메뉴 건너뛰기




Volumn 10, Issue 3, 2016, Pages 118-125

Drug discovery in renin-angiotensin system intervention: Past and future

Author keywords

angiotensin II; cardiovascular remodelling; renin angiotensin system (RAS)

Indexed keywords

ALISKIREN; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN; CAPTOPRIL; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; RENIN INHIBITOR; VALSARTAN; RENIN;

EID: 84976342625     PISSN: 17539447     EISSN: 17539455     Source Type: Journal    
DOI: 10.1177/1753944716642680     Document Type: Conference Paper
Times cited : (25)

References (46)
  • 1
    • 33845362874 scopus 로고    scopus 로고
    • A vaccine for hypertension based on virus-like particles: Preclinical efficacy and phase i safety and immunogenicity
    • Ambuhl P., Tissot A., Fulurija A., Maurer P., Nussberger J., Sabat R., et al.(2007) A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity. J Hypertens 25: 63-72.
    • (2007) J Hypertens , vol.25 , pp. 63-72
    • Ambuhl, P.1    Tissot, A.2    Fulurija, A.3    Maurer, P.4    Nussberger, J.5    Sabat, R.6
  • 3
    • 0014666939 scopus 로고
    • Metabolism of the angiotensins in isolated perfused tissues
    • Bakhle Y., Reynard A., Vane J., (1969) Metabolism of the angiotensins in isolated perfused tissues. Nature 222: 956-959.
    • (1969) Nature , vol.222 , pp. 956-959
    • Bakhle, Y.1    Reynard, A.2    Vane, J.3
  • 4
    • 77957316058 scopus 로고    scopus 로고
    • Combination angiotensin receptor blocker-neutral endopeptidase inhibitor provides additive blood pressure reduction over angiotensin receptor blocker alone
    • Bloch M., Basile J., (2010) Combination angiotensin receptor blocker-neutral endopeptidase inhibitor provides additive blood pressure reduction over angiotensin receptor blocker alone. J Clin Hypertens 12: 809-812.
    • (2010) J Clin Hypertens , vol.12 , pp. 809-812
    • Bloch, M.1    Basile, J.2
  • 5
    • 76449117787 scopus 로고    scopus 로고
    • Stimulation of angiotensin AT2 receptors by the non-peptide agonist, compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats
    • Bosnyak S., Welungoda I., Hallberg A., Alterman M., Widdop R., Jones E., (2010) Stimulation of angiotensin AT2 receptors by the non-peptide agonist, compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br J Pharmacol 159: 709-716.
    • (2010) Br J Pharmacol , vol.159 , pp. 709-716
    • Bosnyak, S.1    Welungoda, I.2    Hallberg, A.3    Alterman, M.4    Widdop, R.5    Jones, E.6
  • 7
    • 12444316765 scopus 로고
    • Synthesis and pharmacology of the octapeptide angiotonin
    • Bumpus F., Schwarz H., Page I., (1957) Synthesis and pharmacology of the octapeptide angiotonin. Science 125: 886-887.
    • (1957) Science , vol.125 , pp. 886-887
    • Bumpus, F.1    Schwarz, H.2    Page, I.3
  • 8
    • 77951702656 scopus 로고    scopus 로고
    • The hypertension-diabetes continuum
    • Cheung B., (2010) The hypertension-diabetes continuum. J Cardiovasc Pharmacol 55: 333-339.
    • (2010) J Cardiovasc Pharmacol , vol.55 , pp. 333-339
    • Cheung, B.1
  • 9
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    • Cohn J., Tognoni G., (2001) A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 345: 1667-1675.
    • (2001) N Engl J Med , vol.345 , pp. 1667-1675
    • Cohn, J.1    Tognoni, G.2
  • 10
    • 0018583165 scopus 로고
    • Development of specific inhibitors of angiotensin i converting enzyme (kininase II)
    • Cushman D., Cheung H., Sabo E., Rubin B., Ondetti M., (1979) Development of specific inhibitors of angiotensin I converting enzyme (kininase II). Fed Proc 38: 2778-2782.
    • (1979) Fed Proc , vol.38 , pp. 2778-2782
    • Cushman, D.1    Cheung, H.2    Sabo, E.3    Rubin, B.4    Ondetti, M.5
  • 12
    • 0015693946 scopus 로고
    • Inhibition of angiotensin-coverting enzyme by analogs of peptides from Bothrops jararaca venom
    • Cushman D., Pluscec J., Williams N., Weaver E., Sabo E., Kocy O., et al.(1973) Inhibition of angiotensin-coverting enzyme by analogs of peptides from Bothrops jararaca venom. Experientia 29: 1032-1035.
    • (1973) Experientia , vol.29 , pp. 1032-1035
    • Cushman, D.1    Pluscec, J.2    Williams, N.3    Weaver, E.4    Sabo, E.5    Kocy, O.6
  • 13
    • 0037472837 scopus 로고    scopus 로고
    • Non-inferiority trials: Design concepts and issues - The encounters of academic consultants in statistics
    • D'agostino R., Sr, Massaro J., Sullivan L., (2003) Non-inferiority trials: design concepts and issues-the encounters of academic consultants in statistics. Stat Med 22: 169-186.
    • (2003) Stat Med , vol.22 , pp. 169-186
    • D'Agostino, R.1    Massaro, J.2    Sullivan, L.3
  • 14
    • 33846294746 scopus 로고    scopus 로고
    • Incident diabetes in clinical trials of antihypertensive drugs: A network meta-analysis
    • Elliott W., Meyer P., (2007) Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet 369: 201-207.
    • (2007) Lancet , vol.369 , pp. 201-207
    • Elliott, W.1    Meyer, P.2
  • 15
    • 0014960193 scopus 로고
    • Activity of various fractions of bradykinin potentiating factor against angiotensin i converting enzyme
    • Ferreira S., Greene L., Alabaster V., Bakhle Y., Vane J., (1970) Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme. Nature 225: 379-380.
    • (1970) Nature , vol.225 , pp. 379-380
    • Ferreira, S.1    Greene, L.2    Alabaster, V.3    Bakhle, Y.4    Vane, J.5
  • 16
    • 84862579572 scopus 로고    scopus 로고
    • Emergence and evolution of the renin-angiotensin-aldosterone system
    • Fournier D., Luft F., Bader M., Ganten D., Andrade-Navarro M., (2012) Emergence and evolution of the renin-angiotensin-aldosterone system. J Mol Med 90: 495-508.
    • (2012) J Mol Med , vol.90 , pp. 495-508
    • Fournier, D.1    Luft, F.2    Bader, M.3    Ganten, D.4    Andrade-Navarro, M.5
  • 17
    • 85024286205 scopus 로고
    • Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia
    • Goldblatt H., Lynch J., Hanzal R., Summerville W., (1934) Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia. J Exp Med 59: 347-379.
    • (1934) J Exp Med , vol.59 , pp. 347-379
    • Goldblatt, H.1    Lynch, J.2    Hanzal, R.3    Summerville, W.4
  • 18
    • 0000243631 scopus 로고
    • Renin und Hypertensin, physiologische oder pathologische Wirkstoffe?
    • Gross F., (1958) Renin und Hypertensin, physiologische oder pathologische Wirkstoffe? Klin Wschr 36: 693.
    • (1958) Klin Wschr , vol.36 , pp. 693
    • Gross, F.1
  • 19
    • 77956817833 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNI)
    • Gu J., Noe A., Chandra P., Al-Fayoumi S., Ligueros-Saylan M., Sarangapani R., et al.(2010) Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNI). J Clin Pharmacol 50: 401-414.
    • (2010) J Clin Pharmacol , vol.50 , pp. 401-414
    • Gu, J.1    Noe, A.2    Chandra, P.3    Al-Fayoumi, S.4    Ligueros-Saylan, M.5    Sarangapani, R.6
  • 20
    • 45149087687 scopus 로고    scopus 로고
    • Ambulatory blood pressure-lowering effects of valsartan and enalapril after a missed dose in previously untreated patients with hypertension: A prospective, randomized, open-label, blinded end-point trial
    • Hermida R., Ayala D., Khder Y., Calvo C., (2008) Ambulatory blood pressure-lowering effects of valsartan and enalapril after a missed dose in previously untreated patients with hypertension: a prospective, randomized, open-label, blinded end-point trial. Clin Ther 30: 108-120.
    • (2008) Clin Ther , vol.30 , pp. 108-120
    • Hermida, R.1    Ayala, D.2    Khder, Y.3    Calvo, C.4
  • 21
    • 84893549987 scopus 로고    scopus 로고
    • 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8)
    • James P., Oparil S., Carter B., Cushman W., Dennison-Himmelfarb C., Handler J., et al.(2014) 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311: 507-520.
    • (2014) JAMA , vol.311 , pp. 507-520
    • James, P.1    Oparil, S.2    Carter, B.3    Cushman, W.4    Dennison-Himmelfarb, C.5    Handler, J.6
  • 22
    • 58149375072 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor stimulation: A novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
    • Kaschina E., Grzesiak A., Li J., Foryst-Ludwig A., Timm M., Rompe F., et al.(2008) Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 118: 2523-2532.
    • (2008) Circulation , vol.118 , pp. 2523-2532
    • Kaschina, E.1    Grzesiak, A.2    Li, J.3    Foryst-Ludwig, A.4    Timm, M.5    Rompe, F.6
  • 23
    • 0037120958 scopus 로고    scopus 로고
    • Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors
    • Maggioni A., Anand I., Gottlieb S., Latini R., Tognoni G., Cohn J., (2002) Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors. J Am Coll Cardiol 40: 1414-1421.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 1414-1421
    • Maggioni, A.1    Anand, I.2    Gottlieb, S.3    Latini, R.4    Tognoni, G.5    Cohn, J.6
  • 24
    • 84896724318 scopus 로고    scopus 로고
    • 2013 ESH/ESC practice guidelines for the management of arterial hypertension
    • Mancia G., Fagard R., Narkiewicz K., Redon J., Zanchetti A., Bohm M., et al.(2014) 2013 ESH/ESC practice guidelines for the management of arterial hypertension. Blood Press 23: 3-16.
    • (2014) Blood Press , vol.23 , pp. 3-16
    • Mancia, G.1    Fagard, R.2    Narkiewicz, K.3    Redon, J.4    Zanchetti, A.5    Bohm, M.6
  • 26
    • 0037338802 scopus 로고    scopus 로고
    • Insulin-induced AKT activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha
    • Motley E., Eguchi K., Gardner C., Hicks A., Reynolds C., Frank G., et al.(2003) Insulin-induced AKT activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha. Hypertension 41: 775-780.
    • (2003) Hypertension , vol.41 , pp. 775-780
    • Motley, E.1    Eguchi, K.2    Gardner, C.3    Hicks, A.4    Reynolds, C.5    Frank, G.6
  • 27
    • 84976414257 scopus 로고    scopus 로고
    • Mylan Pharmaceuticals. Canonsburg, PA: Mylan Pharmaceuticals Inc
    • Mylan Pharmaceuticals (2015) Captopril prescribing information. Canonsburg, PA: Mylan Pharmaceuticals Inc.
    • (2015) Captopril Prescribing Information
  • 30
    • 0002671581 scopus 로고
    • A crystalline pressor substance (angiotonin) resulting from the reaction between renin and renin-activator
    • Page I., Helmer O., (1940) A crystalline pressor substance (angiotonin) resulting from the reaction between renin and renin-activator. J Exp Med 71: 29-42.
    • (1940) J Exp Med , vol.71 , pp. 29-42
    • Page, I.1    Helmer, O.2
  • 32
    • 0242490542 scopus 로고    scopus 로고
    • Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    • Pfeffer M., McMurray J., Velazquez E., Rouleau J., Kober L., Maggioni A., et al.(2003) Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 349: 1893-1906.
    • (2003) N Engl J Med , vol.349 , pp. 1893-1906
    • Pfeffer, M.1    McMurray, J.2    Velazquez, E.3    Rouleau, J.4    Kober, L.5    Maggioni, A.6
  • 33
    • 84856120678 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats
    • Rehman A., Leibowitz A., Yamamoto N., Rautureau Y., Paradis P., Schiffrin E., (2012) Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 59: 291-299.
    • (2012) Hypertension , vol.59 , pp. 291-299
    • Rehman, A.1    Leibowitz, A.2    Yamamoto, N.3    Rautureau, Y.4    Paradis, P.5    Schiffrin, E.6
  • 35
    • 77950472601 scopus 로고    scopus 로고
    • Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB
    • Rompe F., Artuc M., Hallberg A., Alterman M., Stroder K., Thone-Reineke C., et al.(2010) Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension 55: 924-931.
    • (2010) Hypertension , vol.55 , pp. 924-931
    • Rompe, F.1    Artuc, M.2    Hallberg, A.3    Alterman, M.4    Stroder, K.5    Thone-Reineke, C.6
  • 36
    • 34047121150 scopus 로고    scopus 로고
    • Renin-angiotensin system and cardiovascular risk
    • Schmieder R., Hilgers K., Schlaich M., Schmidt B., (2007) Renin-angiotensin system and cardiovascular risk. Lancet 369: 1208-1219.
    • (2007) Lancet , vol.369 , pp. 1208-1219
    • Schmieder, R.1    Hilgers, K.2    Schlaich, M.3    Schmidt, B.4
  • 37
    • 3543021488 scopus 로고    scopus 로고
    • Visceral fat in hypertension: Influence on insulin resistance and beta-cell function
    • Sironi A., Gastaldelli A., Mari A., Ciociaro D., Positano V., Buzzigoli E., et al.(2004) Visceral fat in hypertension: influence on insulin resistance and beta-cell function. Hypertension 44: 127-133.
    • (2004) Hypertension , vol.44 , pp. 127-133
    • Sironi, A.1    Gastaldelli, A.2    Mari, A.3    Ciociaro, D.4    Positano, V.5    Buzzigoli, E.6
  • 38
    • 0017319491 scopus 로고
    • The biochemistry of the renin-angiotensin system and its role in hypertension
    • Skeggs L., Dorer F., Kahn J., Lentz K., Levine M., (1976) The biochemistry of the renin-angiotensin system and its role in hypertension. Am J Med 60: 737-748.
    • (1976) Am J Med , vol.60 , pp. 737-748
    • Skeggs, L.1    Dorer, F.2    Kahn, J.3    Lentz, K.4    Levine, M.5
  • 39
    • 0000051878 scopus 로고
    • The existence of two forms of hypertensin
    • Skeggs L. Jr., Marsh W., Kahn J., Shumway N., (1954a) The existence of two forms of hypertensin. J Exp Med 99: 275-282.
    • (1954) J Exp Med , vol.99 , pp. 275-282
    • Skeggs, L.1    Marsh, W.2    Kahn, J.3    Shumway, N.4
  • 40
    • 0001361875 scopus 로고
    • The purification of hypertensin i
    • Skeggs L. Jr., Marsh W., Kahn J., Shumway N., (1954b) The purification of hypertensin I. J Exp Med 100: 363-370.
    • (1954) J Exp Med , vol.100 , pp. 363-370
    • Skeggs, L.1    Marsh, W.2    Kahn, J.3    Shumway, N.4
  • 41
    • 0010331818 scopus 로고
    • Amino acid composition and electrophoretic properties of hypertensin i
    • Skeggs L. Jr., Marsh W., Kahn J., Shumway N., (1955) Amino acid composition and electrophoretic properties of hypertensin I. J Exp Med 102: 435-440.
    • (1955) J Exp Med , vol.102 , pp. 435-440
    • Skeggs, L.1    Marsh, W.2    Kahn, J.3    Shumway, N.4
  • 42
    • 0036793096 scopus 로고    scopus 로고
    • Strategies to meet lower blood pressure goals with a new standard in angiotensin II receptor blockade
    • Smith D., (2002) Strategies to meet lower blood pressure goals with a new standard in angiotensin II receptor blockade. Am J Hypertens 15: 108s-114s.
    • (2002) Am J Hypertens , vol.15 , pp. 108s-114s
    • Smith, D.1
  • 44
    • 77749273888 scopus 로고    scopus 로고
    • Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): Implications for AT2 receptor research and therapeutic potential
    • Unger T., Dahlof B., (2010) Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potential. J Renin-angiotensin Aldosterone Syst 11: 75-77.
    • (2010) J Renin-angiotensin Aldosterone Syst , vol.11 , pp. 75-77
    • Unger, T.1    Dahlof, B.2
  • 45
    • 84896885011 scopus 로고    scopus 로고
    • Rationale and study design of the prospective comparison of angiotensin receptor neprilysin inhibitor with angiotensin receptor blocker measuring arterial stiffness in the elderly (PARAMETER) study
    • Williams B., Cockcroft J., Kario K., Zappe D., Cardenas P., Hester A., et al.(2014) Rationale and study design of the prospective comparison of angiotensin receptor neprilysin inhibitor with angiotensin receptor blocker measuring arterial stiffness in the elderly (PARAMETER) study. BMJ Open 4: e004254.
    • (2014) BMJ Open , vol.4 , pp. e004254
    • Williams, B.1    Cockcroft, J.2    Kario, K.3    Zappe, D.4    Cardenas, P.5    Hester, A.6
  • 46
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • Yusuf S., Teo K., Pogue J., Dyal L., Copland I., Schumacher H., et al.(2008) Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 358: 1547-1559.
    • (2008) N Engl J Med , vol.358 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.2    Pogue, J.3    Dyal, L.4    Copland, I.5    Schumacher, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.