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Volumn 65, Issue 7, 2016, Pages 869-874

Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells

Author keywords

CD8+ T cell fate; CITIM 2015; Metabolic reprogramming; Uncoupling protein 2

Indexed keywords

CD8 ANTIGEN; CELL PROTEIN; FATTY ACID; GAMMA INTERFERON; GENIPIN; KLRG1 PROTEIN; L SELECTIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; EPITOPE;

EID: 84976328182     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-016-1851-4     Document Type: Review
Times cited : (17)

References (30)
  • 1
    • 84947591002 scopus 로고    scopus 로고
    • T cell metabolism drives immunity
    • COI: 1:CAS:528:DC%2BC2MXhsVyhsb7L, PID: 26261266
    • Buck MD, O’Sullivan D, Pearce EL (2015) T cell metabolism drives immunity. J Exp Med 212(9):1345–1360. doi:10.1084/jem.20151159
    • (2015) J Exp Med , vol.212 , Issue.9 , pp. 1345-1360
    • Buck, M.D.1    O’Sullivan, D.2    Pearce, E.L.3
  • 2
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • COI: 1:CAS:528:DC%2BC3MXhsFyqtbfN, PID: 21985671
    • Lunt SY, Vander Heiden MG (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 27:441–464. doi:10.1146/annurev-cellbio-092910-154237
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 3
    • 84875494365 scopus 로고    scopus 로고
    • Metabolic regulation of T lymphocytes
    • COI: 1:CAS:528:DC%2BC3sXnsFClsLY%3D, PID: 23298210
    • MacIver NJ, Michalek RD, Rathmell JC (2013) Metabolic regulation of T lymphocytes. Annu Rev Immunol 31:259–283. doi:10.1146/annurev-immunol-032712-095956
    • (2013) Annu Rev Immunol , vol.31 , pp. 259-283
    • MacIver, N.J.1    Michalek, R.D.2    Rathmell, J.C.3
  • 4
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • COI: 1:CAS:528:DC%2BD1MXmtVKlsbg%3D, PID: 19460998
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324(5930):1029–1033. doi:10.1126/science.1160809
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 6
    • 0037033433 scopus 로고    scopus 로고
    • Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression
    • COI: 1:CAS:528:DC%2BD38XjslOjsA%3D%3D, PID: 11781366
    • Devadas S, Zaritskaya L, Rhee SG, Oberley L, Williams MS (2002) Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med 195(1):59–70
    • (2002) J Exp Med , vol.195 , Issue.1 , pp. 59-70
    • Devadas, S.1    Zaritskaya, L.2    Rhee, S.G.3    Oberley, L.4    Williams, M.S.5
  • 7
    • 84874222253 scopus 로고    scopus 로고
    • Mitochondrial ROS fire up T cell activation
    • COI: 1:CAS:528:DC%2BC3sXjtVeltL0%3D, PID: 23438817
    • Murphy MP, Siegel RM (2013) Mitochondrial ROS fire up T cell activation. Immunity 38(2):201–202. doi:10.1016/j.immuni.2013.02.005
    • (2013) Immunity , vol.38 , Issue.2 , pp. 201-202
    • Murphy, M.P.1    Siegel, R.M.2
  • 8
    • 84866562625 scopus 로고    scopus 로고
    • Metabolic checkpoints in activated T cells
    • COI: 1:CAS:528:DC%2BC38XhtlKjsrjK, PID: 22990888
    • Wang R, Green DR (2012) Metabolic checkpoints in activated T cells. Nat Immunol 13(10):907–915. doi:10.1038/ni.2386
    • (2012) Nat Immunol , vol.13 , Issue.10 , pp. 907-915
    • Wang, R.1    Green, D.R.2
  • 10
    • 33748954260 scopus 로고    scopus 로고
    • UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism
    • COI: 1:CAS:528:DC%2BD28XhtVanurfF, PID: 16872578
    • Criscuolo F, Mozo J, Hurtaud C, Nubel T, Bouillaud F (2006) UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism. Biochim Biophys Acta 1757(9–10):1284–1291. doi:10.1016/j.bbabio.2006.06.002
    • (2006) Biochim Biophys Acta , vol.1757 , Issue.9-10 , pp. 1284-1291
    • Criscuolo, F.1    Mozo, J.2    Hurtaud, C.3    Nubel, T.4    Bouillaud, F.5
  • 11
    • 69249211307 scopus 로고    scopus 로고
    • UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism?
    • COI: 1:CAS:528:DC%2BD1MXos1antLo%3D, PID: 19514063
    • Pecqueur C, Alves-Guerra C, Ricquier D, Bouillaud F (2009) UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism? IUBMB Life 61(7):762–767. doi:10.1002/iub.188
    • (2009) IUBMB Life , vol.61 , Issue.7 , pp. 762-767
    • Pecqueur, C.1    Alves-Guerra, C.2    Ricquier, D.3    Bouillaud, F.4
  • 12
    • 38049120264 scopus 로고    scopus 로고
    • Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization
    • COI: 1:CAS:528:DC%2BD1cXkslSqug%3D%3D, PID: 17855623
    • Pecqueur C, Bui T, Gelly C, Hauchard J, Barbot C, Bouillaud F, Ricquier D, Miroux B, Thompson CB (2008) Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB J 22(1):9–18. doi:10.1096/fj.07-8945com
    • (2008) FASEB J , vol.22 , Issue.1 , pp. 9-18
    • Pecqueur, C.1    Bui, T.2    Gelly, C.3    Hauchard, J.4    Barbot, C.5    Bouillaud, F.6    Ricquier, D.7    Miroux, B.8    Thompson, C.B.9
  • 14
    • 21444440464 scopus 로고    scopus 로고
    • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production
    • COI: 1:CAS:528:DC%2BD2MXjvFersrs%3D, PID: 15757894
    • Bai Y, Onuma H, Bai X, Medvedev AV, Misukonis M, Weinberg JB, Cao W, Robidoux J, Floering LM, Daniel KW, Collins S (2005) Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. J Biol Chem 280(19):19062–19069. doi:10.1074/jbc.M500566200
    • (2005) J Biol Chem , vol.280 , Issue.19 , pp. 19062-19069
    • Bai, Y.1    Onuma, H.2    Bai, X.3    Medvedev, A.V.4    Misukonis, M.5    Weinberg, J.B.6    Cao, W.7    Robidoux, J.8    Floering, L.M.9    Daniel, K.W.10    Collins, S.11
  • 15
    • 0037047142 scopus 로고    scopus 로고
    • Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages
    • COI: 1:CAS:528:DC%2BD38XlsVGgtro%3D, PID: 12089332
    • Kizaki T, Suzuki K, Hitomi Y, Taniguchi N, Saitoh D, Watanabe K, Onoe K, Day NK, Good RA, Ohno H (2002) Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA 99(14):9392–9397. doi:10.1073/pnas.142206299
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.14 , pp. 9392-9397
    • Kizaki, T.1    Suzuki, K.2    Hitomi, Y.3    Taniguchi, N.4    Saitoh, D.5    Watanabe, K.6    Onoe, K.7    Day, N.K.8    Good, R.A.9    Ohno, H.10
  • 16
    • 84864532231 scopus 로고    scopus 로고
    • Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation
    • COI: 1:CAS:528:DC%2BC38XhtFOlsLvN, PID: 22870219
    • Rupprecht A, Brauer AU, Smorodchenko A, Goyn J, Hilse KE, Shabalina IG, Infante-Duarte C, Pohl EE (2012) Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation. PLoS One 7(8):e41406. doi:10.1371/journal.pone.0041406
    • (2012) PLoS One , vol.7 , Issue.8 , pp. e41406
    • Rupprecht, A.1    Brauer, A.U.2    Smorodchenko, A.3    Goyn, J.4    Hilse, K.E.5    Shabalina, I.G.6    Infante-Duarte, C.7    Pohl, E.E.8
  • 17
    • 34248140693 scopus 로고    scopus 로고
    • Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death
    • COI: 1:CAS:528:DC%2BD2sXltlantr4%3D, PID: 17339328
    • Kaminski M, Kiessling M, Suss D, Krammer PH, Gulow K (2007) Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol 27(10):3625–3639. doi:10.1128/mcb.02295-06
    • (2007) Mol Cell Biol , vol.27 , Issue.10 , pp. 3625-3639
    • Kaminski, M.1    Kiessling, M.2    Suss, D.3    Krammer, P.H.4    Gulow, K.5
  • 18
    • 65549105815 scopus 로고    scopus 로고
    • UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing
    • COI: 1:CAS:528:DC%2BD1MXlslajurs%3D, PID: 19413946
    • Bouillaud F (2009) UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing. Biochim Biophys Acta 1787(5):377–383. doi:10.1016/j.bbabio.2009.01.003
    • (2009) Biochim Biophys Acta , vol.1787 , Issue.5 , pp. 377-383
    • Bouillaud, F.1
  • 19
    • 77951274305 scopus 로고    scopus 로고
    • Uncoupling protein UCP2: when mitochondrial activity meets immunity
    • COI: 1:CAS:528:DC%2BC3cXks1WgtL0%3D, PID: 20227410
    • Emre Y, Nubel T (2010) Uncoupling protein UCP2: when mitochondrial activity meets immunity. FEBS Lett 584(8):1437–1442. doi:10.1016/j.febslet.2010.03.014
    • (2010) FEBS Lett , vol.584 , Issue.8 , pp. 1437-1442
    • Emre, Y.1    Nubel, T.2
  • 20
    • 80053922625 scopus 로고    scopus 로고
    • Metabolic flux and the regulation of mammalian cell growth
    • COI: 1:CAS:528:DC%2BC3MXht12rtL3F, PID: 21982705
    • Locasale JW, Cantley LC (2011) Metabolic flux and the regulation of mammalian cell growth. Cell Metab 14(4):443–451. doi:10.1016/j.cmet.2011.07.014
    • (2011) Cell Metab , vol.14 , Issue.4 , pp. 443-451
    • Locasale, J.W.1    Cantley, L.C.2
  • 21
    • 33845971563 scopus 로고    scopus 로고
    • The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion
    • COI: 1:CAS:528:DC%2BD28Xht1ajtrrJ, PID: 17001083
    • Joseph JW, Jensen MV, Ilkayeva O, Palmieri F, Alarcon C, Rhodes CJ, Newgard CB (2006) The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. J Biol Chem 281(47):35624–35632. doi:10.1074/jbc.M602606200
    • (2006) J Biol Chem , vol.281 , Issue.47 , pp. 35624-35632
    • Joseph, J.W.1    Jensen, M.V.2    Ilkayeva, O.3    Palmieri, F.4    Alarcon, C.5    Rhodes, C.J.6    Newgard, C.B.7
  • 24
    • 84924975551 scopus 로고    scopus 로고
    • Mitochondria in the regulation of innate and adaptive immunity
    • COI: 1:CAS:528:DC%2BC2MXks12jtrk%3D, PID: 25786173
    • Weinberg SE, Sena LA, Chandel NS (2015) Mitochondria in the regulation of innate and adaptive immunity. Immunity 42(3):406–417. doi:10.1016/j.immuni.2015.02.002
    • (2015) Immunity , vol.42 , Issue.3 , pp. 406-417
    • Weinberg, S.E.1    Sena, L.A.2    Chandel, N.S.3
  • 28
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: a common denominator approach to cancer therapy
    • COI: 1:CAS:528:DC%2BC2MXmtVaku7k%3D, PID: 25858804
    • Topalian SL, Drake CG, Pardoll DM (2015) Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27(4):450–461. doi:10.1016/j.ccell.2015.03.001
    • (2015) Cancer Cell , vol.27 , Issue.4 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 29
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC38XksVegtrw%3D, PID: 22437870
    • Pardoll DM (2012) The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12(4):252–264. doi:10.1038/nrc3239
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.