Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat

Pediatric Surgery International

Volumn 22, Issue 1, 2006, Pages 99-105

  Mogilner, Jorge G ^a   Lurie, Michael ^a   Coran, Arnold G ^c   Nativ, Ofer ^a   Shiloni, Eitan ^b   Sukhotnik, Igor ^a  

^a BNAI ZION MEDICAL CENTER   (Israel)

^b CARMEL MEDICAL CENTER   (Israel)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Diclofenac; Germ cell apoptosis; Ischemia reperfusion; Testis

Indexed keywords

DICLOFENAC;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; GERM CELL; ISCHEMIA; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPERMATOGENESIS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TESTIS DISEASE; TESTIS INJURY;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; DICLOFENAC; IMMUNOHISTOCHEMISTRY; INFERTILITY, MALE; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPERMATIC CORD TORSION; SPERMATOGENESIS; SPERMATOZOA; TESTIS;

EID: 30144434554     PISSN: 01790358     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00383-005-1580-9     Document Type: Conference Paper

References (24)

1. Baccetti B, Collodel G, Piomboni P (1996) Apoptosis in human ejaculated sperm cells (notulae seminologicae 9). Submicrosc Cytol Pathol 28:587-596
2. Bartke A (1995) Apoptosis of male germ cells, a generalized or cell type-specific phenomenon. Endocrinology 136:3-4
3. Bartsch G, Frank S, Marberger H, Mikuz G (1980) Testicular torsion: late results with special regard to fertility and endocrine function. J Urol 124:375-378
4. Cheuk BL, Chew SB, Fiscus RR, Wong PY (2002) Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. Biol Reprod 66:374-380
5. Chung CK, Koo HN, Chung KY, Shin T, Kim HR, Chae HJ, An NH, Kim CH, Kim HM (2000) Inhibitory effect of sodium salicylate on nitric oxide production from TM4 sertoli cells. Int J Immunopharmacol 22:685-692
6. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A (2004) Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med 25:199-210
7. Harrison RG, Lewis-Jones DI, Moreno de Marval MJ, Connolly RC (1981) Mechanism of damage to the contralateral testis in rats with an ischemic testis. Lancet 2:723-725
8. Hikim AP, Lue Y, Yamamoto CM, Vera Y, Rodriguez S, Yen PH, Soeng K, Wang C, Swerdloff RS (2003) Key apoptotic pathways for heat-induced programmed germ cell death in the testis. Endocrinology 144:3167-3175
9. Johnsen SG (1970) Testicular biopsy score count - a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1:2-25
10. Keller JJ, Giardiello FM (2003) Chemoprevention strategies using NSAIDs and COX-2 inhibitors. Cancer Biol Ther 2(4 Suppl 1):S140-S149
11. Kimura M, Itoh N, Takagi S, Sasao T, Takahashi A, Masumori N, Tsukamoto T (2003) Balance of apoptosis and proliferation of germ cells related to spermatogenesis in aged men. J Androl 24:185-191
12. Lysiak JJ, Nguyen QA, Turner TT (2002) Peptide and non-peptide reactive oxygen scavengers provide partial rescue of the testis after torsion. J Androl 23:400-409
13. Lysiak JJ, Nguyen QA, Kirby JL, Turner TT (2003) Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of C-Jun N-terminal kinase in a pathway to E-selectin expression. Biol Reprod 69:202-210
14. Miller DC, Peron SE, Keck RW, Kropp KA (1990) Effects of hypothermia on testicular ischemia. J Urol 143:1046-1048
15. Mirshafiey A, Khorramizadeh MR, Saadat F, Rehm BH (2004) Chemopreventive effect of M2000, a new anti-inflammatory agent. Med Sci Monit 10:PI105-PI109
16. Modi DN, Sane S, Bhartiya D (2003) Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads. Mol Hum Reprod 9:219-225
17. Puri P, Barton D, O'Donnell B (1985) Prepubertal testicular torsion: subsequent fertility. J Pediatr Surg 12:563-570
18. Smith WL, DeWitt DL, Garavito RM (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69:145-182
19. Sukhotnik I, Miselevich I, Lurie M, Nativ O, Coran AG, Mogilner G (2005) The time relationship between ipsilateral testicular ischemia-reperfusion and germ cell apoptosis in the contralateral testis in rat. Pediatr Surg Int 15:1-5
20. Tarnawski AS, Jones MK (2003) Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications. Mol Med 81:627-636
21. Tomomasa H, Adachi Y, Oshio S, Umeda T, Irie H, Ishikawa H (2002) Germ cell apoptosis in undescended testis: the origin of its impaired spermatogenesis in the TS inbred rat. Urol 168:343-347
22. Turner TT, Tung KS, Tomomasa H, Wilson LW (1997) Acute testicular ischemia results in germ cell-specific apoptosis in the rat. Biol Reprod 57:1267-1274
23. Vane JR, Botting RM (1996) Mechanism of action of anti-inflammatory drugs. Scand J Rheumatol Suppl 102:9-21
24. Walch L, Morris PL (2002) Cyclooxygenase 2 pathway mediates IL-1beta regulation of IL-1alpha, -1beta, and IL-6 mRNA levels in Leydig cell progenitors. Endocrinology 143:3276-3283