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Volumn 4, Issue 4, 2016, Pages 291-305

Combination therapy versus monotherapy for pulmonary arterial hypertension: A meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

AMBRISENTAN; BOSENTAN; ILOPROST; MACITENTAN; RIOCIGUAT; SELEXIPAG; SILDENAFIL; TADALAFIL; TREPROSTINIL; ANTIHYPERTENSIVE AGENT; ENDOTHELIN RECEPTOR ANTAGONIST; PHOSPHODIESTERASE V INHIBITOR;

EID: 84975763563     PISSN: 22132600     EISSN: 22132619     Source Type: Journal    
DOI: 10.1016/S2213-2600(16)00027-8     Document Type: Article
Times cited : (196)

References (49)
  • 1
    • 84890738424 scopus 로고    scopus 로고
    • Updated clinical classification of pulmonary hypertension
    • Simonneau G, Gatzoulis MA, Adatia I, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2013, 62:D34-D41.
    • (2013) J Am Coll Cardiol , vol.62 , pp. D34-D41
    • Simonneau, G.1    Gatzoulis, M.A.2    Adatia, I.3
  • 2
    • 84943272997 scopus 로고    scopus 로고
    • 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
    • Galiè N, Humbert M, Vachiery J-L, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 2015, 46:903-975.
    • (2015) Eur Respir J , vol.46 , pp. 903-975
    • Galiè, N.1    Humbert, M.2    Vachiery, J.-L.3
  • 3
    • 4644290657 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension
    • Humbert M, Sitbon O, Simonneau G Treatment of pulmonary arterial hypertension. N Engl J Med 2004, 351:1425-1436.
    • (2004) N Engl J Med , vol.351 , pp. 1425-1436
    • Humbert, M.1    Sitbon, O.2    Simonneau, G.3
  • 4
    • 4544383466 scopus 로고    scopus 로고
    • Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
    • Humbert M, Barst RJ, Robbins IM, et al. Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur Respir J 2004, 24:353-359.
    • (2004) Eur Respir J , vol.24 , pp. 353-359
    • Humbert, M.1    Barst, R.J.2    Robbins, I.M.3
  • 5
    • 84880721470 scopus 로고    scopus 로고
    • Riociguat for the treatment of pulmonary arterial hypertension
    • Ghofrani H-A, Galiè N, Grimminger F, et al. Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med 2013, 369:330-340.
    • (2013) N Engl J Med , vol.369 , pp. 330-340
    • Ghofrani, H.-A.1    Galiè, N.2    Grimminger, F.3
  • 6
    • 84890574392 scopus 로고    scopus 로고
    • Updated treatment algorithm of pulmonary arterial hypertension
    • Galiè N, Corris PA, Frost A, et al. Updated treatment algorithm of pulmonary arterial hypertension. J Am Coll Cardiol 2013, 62:D60-D72.
    • (2013) J Am Coll Cardiol , vol.62 , pp. D60-D72
    • Galiè, N.1    Corris, P.A.2    Frost, A.3
  • 7
    • 84863528040 scopus 로고    scopus 로고
    • Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension
    • Simonneau G, Torbicki A, Hoeper MM, et al. Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J 2012, 40:874-880.
    • (2012) Eur Respir J , vol.40 , pp. 874-880
    • Simonneau, G.1    Torbicki, A.2    Hoeper, M.M.3
  • 8
    • 67649588196 scopus 로고    scopus 로고
    • Updated evidence-based treatment algorithm in pulmonary arterial hypertension
    • Barst RJ, Gibbs JSR, Ghofrani HA, et al. Updated evidence-based treatment algorithm in pulmonary arterial hypertension. J Am Coll Cardiol 2009, 54:S78-S84.
    • (2009) J Am Coll Cardiol , vol.54 , pp. S78-S84
    • Barst, R.J.1    Gibbs, J.S.R.2    Ghofrani, H.A.3
  • 10
    • 77955953602 scopus 로고    scopus 로고
    • Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension
    • Humbert M, Sitbon O, Yaïci A, et al. Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension. Eur Respir J 2010, 36:549-555.
    • (2010) Eur Respir J , vol.36 , pp. 549-555
    • Humbert, M.1    Sitbon, O.2    Yaïci, A.3
  • 11
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M, Sitbon O, Chaouat A, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 2010, 122:156-163.
    • (2010) Circulation , vol.122 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 12
    • 84860404865 scopus 로고    scopus 로고
    • Meta-analysis of monotherapy versus combination therapy for pulmonary arterial hypertension
    • Fox BD, Shimony A, Langleben D Meta-analysis of monotherapy versus combination therapy for pulmonary arterial hypertension. Am J Cardiol 2011, 108:1177-1182.
    • (2011) Am J Cardiol , vol.108 , pp. 1177-1182
    • Fox, B.D.1    Shimony, A.2    Langleben, D.3
  • 13
    • 33847368988 scopus 로고    scopus 로고
    • Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
    • Hoeper MM, Leuchte H, Halank M, et al. Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur Respir J 2006, 28:691-694.
    • (2006) Eur Respir J , vol.28 , pp. 691-694
    • Hoeper, M.M.1    Leuchte, H.2    Halank, M.3
  • 14
    • 33845526777 scopus 로고    scopus 로고
    • Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension
    • McLaughlin VV, Oudiz RJ, Frost A, et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am J Respir Crit Care Med 2006, 174:1257-1263.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1257-1263
    • McLaughlin, V.V.1    Oudiz, R.J.2    Frost, A.3
  • 15
    • 54549125950 scopus 로고    scopus 로고
    • Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial
    • Simonneau G, Rubin LJ, Galiè N, et al. Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial. Ann Intern Med 2008, 149:521-530.
    • (2008) Ann Intern Med , vol.149 , pp. 521-530
    • Simonneau, G.1    Rubin, L.J.2    Galiè, N.3
  • 16
    • 77952301237 scopus 로고    scopus 로고
    • Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial
    • McLaughlin VV, Benza RL, Rubin LJ, et al. Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. J Am Coll Cardiol 2010, 55:1915-1922.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 1915-1922
    • McLaughlin, V.V.1    Benza, R.L.2    Rubin, L.J.3
  • 17
    • 67649523052 scopus 로고    scopus 로고
    • Tadalafil therapy for pulmonary arterial hypertension
    • Galiè N, Brundage BH, Ghofrani HA, et al. Tadalafil therapy for pulmonary arterial hypertension. Circulation 2009, 119:2894-2903.
    • (2009) Circulation , vol.119 , pp. 2894-2903
    • Galiè, N.1    Brundage, B.H.2    Ghofrani, H.A.3
  • 18
    • 84863984607 scopus 로고    scopus 로고
    • Validation of 6-minute walk distance as a surrogate end point in pulmonary arterial hypertension trials
    • Gabler NB, French B, Strom BL, et al. Validation of 6-minute walk distance as a surrogate end point in pulmonary arterial hypertension trials. Circulation 2012, 126:349-356.
    • (2012) Circulation , vol.126 , pp. 349-356
    • Gabler, N.B.1    French, B.2    Strom, B.L.3
  • 19
    • 84866362803 scopus 로고    scopus 로고
    • Do changes of 6-minute walk distance predict clinical events in patients with pulmonary arterial hypertension? A meta-analysis of 22 randomized trials
    • Savarese G, Paolillo S, Costanzo P, et al. Do changes of 6-minute walk distance predict clinical events in patients with pulmonary arterial hypertension? A meta-analysis of 22 randomized trials. J Am Coll Cardiol 2012, 60:1192-1201.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 1192-1201
    • Savarese, G.1    Paolillo, S.2    Costanzo, P.3
  • 20
    • 84874027381 scopus 로고    scopus 로고
    • Baseline and follow-up 6-min walk distance and brain natriuretic peptide predict 2-year mortality in pulmonary arterial hypertension
    • Fritz JS, Blair C, Oudiz RJ, et al. Baseline and follow-up 6-min walk distance and brain natriuretic peptide predict 2-year mortality in pulmonary arterial hypertension. Chest 2013, 143:315.
    • (2013) Chest , vol.143 , pp. 315
    • Fritz, J.S.1    Blair, C.2    Oudiz, R.J.3
  • 21
    • 0028895409 scopus 로고
    • Methodologic guidelines for systematic reviews of randomized control trials in health care from the Potsdam Consultation on Meta-Analysis
    • Cook DJ, Sackett DL, Spitzer WO Methodologic guidelines for systematic reviews of randomized control trials in health care from the Potsdam Consultation on Meta-Analysis. J Clin Epidemiol 1995, 48:167-171.
    • (1995) J Clin Epidemiol , vol.48 , pp. 167-171
    • Cook, D.J.1    Sackett, D.L.2    Spitzer, W.O.3
  • 22
    • 0019432398 scopus 로고
    • Clinical biostatistics. LIV. The biostatistics of concordance
    • Kramer MS, Feinstein AR Clinical biostatistics. LIV. The biostatistics of concordance. Clin Pharmacol Ther 1981, 29:111-123.
    • (1981) Clin Pharmacol Ther , vol.29 , pp. 111-123
    • Kramer, M.S.1    Feinstein, A.R.2
  • 23
    • 84859001212 scopus 로고    scopus 로고
    • The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
    • Higgins JPT, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011, 343:d5928.
    • (2011) BMJ , vol.343 , pp. d5928
    • Higgins, J.P.T.1    Altman, D.G.2    Gøtzsche, P.C.3
  • 24
    • 67649574735 scopus 로고    scopus 로고
    • End points and clinical trial design in pulmonary arterial hypertension
    • McLaughlin VV, Badesch DB, Delcroix M, et al. End points and clinical trial design in pulmonary arterial hypertension. J Am Coll Cardiol 2009, 54:S97-107.
    • (2009) J Am Coll Cardiol , vol.54 , pp. S97-107
    • McLaughlin, V.V.1    Badesch, D.B.2    Delcroix, M.3
  • 25
    • 84926434654 scopus 로고    scopus 로고
    • Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range
    • Wan X, Wang W, Liu J, Tong T Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 2014, 14:135.
    • (2014) BMC Med Res Methodol , vol.14 , pp. 135
    • Wan, X.1    Wang, W.2    Liu, J.3    Tong, T.4
  • 27
    • 0033198316 scopus 로고    scopus 로고
    • Random-effects meta-analyses are not always conservative
    • Poole C, Greenland S Random-effects meta-analyses are not always conservative. Am J Epidemiol 1999, 150:469-475.
    • (1999) Am J Epidemiol , vol.150 , pp. 469-475
    • Poole, C.1    Greenland, S.2
  • 28
    • 0033667604 scopus 로고    scopus 로고
    • Publication bias: a brief review for clinicians
    • Montori VM, Smieja M, Guyatt GH Publication bias: a brief review for clinicians. Mayo Clin Proc 2000, 75:1284-1288.
    • (2000) Mayo Clin Proc , vol.75 , pp. 1284-1288
    • Montori, V.M.1    Smieja, M.2    Guyatt, G.H.3
  • 29
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 30
    • 84925548115 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • Moher D, Liberati A, Tetzlaff J, Altman DG Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009, 62:1006-1012.
    • (2009) J Clin Epidemiol , vol.62 , pp. 1006-1012
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 31
    • 79955845135 scopus 로고    scopus 로고
    • Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hypertension
    • Barst RJ, Oudiz RJ, Beardsworth A, et al. Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hypertension. J Heart Lung Transplant 2011, 30:632-643.
    • (2011) J Heart Lung Transplant , vol.30 , pp. 632-643
    • Barst, R.J.1    Oudiz, R.J.2    Beardsworth, A.3
  • 32
    • 84938823530 scopus 로고    scopus 로고
    • Initial use of ambrisentan plus tadalafil in pulmonary arterial hypertension
    • Galiè N, Barberà JA, Frost AE, et al. Initial use of ambrisentan plus tadalafil in pulmonary arterial hypertension. N Engl J Med 2015, 373:834-844.
    • (2015) N Engl J Med , vol.373 , pp. 834-844
    • Galiè, N.1    Barberà, J.A.2    Frost, A.E.3
  • 33
    • 77952019637 scopus 로고    scopus 로고
    • Combination therapy with bosentan and sildenafil in Eisenmenger syndrome: a randomized, placebo-controlled, double-blinded trial
    • Iversen K, Jensen AS, Jensen TV, Vejlstrup NG, Søndergaard L Combination therapy with bosentan and sildenafil in Eisenmenger syndrome: a randomized, placebo-controlled, double-blinded trial. Eur Heart J 2010, 31:1124-1131.
    • (2010) Eur Heart J , vol.31 , pp. 1124-1131
    • Iversen, K.1    Jensen, A.S.2    Jensen, T.V.3    Vejlstrup, N.G.4    Søndergaard, L.5
  • 34
    • 84938903925 scopus 로고    scopus 로고
    • Bosentan added to sildenafil therapy in patients with pulmonary arterial hypertension
    • McLaughlin V, Channick RN, Ghofrani H-A, et al. Bosentan added to sildenafil therapy in patients with pulmonary arterial hypertension. Eur Respir J 2015, 46:405-413.
    • (2015) Eur Respir J , vol.46 , pp. 405-413
    • McLaughlin, V.1    Channick, R.N.2    Ghofrani, H.-A.3
  • 35
    • 84883108940 scopus 로고    scopus 로고
    • Macitentan and morbidity and mortality in pulmonary arterial hypertension
    • Pulido T, Adzerikho I, Channick RN, et al. Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med 2013, 369:809-818.
    • (2013) N Engl J Med , vol.369 , pp. 809-818
    • Pulido, T.1    Adzerikho, I.2    Channick, R.N.3
  • 36
    • 84951967550 scopus 로고    scopus 로고
    • Selexipag for the treatment of pulmonary arterial hypertension
    • Sitbon O, Channick RC, Chin KM, et al. Selexipag for the treatment of pulmonary arterial hypertension. N Engl J Med 2015, 373:2522-2533.
    • (2015) N Engl J Med , vol.373 , pp. 2522-2533
    • Sitbon, O.1    Channick, R.C.2    Chin, K.M.3
  • 37
    • 84880766215 scopus 로고    scopus 로고
    • Oral treprostinil for the treatment of pulmonary arterial hypertension in patients receiving background endothelin receptor antagonist and phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C2 study): a randomized controlled trial
    • Tapson VF, Jing ZC, Xu KF, et al. Oral treprostinil for the treatment of pulmonary arterial hypertension in patients receiving background endothelin receptor antagonist and phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C2 study): a randomized controlled trial. Chest 2013, 144:952-958.
    • (2013) Chest , vol.144 , pp. 952-958
    • Tapson, V.F.1    Jing, Z.C.2    Xu, K.F.3
  • 38
    • 84866515810 scopus 로고    scopus 로고
    • Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study): a randomized controlled trial
    • Tapson VF, Torres F, Kermeen F, et al. Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study): a randomized controlled trial. Chest 2012, 142:1383-1390.
    • (2012) Chest , vol.142 , pp. 1383-1390
    • Tapson, V.F.1    Torres, F.2    Kermeen, F.3
  • 39
    • 84902012561 scopus 로고    scopus 로고
    • Randomized study of adding tadalafil to existing ambrisentan in pulmonary arterial hypertension
    • Zhuang Y, Jiang B, Gao H, Zhao W Randomized study of adding tadalafil to existing ambrisentan in pulmonary arterial hypertension. Hypertens Res 2014, 37:507-512.
    • (2014) Hypertens Res , vol.37 , pp. 507-512
    • Zhuang, Y.1    Jiang, B.2    Gao, H.3    Zhao, W.4
  • 40
    • 45249119855 scopus 로고    scopus 로고
    • Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial
    • Galiè N, Rubin L, Hoeper M, et al. Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet 2008, 371:2093-2100.
    • (2008) Lancet , vol.371 , pp. 2093-2100
    • Galiè, N.1    Rubin, L.2    Hoeper, M.3
  • 41
    • 84920263628 scopus 로고    scopus 로고
    • Effect of macitentan on hospitalizations: results from the SERAPHIN trial
    • Channick RN, Delcroix M, Ghofrani H-A, et al. Effect of macitentan on hospitalizations: results from the SERAPHIN trial. JACC Heart Fail 2015, 3:1-8.
    • (2015) JACC Heart Fail , vol.3 , pp. 1-8
    • Channick, R.N.1    Delcroix, M.2    Ghofrani, H.-A.3
  • 42
    • 84887343852 scopus 로고    scopus 로고
    • Efficacy of riociguat in pretreated versus treatment-naive patients with pulmonary arterial hypertension (PAH) in the phase III PATENT-1 study (ATS journals)
    • Humbert MJC, Galiè N, Hossein AG, et al. Efficacy of riociguat in pretreated versus treatment-naive patients with pulmonary arterial hypertension (PAH) in the phase III PATENT-1 study (ATS journals). Am J Respir Crit Care Med 2013, 187:A3534.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. A3534
    • Humbert, M.J.C.1    Galiè, N.2    Hossein, A.G.3
  • 43
    • 49149103553 scopus 로고    scopus 로고
    • Bosentan improves hemodynamics in patients receiving background sildenafil treatment: results from EARLY a randomized, double-blind, placebo controlled study in patients with mildly symptomatic pulmonary arterial hypertension
    • Rubin LJ, Simonneau G, Hoeper MM, Jansa P, Kusic-Pajic A, Galie N Bosentan improves hemodynamics in patients receiving background sildenafil treatment: results from EARLY a randomized, double-blind, placebo controlled study in patients with mildly symptomatic pulmonary arterial hypertension. Chest 2007, 132:487.
    • (2007) Chest , vol.132 , pp. 487
    • Rubin, L.J.1    Simonneau, G.2    Hoeper, M.M.3    Jansa, P.4    Kusic-Pajic, A.5    Galie, N.6
  • 44
    • 84887371563 scopus 로고    scopus 로고
    • Baseline characteristics and response to treatment in pretreated versus treatment-naïve patients with pulmonary arterial hypertension (PAH) in the phase III PATENT-1 study
    • Langleben D, Galie N, He J, et al. Baseline characteristics and response to treatment in pretreated versus treatment-naïve patients with pulmonary arterial hypertension (PAH) in the phase III PATENT-1 study. American Thoracic Society 2013, A3532.
    • (2013) American Thoracic Society , pp. A3532
    • Langleben, D.1    Galie, N.2    He, J.3
  • 46
    • 84887476582 scopus 로고    scopus 로고
    • Evaluation of the predictive value of a clinical worsening definition using 2-year outcomes in patients with pulmonary arterial hypertension: a REVEAL Registry analysis
    • Frost AE, Badesch DB, Miller DP, Benza RL, Meltzer LA, McGoon MD Evaluation of the predictive value of a clinical worsening definition using 2-year outcomes in patients with pulmonary arterial hypertension: a REVEAL Registry analysis. Chest 2013, 144:1521-1529.
    • (2013) Chest , vol.144 , pp. 1521-1529
    • Frost, A.E.1    Badesch, D.B.2    Miller, D.P.3    Benza, R.L.4    Meltzer, L.A.5    McGoon, M.D.6
  • 47
    • 84907190841 scopus 로고    scopus 로고
    • Effect of pulmonary arterial hypertension-specific therapies on health-related quality of life: a systematic review
    • Rival G, Lacasse Y, Martin S, Bonnet S, Provencher S Effect of pulmonary arterial hypertension-specific therapies on health-related quality of life: a systematic review. Chest 2014, 146:686-708.
    • (2014) Chest , vol.146 , pp. 686-708
    • Rival, G.1    Lacasse, Y.2    Martin, S.3    Bonnet, S.4    Provencher, S.5
  • 48
    • 77954759389 scopus 로고    scopus 로고
    • Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)
    • Benza RL, Miller DP, Gomberg-Maitland M, et al. Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 2010, 122:164-172.
    • (2010) Circulation , vol.122 , pp. 164-172
    • Benza, R.L.1    Miller, D.P.2    Gomberg-Maitland, M.3


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