HIV-specific Th2 and Th17 responses predict HIV vaccine protection efficacy

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Sauce, Delphine ^a   Gorochov, Guy ^a,b   Larsen, Martin ^a,b  

^a SORBONNE UNIVERSITÉ   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERLEUKIN 2;

CLINICAL TRIAL; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PREDICTIVE VALUE; PROGNOSIS; STATISTICAL ANALYSIS; TH17 CELL; TH2 CELL; THEORETICAL MODEL; VACCINATION;

AIDS VACCINES; CD40 LIGAND; DATA INTERPRETATION, STATISTICAL; FOLLOW-UP STUDIES; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MODELS, THEORETICAL; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TH17 CELLS; TH2 CELLS; VACCINATION;

EID: 84975883508     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep28129     Document Type: Article

References (17)

1. Darrah, P. A. et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 13, 843-850 (2007).
2. Haynes, B. F. et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med 366, 1275-1286 (2012).
3. Lin, L. et al. COMPASS identifies T-cell subsets correlated with clinical outcomes. Nat Biotechnol 33, 610-616 (2015).
4. Rerks-Ngarm, S. et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 361, 2209-2220 (2009).
5. Larsen, M. et al. Evaluating cellular polyfunctionality with a novel polyfunctionality index. PLoS One 7, e42403 (2012).
6. Almeida, J. R. et al. Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity. Blood 113, 6351-6360 (2009).
7. Appay, V., Douek, D. C. & Price, D. A. CD8+ T cell efficacy in vaccination and disease. Nat Med 14, 623-628 (2008).
8. Boyd, A. et al. Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection. PLoS One 10, e0128714 (2015).
9. Zhou, L., Chong, M. M. & Littman, D. R. Plasticity of CD4+ T cell lineage differentiation. Immunity 30, 646-655 (2009).
10. Dong, C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol 8, 337-348 (2008).
11. Larsen, M. et al. Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets. Eur J Immunol 41, 2596-2605 (2011).
12. Buchholz, V. R., Schumacher, T. N. & Busch, D. H. T Cell Fate at the Single-Cell Level. Annu Rev Immunol, doi: 10.1146/annurevimmunol-032414-112014 (2015).
13. Lipsky, P. E., Attrep, J. F., Grammer, A. C., McIlraith, M. J. & Nishioka, Y. Analysis of CD40-CD40 ligand interactions in the regulation of human B cell function. Ann N Y Acad Sci 815, 372-383 (1997).
14. Quezada, S. A., Jarvinen, L. Z., Lind, E. F. & Noelle, R. J. CD40/CD154 interactions at the interface of tolerance and immunity. Annu Rev Immunol 22, 307-328 (2004).
15. Khader, S. A., Gaffen, S. L. & Kolls, J. K. Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol 2, 403-411 (2009).
16. DeLong, E. R., DeLong, D. M. & Clarke-Pearson, D. L. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44, 837-845 (1988).
17. Robin, X. et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics 12, 77 (2011).