Synthesis of new secretory phospholipase A2-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents

European Journal of Medicinal Chemistry

Volumn 112, Issue , 2016, Pages 289-297

  Pedada, Srinivasa Rao ^a   Yarla, Nagendra Sastry ^b   Tambade, Pawan J ^c   Dhananjaya, Bhadrapura Lakkappa ^d   Bishayee, Anupam ^e   Arunasree, Kalle M ^f   Philip, Gundala Harold ^g   Dharmapuri, Gangappa ^f,g   Aliev, Gjumrach ^h,i,j   Putta, Swathi ^k   Rangaiah, Gururaja ^l  

^a PRIST UNIVERSITY   (India)

^b GITAM UNIVERSITY   (India)

^c Commerce and Science College ^*  (India)

^d JAIN UNIVERSITY   (India)

^e Larkin Health Science Institute   (United States)

^f UNIVERSITY OF HYDERABAD   (India)

^g SRI KRISHNADEVARAYA UNIVERSITY   (India)

^h GALLY International Biomedical Research Institute Inc   (United States)

ⁱ University of Atlanta   (United States)

^j INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

^k ANDHRA UNIVERSITY   (India)

^l Sarada Vilas College of Pharmacy   (India)

more..

Author keywords

Anti inflammatory activity; Anticancer; Indole; Isooxazole; Secretory phospholipase A2

Indexed keywords

(3 (4 FLUORO 3 (TRIFLUOROMETHYL)PHENYL)ISOXAZOL 5 YL) N ((5 METHYL 1H INDOL 3 YL)METHYL)METHANAMINE; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; DOXORUBICIN; INDOLE; ISOXAZOLE DERIVATIVE; PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG; URSOLIC ACID; INDOLE DERIVATIVE; SECRETORY PHOSPHOLIPASE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; DU145 CELL LINE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MCF-7 CELL LINE; MOLECULAR DOCKING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; FEMALE; METABOLISM; MOLECULAR MODEL; MOUSE; PROSTATIC NEOPLASMS; SYNTHESIS; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; INDOLES; ISOXAZOLES; MALE; MICE; MODELS, MOLECULAR; PHOSPHOLIPASES A2, SECRETORY; PROSTATIC NEOPLASMS; RATS, WISTAR;

EID: 84975783121     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.02.025     Document Type: Article

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