-up of tuberculous meningitis in children: outcome of a metabolomics study disclosing host–pathogen responses

Author keywords

Biosignature; Gas chromatography mass spectrometry (GC MS); Metabolomics; Tuberculous meningitis (TBM); Urine

Indexed keywords

2 OXOGLUTARIC ACID; CARBOXYLIC ACID; METHYLCITRIC ACID; QUINOLINIC ACID; SALICYLURIC ACID; UNCLASSIFIED DRUG;

EID: 84976358808     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-016-1053-2     Document Type: Article
Times cited : (18)

References (52)
  • 1
    • 0023913289 scopus 로고
    • Succinic acidemia: a new syndrome of organic acidemia associated with congenital lactic acidosis and decreased NADH-cytochrome c reductase activity
    • COI: 1:CAS:528:DyaL1cXkt1Whsr4%3D
    • Asano, K., Miyamoto, I., Matsushita, T., Murakami, Y., Minoura, S., Wagatsuma, T., et al. (1988). Succinic acidemia: a new syndrome of organic acidemia associated with congenital lactic acidosis and decreased NADH-cytochrome c reductase activity. Clinica Chimica Acta, 173, 305–312.
    • (1988) Clinica Chimica Acta , vol.173 , pp. 305-312
    • Asano, K.1    Miyamoto, I.2    Matsushita, T.3    Murakami, Y.4    Minoura, S.5    Wagatsuma, T.6
  • 2
    • 84905496772 scopus 로고    scopus 로고
    • A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids
    • COI: 1:CAS:528:DC%2BC2cXhtlagu7nO, PID: 24754494
    • Badenhorst, C. P. S., Erasmus, E., Van der Sluis, R., Nortje, C., & Van Dijk, A. A. (2014). A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids. Drug Metabolism Reviews, 46(3), 343–361.
    • (2014) Drug Metabolism Reviews , vol.46 , Issue.3 , pp. 343-361
    • Badenhorst, C.P.S.1    Erasmus, E.2    Van der Sluis, R.3    Nortje, C.4    Van Dijk, A.A.5
  • 5
    • 84861395618 scopus 로고    scopus 로고
    • M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection
    • COI: 1:CAS:528:DC%2BC38XnvFGqsL4%3D, PID: 22649518
    • Blumenthal, A., Nagalingam, G., Huch, J. H., Walker, L., Guillemin, G. J., & Smythe, G. A. (2012). M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PLoS One, 7, e37314.
    • (2012) PLoS One , vol.7 , pp. e37314
    • Blumenthal, A.1    Nagalingam, G.2    Huch, J.H.3    Walker, L.4    Guillemin, G.J.5    Smythe, G.A.6
  • 6
    • 84883331522 scopus 로고    scopus 로고
    • The human urine metabolome
    • COI: 1:CAS:528:DC%2BC3sXhsVCrsrnJ, PID: 24023812
    • Bouatra, S., Aziat, F., Mandal, R., Guo, A. C., Wilson, M. R., Knox, C., et al. (2013). The human urine metabolome. PloS One, 8(9), e73076.
    • (2013) PloS One , vol.8 , Issue.9 , pp. e73076
    • Bouatra, S.1    Aziat, F.2    Mandal, R.3    Guo, A.C.4    Wilson, M.R.5    Knox, C.6
  • 8
    • 28044450369 scopus 로고    scopus 로고
    • Proton nuclear magnetic resonance—based metabonomics for rapid diagnosis of meningitis and ventriculitis
    • COI: 1:CAS:528:DC%2BD2MXhtlahsbfK, PID: 16267730
    • Coen, M., O’Sullivan, M., Bubb, W. A., Kuchel, P. W., & Sorrell, T. (2005). Proton nuclear magnetic resonance—based metabonomics for rapid diagnosis of meningitis and ventriculitis. Clinical Infectious Diseases, 41(11), 1582–1590.
    • (2005) Clinical Infectious Diseases , vol.41 , Issue.11 , pp. 1582-1590
    • Coen, M.1    O’Sullivan, M.2    Bubb, W.A.3    Kuchel, P.W.4    Sorrell, T.5
  • 10
    • 84880642615 scopus 로고    scopus 로고
    • Organic acid profile of isovaleric acidemia: a comprehensive metabolomics approach
    • COI: 1:CAS:528:DC%2BC3sXhtFCjtb3F
    • Dercksen, M., Koekemoer, G., Duran, M., Wanders, R. J. A., Mienie, L. J., & Reinecke, C. J. (2013). Organic acid profile of isovaleric acidemia: a comprehensive metabolomics approach. Metabolomics, 9, 765–777.
    • (2013) Metabolomics , vol.9 , pp. 765-777
    • Dercksen, M.1    Koekemoer, G.2    Duran, M.3    Wanders, R.J.A.4    Mienie, L.J.5    Reinecke, C.J.6
  • 11
    • 0021958126 scopus 로고
    • The “road–to health” card in tuberculous meningitis
    • COI: 1:STN:280:DyaL2M3jslKnsA%3D%3D, PID: 4009778
    • Donald, P. R., Schoeman, J. F., & van Schalkwyk, H. J. S. (1985). The “road–to health” card in tuberculous meningitis. Journal of Tropical Pediatrics, 31(2), 117–120.
    • (1985) Journal of Tropical Pediatrics , vol.31 , Issue.2 , pp. 117-120
    • Donald, P.R.1    Schoeman, J.F.2    van Schalkwyk, H.J.S.3
  • 12
    • 84875806423 scopus 로고    scopus 로고
    • New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa
    • PID: 23477940
    • du Preez, I., & Loots, D. T. (2013). New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa. Tuberculosis, 93(3), 330–337.
    • (2013) Tuberculosis , vol.93 , Issue.3 , pp. 330-337
    • du Preez, I.1    Loots, D.T.2
  • 15
    • 0035023716 scopus 로고    scopus 로고
    • Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection
    • COI: 1:STN:280:DC%2BD3M3ptV2rsQ%3D%3D, PID: 11335705
    • Heyes, M. P., Ellis, R. J., Childers, L. R., Grant, I., Wolfson, T., Archibald, S., et al. (2001). Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection. Brain, 124, 1033–1042.
    • (2001) Brain , vol.124 , pp. 1033-1042
    • Heyes, M.P.1    Ellis, R.J.2    Childers, L.R.3    Grant, I.4    Wolfson, T.5    Archibald, S.6
  • 17
    • 0017818343 scopus 로고
    • The absolute configuration of urinary 2-hydroxybutyric acid in patients with ketosis and lactic acidosis
    • COI: 1:CAS:528:DyaE1cXlsVCmsrY%3D
    • Kamerling, J. P., Gerwig, G. J., Duran, M., Ketting, D., & Wadman, S. K. (1978). The absolute configuration of urinary 2-hydroxybutyric acid in patients with ketosis and lactic acidosis. Clinica Chimica Acta, 88, 183–188.
    • (1978) Clinica Chimica Acta , vol.88 , pp. 183-188
    • Kamerling, J.P.1    Gerwig, G.J.2    Duran, M.3    Ketting, D.4    Wadman, S.K.5
  • 18
    • 84859568305 scopus 로고    scopus 로고
    • The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders
    • COI: 1:CAS:528:DC%2BC38XmsVejs7Y%3D, PID: 22260426
    • Kandanearatchi, A., & Brew, B. J. (2012). The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders. FEBS Journal, 279, 1366–1374.
    • (2012) FEBS Journal , vol.279 , pp. 1366-1374
    • Kandanearatchi, A.1    Brew, B.J.2
  • 19
    • 79955676357 scopus 로고    scopus 로고
    • Uracil excision repair in Mycobacterium tuberculosis cell-free extracts
    • COI: 1:CAS:528:DC%2BC3MXlslygsro%3D, PID: 21371942
    • Kumar, P., Bharti, S. K., & Varshney, U. (2011). Uracil excision repair in Mycobacterium tuberculosis cell-free extracts. Tuberculosis, 91, 212–218.
    • (2011) Tuberculosis , vol.91 , pp. 212-218
    • Kumar, P.1    Bharti, S.K.2    Varshney, U.3
  • 20
    • 0015506784 scopus 로고
    • Effect of rifampicin and isoniazid on liver function
    • COI: 1:STN:280:DyaE38%2FosVyqtA%3D%3D, PID: 5007842
    • Lal, S., Singhal, S. N., Burley, D. M., & Crossley, G. (1972). Effect of rifampicin and isoniazid on liver function. BMJ, 1, 148–150.
    • (1972) BMJ , vol.1 , pp. 148-150
    • Lal, S.1    Singhal, S.N.2    Burley, D.M.3    Crossley, G.4
  • 21
    • 0016809758 scopus 로고
    • Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis
    • COI: 1:CAS:528:DyaE28XivVymsA%3D%3D
    • Landaas, S. (1975). Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis. Clinica Chimica Acta, 64, 143–154.
    • (1975) Clinica Chimica Acta , vol.64 , pp. 143-154
    • Landaas, S.1
  • 24
    • 84941634758 scopus 로고    scopus 로고
    • Molecular mechanisms of hypermutation
    • Honjo T, (ed), Elsevier Academic Press, Amsterdam
    • Maizels, N., & Scharff, M. D. (2004). Molecular mechanisms of hypermutation. In T. Honjo, et al. (Eds.), Molecular biology of B cells (pp. 327–338). Amsterdam: Elsevier Academic Press.
    • (2004) Molecular biology of B cells , pp. 327-338
    • Maizels, N.1    Scharff, M.D.2
  • 25
    • 79251595354 scopus 로고    scopus 로고
    • The role of metabolites and metabolomics in clinically applicable biomarkers of disease
    • COI: 1:CAS:528:DC%2BC3cXhtlSjur7I, PID: 20953584
    • Mamas, M., Dunn, W. B., Neyses, L., & Goodacre, R. (2011). The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Archives of Toxicology, 85, 5–17.
    • (2011) Archives of Toxicology , vol.85 , pp. 5-17
    • Mamas, M.1    Dunn, W.B.2    Neyses, L.3    Goodacre, R.4
  • 26
    • 0343773016 scopus 로고    scopus 로고
    • New rapid antigen test for diagnosis of pneumococcal meningitis
    • COI: 1:STN:280:DC%2BD3M3psValsg%3D%3D, PID: 11377604
    • Marcos, M. A., Martinez, E., Almela, M., Mensa, J., & Jiménez de Anta, M. T. (2001). New rapid antigen test for diagnosis of pneumococcal meningitis. Lancet, 357, 1499–1500.
    • (2001) Lancet , vol.357 , pp. 1499-1500
    • Marcos, M.A.1    Martinez, E.2    Almela, M.3    Mensa, J.4    Jiménez de Anta, M.T.5
  • 27
    • 84976419824 scopus 로고    scopus 로고
    • KEMREP: A new qualitative method for the assessment of an analyst’s ability to generate a metabolomics data matrix by gas chromatography–mass spectrometry
    • COI: 1:CAS:528:DC%2BC2cXnt1emtLs%3D
    • Mason, S., Moutloatse, G. P., van Furth, A. M., Solomons, R., van Reenen, M., Reinecke, C., et al. (2014). KEMREP: A new qualitative method for the assessment of an analyst’s ability to generate a metabolomics data matrix by gas chromatography–mass spectrometry. Current Metabolomics, 2(1), 15–26.
    • (2014) Current Metabolomics , vol.2 , Issue.1 , pp. 15-26
    • Mason, S.1    Moutloatse, G.P.2    van Furth, A.M.3    Solomons, R.4    van Reenen, M.5    Reinecke, C.6
  • 28
    • 84934999646 scopus 로고    scopus 로고
    • 1H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis
    • COI: 1:CAS:528:DC%2BC2cXhslers7fO, PID: 26109926
    • 1H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis. Metabolomics, 11, 822–837.
    • (2015) Metabolomics , vol.11 , pp. 822-837
    • Mason, S.1    van Furth, A.M.2    Mienie, L.J.3    Engelke, U.F.H.4    Wevers, R.A.5    Solomons, R.6
  • 29
    • 0141840758 scopus 로고    scopus 로고
    • Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria
    • COI: 1:CAS:528:DC%2BD3sXotl2gt7o%3D, PID: 12964115
    • Medana, I. M., Day, N. P., Salahifar-Sabet, H., Stocker, R., Smythe, G., Bwanaisa, L., et al. (2003). Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria. Journal of Infectious Diseases, 188(6), 844–849.
    • (2003) Journal of Infectious Diseases , vol.188 , Issue.6 , pp. 844-849
    • Medana, I.M.1    Day, N.P.2    Salahifar-Sabet, H.3    Stocker, R.4    Smythe, G.5    Bwanaisa, L.6
  • 30
    • 33745235266 scopus 로고    scopus 로고
    • Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
    • PID: 16689789
    • Muñoz-Elías, E. J., Upton, A. M., Cherian, J., & McKinney, J. D. (2006). Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Molecular Microbiology, 60(5), 1109–1122.
    • (2006) Molecular Microbiology , vol.60 , Issue.5 , pp. 1109-1122
    • Muñoz-Elías, E.J.1    Upton, A.M.2    Cherian, J.3    McKinney, J.D.4
  • 32
    • 75149133148 scopus 로고    scopus 로고
    • The quest for biomarkers in tuberculosis
    • COI: 1:CAS:528:DC%2BC3cXhtlOls7s%3D, PID: 19854295
    • Parida, S. K., & Kaufmann, S. H. (2010). The quest for biomarkers in tuberculosis. Drug Discovery Today, 15, 148–157.
    • (2010) Drug Discovery Today , vol.15 , pp. 148-157
    • Parida, S.K.1    Kaufmann, S.H.2
  • 33
    • 0034755665 scopus 로고    scopus 로고
    • The neuroendocrinology of chronic fatigue syndrome and fibromyalgia
    • COI: 1:STN:280:DC%2BD3MnnsFyktA%3D%3D, PID: 11722149
    • Parker, A. J. R., Wessely, S., & Cleare, A. J. (2001). The neuroendocrinology of chronic fatigue syndrome and fibromyalgia. Psychological Medicine, 31(08), 1331–1345.
    • (2001) Psychological Medicine , vol.31 , Issue.8 , pp. 1331-1345
    • Parker, A.J.R.1    Wessely, S.2    Cleare, A.J.3
  • 34
    • 84865466959 scopus 로고    scopus 로고
    • Diagnosis and therapy of tuberculous meningitis in children
    • PID: 22721988
    • Principi, N., & Esposito, S. (2012). Diagnosis and therapy of tuberculous meningitis in children. Tuberculosis, 92, 377–383.
    • (2012) Tuberculosis , vol.92 , pp. 377-383
    • Principi, N.1    Esposito, S.2
  • 35
    • 84857794136 scopus 로고    scopus 로고
    • Metabolomics of urinary organic acids in respiratory chain deficiencies in children
    • COI: 1:CAS:528:DC%2BC38Xjt1CgtLo%3D
    • Reinecke, C. J., Koekemoer, G., van der Westhuizen, F. H., Louw, R., Lindeque, J. Z., Mienie, L. J., et al. (2012). Metabolomics of urinary organic acids in respiratory chain deficiencies in children. Metabolomics, 8, 264–283.
    • (2012) Metabolomics , vol.8 , pp. 264-283
    • Reinecke, C.J.1    Koekemoer, G.2    van der Westhuizen, F.H.3    Louw, R.4    Lindeque, J.Z.5    Mienie, L.J.6
  • 36
    • 70349774893 scopus 로고    scopus 로고
    • Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis
    • PID: 19715562
    • Reither, K., Saathoff, E., Jung, J., Minja, L. T., Kroidl, I., Saad, E., et al. (2009). Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis. BMC Infectious Diseases, 9(1), 141–150.
    • (2009) BMC Infectious Diseases , vol.9 , Issue.1 , pp. 141-150
    • Reither, K.1    Saathoff, E.2    Jung, J.3    Minja, L.T.4    Kroidl, I.5    Saad, E.6
  • 37
    • 44349163542 scopus 로고    scopus 로고
    • Functional characterization of a Vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: Implications for propionate metabolism during growth on fatty acids
    • COI: 1:CAS:528:DC%2BD1cXmsVOms7c%3D, PID: 18375549
    • Savvi, S., Warner, D. F., Kana, B. D., McKinney, J. D., Mizrahi, V., & Dawes, S. S. (2008). Functional characterization of a Vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: Implications for propionate metabolism during growth on fatty acids. Journal of Bacteriology, 190, 3886–3895.
    • (2008) Journal of Bacteriology , vol.190 , pp. 3886-3895
    • Savvi, S.1    Warner, D.F.2    Kana, B.D.3    McKinney, J.D.4    Mizrahi, V.5    Dawes, S.S.6
  • 38
    • 84976357912 scopus 로고    scopus 로고
    • In N. Blau, M. Duran, M. E. Blaskovics, & K. M. Gibson (Eds.), Physician’s guide to the laboratory diagnosis of metabolic diseases
    • Springer Science &, Business Media
    • Scriver, C. R. (2012). In N. Blau, M. Duran, M. E. Blaskovics, & K. M. Gibson (Eds.), Physician’s guide to the laboratory diagnosis of metabolic diseases. Berlin: Springer Science & Business Media.
    • (2012) Berlin
    • Scriver, C.R.1
  • 39
    • 21644465664 scopus 로고    scopus 로고
    • Proton MR CSF analysis and a new software as predictors of the differentiation of meningitis in children
    • COI: 1:CAS:528:DC%2BD2MXntlSrs7s%3D
    • Subramanian, A., Gupta, A., Saxena, S., Gupta, A., Kumar, R., Nigam, A., et al. (2005). Proton MR CSF analysis and a new software as predictors of the differentiation of meningitis in children. NMR Biomedicine, 18, 213–225.
    • (2005) NMR Biomedicine , vol.18 , pp. 213-225
    • Subramanian, A.1    Gupta, A.2    Saxena, S.3    Gupta, A.4    Kumar, R.5    Nigam, A.6
  • 41
    • 0029003510 scopus 로고
    • Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6
    • PID: 7675855
    • Van de Kamp, J. L., & Smolen, A. (1995). Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6. Pharmacology, Biochemistry and Behavior, 51, 753–758.
    • (1995) Pharmacology, Biochemistry and Behavior , vol.51 , pp. 753-758
    • Van de Kamp, J.L.1    Smolen, A.2
  • 43
    • 63849291316 scopus 로고    scopus 로고
    • Twenty years of pediatric tuberculous meningitis: a retrospective cohort study in the western cape of South Africa
    • PID: 19367678
    • van Well, G. T., Paes, B. F., Terwee, C. B., Springer, P., Roord, J. J., Donald, P. R., et al. (2009). Twenty years of pediatric tuberculous meningitis: a retrospective cohort study in the western cape of South Africa. Pediatrics, 123(1), e1–e8.
    • (2009) Pediatrics , vol.123 , Issue.1 , pp. e1-e8
    • van Well, G.T.1    Paes, B.F.2    Terwee, C.B.3    Springer, P.4    Roord, J.J.5    Donald, P.R.6
  • 44
    • 0035103349 scopus 로고    scopus 로고
    • Year-long validation study and reference values for urinary amino acids using a reversed-phase HPLC method
    • COI: 1:CAS:528:DC%2BD3MXhvVOgur8%3D, PID: 11238314
    • Venta, R. (2001). Year-long validation study and reference values for urinary amino acids using a reversed-phase HPLC method. Clinical Chemistry, 47(3), 575–583.
    • (2001) Clinical Chemistry , vol.47 , Issue.3 , pp. 575-583
    • Venta, R.1
  • 45
    • 36649020263 scopus 로고    scopus 로고
    • Metabolomics identifies perturbations in human disorders of propionate metabolism
    • COI: 1:CAS:528:DC%2BD2sXhtl2qt77P, PID: 17951291
    • Wikoff, W. R., Gangoiti, J. A., Barshop, B. A., & Siuzdak, G. (2007). Metabolomics identifies perturbations in human disorders of propionate metabolism. Clinical Chemistry, 53, 2169–2176.
    • (2007) Clinical Chemistry , vol.53 , pp. 2169-2176
    • Wikoff, W.R.1    Gangoiti, J.A.2    Barshop, B.A.3    Siuzdak, G.4
  • 46
    • 46749146517 scopus 로고    scopus 로고
    • Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques
    • COI: 1:CAS:528:DC%2BD1cXot1Omsr4%3D, PID: 18521184
    • Wikoff, W. R., Pendyala, G., Siuzdak, G., & Fox, H. S. (2008). Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques. Journal of Clinical Investigation, 118, 2661–2669.
    • (2008) Journal of Clinical Investigation , vol.118 , pp. 2661-2669
    • Wikoff, W.R.1    Pendyala, G.2    Siuzdak, G.3    Fox, H.S.4
  • 47
    • 0037685217 scopus 로고    scopus 로고
    • Screening newborns for inborn errors of metabolism by tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BD3sXkt1KktrY%3D, PID: 12788994
    • Wilcken, B., Wiley, V., Hammond, J., & Carpenter, K. (2003). Screening newborns for inborn errors of metabolism by tandem mass spectrometry. New England Journal of Medicine, 348, 2304–2312.
    • (2003) New England Journal of Medicine , vol.348 , pp. 2304-2312
    • Wilcken, B.1    Wiley, V.2    Hammond, J.3    Carpenter, K.4
  • 48
    • 84901269480 scopus 로고    scopus 로고
    • Aerosol Mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota
    • PID: 24819223
    • Winglee, K., Eloe-Fadrosh, E., Gupta, S., Guo, H., Fraser, C., & Bishai, W. (2014). Aerosol Mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota. PLoS One, 9(5), e97048.
    • (2014) PLoS One , vol.9 , Issue.5 , pp. e97048
    • Winglee, K.1    Eloe-Fadrosh, E.2    Gupta, S.3    Guo, H.4    Fraser, C.5    Bishai, W.6
  • 50
    • 84870408343 scopus 로고    scopus 로고
    • The changing profile of pediatric meningitis at a referral centre in Cape Town, South Africa
    • PID: 22791086
    • Wolzak, N. K., Cooke, M. L., Orth, H., & van Toorn, R. (2012). The changing profile of pediatric meningitis at a referral centre in Cape Town, South Africa. Journal of Tropical Pediatrics, 58, 491–495.
    • (2012) Journal of Tropical Pediatrics , vol.58 , pp. 491-495
    • Wolzak, N.K.1    Cooke, M.L.2    Orth, H.3    van Toorn, R.4
  • 51
    • 84885206980 scopus 로고    scopus 로고
    • Application of 1H NMR spectroscopy-based metabolomics to sera of tuberculosis patients
    • COI: 1:CAS:528:DC%2BC3sXhtlakt73M, PID: 23980697
    • Zhou, A., Ni, J., Xu, Z., Wang, Y., Lu, S., Sha, W., et al. (2013). Application of 1H NMR spectroscopy-based metabolomics to sera of tuberculosis patients. Journal of Proteome Research, 12(10), 4642–4649.
    • (2013) Journal of Proteome Research , vol.12 , Issue.10 , pp. 4642-4649
    • Zhou, A.1    Ni, J.2    Xu, Z.3    Wang, Y.4    Lu, S.5    Sha, W.6
  • 52
    • 84883128734 scopus 로고    scopus 로고
    • Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
    • PID: 23977941
    • Zysset-Burri, D. C., Bellac, C. L., Leibm, S. L., & Wittwerm, M. (2013). Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis. BMC Infectious Diseases, 13, 393–407.
    • (2013) BMC Infectious Diseases , vol.13 , pp. 393-407
    • Zysset-Burri, D.C.1    Bellac, C.L.2    Leibm, S.L.3    Wittwerm, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.