Protective effect of metformin on testicular ischemia/reperfusion injury in rats

Acta Cirurgica Brasileira

Volumn 31, Issue 6, 2016, Pages 411-416

  Asghari, Ahmad ^a   Akbari, Ghasem ^a   Meghdadi, Afshin ^a   Mortazavi, Pejman ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Ischemia; Metformin; Rats; Reperfusion; Testis

Indexed keywords

MALONALDEHYDE; METFORMIN; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE; PEROXIDASE; PROTECTIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ISCHEMIA; JOHNSENS SCORE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; SCORING SYSTEM; SEMINIFEROUS TUBULE; SPERMATOZOON MATURATION; TESTICULAR REPERFUSION INJURY; TESTIS INJURY; TESTIS TORSION; ANIMAL; DRUG EFFECTS; METABOLISM; RANDOMIZATION; TESTIS; VASCULARIZATION; WISTAR RAT;

ANIMALS; MALE; MALONDIALDEHYDE; METFORMIN; MODELS, ANIMAL; OXIDATIVE STRESS; PEROXIDASE; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS, WISTAR; REPERFUSION INJURY; SUPEROXIDE DISMUTASE; TESTIS;

EID: 84976335285     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-865020160060000008     Document Type: Article

References (34)

1. Akgur FM, Kilinc K, Aktug T. Reperfusion injury after detorsion of unilateral testicular torsion. Urol Res. 1993;21:395-9. PMID: 8171761.
2. Turner TT, Brown KJ. Spermatic cord torsion: loss of spermatogenesis despite return of blood flow. Biol Reprod. 1993 Aug;49:401-7. PMID: 8373967.
3. Turner TT, Tung KS, Tomomasa H. Acute testicular ischemia results in germ cell-specific apoptosis in the rat. Biol Reprod. 1997 Dec;57:1267-74. PMID: 9408230.
4. Lysiak JJ, Turner SD, Turner TT. Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis. Biol Reprod. 2000 Nov;63:1465-72. PMID: 11058553.
5. Lysiak JJ, Turner SD, Nguyen QA, Singbartl K, Ley K, Turner TT. Essential role of neutrophils in germ cell-specific apoptosis following ischemia/ reperfusion injury of the mouse testis. Biol Reprod. 2001 Sep;65:718-25. PMID: 11514333.
6. Lysiak JJ, Nguyen QA, Kirby JL, Turner TT. Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expression. Biol Reprod. 2003 Jul;69:202-10. PMID: 12620934.
7. Mogilner JG, Lurie M, Coran AG, Nativ O, Shiloni E, Sukhotnik I. Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat. Pediatr Surg Int. 2006 Jan;22:99-105. PMID: 16283337.
8. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med. 2004 Feb- Apr;2:199-210. PMID: 15051328.
9. Cay A, Alver A, Kucuk M, Isik O, Eminagaoglu MS, Karahan SC, Deger O. The effects of N-acetylcysteine on antioxidant enzyme activities in experimental testicular torsion. J Surg Res. 2006 Apr;131:199-203. PMID: 16412470.
10. Unsal A, Eroglu M, Avci A, Cimentepe E, Guven C, Derya Balbay M, Durak I. Protective role of natural antioxidant supplementation on testicular tissue after testicular torsion and detorsion. Scand J Urol Nephrol. 2006;40:17-22. PMID: 16452050.
11. Charlon V, Boucher F, Mouhieddine S, Deleiris J. Reduction of myocardial infarct size by metformin in rats submitted to permanent left coronary-artery ligation. Diabetes Metab. 1988;14:591-5.
12. Wang ZS, Liu XH, Wang M, Jiang GJ, Qiu T, Chen ZY, Wang L. Metformin attenuated the inflammation after renal ischemia/ reperfusion and suppressed apoptosis of renal tubular epithelial cell in rats. Acta Cir Bras. 2015 Sep;30(9):617-23. PMID: 26465106.
13. Barthelmebs M, Wiernsperger N, Krieger J, Rapin J, Radziuk J, Grima M, Imbs JI. Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function. Diabetes Metab. 2003 Apr;29(2):163-70.
14. Takhtfooladi HA, Takhtfooladi MA, Karimi P, Asl HA, Mobarakeh SZ. Influence of tramadol on ischemia-reperfusion injury of rats’ skeletal muscle. Int J Surg. 2014;12(9):963-8. PMID: 25062899.
15. Parlaktas BS, Atilgan D, Gencten Y, Akbas A, Markoc F, Erdemir F, Ozyurt H, Uluocak N. The effects of carvedilol on ischemiareperfusion injury in the rat testis. Int Braz J Urol. 2014 Jan- Feb;40(1):109-17. PMID: 24642157.
16. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988 Mar; 34(3):497-500. PMID: 3349599.
17. Durak I, Yurtarslanl Z, Canbolat O, Akyol O. A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chim Acta. 1993 Jan;214:103-4. PMID: 8453769.
18. Wasowicz W, Nève J, Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem. 1993 Dec;39:2522-6. PMID: 8252725.
19. Yang CH, Tsai PS, Wang TY, Huang CJ. Dexmedetomidineketamine combination mitigates acute lung injury in haemorrhagic shock rats. Resuscitation. 2009 Oct;80:1204-10. PMID: 19608326.
20. Johnsen SG. Testicular biopsy score count-A method for registration of spermatogenesis in human testis: normal values and result in 352 hypogonadal males. Hormones. 1970;1:2-25. PMID: 5527187.
21. Takhtfooladi MA, Shahzamani M, Takhtfooladi HA, Moayer F, Allahverdi A. Effects of light-emitting diode (LED) therapy on skeletal muscle ischemia reperfusion in rats. Lasers Med Sci. 2015 Jan;30(1):311-6. PMID: 25274196.
22. Takhtfooladi MA, Jahanshahi A, Sotoudeh A, Daneshi MH, Khansari M, Takhtfooladi HA. The antioxidant role of N-acetylcysteine on the testicular remote injury after skeletal muscle ischemia and reperfusion in rats. Pol J Pathol. 2013 Oct;64(3):204-9. PMID: 24166607.
23. Gezici A, Ozturk H, Buyukbayram H, Ozturk H, Okur H. Effects of gabexate mesilate on ischemia-reperfusion-induced testicular injury in rats. Pediatr Surg Int. 2006 May;22(5):435-41. PMID: 16557390.
24. Pekcetin C, Ergur BU, Kiray M, Bagriyanik A, Tugyan K, Erbil G, Ozogul C. The protective effects of trimetazidine on testicular ischemia and reperfusion injury in rats. Pediatr Surg Int. 2007 Nov;23(11):1113-8. PMID: 17704922.
25. Salmasi AH, Beheshtian A, Payabvash S, Demehri S, Ebrahimkhani MR, Karimzadegan M, Bahadori M, Pasalar P, Dehpour AR. Effect of morphine on ischemia-reperfusion injury: experimental study in testicular torsion rat model. Urology. 2005 Dec;66(6):1338-42. PMID: 16360480.
26. Takhtfooladi MA, Moayer F, Takhtfooladi HA. Beneficial effect of pentoxifylline into the testis of rats in an experimental model of unilateral hindlimb ischemia/reperfusion injury. Int Braz J Urol. 2015 May-Jun;41(3):576-83. PMID: 26200554.
27. Takhtfooladi MA, Asghari A, Takhtfooladi HA, Shabani S. The protective role of curcumin on testicular tissue after hindlimb ischemia reperfusion in rats. Int Urol Nephrol. 2015 Oct;47(10):1605-10. PMID: 26347078.
28. Rosen P, Wiernsperger NF. Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress. Diabetes Metab Res Rev. 2006 Jul-Aug;22:323-30. PMID: 16444763.
29. Cicero AF, Tartagni E, Ertek S. Metformin and its clinical use: new insights for an old drug in clinical practice. Arch Med Sci. 2012 Nov;8:907-17. PMID: 23185203.
30. Detaille D, Guigas B, Chauvin C, Batandier C, Fontaine E, Wiernsperger N, Leverve X. Metformin prevents high-glucoseinduced endothelial cell death through a mitochondrial permeability transition-dependent process. Diabetes. 2005 Jul;54:2179-87. PMID: 15983220.
31. Taheri N, Azarmi Y, Neshat M, Garjani A, Doustar Y. Study the effects of metformin on renal function and structure after unilateral ischemia-reperfusion in rat. Res Pharm Sci. 2012;7:77. PMCID: PMC3658943.
32. Rafieian Kopaei M, Baradaran A, Merrikhi A, Nematbakhsh M, Madihi Y, Nasri H. Efficacy of co-administration of garlic extract and metformin for prevention of gentamicin-renal toxicity in wistar rats: a biochemical study. Int J Prev Med. 2013 Mar;4:258-64. PMID: 23626881.
33. Sung JY, Choi HC. Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta. Biochem Biophys Res Commun. 2012 May;421:599-604. PMID: 22525678.
34. Tunckiran A, Cayan S, Bozlu M, Yilmaz N, Acar D, Akbay E. Protective effect of vascular endothelial growth factor on histologic changes in testicular ischemia-reperfusion injury. Fertil Steril. 2003 Aug;84(2):468-73. PMID: 16084892.