Novel measures of inflammation and insulin resistance are related to obesity and fitness in a diverse sample of 11-14 year olds: The HEALTHY Study

International Journal of Obesity

Volumn 40, Issue 7, 2016, Pages 1157-1163

  Jago, R ^a   Drews, K L ^b   Otvos, J D ^c   Willi, S M ^d   Buse, J B ^e  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

^c LABORATORY CORPORATION OF AMERICA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCA PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GLYCOPROTEIN;

ADOLESCENT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD ANALYSIS; BODY MASS; BODY WEIGHT; CHILD; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; EVIDENCE BASED PRACTICE; FEMALE; FITNESS; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; PRIORITY JOURNAL; SEX DIFFERENCE; ADIPOSE TISSUE; BLOOD; CHILDHOOD OBESITY; CLUSTER ANALYSIS; COMPLICATION; GLUCOSE BLOOD LEVEL; HEALTH SURVEY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; UNITED STATES;

ADIPOSE TISSUE; ADIPOSITY; ADOLESCENT; BIOMARKERS; BLOOD GLUCOSE; BODY MASS INDEX; CHILD; CLUSTER ANALYSIS; FEMALE; GLYCOPROTEINS; HEALTH SURVEYS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; LIPOPROTEINS; MALE; PEDIATRIC OBESITY; PHYSICAL FITNESS; UNITED STATES;

EID: 84976306075     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2016.84     Document Type: Article

References (52)

1. Lee CD, Blair SN, Jackson AS. Cardiorespiratory fitness, body composition, and allcause and cardiovascular disease mortality in men. Am J Clin Nutr 1999; 69: 373-380
2. Sui X, Hooker SP, Lee IM, Church TS, Colabianchi N, Lee CD, et al. A prospective study of cardiorespiratory fitness and risk of type 2 diabetes in women. Diabetes Care 2007; 31: 550-555
3. Shah RV, Murthy VL, Colangelo LA, Reis J, Venkatesh BA, Sharma R, et al. Association of fitness in young adulthood with survival and cardiovascular risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Intern Med 2016; 176: 87-95
4. Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients 2013; 5: 1218-1240
5. Lavie CJ, Arena R, Swift DL, Johannsen NM, Sui X, Lee DC, et al. Exercise and the cardiovascular system: clinical science and cardiovascular outcomes. Circ Res 2015; 117: 207-219
6. Vasconcellos F, Seabra A, Katzmarzyk PT, Kraemer-Aguiar LG, Bouskela E, Farinatti P. Physical activity in overweight and obese adolescents: systematic review of the effects on physical fitness components and cardiovascular risk factors. Sports Med 2014; 44: 1139-1152
7. Tam CS, Clement K, Baur LA, Tordjman J. Obesity and low-grade inflammation: a paediatric perspective. Obes Rev 2010; 11: 118-126
8. Whitaker RC, Wright JA, Pepe MS, Seidel KD. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997; 337: 869-873
9. Twisk JWR, Kemper HCG, Mechelen WV. Tracking of activity and fitness and the relationsship with cardiovascualr disease risk factors. Med Sci Sports Exerc 2000; 32: 1455-1461
10. McMurray RG, Harrell JS, Bangdiwala SI, Hu J. Tracking of physical activity and aerobic power from childhood through adolescence. Med Sci Sports Exerc 2003; 35: 1914-1922
11. Choi J, Joseph L, Pilote L. Obesity and C-reactive protein in various populations: a systematic review and meta-Analysis. Obes Rev 2013; 14: 232-244
12. Otvos JD, Shalaurova I, Wolak-Dinsmore J, Connelly MA, Mackey RH, Stein JH, et al. GlycA: A novel nuclear magnetic resonance biomarker of systemic inflamation. Clin Chem 2015; 61: 714-723
13. Shalaurova I, Connelly MA, Garvey WT, Otvos JD. Lipoprotein insulin resistance index: a lipoprotein particle-derived measure of insulin resistance. Metab Syndr Relat Disord 2014; 12: 422-429
14. Jeyarajah EJ, Cromwell WC, Otvos JD. Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy. Clin Lab Med 2006; 26: 847-870
15. Akinkuolie AO, Pradhan AD, Ridker PM, Mora S. Novel protein glycan derived biomarker is associated with incident diabetes. Circulation 2013; 2013: A18807
16. Connelly MA, Gruppen EG, Wolak-Dinsmore J, Matyus SP, Riphagen IJ, Shalaurova I, et al. GlycA, a marker of acute phase glycoproteins, and the risk of incident type 2 diabetes mellitus: PREVEND study. Clin Chim Acta 2016; 452: 10-17
17. Akinkuolie AO, Buring JE, Ridker PM, Mora S. A novel protein glycan biomarker and future cardiovascular disease events. J Amer Heart Assoc 2014; 3: e001221
18. Akinkuolie AO, Glynn RJ, Ridker PM, Mora S. Protein glycan side-chains, rosuvatatin theraphy, and incident vascular events: an analysis from the JUPITER trial. Circulation 2014; 130: A2509
19. Duprez D, Neuhaus J, Otvos J, Neaton JD, Lundgren JD. GlycA, a novel marker of inflammataion, predicts cardiovascualr events in HIC-positive patients: results of SMART study. Circulation 2014; 130: A14731
20. Gruppen EG, Riphagen IJ, Connelly MA, Otvos JD, Bakker SJ, Dullaart RP. GlycA, a pro-inflammatory glycoprotein biomarker, and incident cardiovascular disease: relationship with C-reactive protein and renal function. PLoS One 2015; 10: e0139057
21. Mora S, Otvos JD, Rosenson RS, Pradhan A, Buring JE, Ridker PM. Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women. Diabetes 2010; 59: 1153-1160
22. Mackey RH, Mora S, Bertoni AG, Wassel CL, Carnethon MR, Sibley CT, et al. Lipoprotein particles and incident type 2 diabetes in the multi-ethnic study of atherosclerosis. Diabetes Care 2015; 38: 628-636
23. Mietus-Snyder M, Drews KL, Otvos JD, Willi SM, Foster GD, Jago R, et al. Low-density lipoprotein cholesterol versus particle number in middle school children. J Pediatr 2013; 163: 355-362
24. Jago R, Drews KL, Otvos JD, Foster GD, Marcus MD, Buse JB, et al. Effect of relative weight group change on nuclear magnetic resonance spectroscopy derived lipoprotein particle size and concentrations among adolescents. J Pediatr 2014; 164: 1091-1098 e3
25. Buse J, Hirst K. The HEALTHY study: introduction. Int J Obes (Lond) 2009; 33(Suppl 4): S1-S2
26. The Healthy Study Group. A school-vased intervention for diabetes risk reduction. N Engl J Med 2010; 363: 445-453
27. DeBar LL, Schneider M, Ford EG, Hernandez AE, Showell B, Drews KL, et al. Social marketing-based communications to integrate and support the HEALTHY study intervention. Int J Obes (Lond) 2009; 33 (Suppl 4): S52-S59
28. Gillis B, Mobley C, Stadler DD, Hartstein J, Virus A, Volpe SL, et al. Rationale, design and methods of the HEALTHY study nutrition intervention component. Int J Obes (Lond) 2009; 33 (Suppl 4): S29-S36
29. Jago R, McMurray RG, Drews KL, Moe EL, Murray T, Pham TH, et al. HEALTHY intervention: fitness, physical activity, and metabolic syndrome results. Med Sci Sports Exerc 2011; 43: 1513-1522
30. Venditti EM, Elliot DL, Faith MS, Firrell LS, Giles CM, Goldberg L, et al. Rationale, design and methods of the HEALTHY study behavior intervention component. Int J Obes (Lond) 2009; 33 (Suppl 4): S44-S51
31. Foster GD, Linder B, Baranowski T, Cooper DM, Goldberg L, Harrell JS, et al. A school-based intervention for diabetes risk reduction. N Engl J Med 2010; 363: 443-453
32. McMurray RG, Bassin S, Jago R, Bruecker S, Moe EL, Murray T, et al. Rationale, design and methods of the HEALTHY study physical education intervention component. Int J Obes (Lond) 2009; 33 (Suppl 4): S37-S43
33. Jago R, Bailey R. Ethics and paediatric exercise science: Issues and making a submission to a local ethics and research committee. J Sport Sci 2001; 19: 527-535
34. Petersen AC, Crockett L, Richards M, Boxer A. A self-report measure of pubertal status: reliability, validity, and initial norms. Youth Adol 1988; 17: 117-133
35. Tanner JM. Growth at Adolescence. Blackwell: Oxford, 1962
36. Centers for Disease Control National Center for Health Statistics. 2000 CDC growth charts for the United States. In. Atlanta Centers for Disease Control, 2009
37. Leger LA, Lambert J. A maximal multistage 20-m shuttle run test to predict VO2 max. Eur J Appl Physiol Occup Physiol 1982; 49: 1-12
38. Leger LA, Mercier D, Gadoury C, Lambert J. The multistage 20 metre shuttle run test for aerobic fitness. J Sports Sci 1988; 6: 93-101
39. Willi SM, Hirst K, Jago R, Buse J, Kaufman F, El Ghormli L, et al. Cardiovascular risk factors in multi-ethnic middle school students: the HEALTHY primary prevention trial. Pediatr Obes 2012; 7: 230-239
40. Fridewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502
41. Marcovina S, Bowsher RR, Miller WG, Staten M, Myers G, Caudill SP, et al. Standardization of insulin immunoassays: report of the American Diabetes Association Workgroup. Clin Chem 2007; 53: 711-716
42. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419
43. Williams MJ, Milne BJ, Hancox RJ, Poulton R. C-reactive protein and cardiorespiratory fitness in young adults. Eur J Cardiovasc Prev Rehabil 2005; 12: 216-220
44. Balducci S, Zanuso S, Cardelli P, Salvi L, Mazzitelli G, Bazuro A, et al. Changes in physical fitness predict improvements in modifiable cardiovascular risk factors independently of body weight loss in subjects with type 2 diabetes participating in the Italian Diabetes and Exercise Study (IDES). Diabetes Care 2012; 35: 1347-1354
45. Martinez-Gomez D, Eisenmann JC, Warnberg J, Gomez-Martinez S, Veses A, Veiga OL, et al. Associations of physical activity, cardiorespiratory fitness and fatness with low-grade inflammation in adolescents: the AFINOS Study. Int J Obes (Lond) 2010; 34: 1501-1507
46. Lakoski SG, Cushman M, Criqui M, Rundek T, Blumenthal RS, D'Agostino RB Jr., et al. Gender and C-reactive protein: data from the Multiethnic Study of Atherosclerosis (MESA) cohort. Amer Heart J 2006; 152: 593-598
47. Ford ES, Giles WH, Mokdad AH, Myers GL. Distribution and correlates of C-reactive protein concentrations among adult US women. Clin Chem 2004; 50: 574-581
48. Cushman M, Arnold AM, Psaty BM, Manolio TA, Kuller LH, Burke GL, et al. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. Circulation 2005; 112: 25-31
49. Moran A, Jacobs DR Jr., Steinberger J, Hong CP, Prineas R, Luepker R, et al. Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 1999; 48: 2039-2044
50. Liu NY, Plowman SA, Looney MA. The reliability and validity of the 20-meter shuttle test in American students 12 to 15 years old. Res Q Exerc Sport 1992; 63: 360-365
51. van Mechelen W, Hlobil H, Kemper HC. Validation of two running tests as estimates of maximal aerobic power in children. Eur J Appl Physiol Occup Physiol 1986; 55: 503-506
52. Boreham CA, Paliczka VJ, Nichols AK. A comparison of the PWC170 and 20-MST tests of aerobic fitness in adolescent schoolchildren. J Sports Med Phys Fitness 1990; 30: 19-23